Diffusion tensor imaging and PET abnormality in cryptogenic West syndrome

• Project/Area Number: 23591492
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Nagoya University
• Principal Investigator: NATSUME Jun 名古屋大学, 医学(系)研究科(研究院), 准教授 (60422771)
• Co-Investigator(Kenkyū-buntansha): ISHIHARA Naoko 名古屋大学, 大学院医学系研究科, 助教 (30393143)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 小児神経学 / ウェスト症候群 / 拡散テンソル画像 / 髄鞘化遅延 / 発達指数 / 脳波 / TBSS

Research Abstract

We performed diffusion tensor imaging (DTI) to assess white matter abnormalities in 23 patients with Cryptogenic West syndrome. DTI was acquired at 12 months and 24 months of age. Fractional anisotropy (FA) images in patients were compared with those of controls. DTI at 12 months of age in patients showed significantly decreased FA in widespread white matters. Radial diffusivity was increased in the skeleton. Developmental quotient (DQ) was positively correlated with FA. Patients with EEG abnormalities and seizures after treatments had lower FA than those of patients with normal EEG and seizure freedom at 12 months of age. DTI at 24 months of age did not show significant difference of FA between patients and controls. However, Patients with DQ lower than 70 showed decreased FA in widespread white matters. Laterality of PET abnormality and DTI abnormality was consistent. Decreased FA may represent delayed myelination and underlying pathology such as focal cortical dysplasia.

Research Products

• [Journal Article] PET in infancy predicts long-term outcome during adolescence in cryptogenic West syndrome (2014)
  • Author(s): Natsume J, Maeda N, Itomi K, Kidokoro H, Ishihara N, Takada H, Okumura A, Kubota T, Miura K, Aso K, Morikawa T, Kato K, Negoro T, Watanabe K
  • Journal Title: AJNR Am J Neuroradiol Volume: (in press)
  • Peer Reviewed
• [Journal Article] PET in Infancy Predicts Long-Term Outcome during Adolescence in Cryptogenic West Syndrome. (2014)
  • Author(s): Natsume J, Maeda N, Itomi K, Kidokoro H, Ishihara N, Takada H, Okumura A, Kubota T, Miura K, Aso K, Morikawa T, Kato K, Negoro T, Watanabe K.
  • Journal Title: AJNR Am J Neuroradiol. Volume: 10.3174/ajnr.A3899
  • Peer Reviewed
• [Journal Article] Epileptic seizures induced by dexmedetomidine in a neonate (2013)
  • Author(s): Kubota T, Fukasawa T, Kitamura E, Magota M, Kato Y, Natsume J, Okumura A
  • Journal Title: Brain Dev Volume: 35(4) Pages: 360-2
  • Peer Reviewed
• [Journal Article] Epileptic seizures induced by dexmedetomidine in a neonate. (2013)
  • Author(s): Kubota T, Fukasawa T, Kitamura E, Magota M, Kato Y, Natsume J, Okumura A.
  • Journal Title: Brain Dev. Volume: 35 Pages: 360-2
  • Peer Reviewed
• [Journal Article] Amplitude-integrated electroencephalogram 1 h after birth in a preterm infant with cystic periventricular leukomalacia. (2013)
  • Author(s): Kato T, Okumura A, Hayakawa F, Tsuji T, Hayashi S, Natsume J.
