Neurological mechanism for auditory hypersensitivity in autism spectrum disorder: MEG study

• Project/Area Number: 23591494
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Osaka University
• Principal Investigator: SHIMONO KURIKO 大阪大学, その他の研究科, 講師 (60403185)
• Co-Investigator(Kenkyū-buntansha): OKINAGA Takeshi 大阪大学, 医学系研究科, 講師 (30362734) ; HIRATA Masayuki 大阪大学, 医学系研究科, 準教授 (30372626) ; TANIIKE Masako 大阪大学, 連合小児発達学研究科, 教授 (30263289)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 脳磁図 / 自閉症スペクトラム障害 / 聴覚過敏性 / 広汎性発達障害 / 自閉症

Research Abstract

To investigate the neurological mechanism of the auditory hypersensitivity in autism spectrum disorder, we measured auditory-evoked field values (M50, M100) to tone pip stimuli using magnetoencephalography (MEG), and analyzed their association with severity of hypersensitivity. In ASD with hypersensitivity group, the latency for M50 and M100 were prolonged, increased response power and correlated with severity of hypersensitivity. Furthermore, M50 responses were progressively increased to repeated sounds, and response duration was prolonged in ASD with hypersensitivity.
Those results were suggested that auditory hypersensitivity in ASD could be related with abnormality of sensory gating system in thalamus and /or reduction of cortical inhibitory system.

