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Analysis of pathogenesis of acute encephalopathy in children

Research Project

Project/Area Number 23591518
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionJuntendo University

Principal Investigator

OKUMURA Akihisa  順天堂大学, 医学部, 准教授 (60303624)

Co-Investigator(Kenkyū-buntansha) HAYAKAWA Masahiro  名古屋大学, 医学部附属病院, 教授 (40343206)
HAYASHI Masaharu  財団法人東京都医学総合研究所, 脳発達神経再生研究分野, プロジェクトリーダー (00280777)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords自己免疫 / 抗神経抗体 / 急性脳症 / 免疫組織化学染色法 / 辺縁系脳炎 / 基底核脳炎 / 急性脳炎・脳症 / 自己抗体 / イムノブロット / 免疫組織染色 / 刺激試験 / ウエスタンブロット
Research Abstract

Autoimmune process is presumed to contribute in acute encephalopathy in children. However, the methods for detecting autoantibodies have not been established. We measured serum autoantibodies in children with acute encephalopathy using several different methods. The subject of this study is 16 children with acute encephalopathy suspected to have autoimmune encephalopathy. We measured autoantibodies using the following methods: 1) immunoblot using prepared membrane with human brain derived proteins (IB), 2) immunohistochemical studies using rat brain tissue (rat IHC), 3) immunohistochemical studies using control human brain tissue (human IHC). Autoantibodies were detected in 5 children by IB, 11 by rat IHC, and 10 by human IHC. The results of examinations were not always consistent among methods of measurement. Our study revealed that IHC will be more sensitive than IB. However, the detection of autoantibody should be made in combination of several detection methods.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (79 results)

All 2013 2012 2011

All Journal Article (50 results) (of which Peer Reviewed: 50 results) Presentation (28 results) (of which Invited: 4 results) Book (1 results)

  • [Journal Article] Unexpected cardiopulmonary arrest associated with influenza : our experience during the 2009 pandemic in Japan2013

    • Author(s)
      Okumura A, et al.
    • Journal Title

      Influenza Other Respi Viruses

      Volume: 7 Pages: 759-760

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Severe form of encephalopathy associated with 2009 pandemic influenza A (H1N1) in Japan2013

    • Author(s)
      Okumura A, et al.
    • Journal Title

      J Clin Virol

      Volume: 56 Pages: 25-30

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Whole-exome sequencing of a unique brain malformation with periventricular heterotopia, cingulate polymicrogyria and midbrain tectal hyperplasia2013

    • Author(s)
      Okumura A, Hayashi M, et al.
    • Journal Title

      Neuropathology

      Volume: 33 Pages: 553-560

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acute limbic encephalitis with focal hyperperfusion on single photon emission computed tomography2013

    • Author(s)
      Igarashi A, Okumura A, Hayashi M, et al. (5名省略)
    • Journal Title

      Brain Dev

      Volume: 35 Pages: 181-184

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neonatal seizure identification on reduced channel EEG2013

    • Author(s)
      Kidokoro H, Kubota T, Hayakawa M, Kato Y, Okumura A.
    • Journal Title

      Arch Dis Child Fetal Neonatal Ed

      Volume: 98

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Safety evaluation of laninamivir octanoate hydrate through analysis of adverse events reported during early post-marketing phase vigilance2013

    • Author(s)
      Nakano T, Okumura A, et al. (6名省略)
    • Journal Title

      Scand J Infect Dis

      Volume: 45 Pages: 469-477

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Severe form of encephalopathy associated with 2009 pandemic influenza A (H1N1) in Japan.2013

    • Author(s)
      Okumura A, Nakagawa S, Kawashima H, Morichi S, Muguruma T, Saito O, Fujimoto JI, Toida C, Kuga S, Imamura T, Shimizu T, Kondo N, Morishima T.
    • Journal Title

      J Clin Virol

      Volume: 56 Issue: 1 Pages: 25-30

    • DOI

      10.1016/j.jcv.2012.10.007

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unexpected cardiopulmonary arrest associated with influenza: our experience during the 2009 pandemic in Japan.2013