  • Journal Title: Brain Dev. Volume: 35 Pages: 75-8
  • Peer Reviewed
• [Journal Article] EEG for predicting early neurodevelopment in preterm infants : an observational cohort study (2012)
  • Author(s): Hayashi-Kurahashi N, Kidokoro H, Kubota T, Maruyama K, Kato Y, Kato T, Natsume J, Hayakawa F, Watanabe K, Okumura A
  • Journal Title: Pediatrics Volume: 130(4)
  • Peer Reviewed
• [Journal Article] Isolated cystic lesion of the callosal genu after traumatic brain injury (2012)
  • Author(s): Kato T, Okumura A, Tsuji T, Emi M, Natsume J
  • Journal Title: Neuropediatrics Volume: 43(3) Pages: 162-3
  • Peer Reviewed
• [Journal Article] Differences in amplitude among electrode locations on amplitude-integrated electroencephalograms in preterm infants (2012)
  • Author(s): Kato T, Sugiyama Y, Tsuji T, Hayashi S, Natsume J, Okumura A
  • Journal Title: Pediatr.Res Volume: (Epub ahead of print) Issue: 1 Pages: 57-62
  • DOI: 10.1038/pr.2012.50
  • Peer Reviewed
• [Journal Article] Punctate white matter lesions in a late preterm-born infant with hypoxic ischaemic encephalopathy : chronological change in magnetic resonance imaging (2012)
  • Author(s): Kato T, Okumura A, Tsuji T, Hayashi S, Kito M, Natsume J
  • Journal Title: Dev Med Child Neurol Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Transient reduced diffusion in the cortex in a child with prolonged febrile seizures (2012)
  • Author(s): Kato T, Okumura A, Hayakawa F, Tsuji T, Natsume J
  • Journal Title: Brain Dev Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] けいれん重積とは (2012)
  • Author(s): 夏目淳
  • Journal Title: 小児科学レクチャー Volume: 2(4) Pages: 703-707
• [Journal Article] Amplitude-integrated electroencephalogram 1h after birth in a preterminfant with cystic periventricular leukomalacia (2011)
  • Author(s): Kato T, Okumura A, Hayakawa F, Tsuji T, Hayashi S, Natsume J
  • Journal Title: Brain Dev Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Prognostic factors in acute encephalopathy with reduced subcortical diffusion (2011)
  • Author(s): Hayashi N, Okumura A, Kubota T, Tsuji T, Kidokoro H, Fukasawa T, Hayakawa F, Ando N, Natsume J
  • Journal Title: Brain Dev Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Transient and mild reduction of consciousness during febrileillness in children (2011)
  • Author(s): Kato T, Okumura A, Hayakawa F, Tsuji T, Natsume J, Watanabe K
  • Journal Title: Neuropediatrics Volume: 42(5) Pages: 183-7
  • Peer Reviewed
• [Journal Article] CDKL5 alterations lead to early epileptic encephalopathy in both genders (2011)
  • Author(s): Liang JS, Shimojima K, Takayama R, Natsume J, Shichiji M, Hirasawa K, Imai K, Okanishi T, Mizuno S, Okumura A, Sugawara M, Ito T, Ikeda H, Takahashi Y, Oguni H, Imai K, Osawa M, Yamamoto T
  • Journal Title: Epilepsia Volume: 52(10) Pages: 1835-42
  • Peer Reviewed
• [Journal Article] Evaluation of brain maturation in pre-term infants using conventional and amplitude-integrated electroencephalograms (2011)