Research Products

• [Journal Article] Abnormal Corpus Callosum Connectivity, Socio-communicative Deficits, and Motor Deficits in Children with Autism Spectrum Disorder : A Diffusion Tensor Imaging Study (2014)
  • Author(s): Hanaie R, Mohri I, Kagitani-Shimono K, Tachibana M, Matsuzaki J, Watanabe Y, Fujita N, Taniike M
  • Journal Title: J Autism Dev Disord
• [Journal Article] Psychometric properties and population-based score distributions of the Japanese Sleep Questionnaire for Preschoolers (2014)
  • Author(s): Shimizu S, Kato-Nishimura K, Mohri I, Kagitani-Shimono K, Tachibana M, Ohno Y, Taniike M
  • Journal Title: Sleep Med Volume: 15 (4) Pages: 451-8
• [Journal Article] Prognostic factors for acute encephalopathy with bright tree appearance (2014)
  • Author(s): Azuma J, Nabatame S, Nakano S, Iwatani Y, Kitai Y, Tominaga K, Kagitani-Shimono K, Okinaga T, Yamamoto T, Nagai T, Ozono K
  • Journal Title: BrainDev
• [Journal Article] A case of cerebral hypomyelination with spondylo-epi-metaphyseal dysplasia (2013)
  • Author(s): Kimura-Ohba S, Kagitani-Shimono K, Hashimoto N, Nabatame S, Okinaga T, Murakami A, Miyake, Matsumoto N, Osaka H, Hojo K, Tomita R, Taniike M, Ozono K
  • Journal Title: Am J Med Genet Volume: 161A(1) Pages: 203-7
• [Journal Article] Altered microstructural connectivity of the superior cerebellar peduncle is related to motor dysfunction in children with autistic spectrum disorders (2013)
  • Author(s): Hanaie R, Mohri I, Kagitani-Shimono K, Tachibana, Azuma J, Matsuzaki J, Watanabe Y, Fujita N, Taniike M
  • Journal Title: Cerebellum Volume: 12 (5) Pages: 645-56
• [Journal Article] Long-term administration of intranasal oxytocin is a safe and promising therapy for early adolescent boys with autism spectrum disorders (2013)
  • Author(s): Tachibana M, Kagitani-Shimono K, Mohri I, Yamamoto T, Sanefuji W, Nakamura A, Oishi M, Kimura T, Onaka T, Ozono K, Taniike M
  • Journal Title: J Child Adolesc Psychopharmacol Volume: 23(2) Pages: 123-7
• [Journal Article] Which is the most appropriate disconnection surgery for refractory epilepsy in childhood? (2013)
  • Author(s): Kishima H, Oshino S, Tani N, Maruo Y, Morris S, Ming Khoo H, Yanagisawa T, Shimono K, Okinaga T, Hirata M, Kato A, Yoshimine T
  • Journal Title: Neurol Med Chir(Tokyo) Volume: 53(11) Pages: 814-20
  • NAID: 10031196793
• [Journal Article] Oral mexiletine for lidocaine-responsive neonatal epilepsy (2013)
  • Author(s): Nakazawa M, Okumura A, Niijima S, Yamashita S, Shimono K, Hirose S, Shimizu T
  • Journal Title: Brain Dev Volume: 35(7) Pages: 667-9
• [Journal Article] Long-term administration of intranasal oxytocin is a safe and promising therapy for early adolescent boys with autism spectrum disorders. (2013)
  • Author(s): Tachibana M
  • Journal Title: J Child Adolesc Psychopharmacol. Volume: 23 Issue: 2 Pages: 123-7
  • DOI: 10.1089/cap.2012.0048
  • Peer Reviewed
• [Journal Article] A case of cerebral hypomyelination with spondylo-epi-metaphyseal dysplasia. (2013)
  • Author(s): 97. Kimura-Ohba S, Kagitani-Shimono K, Hashimoto N, Nabatame S, Okinaga T,Murakami A, Miyake N, Matsumoto N, Osaka H, Hojo K, Tomita R, Taniike M, Ozono K.
  • Journal Title: Am J Med Genet A. Volume: 161 Issue: 1 Pages: 203-7
  • DOI: 10.1002/ajmg.a.35686
  • Peer Reviewed
• [Journal Article] Altered microstructural connectivity of the superior cerebellar peduncle is related to motor function in children with autistic spectrum disorders (2013)
  • Author(s): Ryuzo Hanaiea, Ikuko Mohria,b,c, Kuriko Kagitani-Shimonoa,c, Masaya Tachibanab,c, Junji Azumac, Junko Matsuzakib, Yoshiyuki Watanabed, Norihiko Fujitad, Masako Taniikea,b,c
  • Journal Title: The Cerebellum Volume: 未定
  • Peer Reviewed
• [Journal Article] Differential responses of primary auditory cortex in autistic spectrum disorder with auditory hypersensitivity (2012)
  • Author(s): Matsuzaki J, Kagitani-Shimono K, Goto T, Sanefuji W, Yamamoto T, Sakai S, Uchida H, Hirata M, Mohri I, Yorifuji S, Taniike M
  • Journal Title: Neuroreport Volume: 23(2) Pages: 113-8
• [Journal Article] Long-term developmental outcome in patients with West syndrome after epilepsy surgery (2012)
  • Author(s): Iwatani Y, Kagitani-Shimono K, Tominaga K, Okinaga T, Mohri I, Kishima H, Kato A, Sanefuji W, Yamamoto T, Tatsumi A, Murata E, Taniike M, Nagai T, Ozono K
  • Journal Title: Brain Dev Volume: 34(9) Pages: 731-8
