Analysis of the role transcription factors, especially c-Maf, play in the differentiation and functions of T helper cells

• Project/Area Number: 23591467
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Saitama Medical University
• Principal Investigator: SATO Kojiro 埼玉医科大学, 医学部, 講師 (10372434)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: c-Maf / メモリー / Th細胞 / リンパ球 / IL-17 / Th17 / エフェクター細胞 / メモリー細胞 / ヘルパーT細胞 / 転写因子

Research Abstract

In the analysis of T-cell specific c-Maf transgenic (Tg) mice, we observed that Tg Th cells have effector/memory phenotypes. When effector/memory Th cells were induced by transferring WT Th cells into Rag2 deficient mice, these cells also expressed c-Maf at high level. Based on these observations, we performed transcriptome analysis of c-Maf deficient Th cells. We also analyzed human naive/central memory/effector memory Th cells derived from peripheral blood and confirmed that the expression of MAF was also increased significantly in human memory Th cells.

Research Products

• [Journal Article] A significant induction of neutrophilic chemoattractants but not RANKL in synoviocytes stimulated with interleukin 17 (2014)
  • Author(s): Ota M, Yanagisawa M, Tachibana H, Yokota K, Araki Y, Sato K, Mimura T
  • Journal Title: J Bone Miner Metab Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Aberrant histone acetylation contributes to elevated interleukin-6 production in rheumatoid arthritis synovial fibroblasts (2014)
  • Author(s): Wada TT, Araki Y, Sato K, Aizaki Y, Yokota K, Kim YT, Oda H, Kurokawa R, Mimura T.
  • Journal Title: Biochem Biophys Res Commun. Volume: 444 Issue: 4 Pages: 682-686
  • DOI: 10.1016/j.bbrc.2014.01.195
  • Peer Reviewed
• [Journal Article] Combination of tumor necrosis factor α and interleukin-6 induces mouse osteoclast-like cells with bone resorption activity both in vitro and in vivo (2014)
  • Author(s): Yokota K, Sato K, Miyazaki T, Kitaura H, Kayama H, Miyoshi F, Araki Y, Akiyama Y, Takeda K, Mimura T.
  • Journal Title: Arthritis Rheumatol. Volume: 66 Issue: 1 Pages: 121-129
  • DOI: 10.1002/art.38218
  • Peer Reviewed
• [Journal Article] Pentraxin 3 is associated with disease activity but not atherosclerosis in patients with systemic lupus erythematosus (2014)
  • Author(s): Shimada Y, Asanuma YF, Yokota K, Yoshida Y, Kajiyama H, Sato K, Akiyama Y, Mimura T
  • Journal Title: Mod Rheumatol Volume: 24(1) Issue: 1 Pages: 78-85
  • DOI: 10.3109/14397595.2013.852837
  • Peer Reviewed
• [Journal Article] A significant induction of neutrophilic chemoattractants but not RANKL in synoviocytes stimulated with interleukin 17 (2014)
  • Author(s): Ota M, Yanagisawa M, Tachibana H, Yokota K, Araki Y, Sato K, Mimura T.
  • Journal Title: J Bone Miner Metab. Volume: 未定
  • Peer Reviewed
• [Journal Article] The IL-23/IL-17 axis as a therapeutic target (2013)
  • Author(s): Sato K
  • Journal Title: Nihon Rinsho Meneki Gakkai Kaishi Volume: 36(4) Pages: 203-8
  • NAID: 10031196417
• [Journal Article] Serum osteoprotegerin concentration is associated with carotid atherosclerotic plaque in patients with rheumatoid arthritis (2013)
  • Author(s): Asanuma YF, Shimada Y, Kouzu N, Yokota K, Nakajima K, Sato K, Akiyama Y, Isozaki M, Mikami AS, Kobayashi H, Mimura T
  • Journal Title: Mod Rheumatol Volume: 23 Issue: 2 Pages: 269-275
  • DOI: 10.1007/s10165-012-0654-5
  • NAID: 10031167698
  • Peer Reviewed
• [Journal Article] Epidermal phospholipase C δ1 regulates granulocyte counts and systemic interleukin-17 levels in mice. (2012)
  • Author(s): Kaori Kanemaru
  • Journal Title: Nat. Commun. Volume: 3 Issue: 1 Pages: 963-963
  • DOI: 10.1038/ncomms1960
  • Peer Reviewed
• [Journal Article] Immunopathological analysis of Erdheim-Chester disease with massive ascites. (2012)
  • Author(s): Ota M, Sakamoto M, Sato K, Yoshida Y, Funakubo Asanuma Y, Akiyama Y, Yamakawa M, Mimura T
  • Journal Title: Internal Medicine Volume: 51 Pages: 2825-30
  • NAID: 130002062044
  • Peer Reviewed
• [Journal Article] Tocilizumab improved both clinical and laboratory manifestations except for interleukin-18 in a case of multiple drug-resistant adult-onset Still's disease (2011)