  • Author(s): Kato T, Okumura A, Hayakawa F, Tsuji T, Natsume J, Watanabe K
  • Journal Title: Clin Neurophysiol Volume: 122(10) Pages: 1967-72
  • Peer Reviewed
• [Journal Article] 熱性けいれん:熱性けいれん重積と側頭葉てんかんについて (2011)
  • Author(s): 夏目淳
  • Journal Title: 現代医学 Volume: 59 Pages: 69-74
• [Presentation] TBSS analysis of diffusion tensor imaging in cryptogenic West syndrome : Comparison with PET hypometabolism (2013)
  • Author(s): Natsume J, Ogawa C, Fukasawa T, Yamamoto H, Kidokoro H, Yokoi S, Takeuchi T, Azuma Y, Ishihara N, Ando N, Kubota T, Negoro T, Watanabe K
  • Organizer: 67th annual meeting of the American Epilepsy Society
  • Place of Presentation: Washington D.C., USA
  • Year and Date: 2013-12-09
• [Presentation] Diffusion tensor imaging in cryptogenic West syndrome : Tract-based spatial statistics analysis at onset (2013)
  • Author(s): Ogawa C, Natsume J, Fukasawa T, Yamamoto H, Kidokoro H, Yokoi S, Takeuchi T, Azuma Y, Ishihara N, Ando N, Kubota T, Negoro T, Watanabe K
  • Organizer: 67thannual meeting of the American Epilepsy Society
  • Place of Presentation: Washington D.C., USA
  • Year and Date: 2013-12-09
• [Presentation] Diffusion tensor imaging in cryptogenic West syndrome (2013)
  • Author(s): Natsume J
  • Organizer: KES-JES joint symposium第47回日本てんかん学会
  • Place of Presentation: 北九州国際会議場、北九州
  • Year and Date: 2013-10-11
• [Presentation] 潜因性West症候群の拡散テンソル画像とFDG-PET所見の比較 (2013)
  • Author(s): 夏目淳、深沢達也、小川千香子、山本啓之、竹内智哉、横井摂理、石原尚子、東慶輝、城所博之、三浦清邦、安藤直樹、久保田哲夫、根来民子、渡邊一功
  • Organizer: 第47回日本てんかん学会
  • Place of Presentation: 北九州国際会議場、北九州
  • Year and Date: 2013-10-10
• [Presentation] Diffusion tensor imaging in cryptogenic West syndrome : Tract-based spatial statistics analysis at onset (2013)
  • Author(s): Ogawa C, Natsume J, Ishihara N, Kidokoro H, Azuma Y, Yokoi S, Yamamoto H, Takeuchi T, Miura K, Negoro T, Watanabe K
  • Organizer: 第47回日本てんかん学会
  • Place of Presentation: 北九州国際会議場、北九州
  • Year and Date: 2013-10-10
• [Presentation] FDG-PET in infancy predicts long-term outcome during adolescence in cryptogenic West syndrome (2013)
  • Author(s): Natsume J, Maeda N, Itomi K, Ishihara N, Okumura A, Kubota T, Miura K, Aso K, Morikawa T, Kato K, Negoro T, Watanabe K
  • Organizer: 30th International Epilepsy Congress
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2013-06-24
• [Presentation] 潜因性West症候群において生後10カ月のFDG-PET所見は青年・成人期の発達予後予測に有用である (2013)
  • Author(s): 夏目淳、前田規秀、糸見和也、奥村彰久、久保田哲夫、三浦清邦、麻生幸三郎、森川建基、根来民子、渡邊一功
  • Organizer: 第55回日本小児神経学会
  • Place of Presentation: iichiko総合文化センター、大分
  • Year and Date: 2013-05-30
• [Presentation] TBSS analysis of diffusion tensor imaging in cryptogenic West syndrome : Comparison with EEG and seizure outcome (2012)
  • Author(s): Natsume J, Fukasawa T, Yamamoto H, Ishihara N, Azuma Y, Nakata Y, Ando N, Kubota T, Negoro T, Watanabe K
  • Organizer: 66th annual meeting of the American Epilepsy Society
  • Place of Presentation: San Diego, USA
  • Year and Date: 2012-12-01
