| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Neuroglycan C is a brain specific chondroitin sulfate proteoglycan, which locates at dendritic spines. In this study, we revealed that Neuroglycan C interacts with some of molecules of FGF, fibroblast growth factor family. We observed that the expression levels of both Neuroglycan C and its binding partner, FGFs are enhanced by drug in the some of nucleus in the brain including the nucleus accumbens, which is known to be closely related to methamphetamine addiction. Interestingly, it has been demonstrated that some of FGFs has significant effects on presynaptic formation of both glutamatergic and GABAergic neurons. Moreover, Neuroglycan C can form molecular complex with the FGF, we thus speculate that up-regulated FGFs could be accumulated at spines with Neuroglycan C expressed on post synaptic neuronal membranes to promote neural circuit formation in these nuclei.
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