• [Journal Article] Ictal high-frequency oscillations on scalp EEG recordings in symptomatic West syndrome (2012)
  • Author(s): Iwatani Y, Kagitani-Shimono K, Tominaga K, Okinaga T, Kishima H, Kato A, Nagai T, Ozono K
  • Journal Title: Epilepsy Res Volume: 102(1-2) Pages: 60-70
• [Journal Article] Evaluation of oral iron treatment in pediatric restless legs syndrome (RLS) (2012)
  • Author(s): Mohri I, Kato-Nishimura K, Kagitani-Shimono K, Kimura-Ohba S, Ozono K, Tachibana N, Taniike M
  • Journal Title: Sleep Med Volume: 13(4) Pages: 429-32
• [Journal Article] Differential responses of primary auditory cortex in autistic spectrum disorder with auditory hypersensitivity. (2012)
  • Author(s): Matsuzaki J
  • Journal Title: Neuroreport Volume: 23 Issue: 2 Pages: 113-118
  • DOI: 10.1097/wnr.0b013e32834ebf44
  • Peer Reviewed
• [Presentation] Differential responses of mismatch field in autistm spectrum disorder with auditory hypersensitivity : a MEG study (2013)
  • Author(s): Matsuzaki J, Kagitani-Shimono K, Sugata H, Hirata M, Hirata I, Hanaie R, Nagatani F, Tachibana M, Tominaga K, Mohri I, Taniike M
  • Organizer: Society for neuroscience
  • Place of Presentation: SanDiego (USA)
  • Year and Date: 2013-11-15
• [Presentation] Differential responses to aversive sound in autistic spectrum disorder with auditory hypersensitivity : A MEG study (2013)
  • Author(s): Kagitani-Shimono K, Matsuzaki J, Sugata H, Hirata M, Hirata I, Hanaie R, Nagatani F, Tachibana M, Tominaga K, Mohri I, Taniike M
  • Organizer: ISACM
  • Place of Presentation: Sapporo
  • Year and Date: 2013-08-28
• [Presentation] 自閉症スペクトラム障害児の聴覚過敏性と聴性誘発脳磁場(AEF)の慣れの現象についての検討 (2013)
  • Author(s): 松嵜順子、下野九理子、毛利育子、谷池雅子
  • Organizer: 日本小児神経学会
  • Place of Presentation: 大分
• [Presentation] 聴覚過敏性を有する後半生発達障害児における嫌悪音刺激に対する聴性誘発磁場反応(AEF)の検討 (2013)
  • Author(s): 下野九理子, 松嵜順子, 毛利育子, 谷池雅子
  • Organizer: 日本小児神経学会
  • Place of Presentation: 大分
• [Presentation] Differential responses of mismatch field in autistic spectrum disorder with auditory hypersensitivity: a MEG study (2013)
  • Author(s): Junko Matsuzaki1, Kuriko Kagitani-Shimono1, Hisato Sugata2, Masayuki Hirata2, Ikuko Hirata1, Ryuzo Hanaie1, Fumiyo Nagatani1, Masaya Tachibana1, KojiTominaga1, Ikuko Mohri1, Masako Taniike1
  • Organizer: Society for neuroscience
  • Place of Presentation: SanDiego (USA)
• [Presentation] Differential responses to aversive sound in autistic spectrum disorder with auditory hypersensitivity: A MEG study (2013)
  • Author(s): Kuriko Kagitani-Shimono1.2, Junko Matsuzaki1, Hisato Sugata3, Masayuki Hirata3, Ikuko Hirata1.2, Ryuzo Hanaie1, Fumiyo Nagatani1, Masaya Tachibana1.2, Koji Tominaga1.2, Ikuko Mohri1.2, Masako Taniike1.2
  • Organizer: ISACM
  • Place of Presentation: Sapporo
• [Presentation] 自閉症スペクトラム障害児の聴覚過敏性と聴性誘発脳磁(AEF)の慣れの現象についての検討 (2013)
  • Author(s): 松嵜 順子1 下野 九理子2 毛利 育子2 谷池 雅子2
  • Organizer: 日本小児神経学会
  • Place of Presentation: 大分
• [Presentation] 聴覚過敏性を有する広汎性発達障害児における嫌悪音刺激に対する聴性誘発磁場反応(AEF)の検討 (2013)
  • Author(s): 下野 九理子2 松嵜 順子1 毛利 育子2 谷池 雅子2
  • Organizer: 日本小児神経学会
  • Place of Presentation: 大分
• [Presentation] Time course of responses of primary auditory cortex in autistic spectrum disorder with auditory hypersensitivity : A MEG study (2012)
  • Author(s): Matsuzaki J, Kagitani-Shimono K, Hirata M, Tachibana M, Mohri I, Taniike M
  • Organizer: Society for neuroscience
  • Place of Presentation: New Orleans (USA)
• [Presentation] Time course of responses of primary auditory cortex in autistic spectrum disorder with auditory hypersensitivity: a MEG study (2012)
  • Author(s): Junko Matsuzaki1, Kuriko Kagitani-Shimono1, Masayuki Hirata2, Masaya Tachibana3, Ikuko Mohri1, Masako Taniike1
  • Organizer: Society for Neuroscience 2012
  • Place of Presentation: New Orleans USA
• [Presentation] 自閉症スペクトラム障害児の聴覚過敏性の神経基盤に関する研究〜一次聴覚野における反応相違について〜 (2011)
  • Author(s): 松嵜順子,下野九理子,後藤哲,實藤和佳子,山本知加,酒井佐枝子,平田雅之,毛利育子,依藤史郎,谷池雅子
  • Organizer: 第41回日本臨床神経生理学会学術大会
  • Place of Presentation: 静岡
• [Presentation] 自閉症スペクトラム障害児の聴覚過敏性の神経基盤に関する研究 (2011)
  • Author(s): 松嵜準子、下野九理子 ほか
  • Organizer: 日本臨床神経生理学会学術大会
  • Place of Presentation: 静岡
• [Book] 分子精神医学特集:自閉症の分子基盤 (2014)
  • Author(s): 下野九理子、谷池雅子
  • Publisher: 先端医学社
• [Book] 先天代謝異常ハンドブック(Glut1欠損症) (2013)
  • Author(s): 下野九理子、酒井規夫.遠藤文夫編
  • Total Pages: 440
  • Publisher: 中山書店
• [Book] 先天代謝異常ハンドブック （Glut1欠損症） (2013)
  • Author(s): 遠藤文夫編 （下野 九理子、酒井規夫）
  • Total Pages: 440
  • Publisher: 中山書店