  • Author(s): Yoshida Y, Sakamoto M, Yokota K, Sato K, Mimura T
  • Journal Title: Intern Med Volume: 50(16) Pages: 1757-60
  • NAID: 130000969383
  • Peer Reviewed
• [Journal Article] Marked induction of c-Maf protein during Th17 cell differentiation and its implication in memory Th cell development (2011)
  • Author(s): Sato K, Miyoshi F, Yokota K, Araki Y, Asanuma Y, Akiyama Y, Yoh K, Takahashi S, Aburatani H, Mimura T
  • Journal Title: J Biol Chem Volume: 286 Issue: 17 Pages: 14963-14971
  • DOI: 10.1074/jbc.m111.218867
  • Peer Reviewed
• [Journal Article] Tocilizumab improved both clinical and laboratory manifestations except for interleukin-18 in a case of multiple drug-resistant adult-onset Still's disease. (2011)
  • Author(s): Yoshida Y, et al.
  • Journal Title: Internal Medicine Volume: 50 Pages: 1757-1760
  • Peer Reviewed
• [Presentation] The combination of TNF and IL-6 induces the differentiation of osteoclast-like cells with a bone-resorbing activity both in vitro and in vivo (2013)
  • Author(s): 佐藤浩二郎
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2013-12-12
• [Presentation] The combination of TNF and IL-6 induces the differentiation of osteoclast-like cells with a bone-resorbing activity both in vitro and in vivo (2013)
  • Author(s): Sato K, Yokota K, Mimura T
  • Organizer: 第42階日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ
• [Presentation] Analysis of transcription-factor network in memory Th cells using c-Maf transgenic and c-Maf deficient mice (2012)
  • Author(s): 佐藤浩二郎
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2012-12-05
• [Presentation] T細胞性サイトカインと破骨細胞分化 (2012)
  • Author(s): 佐藤浩二郎
  • Organizer: 第40回日本臨床免疫学会総会 シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2012-09-27
• [Presentation] Th17と炎症 (2012)
  • Author(s): 佐藤浩二郎
  • Organizer: 第33回日本炎症・再生医学会 シンポジウム
  • Place of Presentation: 福岡
  • Year and Date: 2012-07-05
• [Presentation] THE TRANSCRIPTION FACTOR C-MAF PLAYS AN ESSENTIAL ROLE IN A MEMORY TH-CELL DEPENDENT MODEL OF INFLAMMATION (2012)
  • Author(s): Kojiro Sato
  • Organizer: Annual European Congress of Rheumatology (EULAR 2012)
  • Place of Presentation: Berlin
  • Year and Date: 2012-06-08
• [Presentation] ヘルパーT細胞分化メカニズムと自己免疫 (2012)
  • Author(s): 佐藤浩二郎
  • Organizer: 第56回日本リウマチ学会総会・学術集会 第21回国際リウマチシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2012-04-27
• [Presentation] THE TRANSCRIPTION FACTOR C-MAF PLAYS AN ESSENTIAL ROLE IN A MEMORY TH-CELL DEPENDENT MODEL OF INFLAMMATION (2012)
  • Author(s): Kojiro Sato , Toshihide Mimura
  • Organizer: EULAR2012
  • Place of Presentation: ベルリン、ドイツ
• [Presentation] ヘルパーT細胞分化メカニズムと自己免疫 (2012)
  • Author(s): 佐藤 浩二郎
  • Organizer: 第56 回 日本リウマチ学会総会・学術集会
  • Place of Presentation: 東京
  • Invited
• [Presentation] Th17と炎症 (2012)
  • Author(s): 佐藤 浩二郎
  • Organizer: 第33回日本炎症・再生医学会
  • Place of Presentation: 博多
  • Invited
• [Presentation] T細胞性サイトカインと破骨細胞分化 (2012)
  • Author(s): 佐藤 浩二郎
  • Organizer: 第40回日本臨床免疫学会総会
  • Place of Presentation: 東京
  • Invited
• [Presentation] Analysis of transcription-factor network in memory Th cells using c-Maf transgenic and c-Maf deficient mice (2012)
  • Author(s): Kojiro Sato, Fumihiko Miyoshi and Toshihide Mimura
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] The role transcription factor c-Maf plays in memory Th17 cells (2011)
  • Author(s): 佐藤浩二郎
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-28
• [Presentation] The role transcription factor c-Maf plays in memory Th17 cells (2011)
  • Author(s): Kojiro Sato, et al.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ（千葉県）
• [Book] 臨床検査データブック2003-2014 (2013)
  • Author(s): 佐藤浩二郎, 他
  • Publisher: ナツメ社
• [Book] 基礎からわかる免疫学 (2011)
  • Author(s): 佐藤浩二郎, 他
  • Publisher: ナツメ社
• [Book] 基礎からわかる免疫学 (2011)
  • Author(s): 三村俊英編
  • Publisher: ナツメ社
• [Remarks]
  • URL: http://www.saitama-med.ac.jp/uinfo/riumachi/index.html
• [Remarks] 埼玉医科大学リウマチ膠原病科
  • URL: http://www.saitama-med.ac.jp/uinfo/riumachi/index.html
• [Remarks] 埼玉医科大学リウマチ膠原病科
  • URL: http://www.saitama-med.ac.jp/uinfo/riumachi/index.html
• [Remarks]
  • URL: http://www.saitama-med.ac.jp/uinfo/riumachi/index.html