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The role of biological clock in fetal programming by maternal overnutrition

Research Project

Project/Area Number 23591526
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionResearch Institute, Osaka Medical Center for Maternal and Child Health

Principal Investigator

KAWAI Masanobu  地方独立行政法人大阪府立病院機構大阪府立母子保健総合医療センター(研究所), その他部局等, 研究員 (50598117)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords概日リズム / 胎児期プログラミング / PPARガンマ / 胎仔プログラミング / 胎児プログラミング
Research Abstract

Fetal exposure to high fat diet (HFD) has been implicated in metabolic syndrome in later life.In addition, accumulating evidence indicates the critical role of biological clock in the development of metabolic syndrome. Based on these, the effect of fetal exposure to HFD on the circadian rhythm of genes involved in glucose and lipid metabolism was analyzed. Fetal exposure to HFD caused a significant increase in the fat accumulation in the abdomen accompanied by the impaired glucose tolerance and insulin sensitivity. Expression profile of Pparg showd the circadian pattren in the epididymal adipose tissue with lower expression during the dark phase, whereas its expression was enhanced in mice exposed to HFD during fetal period. These findings suggest that the alteration of Pparg expression profile may have a significant impact on the development of metabolic syndrome in mice exposed to HFD during fetal life.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (39 results)

All 2014 2013 2012 2011 Other

All Journal Article (24 results) (of which Peer Reviewed: 13 results,  Open Access: 2 results) Presentation (15 results)

  • [Journal Article] Sympathetic activation induces skeletal Fgf23 expression in a circadian rhythm-dependent manner.2014

    • Author(s)
      Kawai M, Kinoshita S, Shimba S, Ozono K, Michigami T
    • Journal Title

      J Biol Chem

      Volume: 289 Issue: 3 Pages: 1457-1466

    • DOI

      10.1074/jbc.m113.500850

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevated fibroblast growth factor 23 exerts its effects on placenta and regulates vitamin D metabolism in pregnancy of hyp mice2014

    • Author(s)
      Okano T(12), 他13人
    • Journal Title

      J Bone Miner Res

      Volume: 印刷中 Issue: 7 Pages: 0-0

    • DOI

      10.1002/jbmr.2186

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dysregulated gene expression in the primary osteoblasts and osteocytes isolated from hypophosphatemic Hyp mice.2014

    • Author(s)
      Miyagawa K, Yamazaki M, Kawai M, Nishino J, Koshimizu T, Ohata Y, Tachikawa K, Mikuni-Takagaki Y, Kogo M, Ozono K, Michigami T
    • Journal Title

      PLoS One

      Volume: 9 Issue: 4 Pages: 0-0

    • DOI

      10.1371/journal.pone.0093840

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] FGF23 suppresses chondrocyte proliferation in the presence of solubleα-Klotho both in vitro and in vivo2013

    • Author(s)
      Kawai M, Kinoshita S, Kimoto A, Hasegawa Y, Miyagawa K, Yamazaki M, Ohata Y, Ozono K, Michigami T
    • Journal Title

      J Biol Chem

      Volume: 25;288(4) Pages: 2414-27

    • Related Report
      2013 Final Research Report
  • [Journal Article] Sodium-coupled Neutral Amino Acid Transporter 4 Functions as a Regulator of Protein Synthesis during Liver Development2013

    • Author(s)
      Kondou H, Kawai M, Tachikawa K, Kimoto A, Yamagata M, Koinuma T, Yamazaki M, Nakayama M, Mushiake S, Ozono K, Michigami T
    • Journal Title

      Hepatol Res

      Volume: 43(11) Pages: 1211-23

    • Related Report
      2013 Final Research Report
  • [Journal Article] Altered thermogenesis and impaired bone remodeling in Misty mice2013

    • Author(s)
      Motyl KJ, Bishop KA, DeMambro VE, Bornstein SA, Le P, Kawai M, Lotinun S, Horowitz MC, Baron R, Bouxsein ML, Rosen CJ
    • Journal Title

      J Bone Miner Res

      Volume: 28(9) Pages: 1885-97

    • Related Report
      2013 Final Research Report
  • [Journal Article] Adipose tissue and bone : role of PPARγin adipogenesis and osteogenesis2013

    • Author(s)
      Kawai M
    • Journal Title

      Horm Mol Biol Clin Invest

      Volume: 15(3)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Adipose tissue and bone: role of PPARγ in adipogenesis and osteogenesis2013

    • Author(s)
      Kawai M
    • Journal Title

      Horm Mol Biol Clin Invest

      Volume: 15 Issue: 3 Pages: 105-113

    • DOI

      10.1515/hmbci-2013-0036

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sodium-coupled Neutral Amino Acid Transporter 4 Functions as a Regulator of Protein Synthesis during Liver Development.2013

    • Author(s)
      Kondou H, Kawai M, Tachikawa K, Kimoto A, Yamagata M, Koinuma T, Yamazaki M, Nakayama M, Mushiake S, Ozono K, Michigami T
    • Journal Title

      Hepatol Res

      Volume: 43 Issue: 11 Pages: 1211-1223

    • DOI

      10.1111/hepr.12069

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered thermogenesis and impaired bone remodeling in Misty mice.2013

    • Author(s)
      Motyl KJ, Bishop KA, Demambro VE, Bornstein SA, Le P, Kawai M, Lotinun S, Horowitz MC, Baron R, Bouxsein ML, Rosen CJ.
    • Journal Title

      J Bone Miner Res.