    • Author(s)
      Okumura A, Nakagawa S, Kawashima H, Muguruma T, Saito O, Fujimoto J, Toida C, Kuga S, Imamura T, Shimizu T, Kondo N, Morishima T
    • Journal Title

      Influenza Other Respi Viruses

      Volume: 7 Issue: 5 Pages: 759-760

    • DOI

      10.1111/irv.12032

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute limbic encephalitis with focal hyperperfusion on single photon emission computed tomography.2013

    • Author(s)
      Igarashi A et al.
    • Journal Title

      Brain Dev.

      Volume: 35 Issue: 2 Pages: 181-184

    • DOI

      10.1016/j.braindev.2012.03.014

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human herpesvirus 6-associated encephalopathy in a child with dravet syndrome2013

    • Author(s)
      Hiraiwa-Sofue A, Ito Y, Ohta R, Kimura H, Okumura A
    • Journal Title

      Neuropediatrics

      Volume: 44 Issue: 03 Pages: 155-158

    • DOI

      10.1055/s-0032-1327772

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Safety evaluation of laninamivir octanoate hydrate through analysis of adverse events reported during early post-marketing phase vigilance.2013

    • Author(s)
      Nakano T, Okumura A, Tanabe T, Niwa S, Fukushima M, Yonemochi R, Eda H, Tsutsumi H.
    • Journal Title

      Scand J Infect Dis

      Volume: 45 Issue: 6 Pages: 469-477

    • DOI

      10.3109/00365548.2012.763104

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute encephalopathy in children with Dravet syndrome2012

    • Author(s)
      Okumura A, et al. (14名省略)
    • Journal Title

      Epilepsia

      Volume: 53 Pages: 79-86

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acute encephalopathy with 2009 pandemic flu : Comparison with seasonal flu2012

    • Author(s)
      Okumura A, et al. (8名省略)
    • Journal Title

      Brain Dev

      Volume: 34 Pages: 13-19

    • NAID

      10031049369

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress in patients with clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS)2012

    • Author(s)
      Miyata R, Hayashi M, Okumura A, et al. (8名省略)
    • Journal Title

      Brain Dev

      Volume: 34 Pages: 124-127

    • NAID

      10031049788

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] National survey of pandemic influenza A (H1N1) 2009-associated encephalopathy in Japanese children2012

    • Author(s)
      Kawashima H, Okumura A, et al. (3名省略、)
    • Journal Title

      J Med Virol

      Volume: 84 Pages: 1151-1156

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic factors in acute encephalopathy with reduced subcortical diffusion2012

    • Author(s)
      Hayashi N, Okumura A, et al. (7名省略)
    • Journal Title

      Brain Dev

      Volume: 34 Pages: 632-639

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Treatment of pandemic influenza A (H1N1) 2009-associated encephalopathy in children2012

    • Author(s)
      Kawashima H, Okumura A, et al. (3名省略)
    • Journal Title

      Scand J Infect Dis

      Volume: 44 Pages: 941-947

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acute encephalopathy with 2009 pandemic flu: Comparison with seasonal flu.2012

    • Author(s)
      Okumura A, Tsuji T, Kubota T, Ando N, Kobayashi S, Kato T, Natsume J, Hayakawa F, Shimizu T.
    • Journal Title

      Brain Dev

      Volume: 34 Issue: 1 Pages: 13-19

    • DOI

      10.1016/j.braindev.2011.01.004

    • NAID

      10031049369

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acute encephalopathy in children with Dravet syndrome.2012

    • Author(s)
      Okumura A, Uematsu M, Imataka G, Tanaka M, Okanishi T, Kubota T, Sudo A, Tohyama J, Tsuji M, Ohmori I, Naiki M, Hiraiwa-Sofue A, Sato H, Saitoh S, Shimizu T.
    • Journal Title

