| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
Fecal samples were collected from 171 asymptomatic patients in a long-term care facility for the elderly. A hundred ten (64.3%) were not colonized, and 61 (35.7%) had Clostridium difficile (CD). Data on demographic or clinical information, including age, sex, body mass index, major diagnosis leading to admission, duration of facility stay, medication use of antibiotics, proton pump inhibitors (PPI), H2 blockers, or probiotics, and concurrent diabetes mellitus were studied between CD-colonized and -uncolonized patients. Multivariate analysis showed asymptomatic CD carriage was significant association with PPI use.
Over the study period of the last 10 years, 307 inpatients with CD infection (CDI) were identified at a university hospital. Overall incidence of CDI was 1.44 cases per 10,000 patient-days. CDI incidence did not increase over the study period. CDI incidence was highest in the fall (1.56), followed by the winter (1.48), summer (1.42), and spring (1.29).
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