Pathogenic role of CADM-140 antigen (MDA5) in patients with dermatomyositis
| Project/Area Number |
23591469
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Tokai University |
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Principal Investigator |
SATO Shinji 東海大学, 医学部, 准教授 (90276238)
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| Co-Investigator(Renkei-kenkyūsha) |
WAKABAYASHI Takayuki 東海大学, 医学部, 助教 (40349410)
SAITO Eiko 東海大学, 医学部, 助教 (70514503)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 皮膚筋炎 / 急速進行性間質性肺炎 / 抗CADM-140抗体 / 抗MDA5抗体 / 間質性肺炎 / 自己抗体 / CADM / RP-ILD / MDA5 / IFIH1 |
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| Research Abstract |
Anti-CADM-140/MDA5 (Melanoma Differentiation-Associated Gene 5) antibody is a recently-reported antibody that recognized a 140 kDa polypeptide in patients with dermatomyositis (DM). This autoantibody has a close association with rapidly progressive interstitial lung disease (RP-ILD) and may be useful marker for presence of RP-ILD. In this study, we demonstrated close association between anti-CADM-140/MDA5 antibody titer by ELISA and RP-ILD disease activity in patients with DM and RP-ILD. Our findings also highlight the usefulness of this antibody not only in the prediction of RP-ILD but also in monitoring of the disease activity and prediction of disease outcome in daily clinical practice. Moreover, our data might be suggested that complexes of MDA5 and anti-CADM-140/MDA5 antibody might play a significant role in pathogenesis of RP-ILD and DM rather than being an epiphenomenon.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] Anti-MDA5 antibody, ferritin and IL-18 are useful for the evaluation of response to treatment in interstitial lung disease with anti-MDA5 antibody- positive dermatomyositis2012
Author(s)
Gono T, Sato S, Kawaguchi Y, Kuwana M, Hanaoka M, Katsumata Y, Takagi K, Baba S, Okamoto Y, Ota Y, Yamanaka H
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Journal Title
Rheumatology (Oxford)
Volume: 51(9)
Pages: 1563-70
Related Report
Peer Reviewed
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[Journal Article] Anti-MDA5 antibody, ferritin and IL-18 are useful for the evaluation of response to treatment in interstitial lung disease with anti-MDA5 antibody-positive dermatomyositis.2012
Author(s)
Gono T, Sato S, Kawaguchi Y, Kuwana M, Hanaoka M, Katsumata Y, Takagi K, Baba S, Okamoto Y, Ota Y, Yamanaka H.
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Journal Title
Rheumatology
Volume: 51
Issue: 9
Pages: 1563-70
DOI
Related Report
Peer Reviewed
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[Journal Article] Clinical Phenotype of Japanese Patients with Dermatomyositis–Classification Based on Dermatomyositis-Specific Autoantibodies–
Author(s)
Sato S, Kuwana M, Hirakata M, Nogi S, Sasaki N, Chinen N, Honda K, Saito E, Wakabayashi T, Yamada C, Suzuki Y
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Journal Title
Open Journal of Rheumatology and Autoimmune Diseases
Volume: (in press)
Related Report
Peer Reviewed
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[Presentation] 皮膚筋炎の併発する急速進行性間質性肺炎に対する大量ステロイドおよびシクロホスファミド間歇静注/シクロスポリンA併用療法の効果は抗CADM-140/MDA5抗体力価と関連する2014
Author(s)
佐藤慎二,倉林賢慶,佐々木翔,小山泰,野木真一,佐々木則子,知念直史,本田桐,齋藤榮子,山田千穂,若林孝幸,鈴木康夫
Organizer
第587回日本リウマチ学会総会・学術集会
Place of Presentation
東京
Year and Date
2014-04-26
Related Report
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