Chronic inflammation and molecular mechanism: atypical pneumonia and COPD
Project/Area Number |
23591481
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Infectious disease medicine
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Research Institution | Juntendo University (2014) Kyorin University (2011-2013) |
Principal Investigator |
WADA HIROO 順天堂大学, 医学(系)研究科(研究院), 准教授 (50407053)
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Co-Investigator(Renkei-kenkyūsha) |
GOTO Hajime 杏林大学, 医学部, 教授 (80134617)
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Project Period (FY) |
2011-04-28 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | IL-10 / IL-17 / マウスモデル / マイコプラズマ / 感染症 / MMP-9 / マウス / COPD / 環境曝露 / 感染 / 喫煙 / 動物モデル / 気道炎症 / 肺 / 分子病態 / マクロライド |
Outline of Final Research Achievements |
Because it is observed that Mycoplasma pneumonia (Mp) pneumonia exacerbates COPD, both Mp pneumonia and COPD may share common molecular pathogenesis. In order to the common pathogenesis, mice were exposed to either Mp compoents or to cigarette smoke, and then analyzed. Immunihistochemical analyses on mice exposed to Mp pneumonia revealed that pulmonary migration of neutrophil increased which increasingly expressed IL-23 protein. Mice deficient with IL-10 gene showed that pulmonary chemotaxis and MMP-9 expression in the lung were enhanced, compared to the wild type controls. Both data suggested that IL-17 was involved in the pathogenesis. Since IL-17 has at least 6 subtypes, and its detection is rather difficult, further analyses, probably using IL-17 deficient mice, are essential.
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Report
(5 results)
Research Products
(18 results)
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[Journal Article] Identification of a mechanism for lung inflammation caused by Mycoplasma pneumoniae using a novel mouse model.2011
Author(s)
Saraya T, Nakata K, Nakagaki K, Motoi N, Iihara K, Fujioka Y, Oka T, Kurai D, Wada H, Ishii H, Taguchi H, Kamiya S and Goto H
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Journal Title
Results in Immunology誌
Volume: 1
Pages: 76-87
Related Report
Peer Reviewed
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[Presentation] Interleukin-17A/F regulates MMP-9 expression in the lung of mice after inhalation of cigarette smoke.2014
Author(s)
Nakamura M, Wada H, Sata M, Inui T, Honda K, Nakamoto K, Higaki M, Takata S,Yokoyama T, Kudo A, Inoue S, Hanawa T, Kobayashi F, Kamma H, Takizawa H, Goto H
Organizer
European Respiratory Society
Place of Presentation
Munich, Germany
Year and Date
2014-09-08
Related Report
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[Presentation] Enhanced neutrophilic inflammation in IL-10-deficient mice exposed to cigarette smoke via TNF-α regulation2012
Author(s)
Higaki M, Wada H, Mikura S, Yasutake T, Nakamura M, Niikura M, Kobabyashi F, Kamma H, Kamiya S, Takizawa H and Goto H.
Organizer
European Respiratory Society 2012
Place of Presentation
Vienna, Austria
Related Report
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