| Project/Area Number |
23591501
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
GAMOH Keji 高知大学, 総合科学系, 教授 (90204817)
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| Co-Investigator(Renkei-kenkyūsha) |
YURI Kazunari 高知大学, 医歯学系, 教授 (10220534)
OSAKO Yoji 高知大学, 医歯学系, 准教授 (40335922)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 知的発達障害 / プロテアーゼ / 社会行動 / motopsin / neurotrypsin / sez-6 / prss12 / 精神遅滞 / 発達障害 / Neurotrypsin / PRSS12 / テトラサイクリン系 |
|---|
| Research Abstract |
The principal investigator has reported that the loss of motopsin, a serine protease in the brain, enhances social behaviors. In this research, we analyzed the effects of motopsin and sez-6, which was identified as a motopsin-binding protein, on the cell morphology when they were transfected in neuroblastoma cells. The results suggested that these proteinases coordinately modulate the morphology of neuronal cells. Further, we showed a possibility that serine proteases in the brain ordinarily modulate social behaviors, since the mice lacking tissue plasminogen activator, another protease in the brain, showed enhanced social anxiety in behavioral tests.
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