      Volume: Apr2 Issue: 9 Pages: 1885-1897

    • DOI

      10.1002/jbmr.1943

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] FGF23 suppresses chondrocyte proliferation in the presence of soluble α-Klotho both in vitro and in vivo.2013

    • Author(s)
      Kawai M, Kinoshita S, Kimoto A, Hasegawa Y, Miyagawa K, Yamazaki M, Ohata Y, Ozono K, Michigami T.
    • Journal Title

      J Biol Chem

      Volume: 288 Issue: 4 Pages: 2414-2427

    • DOI

      10.1074/jbc.m112.410043

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Insulin-like growth factor binding protein-2 is required for osteoclast differentiation2012

    • Author(s)
      DeMambro VE, Maile L, Wai C, Kawai M, Cascella T, Rosen CJ, Clemmons DR
    • Journal Title

      J Bone Miner Res

      Volume: 27(2) Pages: 390-400

    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Journal Article] A High Fat Diet Induces Bone Loss in Mice Lacking the Alox5 Gene2012

    • Author(s)
      Le P, Kawai M, Bornstein S, DeMambro VE, Horowitz MC, Rosen CJ
    • Journal Title

      Endocrinology

      Volume: 153(1) Pages: 6-16

    • Related Report
      2013 Final Research Report
  • [Journal Article] Vinculin Functions as a Regulator of Chondrogenesis2012

    • Author(s)
      Koshimizu T, Kawai M, Kondou H, Tachikawa K, Sakai N, Ozono K, Michigami T
    • Journal Title

      J Biol Chem

      Volume: 4;287(19) Pages: 15760-75

    • Related Report
      2013 Final Research Report
  • [Journal Article] New Insights into Osteoporosis : The Bone-Fat Connection2012

    • Author(s)
      Kawai M, de Paula FJ, Rosen CJ
    • Journal Title

      J Intern Med

      Volume: 272(4) Pages: 317-29

    • Related Report
      2013 Final Research Report
  • [Journal Article] The IGF system in bone : Basic and Clinical Implications2012

    • Author(s)
      Kawai M, Rosen CJ
    • Journal Title

      Endocrinol Metab Clin North Am

      Volume: 41(2) Pages: 323-33

    • Related Report
      2013 Final Research Report
  • [Journal Article] Vinculin functions as regulator of chondrogenesis.2012

    • Author(s)
      Koshimizu T, Kawai M, Kondou H, Tachikawa K, Sakai N, Ozono K, Michigami T.
    • Journal Title

      J Biol Chem

      Volume: 287 Issue: 19 Pages: 15760-15775

    • DOI

      10.1074/jbc.m111.308072

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The insulin-like growth factor system in bone: basic and clinical implications.2012

    • Author(s)
      Kawai M, Rosen CJ.
    • Journal Title

      Endocrinol Metab Clin North Am.

      Volume: 41(2): Issue: 2 Pages: 323-333

    • DOI

      10.1016/j.ecl.2012.04.013

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] New insights into osteoporosis: the bone-fat connection.2012

    • Author(s)
      Kawai M, de Paula FJ, Rosen CJ.
    • Journal Title

      J Intern Med

      Volume: 272(4) Issue: 4 Pages: 317-329

    • DOI

      10.1111/j.1365-2796.2012.02564.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A High Fat Diet Induces Bone Loss in Mice Lacking the Alox5 Gene.2012

    • Author(s)
      Le P, Kawai M, Bornstein S, DeMambro VE, Horowitz MC, Rosen CJ
    • Journal Title

      Endocrinology

      Volume: 153 Pages: 6-16

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Emerging therapeutic opportunities for skeletal restoration2011

    • Author(s)
      Kawai M, Mödder UI, Khosla S, Rosen CJ
    • Journal Title

      Nat Rev Drug Discov

      Volume: 10(2) Pages: 141-156

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The heparin-binding domain of IGFBP-2 has IGF binding-independent biologic activity in the growing skeleton2011

    • Author(s)
      Kawai M, Breggia AC, DeMambro VE, Shen X, Canalis E, Bouxsein ML, Beamer WG, Clemmons DR, Rosen CJ
    • Journal Title

      J Biol Chem

      Volume: 22(286) Pages: 14670-80

    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Journal Article] An essential role for the circadian-regulated gene Nocturnin in Osteogenesis : The Importance of local timekeeping in skeletal homeostasis2011

    • Author(s)
      Guntur AR, Kawai M, Le P, Bouxsein M, Bornstein S, Green C, Rosen CJ
    • Journal Title