      Epilepsia

      Volume: 53 Issue: 1 Pages: 79-86

    • DOI

      10.1111/j.1528-1167.2011.03311.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A severe form of epidermal nevus syndrome associated with brainstem and cerebellar malformations and neonatal medulloblastoma.2012

    • Author(s)
      Okumura A, Lee T, Ikeno M, Shimojima K, Kajino K, Inoue Y, Yoshikawa N, Suganuma H, Suzuki M, Hisata K, Shoji H, Takanashi J, James Barkovich A, Shimizu T, Yamamoto T, Hayashi M.
    • Journal Title

      Brain Dev

      Volume: 34 Issue: 10 Pages: 881-885

    • DOI

      10.1016/j.braindev.2012.03.003

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress in patients with clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS).2012

    • Author(s)
      Miyata R et al.
    • Journal Title

      Brain Dev.

      Volume: 34 Issue: 2 Pages: 124-127

    • DOI

      10.1016/j.braindev.2011.04.004

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A 15-month-old boy with reduced consciousness and convulsion.2012

    • Author(s)
      Oikawa N, Okumura A, Oyama S, Baba H, Shimizu T, Kato A.
    • Journal Title

      J Clin Virol

      Volume: 53 Issue: 4 Pages: 276-279

    • DOI

      10.1016/j.jcv.2012.01.021

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pertussis-associated encephalitis/encephalopathy with marked demyelination in an unimmunized child.2012

    • Author(s)
      Hiraiwa-Sofue A, Ito Y, Mori H, Ichiyama T, Okumura A
    • Journal Title

      J Neurol Sci

      Volume: 320 Issue: 1-2 Pages: 145-148

    • DOI

      10.1016/j.jns.2012.06.010

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] EEG for predicting early neurodevelopment in preterm infants: an observational cohort study.2012

    • Author(s)
      Hayashi-Kurahashi N, Kidokoro H, Kubota T, Maruyama K, Kato Y, Kato T, Natsume J, Hayakawa F, Watanabe K, Okumura A
    • Journal Title

      Pediatrics

      Volume: 130 Issue: 4 Pages: e891-e897

    • DOI

      10.1542/peds.2012-1115

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic factors in acute encephalopathy with reduced subcortical diffusion.2012

    • Author(s)
      Hayashi N, Okumura A, Kubota T, Tsuji T, Kidokoro H, Fukasawa T, Hayakawa F, Ando N, Natsume J.
    • Journal Title

      Brain Dev

      Volume: 34 Issue: 8 Pages: 632-639

    • DOI

      10.1016/j.braindev.2011.11.007

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] National survey of pandemic influenza A (H1N1) 2009-associated encephalopathy in Japanese children.2012

    • Author(s)
      Kawashima H, Morichi S, Okumura A, Nakagawa S, Morishima T; collaborating study group on influenza-associated encephalopathy in Japan.
    • Journal Title

      J Med Virol

      Volume: 84 Issue: 8 Pages: 1151-1156

    • DOI

      10.1002/jmv.23317

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Treatment of pandemic influenza A (H1N1) 2009-associated encephalopathy in children.2012

    • Author(s)
      Kawashima H, Morichi S, Okumura A, Nakagawa S, Morishima T; The Collaborating Study Group On Influenza-Associated Encephalopathy In Japan.
    • Journal Title

      Scand J Infect Dis

      Volume: 44 Issue: 12 Pages: 941-947

    • DOI

      10.3109/00365548.2012.700769

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Deaths associated with pandemic (H1N1) 2009 among children, Japan, 2009–20102011

    • Author(s)
      Okumura A, et al. (11名省略)
    • Journal Title

      Emerg Infect Dis

      Volume: 17 Pages: 1993-2000

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acute encephalopathy in a child with secondary carnitine deficiency due to pivalate-conjugated antibiotics2011

    • Author(s)
      Okumura A, et al. (4名省略)
    • Journal Title

      Pediatr Infect Dis J

      Volume: 30 Pages: 92-92

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amplitude-integrated electroencephalography in patients with acute encephalopathy with refractory, repetitive partial seizures2011

