Diffusion tensor imaging and PET abnormality in cryptogenic West syndrome
| Project/Area Number |
23591492
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Nagoya University |
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Principal Investigator |
NATSUME Jun 名古屋大学, 医学(系)研究科(研究院), 准教授 (60422771)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIHARA Naoko 名古屋大学, 大学院医学系研究科, 助教 (30393143)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 小児神経学 / ウェスト症候群 / 拡散テンソル画像 / 髄鞘化遅延 / 発達指数 / 脳波 / TBSS |
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| Research Abstract |
We performed diffusion tensor imaging (DTI) to assess white matter abnormalities in 23 patients with Cryptogenic West syndrome. DTI was acquired at 12 months and 24 months of age. Fractional anisotropy (FA) images in patients were compared with those of controls. DTI at 12 months of age in patients showed significantly decreased FA in widespread white matters. Radial diffusivity was increased in the skeleton. Developmental quotient (DQ) was positively correlated with FA. Patients with EEG abnormalities and seizures after treatments had lower FA than those of patients with normal EEG and seizure freedom at 12 months of age. DTI at 24 months of age did not show significant difference of FA between patients and controls. However, Patients with DQ lower than 70 showed decreased FA in widespread white matters. Laterality of PET abnormality and DTI abnormality was consistent. Decreased FA may represent delayed myelination and underlying pathology such as focal cortical dysplasia.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] PET in infancy predicts long-term outcome during adolescence in cryptogenic West syndrome2014
Author(s)
Natsume J, Maeda N, Itomi K, Kidokoro H, Ishihara N, Takada H, Okumura A, Kubota T, Miura K, Aso K, Morikawa T, Kato K, Negoro T, Watanabe K
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Journal Title
AJNR Am J Neuroradiol
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] PET in Infancy Predicts Long-Term Outcome during Adolescence in Cryptogenic West Syndrome.2014
Author(s)
Natsume J, Maeda N, Itomi K, Kidokoro H, Ishihara N, Takada H, Okumura A, Kubota T, Miura K, Aso K, Morikawa T, Kato K, Negoro T, Watanabe K.
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Journal Title
AJNR Am J Neuroradiol.
Volume: 10.3174/ajnr.A3899
Related Report
Peer Reviewed
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[Journal Article] CDKL5 alterations lead to early epileptic encephalopathy in both genders2011
Author(s)
Liang JS, Shimojima K, Takayama R, Natsume J, Shichiji M, Hirasawa K, Imai K, Okanishi T, Mizuno S, Okumura A, Sugawara M, Ito T, Ikeda H, Takahashi Y, Oguni H, Imai K, Osawa M, Yamamoto T
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Journal Title
Epilepsia
Volume: 52(10)
Pages: 1835-42
Related Report
Peer Reviewed
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[Presentation] TBSS analysis of diffusion tensor imaging in cryptogenic West syndrome : Comparison with PET hypometabolism2013
Author(s)
Natsume J, Ogawa C, Fukasawa T, Yamamoto H, Kidokoro H, Yokoi S, Takeuchi T, Azuma Y, Ishihara N, Ando N, Kubota T, Negoro T, Watanabe K
Organizer
67th annual meeting of the American Epilepsy Society
Place of Presentation
Washington D.C., USA
Year and Date
2013-12-09
Related Report
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[Presentation] Diffusion tensor imaging in cryptogenic West syndrome : Tract-based spatial statistics analysis at onset2013
Author(s)
Ogawa C, Natsume J, Fukasawa T, Yamamoto H, Kidokoro H, Yokoi S, Takeuchi T, Azuma Y, Ishihara N, Ando N, Kubota T, Negoro T, Watanabe K
Organizer
67thannual meeting of the American Epilepsy Society
Place of Presentation
Washington D.C., USA
Year and Date
2013-12-09
Related Report
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[Presentation] Diffusion tensor imaging in cryptogenic West syndrome : Tract-based spatial statistics analysis at onset2013
Author(s)
Ogawa C, Natsume J, Ishihara N, Kidokoro H, Azuma Y, Yokoi S, Yamamoto H, Takeuchi T, Miura K, Negoro T, Watanabe K
Organizer
第47回日本てんかん学会
Place of Presentation
北九州国際会議場、北九州
Year and Date
2013-10-10
Related Report
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[Presentation] FDG-PET in infancy predicts long-term outcome during adolescence in cryptogenic West syndrome2013
Author(s)
Natsume J, Maeda N, Itomi K, Ishihara N, Okumura A, Kubota T, Miura K, Aso K, Morikawa T, Kato K, Negoro T, Watanabe K
Organizer
30th International Epilepsy Congress
Place of Presentation
Montreal, Canada
Year and Date
2013-06-24
Related Report
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[Presentation] TBSS analysis of diffusion tensor imaging in cryptogenic West syndrome : Comparison with EEG and seizure outcome2012
Author(s)
Natsume J, Fukasawa T, Yamamoto H, Ishihara N, Azuma Y, Nakata Y, Ando N, Kubota T, Negoro T, Watanabe K
Organizer
66th annual meeting of the American Epilepsy Society
Place of Presentation
San Diego, USA
Year and Date
2012-12-01
Related Report
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[Presentation] TBSS analysis of diffusion tensor imaging in cryptogenic West syndrome : Comparison with EEG and seizure outcome.2012
Author(s)
Natsume J, Fukasawa T, Yamamoto H, Ishihara N, Azuma Y, Nakata Y, Ando N, Kubota T, Negoro T, Watanabe K.
Organizer
66th annual meeting of the American Epilepsy Society
Place of Presentation
San Diego, USA,
Related Report
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[Presentation] Correlation between diffusion tensor imaging and developmental prognosis in cryptogenic West syndrome2011
Author(s)
Fukasawa T, Natsume J, Yamamoto H, Nakata T, Naiki M, Azuma Y, Ishihara N, Ikuta T, Okumura A, Negoro T, Watanabe K
Organizer
65th annual meeting of the American Epilepsy Society
Place of Presentation
Baltimore, USA
Year and Date
2011-12-05
Related Report
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[Presentation] Correlation between diffusion tensor imaging and developmental prognosis in cryptogenic West syndrome.2011
Author(s)
Fukasawa T, Natsume J, Yamamoto H, Nakata T, Naiki M, Azuma Y, Ishihara N, Ikuta T, Okumura A, Negoro T, Watanabe K.
Organizer
65th annual meeting of the American Epilepsy Society.
Place of Presentation
Baltimore, USA
Related Report
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[Presentation] TBSS analysis of diffusion tensor imaging in cryptogenic West syndrome : Comparison with PET hypometabolism.
Author(s)
Natsume J, Ogawa C, Fukasawa T, Yamamoto H, Kidokoro H, Yokoi S, Takeuchi T, Azuma Y, Ishihara N, Ando N, Kubota T, Negoro T, Watanabe K.
Organizer
67th annual meeting of the American Epilepsy Society.
Place of Presentation
Washington D.C., USA
Related Report
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[Presentation] FDG-PET in infancy predicts long-term outcome during adolescence in cryptogenic West syndrome.
Author(s)
Natsume J, Maeda N, Itomi K, Ishihara N, Okumura A, Kubota T, Miura K, Aso K, Morikawa T, Kato K, Negoro T, Watanabe K.
Organizer
30th International Epilepsy Congress.
Place of Presentation
Montreal, Canada
Related Report
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