| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
The cortisol as a stress hormone affects brain function through the GR receptor in hippocampus and hypothalamus. In this study, we evaluated the activation mechanism through GR receptor in mouse hippocampal neurons using Ca2+ imaging method. The results suggested that corticosterone effect to the up-regulation of translation of NR2A, one of the NMDA receptor subunit. And this phenomenon could reappear by D-serine, a NR2A specific agonist. Moreover, in mouse maternal separation stress experiment, although the mRNA expression of GR was changeless in hippocampus, protein expression of GR was remarkable decreased. these results suggested that corticosterone have regulate the synaptic transmission and GR expression in immature stage.
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