    • Author(s)
      Okumura A, et al. (6名省略)
    • Journal Title

      Brain Dev

      Volume: 33

    • NAID

      10029560284

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amplitude-integrated electroencephalography in preterm infants with cystic periventricular leukomalacia2011

    • Author(s)
      Kato T, Okumura A, Hayakawa M, et al. (3名省略)
    • Journal Title

      Early Hum Dev

      Volume: 87 Pages: 217-221

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chronological diffusion-weighted imaging changes and mutism in the course of rotavirus-associated acute cerebellitis/cerebellopathy concurrent with encephalitis/encephalopathy2011

    • Author(s)
      Kubota T, Okumura A, et al. (6名省略)
    • Journal Title

      Brain Dev

      Volume: 33 Pages: 21-27

    • NAID

      10029560057

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transient and mild reduction of consciousness during febrile illness in children2011

    • Author(s)
      Kato T, Okumura A, et al. (4名省略)
    • Journal Title

      Neuropediatrics

      Volume: 42 Pages: 183-187

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epidemiology of acute encephalopathy in Japan, with emphasis on the association of viruses and syndromes2011

    • Author(s)
      Hoshino A, Saitoh M, Oka A, Okumura A, Kubota M, Saito Y, Takanashi J, Hirose S, Yamagata T, Yamanouchi H, Mizuguchi M
    • Journal Title

      Brain Dev

      Volume: 34 Issue: 5 Pages: 337-343

    • DOI

      10.1016/j.braindev.2011.07.012

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Amplitude-integrated electroencephalography in patients with acute encephalopathy with refractory, repetitive partial seizures.2011

    • Author(s)
      Okumura A, Komatsu M, Abe S, Kitamura T, Matsui K, Ikeno M, Shimizu T.
    • Journal Title

      Brain Dev

      Volume: 33 Issue: 1 Pages: 77-82

    • DOI

      10.1016/j.braindev.2009.12.009

    • NAID

      10029560284

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acute encephalopathy in a child with secondary carnitine deficiency due to pivalate-conjugated antibiotics.2011

    • Author(s)
      Okumura A, Morita M, Ikeno M, Abe S, et al.
    • Journal Title

      Pediatr Infect Dis J

      Volume: 30 Issue: 1 Pages: 92-92

    • DOI

      10.1097/inf.0b013e3181fe3953

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transiently restricted diffusion in the corpus callosum in bacterial meningitis.2011

    • Author(s)
      Okumura A, Kitamura Y, Abe S, Ikeno M, Shimizu T.
    • Journal Title

      J Pediatr Infect Dis

      Volume: 6 Pages: 51-53

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Refractory neonatal epilepsy with a de novo duplication of chromosome 2q24.2q24.32011

    • Author(s)
      Okumura, A., et al
    • Journal Title

      Epilepsia

      Volume: 52 Issue: 7 Pages: e66-e69

    • DOI

      10.1111/j.1528-1167.2011.03139.x

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Deaths associated with pandemic (H1N1) 2009 among children, Japan, 2009-2010.2011

    • Author(s)
      Okumura A, Nakagawa S, et al.
    • Journal Title

      Emerg Infect Dis 2011; 17:

      Volume: 17 Issue: 11 Pages: 1993-2000

    • DOI

      10.3201/eid1711.110649

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chronological diffusion-weighted imaging changes and mutism in the course of rotavirus-associated acute cerebellitis/cerebellopathy concurrent with encephalitis/encephalopathy.2011

    • Author(s)
      Kubota T, Suzuki T, et al..
    • Journal Title

      Brain Dev

      Volume: 33 Issue: 1 Pages: 21-27

    • DOI

      10.1016/j.braindev.2010.04.007

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Early infantile manifestations of incontinentia pigmenti mimicking acute encephalopathy2011

