The epigenetic regulation of brain development by maternal stress
| Project/Area Number |
23591491
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | University of Yamanashi |
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Principal Investigator |
HIRASAWA Takae 山梨大学, 医学工学総合研究部, 助教 (10402083)
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| Co-Investigator(Kenkyū-buntansha) |
KUBOTA Takeo 山梨大学, 大学院医学工学総合研究部, 教授 (70293511)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 脳 / ストレス / 母子分離 / 脳機能 / グルココルチコイド / エピジェネティクス / 発達障害 |
|---|
| Research Abstract |
The cortisol as a stress hormone affects brain function through the GR receptor in hippocampus and hypothalamus. In this study, we evaluated the activation mechanism through GR receptor in mouse hippocampal neurons using Ca2+ imaging method. The results suggested that corticosterone effect to the up-regulation of translation of NR2A, one of the NMDA receptor subunit. And this phenomenon could reappear by D-serine, a NR2A specific agonist. Moreover, in mouse maternal separation stress experiment, although the mRNA expression of GR was changeless in hippocampus, protein expression of GR was remarkable decreased. these results suggested that corticosterone have regulate the synaptic transmission and GR expression in immature stage.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Comparison of genomic and epigenomic expression in monozygotic twins discordant for Rett syndrome2013
Author(s)
Miyake K, Yang C, Minakuchi Y, Ohori K, Soutome M, Hirasawa T, Kazuki Y, Adachi N, Suzuki S, Itoh M, Goto Y, Andoh T, Kurosawa H, Akamatsu W, Oyama M, Okano H, Oshimura M, Sasaki M, Toyoda A, Kubota T
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Journal Title
PLoS ONE
Volume: 8
Issue: 6
Pages: e66729-e66729
DOI
Related Report
Peer Reviewed
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[Journal Article] The protocadherins, PCDHB1 and PCDH7, are regulated by MeCP2 in neuronal cells and brain tissues : implication for pathogenesis of Rett syndrome2011
Author(s)
Miyake K#, Hirasawa T#, Soutome M, Itoh M, Goto Y, Endoh K, Takahashi K, Kudo S, Nakawaga T, Yokoi S, Taira T, Inazawa J, Kubota T(# Equal contribution)
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Journal Title
BMC Neurosci
Volume: 12(81)
Issue: 1
DOI
Related Report
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