Immunomodulatory therapy of acute encephalopathy associated with hemolytic uremic syndrome

• Project/Area Number: 23591512
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Wakayama Medical University
• Principal Investigator: MINAMI KOICHI 和歌山県立医科大学, 医学部, 講師 (60301438)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Hiroyuki 和歌山県立医科大学, 医学部, 准教授 (80196865) ; YOSHIKAWA Norishige 和歌山県立医科大学, 医学部, 教授 (10158412)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 溶血性尿毒症症候群 / 急性脳症 / グリア細胞 / ケモカイン / Cannabinoids / 志賀毒素

Research Abstract

Infection with Shiga toxin (Stx)-producing Escherichia coli can lead to development of hemolytic uremic syndrome (HUS). Approximately 30% of patients with HUS suffer from central nervous system (CNS) complications and these patients have the poorest prognosis. It has been suggested that vascular endothelial injuries caused by Stxs play a crucial role in the development of the disease. Furthermore, the relationship of glial cell damage and Stxs is considered.
In this study, we investigated chemokine suppression mechanism using Cannabinoids in human astrocyte, and aimed to confirm the effect of disease specific therapy development based on the pathophysiology of HUS encephalopathy.

Research Products

• [Journal Article] 広範囲の白質裂傷を伴ったshaken baby syndromeの1乳児例 (2013)
  • Author(s): 南弘一,奥谷貴弘,津野嘉伸,杉本卓也,津田祐子,田村彰,柳川敏彦,吉川徳茂
  • Journal Title: 小児科臨床 Volume: 66(7) Pages: 1601-1605
  • Peer Reviewed
• [Journal Article] 広範囲の白質裂傷を伴ったshaken baby syndromeの1乳児例 (2013)
  • Author(s): 南 弘一, 奥谷貴弘, 津野嘉伸, 杉本卓也, 津田祐子, 田村 彰, 柳川敏彦, 吉川徳茂
  • Journal Title: 小児科臨床 Volume: 66 Pages: 1601-1605
  • Peer Reviewed
• [Journal Article] Chemokine expression in human astrocytes in response to shiga toxin 2 (2012)
  • Author(s): Kioka N, Minami K, Tamura A, Yoshikawa N.
  • Journal Title: Int J Inflam. 2012 Pages: 135803-135803
  • Peer Reviewed
• [Journal Article] Chemokine expression in human astrocytes in response to shiga toxin 2. (2012)
  • Author(s): Kioka N, Minami K, Tamura A, Yoshikawa N
  • Journal Title: Int J Inflam. Volume: 2012 Pages: 135803-135803
  • DOI: 10.1155/2012/135803
  • Peer Reviewed
• [Journal Article] Constructive Interference in Steady State (CISS)-MRI法が診断に有効であった前頭蓋底髄膜脳瘤の1例 (2011)
  • Author(s): 南弘一,五嶋文彦,中尾直之,大川都史香,田村彰,泉鉉吉,木岡直美,津田祐子,大松泰生,赤井美津代,吉川徳茂
  • Journal Title: 小児科臨床 Volume: 64(8) Pages: 1887-1890
  • Peer Reviewed
• [Journal Article] Constructive Interference in Steady State (CISS)-MRI法が診断に有効であった 前頭蓋底髄膜脳瘤の1例 (2011)
  • Author(s): 南 弘一, 五嶋文彦, 中尾直之, 大川都史香, 田村 彰, 泉 鉉吉, 木岡直美, 津田祐子，大松泰生，赤井美津代，吉川徳茂
  • Journal Title: 小児科臨床 Volume: 64(8) Pages: 1887-1890
• [Book] 神経症候群(第2版)-その他の神経疾患を含めて-】感染性疾患細菌感染症サルモネラ日本臨床別冊神経症候群I (2013)
  • Author(s): 南弘一
• [Book] 【神経症候群（第2版）ｰその他の神経疾患を含めて-】感染性疾患 細菌感染症 サルモネラ 別冊神経症候群I (2013)
  • Author(s): 南 弘一
  • Publisher: 日本臨床
• [Book] 非チフス性サルモネラ菌,小児感染症マニュアル2012日本小児感染症学会編 (2012)
  • Author(s): 南弘一(東京)
  • Publisher: 東京医学社
• [Book] 非チフス性サルモネラ菌，小児感染症マニュアル2012 日本小児感染症学会 編 (2012)
  • Author(s): 南 弘一
  • Publisher: 東京医学社，東京
• [Book] サルモネラ脳症,小児科臨床ピクシス28急性脳炎(急性脳症総編集五十嵐隆専門編集塩見正司) (2011)
  • Author(s): 南弘一(東京)
  • Publisher: 中山書店
• [Book] サルモネラ脳症 小児科臨床ピクシス28 急性脳炎・急性脳症 (2011)
  • Author(s): 南 弘一
  • Publisher: 中山書店