| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Human herpesvirus 6 (HHV-6) replicates predominantly in CD4-positive lymphocytes in vivo and in vitro and may establish latent infection in the monocyte/macrophage-lineage cells. It has been proved that HHV-6B is the etiologic agent of exanthem subitum, whereas HHV-6A has not yet been associated with any human diseases. Here, we showed that HHV-6 induced the expression of S100A8 and S100A9 in HHV-6 infected CD4+ T cells. Furthermore, we found that S100A9 interacted with HHV-6B U83. S100A9 significantly enhanced the HHV-6 replication. These findings suggest the S100A8/S100A9 may have an important role in the HHV-6 replication and pathogenesis.
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