    • Author(s)
      Abe S, Okumura A, et al.
    • Journal Title

      Brain Dev

      Volume: 33 Issue: 1 Pages: 28-34

    • DOI

      10.1016/j.braindev.2010.04.002

    • NAID

      10029560087

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical trial of minimal treatment for clustering seizures in cases of convulsions with mild gastroenteritis2011

    • Author(s)
      Tanabe T, et al.
    • Journal Title

      Brain Dev

      Volume: 33 Issue: 2 Pages: 120-124

    • DOI

      10.1016/j.braindev.2010.02.007

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Epilepsies and epileptic syndromes starting in the neonatal period.2011

    • Author(s)
      Yamamoto H, Okumura A, Fukuda M.
    • Journal Title

      Brain Dev

      Volume: 33 Issue: 3 Pages: 213-220

    • DOI

      10.1016/j.braindev.2010.10.009

    • NAID

      10029560830

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Amplitude-integrated electroencephalography in preterm infants with cystic periventricular leukomalacia.2011

    • Author(s)
      Kato T, et al.
    • Journal Title

      Early Hum Dev

      Volume: 87 Issue: 3 Pages: 217-221

    • DOI

      10.1016/j.earlhumdev.2010.12.008

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Late-onset sensorineural hearing loss due to asymptomatic congenital cytomegalovirus infection retrospectively diagnosed by polymerase chain reaction using preserved umbilical cord.2011

    • Author(s)
      Ikeno M, et al.
    • Journal Title

      Clin Pediatr

      Volume: 50 Issue: 7 Pages: 666-668

    • DOI

      10.1177/0009922810380903

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acute encephalopathy in a patient with Dravet syndrome.2011

    • Author(s)
      Tsuji M, Mazaki E, Ogiwara I, Wada T, Iai M, Okumura A, Yamashita S, Yamakawa K, Osaka H
    • Journal Title

      Neuropediatrics

      Volume: 42 Issue: 02 Pages: 78-81

    • DOI

      10.1055/s-0031-1279725

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of brain maturation in pre-term infants using conventional and amplitude-integrated electroencephalograms.2011

    • Author(s)
      Kato T, et al.
    • Journal Title

      Clin Neurophysiol

      Volume: 122 Issue: 10 Pages: 1967-1972

    • DOI

      10.1016/j.clinph.2010.12.063

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] SCN1B is not related to benign partial epilepsy in infancy or convulsions with gastroenteritis2011

    • Author(s)
      Yamashita, S., et al
    • Journal Title

      Neuropediatrics

      Volume: 42 Issue: 04 Pages: 135-137

    • DOI

      10.1055/s-0031-1285837

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] CDKL5 alterations lead to early epileptic encephalopathy in both genders2011

    • Author(s)
      Jao-Shwann Liang, Keiko Shimojima, Rumiko Takayama, Jun Natsume, MinobuShichiji, Kyoko Hirasawa, Kaoru Imai, Tohru Okanishi, Seiji Mizuno, Akihisa Okumura, Midori Sugawara, Tomoshiro Ito, Hiroko Ikeda, Yukitoshi Takahashi, Hirokazu Oguni, Katsumi Imai, Makiko Osawa, Toshiyuki Yamamoto
    • Journal Title

      Epilepsia

      Volume: 52-10 Issue: 10 Pages: 1835-1842

    • DOI

      10.1111/j.1528-1167.2011.03174.x

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transient and Mild Reduction of Consciousness during Febrile Illness in Children.2011

    • Author(s)
      Kato T, et al.
    • Journal Title

      Neuropediatrics

      Volume: 42 Issue: 05 Pages: 183-187

    • DOI

      10.1055/s-0031-1295411

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Attitude toward Epilepsy after Media Coverage of Car Accidents Related to Persons with Epilepsy in Japan2013

    • Author(s)
      Akihisa Okumura, et al
    • Organizer
      第47回日本てんかん学会学術集会
    • Place of Presentation
      北九州
    • Year and Date
      2013-10-11
    • Related Report
      2013 Final Research Report
  • [Presentation] 新生児発作に対するホスフェニトインの使用経験2013