• [Presentation] 拡散テンソル画像による小児神経疾患の解析ーWest症候群を中心にー (2012)
  • Author(s): 夏目淳
  • Organizer: (シンポジウム小児の精神神経発達の最近の治験)第42回日本臨床神経生理学会学術大会
  • Place of Presentation: 京王プラザホテル、東京
  • Year and Date: 2012-11-10
• [Presentation] TBSS analysis of diffusion tensor imaging in cryptogenic West syndrome : Comparison with EEG and seizure outcome (2012)
  • Author(s): 夏目淳、深沢達也、山本啓之、石原尚子、竹内智哉、安藤直樹、久保田哲也、根来民子、渡邊一功
  • Organizer: 第46回日本てんかん学会
  • Place of Presentation: 都市センターホテル、東京
  • Year and Date: 2012-10-11
• [Presentation] Diffusion tensor imaging in cryptogenic West syndrome : TBSS analysis (2012)
  • Author(s): Natsume J, Fukasawa T, Ishihara N, Yamamoto H, Takeuchi T, Ando N, Negoro T, Watanabe K
  • Organizer: 12th International Child Neurology Congress
  • Place of Presentation: Brisbane, Australia
  • Year and Date: 2012-05-30
• [Presentation] 画像解析からみたWest症候群の病態 (2012)
  • Author(s): 夏目淳
  • Organizer: 第2回桜山神経セミナー
  • Place of Presentation: 名古屋市立大学、名古屋
  • Year and Date: 2012-05-22
• [Presentation] Diffusion tensor imaging in cryptogenic West syndrome : TBSS analysis at one and two years of age (2012)
  • Author(s): Natsume J, Fukasawa T, Ishihara N, Yamamoto H, Takeuchi T, Azuma Y, Ando N, Negoro T, Watanabe K
  • Organizer: 第54回日本小児神経学会総会
  • Place of Presentation: ロイトン札幌、札幌
  • Year and Date: 2012-05-17
• [Presentation] Diffusion tensor imaging in cryptogenic West syndrome : TBSS analysis (2012)
  • Author(s): Natsume J, Fukasawa T, Ishihara N, Ymamamoto H, Takeuchi T, Ando N, Negoro T, Watanabe K
  • Organizer: The 14th annual meeting of infantile seizure society
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2012-02-18
• [Presentation] TBSS analysis of diffusion tensor imaging in cryptogenic West syndrome : Comparison with EEG and seizure outcome. (2012)
  • Author(s): Natsume J, Fukasawa T, Yamamoto H, Ishihara N, Azuma Y, Nakata Y, Ando N, Kubota T, Negoro T, Watanabe K.
  • Organizer: 66th annual meeting of the American Epilepsy Society
  • Place of Presentation: San Diego, USA,
• [Presentation] Diffusion tensor imaging in cryptogenic West syndrome : TBSS analysis. (2012)
  • Author(s): Natsume J, Fukasawa T, Ishihara N, Yamamoto H, Takeuchi T, Ando N, Negoro T, Watanabe K.
  • Organizer: 12th International Child Neurology Congress
  • Place of Presentation: Brisben, Australia
• [Presentation] 拡散テンソル画像による小児神経疾患の解析 ーWest症候群を中心にー（シンポジウム 小児の精神神経発達の最近の治験） (2012)
  • Author(s): 夏目 淳
  • Organizer: 第42回日本臨床神経生理学会学術大会
  • Place of Presentation: 東京
• [Presentation] TBSS analysis of diffusion tensor imaging in cryptogenic West syndrome : Comparison with EEG and seizure outcome (2012)
  • Author(s): 夏目淳、深沢達也、山本啓之、石原尚子、竹内智哉、安藤直樹、久保田哲也、根来民子、渡邊一功
  • Organizer: 第46回日本てんかん学会
  • Place of Presentation: 東京
• [Presentation] Diffusion tensor imaging in cryptogenic West syndrome : TBSS analysis at one and two years of age. (2012)
  • Author(s): Natsume J, Fukasawa T, Ishihara N, Yamamoto H, Takeuchi T, Azuma Y, Ando N, Negoro T, Watanabe K.
