Inflammatory mechanisms of periventricular leukomalicia
Project/Area Number |
23591515
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | The University of Tokyo (2013) Kyorin University (2011-2012) |
Principal Investigator |
OKA Akira 東京大学, 医学部附属病院, 教授 (00251273)
|
Co-Investigator(Kenkyū-buntansha) |
伊藤 雅之 独立行政法人国立精神神経医療研究センター, 室長 (50243407)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | 脳室周囲白質軟化症 / 脳性麻痺 / 敗血症 / 周産期医学 / 脳障害 / 新生児敗血症 / リポ多糖 / 黄色ブドウ球菌 / 周産期脳障害 |
Research Abstract |
In order to investigate the role of infection and inflammation in the pathogenesis of periventricular leukomalacia (PVL), an important cause of cerebral palsy, models of neonatal sepsis were developed in rat pups. The intraperitoneal administration of lipopolysaccharides from E. Coli to neonatal rats caused PVL-like lesions in periventricular white matter, where the infiltration of inflammatory cells as well as the reduction of oligodendrocytes was observed, leading to the impaired myelination. These findings were regarded to be consistent with the damages of immature oligodendrocytes observed in human PVL. In another experimental model of neonatal sepsis of Gram-positive bacteria, the intraperitoneal injection of a toxin derived from Staphylococcus aureus caused neuronal loss in hippocampus, lacking lesion of cerebral white matter. Therefore, neonatal sepsis caused distinct lesions in neonatal brains, depending on the species of bacteria and related toxins.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Epidemiology of acute encephalopathy in Japan, with emphasis on the association of viruses and syndromes2012
Author(s)
Hoshino A, Saitoh M, Oka A, Okumura A, Kubota M, Saito Y, Takanashi JI, Hirose S, Yamagata T, Yamanouchi H, Mizuguchi M.
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Journal Title
Brain Dev
Volume: 34
Pages: 337-343
NAID
Related Report
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[Journal Article] Abnormal maturation and differentiation of neocortical neurons in epileptogenic cortical malformation : unique distribution of layer-specific marker cells of focal cortical dysplasia and hemimegalencephaly2012
Author(s)
Arai A, Saito T, Hanai S, Sukigara S, Nabatame S, Otsuki T, Nakagawa E, Takahashi A, Kaneko Y, Kaido T, Saito Y, Sugai K, Sasaki M, Goto Y, Itoh M.
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Journal Title
Brain Res
Volume: 1470
Pages: 89-97
Related Report
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[Journal Article] Delayed maturation and differentiation of neurons in focal cortical dysplasia with the transmantle sign : analysis of layer-specific marker expression2012
Author(s)
Sakakibara T, Sukigara S, Saito T, Otsuki T, Takahashi A, Kaneko Y, Kaido T, Saito Y, Sato N, Kimura Y, Nakagawa E, Sugai K, Sasaki M, Goto Y, Itoh M.
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Journal Title
J Neuropathol Exp Neurol
Volume: 71
Pages: 741-9
Related Report
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[Journal Article] Novel pathological abnormalities of deep brain structures including dysplastic neurons in anterior striatum associated with focal cortical dysplasia in epilepsy2012
Author(s)
Kaido T, Otsuki T, Kakita A, Sugai K, Saito Y, Sakakibara T, Takahashi A, Kaneko Y, Saito Y, Takahashi H, Honda R, Nakagawa E, Sasaki M, Itoh M.
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Journal Title
J Neurosurg Pediatr
Volume: 10
Pages: 217-25
Related Report
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[Journal Article] Imbalance of interneuron distribution between neocortex and basal ganglia : consideration of epileptogenesis of focal cortical dysplasia2012
Author(s)
Sakakibara T, Sukigara S, Otsuki T, Takahashi A, Kaneko Y, Kaido T, Saito Y, Sato N, Nakagawa E, Sugai K, Sasaki M, Goto Y, Itoh M.
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Journal Title
J Neurol Sci
Volume: 323
Pages: 128-33
Related Report
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[Journal Article] Epidemiology of acute encephalopathy in Japan, with emphasis on the association of viruses and syndromes.2012
Author(s)
Hoshino A, Saitoh M, Oka A, Okumura A, Kubota M, Saito Y, Takanashi JI, Hirose S, Yamagata T, Yamanouchi H, Mizuguchi M.
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Journal Title
Brain Dev
Volume: 34
Pages: 337-343
NAID
Related Report
Peer Reviewed
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