| Project/Area Number |
23591515
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | The University of Tokyo (2013)
Kyorin University (2011-2012) |
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Principal Investigator |
OKA Akira 東京大学, 医学部附属病院, 教授 (00251273)
|
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| Co-Investigator(Kenkyū-buntansha) |
伊藤 雅之 独立行政法人国立精神神経医療研究センター, 室長 (50243407)
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| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
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| Keywords | 脳室周囲白質軟化症 / 脳性麻痺 / 敗血症 / 周産期医学 / 脳障害 / 新生児敗血症 / リポ多糖 / 黄色ブドウ球菌 / 周産期脳障害 |
|---|
| Research Abstract |
In order to investigate the role of infection and inflammation in the pathogenesis of periventricular leukomalacia (PVL), an important cause of cerebral palsy, models of neonatal sepsis were developed in rat pups. The intraperitoneal administration of lipopolysaccharides from E. Coli to neonatal rats caused PVL-like lesions in periventricular white matter, where the infiltration of inflammatory cells as well as the reduction of oligodendrocytes was observed, leading to the impaired myelination. These findings were regarded to be consistent with the damages of immature oligodendrocytes observed in human PVL. In another experimental model of neonatal sepsis of Gram-positive bacteria, the intraperitoneal injection of a toxin derived from Staphylococcus aureus caused neuronal loss in hippocampus, lacking lesion of cerebral white matter. Therefore, neonatal sepsis caused distinct lesions in neonatal brains, depending on the species of bacteria and related toxins.
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