| Project/Area Number |
23591503
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
吉良 龍太郎 九州大学, 大学病院, その他 (70304805)
實藤 雅文 九州大学, 大学病院, 助教 (50467940)
石崎 義人 九州大学, 大学病院, 助教 (20572944)
李 守永 九州大学, 大学病院, 助教 (10529796)
酒井 康成 九州大学, 大学病院, 講師 (10380396)
楠田 剛 九州大学, 学内共同利用施設等, 研究員 (90710533)
礒部 菜摘 福岡歯科大学, 歯学部, 助教 (50645992)
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| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 急性脳症 / 急性脳炎 / バイオマーカー / 質量分析 / 小児科 / プロテオミクス |
|---|
| Research Abstract |
The virus-related encephalopathy in childhood is mostly developed with non-specific CNS symptoms. Therefore it is clinically important to diagnose acute encephalopathy and to evaluate disease severity by laboratory findings. We carried out liquid chromatograph mass spectrometry using a cerebrospinal fluid specimen of patients with acute encephalopathy and controls. As a result, six specific fragments were detected. The signal level of the patients with acute encephalopathy was significantly higher than those of controls. The difference was clearer in the multivariate analysis. In addition, a detection power was the highest in a signal level of fragment 3, as a result of ROC analysis. But the association between signal level and clinical features such as a type or the pathogen was not clear.
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