| Project/Area Number |
23591494
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Osaka University |
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Principal Investigator |
SHIMONO KURIKO 大阪大学, その他の研究科, 講師 (60403185)
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| Co-Investigator(Kenkyū-buntansha) |
OKINAGA Takeshi 大阪大学, 医学系研究科, 講師 (30362734)
HIRATA Masayuki 大阪大学, 医学系研究科, 準教授 (30372626)
TANIIKE Masako 大阪大学, 連合小児発達学研究科, 教授 (30263289)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 脳磁図 / 自閉症スペクトラム障害 / 聴覚過敏性 / 広汎性発達障害 / 自閉症 |
|---|
| Research Abstract |
To investigate the neurological mechanism of the auditory hypersensitivity in autism spectrum disorder, we measured auditory-evoked field values (M50, M100) to tone pip stimuli using magnetoencephalography (MEG), and analyzed their association with severity of hypersensitivity. In ASD with hypersensitivity group, the latency for M50 and M100 were prolonged, increased response power and correlated with severity of hypersensitivity. Furthermore, M50 responses were progressively increased to repeated sounds, and response duration was prolonged in ASD with hypersensitivity.
Those results were suggested that auditory hypersensitivity in ASD could be related with abnormality of sensory gating system in thalamus and /or reduction of cortical inhibitory system.
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