  • Organizer: 第54回日本小児神経学会総会
  • Place of Presentation: 札幌
• [Presentation] Correlation between diffusion tensor imaging and developmental prognosis in cryptogenic West syndrome (2011)
  • Author(s): Fukasawa T, Natsume J, Yamamoto H, Nakata T, Naiki M, Azuma Y, Ishihara N, Ikuta T, Okumura A, Negoro T, Watanabe K
  • Organizer: 65th annual meeting of the American Epilepsy Society
  • Place of Presentation: Baltimore, USA
  • Year and Date: 2011-12-05
• [Presentation] 潜因性West症候群における拡散テンソル画像のTBSS解析 (2011)
  • Author(s): 夏目淳、深沢達也、石原尚子、山本啓之、横井摂理、安藤直樹、奥村彰久、根来民子、渡邊一功
  • Organizer: 第53回日本小児神経学会総会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2011-05-26
• [Presentation] 潜因性West症候群における拡散テンソル画像のTBSS解析 (2011)
  • Author(s): ) 夏目淳、深沢達也、石原尚子、山本啓之、横井摂理、安藤直樹、奥村彰久、根来民子、渡邊一功
  • Organizer: 第53回日本小児神経学会総会
  • Place of Presentation: 横浜
• [Presentation] Correlation between diffusion tensor imaging and developmental prognosis in cryptogenic West syndrome. (2011)
  • Author(s): Fukasawa T, Natsume J, Yamamoto H, Nakata T, Naiki M, Azuma Y, Ishihara N, Ikuta T, Okumura A, Negoro T, Watanabe K.
  • Organizer: 65th annual meeting of the American Epilepsy Society.
  • Place of Presentation: Baltimore, USA
• [Presentation] TBSS analysis of diffusion tensor imaging in cryptogenic West syndrome : Comparison with PET hypometabolism.
  • Author(s): Natsume J, Ogawa C, Fukasawa T, Yamamoto H, Kidokoro H, Yokoi S, Takeuchi T, Azuma Y, Ishihara N, Ando N, Kubota T, Negoro T, Watanabe K.
  • Organizer: 67th annual meeting of the American Epilepsy Society.
  • Place of Presentation: Washington D.C., USA
• [Presentation] FDG-PET in infancy predicts long-term outcome during adolescence in cryptogenic West syndrome.
  • Author(s): Natsume J, Maeda N, Itomi K, Ishihara N, Okumura A, Kubota T, Miura K, Aso K, Morikawa T, Kato K, Negoro T, Watanabe K.
  • Organizer: 30th International Epilepsy Congress.
  • Place of Presentation: Montreal, Canada
• [Presentation] 画像解析からみたWest症候群の病態
  • Author(s): 夏目 淳
  • Organizer: 第2回桜山神経セミナー
  • Place of Presentation: 名古屋
• [Presentation] Diffusion tensor imaging in cryptogenic West syndrome : TBSS analysis.
  • Author(s): Natsume J, Fukasawa T, Ishihara N, Ymamamoto H, Takeuchi T, Ando N, Negoro T, Watanabe K .
  • Organizer: The 14th annual meeting of infantile seizure society.
  • Place of Presentation: Tokyo, Japan,
• [Book] てんかん症候群分類の考え方子どものけいれん・てんかん見つけ方・見分け方から治療戦略へ (2013)
  • Author(s): 夏目淳
  • Total Pages: 268
  • Publisher: 中山書店
• [Book] PET子どものけいれん・てんかん見つけ方・見分け方から治療戦略へ (2013)
  • Author(s): 夏目淳
  • Total Pages: 268
  • Publisher: 中山書店
• [Book] 「てんかん症候群分類の考え方」 子どものけいれん・てんかん-見つけ方・見分け方から治療戦略へ- (2013)
  • Author(s): 夏目 淳、奥村彰久、浜野晋一郎、渡邊一功、根来民子、斎藤義朗、松尾宗明、丸山幸一、鈴木基正、白石秀明、森 墾、桂 正樹、國松 聡、安部信平、山本俊至、齋藤伸治、諸岡輝子、岡 牧郎、秋山倫之、久保田哲夫、他18名
  • Total Pages: 268
  • Publisher: 中山書店
• [Book] 「PET」 子どものけいれん・てんかん-見つけ方・見分け方から治療戦略へ- (2013)
  • Author(s): 夏目 淳、奥村彰久、浜野晋一郎、渡邊一功、根来民子、斎藤義朗、松尾宗明、丸山幸一、鈴木基正、白石秀明、森 墾、桂 正樹、國松 聡、安部信平、山本俊至、齋藤伸治、諸岡輝子、岡 牧郎、秋山倫之、久保田哲夫、他18名
  • Total Pages: 268
  • Publisher: 中山書店