    • Author(s)
      奥村彰久、他
    • Organizer
      第49回日本周産期・新生児医学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2013-07-15
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Attitude toward Epilepsy after Media Coverage of Car Accidents Related to Persons with Epilepsy in Japan2013

    • Author(s)
      Akihisa Okumura, et al
    • Organizer
      30th International Epilepsy Congress
    • Place of Presentation
      Montreal
    • Year and Date
      2013-06-24
    • Related Report
      2013 Final Research Report
  • [Presentation] Whole-exome sequencing identifies FLNB variant in a unique brain malformation2013

    • Author(s)
      Akihisa Okumura, et al
    • Organizer
      第55回小児神経学会総会
    • Place of Presentation
      大分
    • Year and Date
      2013-05-30
    • Related Report
      2013 Final Research Report
  • [Presentation] インフルエンザに伴う予期せぬ心肺停止:パンデミック2009小児死亡例の実態調査から2013

    • Author(s)
      奥村彰久、他
    • Organizer
      第116回日本小児科学会学術集会
    • Place of Presentation
      広島
    • Year and Date
      2013-04-20
    • Related Report
      2013 Final Research Report
  • [Presentation] インフルエンザに伴う予期せぬ心肺停止:パンデミック2009 小児死亡例の実態調査から.2013

    • Author(s)
      奥村彰久、中川聡、河島尚志、清水俊明、近藤直実、森島恒雄、新型インフルエンザ死亡例調査グループ.
    • Organizer
      第116回日本小児科学会学術集会
    • Place of Presentation
      広島
    • Related Report
      2013 Annual Research Report
  • [Presentation] Whole-exome sequencing identifies FLNB variant in a unique brain malformation.2013

    • Author(s)
      Akihisa Okumura, Masaharu Hayashi, Keiko Shimojima, Mitsuru Ikeno, Shinpei Abe, Jun-ichi Takanashi, Nobuhiko Okamoto, Toshiaki Shimizu, Toshiyuki Yamamoto.
    • Organizer
      第55回小児神経学会総会
    • Place of Presentation
      大分
    • Related Report
      2013 Annual Research Report
  • [Presentation] 急性脳症をいかに理解するか:今後の研究アプローチ2013

    • Author(s)
      奥村彰久
    • Organizer
      第55回小児神経学会総会
    • Place of Presentation
      大分
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] PRRT2 Mutation in Japanese Children with Benign Infantile Epilepsy2012

    • Author(s)
      Okumura, et al
    • Organizer
      The 16th Anunal Meeting of American Epilepsy Society
    • Place of Presentation
      San Diego
    • Year and Date
      2012-12-02
    • Related Report
      2013 Final Research Report
  • [Presentation] 新生児および乳幼児の発作-aEEGによる評価-2012

    • Author(s)
      奥村彰久
    • Organizer
      第46回日本てんかん学会
    • Place of Presentation
      東京
    • Year and Date
      2012-10-10
    • Related Report
      2013 Final Research Report
  • [Presentation] Neonatal EEG in determining risk to the preterm brain2012

    • Author(s)
      Akihisa Okumura
    • Organizer
      Joint congress of the 12th International Child Neurology Congress and the 11th Asian and Oceanian Congress of Child Neurology
    • Place of Presentation
      Brisbane
    • Year and Date
      2012-06-01
    • Related Report
      2013 Final Research Report
  • [Presentation] Autoimmune encephalitis proven by immunohistochemical study2012

    • Author(s)
      Akihisa Okumura, et al
    • Organizer
      第54回日本小児神経学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-05-17
    • Related Report
      2013 Final Research Report
  • [Presentation] アトキンス食に伴う成長障害2012

    • Author(s)
      奥村彰久、他
    • Organizer
      第115回日本小児科学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2012-04-19
    • Related Report
      2013 Final Research Report
  • [Presentation] Autoimmune Encephalitis Proven by Immunohistochemical Study2012

