| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
To understand the pathophysiological mechanism of acute encephalopathy, and analyze the aggregative action of diclofenac sodium (DCF) on acute encephalopathy, we stimulated primary cultured rat astrocytes and microglia with IL-1beta;, TNF-alpha and IFN-gamma. The expression of iNOS and AQP4 and the production of NO were upregulated in astrocytes and the expression of iNOS and the activities of phagocytosis were increased in microglia. The addition of DCF highly enhanced the expression of iNOS and AQP4, and the activities of phagocytosis. This enhancement may explain the significantly increased mortality rates in acute encephalopathy patients treated with DCF.
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