Investigation on prevention of perinatal infections caused by group B Streptococcus (GBS)
| Project/Area Number |
23591485
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Aichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGISHI Yuka 愛知医科大学, 医学部, 准教授 (60512241)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | Ｂ群溶血性レンサ球菌（GBS） / 周産期感染症 / 早産 / 絨毛膜羊膜炎 / 血清型 / ペニシリン / 耐性菌 / 予防 / B群溶血性連鎖球菌(GBS) |
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| Research Abstract |
The prevalence of group B Streptococcus (GBS) isolated from vaginal secretions among 49 Japanese pregnant women has been 24.5 % (12 strains), 24.3 % (7 strains), 12.2 % (6 strains) and 10.2 % (5 strains) in serotypes III, V, Ia and VI, respectively. Also, GBS isolated from vaginal secretions among 49 Japanese non-pregnant women has been 16.3 % (8 strains), 14.3 % (7 strains), 12.2 % (6 strains) and 12.2 % (6 strains) in serotypes Ia, Ib, III and V, respectively. Moreover, we have observed the first isolation of penicillin G-resistant (intermediate) GBS from vaginal secretion in Japanese woman. Continuous surveillance on penicillin G-resistant GBS should be needed in future, since the increase of penicillin G-resistant GBS might lead to the revision of perinatal prevention guideline on GBS. The attachment and invasion of serotype VI GBS to A549 was significantly higher than those of serotype III GBS. This means there exists the difference of immunological response among GBS serotypes.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Practice guidelines for therapeutic drug monitoring of vancomycin: a consensus review of the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring2013
Author(s)
Matsumoto K, Takesue Y, Ohmagari N, Mochizuki T, Mikamo H, Seki M, Takakura S, Tokimatsu I, Takahashi Y, Kasahara K, Okada K, Igarashi M, Kobayashi M, Hamada Y, Kimura M, Nishi Y, Tanigawara Y, Kimura T
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Journal Title
J Infect Chemother
Volume: 19(3)
Issue: 3
Pages: 365-380
DOI
Related Report
Peer Reviewed
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[Journal Article] Azithromycin attenuates lung inflammation in a mouse model of ventilator-associated pneumonia by multidrug-resistant Acinetobacter baumannii2013
Author(s)
Yamada K, Yanagihara K, Kaku N, Harada Y, Migiyama Y, Nagaoka K, Morinaga Y, Nakamura S, Imamura Y, Miyazaki T, Izumikawa K, Kakeya H, Hasegawa H, Mikamo H, Kohno S
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Journal Title
Antimicrob Agents Chemother
Volume: 57(8)
Issue: 8
Pages: 3883-3888
DOI
Related Report
Peer Reviewed
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[Presentation] Is It Possible to Discriminate the Serotypes and Penicillin-resistance of Group B Streptococci by MALDI-TOF ?2013
Author(s)
Ohno T, Mikamo H, Sawamura H, Yamashita R, Koita I, Yamada A, Suzuki T, Miyajima S, Matsukawa Y, Matsuyama Y, Suematsu H, Yamagishi Y
Organizer
53rd ICAAC
Place of Presentation
Denver, USA
Related Report
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