    • Author(s)
      Akihisa Okumura, Tetsuo Kubota, Motomasa Suzuki, Tatsuya Fukazawa, Shinpei Abe, Mitsuru Ikeno, Mariko Hosozawa, Toshiaki Shimizu, Masaharu Hayashi.
    • Organizer
      第54回日本小児神経学会総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] Neonatal EEG in determining risk to the preterm brain2012

    • Author(s)
      Akihisa Okumura
    • Organizer
      Joint congress of the 12th International Child Neurology Congress and the 11th Asian and Oceanian Congress of Child Neurology
    • Place of Presentation
      Brisbane, Austlaria
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] TUBA1A変異による滑脳症・脳室拡大・小脳低形成の1剖検例2012

    • Author(s)
      奥村彰久、池野充、久田研、東海林宏道、清水俊明
    • Organizer
      第48回日本周産期・新生児医学会学術集会
    • Place of Presentation
      さいたま
    • Related Report
      2012 Research-status Report
  • [Presentation] PRRT2 Mutation in Japanese Children with Benign Infantile Epilepsy2012

    • Author(s)
      Akihisa Okumura, Keiko Shimojima, Tetsuo Kubota, et al.
    • Organizer
      第46回日本てんかん学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 小児急性脳症の脳波2012

    • Author(s)
      奥村彰久
    • Organizer
      第17回日本神経感染症学会総会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 新生児および小児におけるamplitude-integrated EEGの臨床応用2012

    • Author(s)
      奥村彰久
    • Organizer
      第42回日本臨床神経生理学会・学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] PRRT2 Mutation in Japanese Children with Benign Infantile Epilepsy.2012

    • Author(s)
      Akihisa Okumura, Keiko Shimojima , Tetsuo Kubota , et al.
    • Organizer
      he 16th Anunal Meeting of American Epilepsy Society
    • Place of Presentation
      San Diego, CA, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] 新生児発作・新生児発作様イベントの症状型分類の実証的検討2011

    • Author(s)
      奥村彰久、他
    • Organizer
      第56回日本未熟児新生児学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-14
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] 2番染色体長腕の微小重複を伴う難治性新生児てんかんの1例2011

    • Author(s)
      奥村彰久、他
    • Organizer
      第45回日本てんかん学会総会
    • Place of Presentation
      新潟
    • Year and Date
      2011-10-06
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] Neonatal seizures and epilepsy2011

    • Author(s)
      Akihisa Okumura
    • Organizer
      29th International Epilepsy Congress
    • Place of Presentation
      Rome
    • Year and Date
      2011-09-01
    • Related Report
      2013 Final Research Report
  • [Presentation] 2009 Pandemic Flu A (H1N1)小児死亡例の実態調査2011

    • Author(s)
      奥村彰久、他
    • Organizer
      第114回日本小児科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-08-14
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] 2009 Pandemic Flu A (H1N1)による急性脳症死亡例の臨床像2011

    • Author(s)
      奥村彰久、他
    • Organizer
      第53回日本小児神経学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-05-27
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] Neonatal seizures2011

    • Author(s)
      Akihisa Okumura
    • Organizer
      The 15th Annual Meetings of Taiwan Child Neurology Society(招待講演)
    • Place of Presentation
      Taipei
    • Related Report
      2011 Research-status Report
  • [Presentation] Acute encephalopathy in children2011

    • Author(s)
      Akihisa Okumura
    • Organizer
      Invited lecture at National Taiwan University Hospita(招待講演)
    • Place of Presentation
      Taipei
    • Related Report
      2011 Research-status Report
  • [Presentation] Neonatal seizures and epilepsy2011

    • Author(s)
      Akihisa Okumura
    • Organizer
      29th International Epilepsy Congress(招待講演)
    • Place of Presentation
      Rome
    • Related Report
      2011 Research-status Report
  • [Book] 発作時脳波からみた小児てんかん2011

    • Author(s)
      奥村彰久、根来民子、夏目淳、渡邊一功
    • Total Pages
      150
    • Publisher
      診断と治療社
    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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