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The pathophysiological and genetic analysis of Moyamoya disease using the patients-derived endothelial colony forming cells.

Research Project

Project/Area Number 23591502
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionKyushu University

Principal Investigator

YOSHITO Ishizaki  九州大学, 大学病院, 助教 (20572944)

Co-Investigator(Kenkyū-buntansha) TORISU Hiroyuki  九州大学, 大学病院, 助教 (10398076)
吉良 龍太郎  九州大学, 大学病院, その他 (70304805)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsもやもや病 / 細胞増殖 / マイクロアレイ
Research Abstract

We separated the endothelial colony forming cells from 6 patients with Moyamoya disease and control subjects. Then we analyzed the functions of RNF213 gene, that was reported as the first susseptibility gene of Moymoya disease. We found that RNF213 contributed to the pathogenesis of Moymoya disease in the process of inflammatory responses and the proliferation of endothelial cells and smooth muscle cells.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (5 results)

All 2012 Other

All Journal Article (2 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] もやもや病感受性遺伝子RNF213の検討2012

    • Author(s)
      石崎義人、 鳥巣 浩幸, 酒井 康成, 實藤 雅文, 山口 結, 原 寿郎
    • Journal Title

      脳と発達

      Volume: 44

    • Related Report
      2012 Research-status Report
  • [Journal Article] もやもや病感受性遺伝子RNF213の検討

    • Author(s)
      石崎義人,鳥巣浩幸,酒井康成,實藤雅文,山口結,原寿郎
    • Journal Title

      日本小児神経学会雑誌

      Volume: 44巻Suppl

    • Related Report
      2013 Final Research Report
  • [Presentation] もやもや病感受性遺伝子RNF213の検討2012

    • Author(s)
      石崎義人,鳥巣浩幸,酒井康成,實藤雅文,山口結,原寿郎
    • Organizer
      日本小児神経学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] もやもや病感受性遺伝子RNF213の検討2012

    • Author(s)
      石崎義人
    • Organizer
      日本小児神経学会学術集会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Remarks] 九州大学医学部小児科HP

    • URL

      http://www.med.kyushu-u.ac.jp/pediatr/

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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