      Ann N Y Acad Sci

      Volume: 1237 Pages: 58-63

    • Related Report
      2013 Final Research Report
  • [Journal Article] An essential role for the circadian-regulated gene Nocturnin in Osteogenesis: The Importance of local timekeeping in skeletal homeostasis.2011

    • Author(s)
      Guntur AR, Kawai M, Le P, Bouxsein M, Bornstein S, Green C, Rosen CJ
    • Journal Title

      Ann N Y Acad Sci

      Volume: 1237 Issue: 1 Pages: 58-63

    • DOI

      10.1111/j.1749-6632.2011.06213.x

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] FGF23 suppresses chondrocyte proliferation in the presence of solubleα-Klotho2013

    • Author(s)
      Oral Presentation
    • Organizer
      2nd Joint Meeting of the International Bone and Mineral Society and The Japanese Society for Bone and Mineral Research
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] Sympathetic activation induces skeletal Fgf23 expression in a circadian rhythm dependent manner2013

    • Author(s)
      Poster Presentation
    • Organizer
      Annual Meeting of American Society for Bone and Mineral Research
    • Place of Presentation
      Baltimore, Maryland USA
    • Related Report
      2013 Final Research Report
  • [Presentation] 細胞外無機リン酸シグナルは、脂肪細胞においてPTENの発現を抑制し、インスリンシグナルを増強する。2013

    • Author(s)
      川井正信
    • Organizer
      第86回日本内分泌学会学術集会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] GF23 suppresses chondrocyte proliferation in the presence of soluble alpha-Klotho2013

    • Author(s)
      Kawai M
    • Organizer
      2nd Joint Meeting of the International Bone and Mineral Society and The Japanese Society for Bone and Mineral Research
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Sympathetic activation induces skeletal Fgf23 expression in a circadian rhythm dependent manner.2013

    • Author(s)
      Kawai M
    • Organizer
      Annual Meeting of American Society for Bone and Mineral Research
    • Place of Presentation
      Baltimore, Maryland, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] FGF23 suppresses chondrocyte proliferation and maturation in the presence of solubleα-klotho both in vitro and in vivo2012

    • Author(s)
      Plenary Poster
    • Organizer
      Annual Meeting of American Society for Bone and Mineral Research
    • Place of Presentation
      Minneapolis, Minnesota, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] FGF23は可溶型klotho存在下で軟骨細胞分化を抑制する2012

    • Author(s)
      川井正信
    • Organizer
      第30回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] FGF23は軟骨細胞増殖をリン代謝非依存性に抑制し、X連鎖性低リン性くる病に伴う低身長の一因となりうる2012

    • Author(s)
      川井正信、木下さおり、大幡泰久、大薗恵一、道上敏美
    • Organizer
      小児内分泌学会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] FGF23は可溶型klotho存在下で軟骨細胞分化を抑制する2012

    • Author(s)
      川井正信、木下さおり、大幡泰久、宮川和晃、越水隆雄、山崎美和、大薗恵一、道上敏美
    • Organizer
      日本骨代謝学会
    • Place of Presentation
      京王プラザホテル
    • Related Report
      2012 Research-status Report
  • [Presentation] FGF23 suppresses chondrocyte proliferation and maturation in the presence of soluble alpha-klotho both in vitro and in vivo2012

    • Author(s)
      Masanobu Kawai, Saori Kinoshita, Yasuhisa Ohata, Kazuaki Miyagawa, Miwa Yamazaki, Keiichi Ozono, Toshimi Michigami
    • Organizer
      アメリカ骨代謝学会
    • Place of Presentation
      ミネアポリス、米国
    • Related Report
      2012 Research-status Report
  • [Presentation] Brown adipose dysfunction causes bone loss2011

    • Author(s)
      Oral Presentation
    • Organizer
      IOF Regionals 2nd Asia-Pacific Osteoporosis and Bone Meeting
    • Place of Presentation
      Gold Coast, Australia
    • Related Report
      2013 Final Research Report
  • [Presentation] Brown adipose dysfunction causes bone loss.2011

    • Author(s)
      Masanobu Kawai
    • Organizer
      IOF Regionals 2nd Asia-Pacific Osteoporosis and Bone Meeting
    • Place of Presentation
      , Gold Coast, Australia
    • Related Report
      2011 Research-status Report
  • [Presentation] Alox5欠損マウスでは高脂肪食摂取により骨量が減少する。2011

    • Author(s)
      川井正信
    • Organizer
      第29回日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2011 Research-status Report
  • [Presentation] Meet the Experts 2 脂肪細胞機能と骨代謝2011

    • Author(s)
      川井正信
    • Organizer
      第29回日本骨代謝学会学術集会(招待講演)
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2011 Research-status Report
  • [Presentation] FGF23は軟骨細胞増殖をリン代謝非依存性に抑制し、X連鎖性低リン性くる病に伴う低身長の一因となりうる

    • Author(s)
      川井正信
    • Organizer
      第46回小児内分泌学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2022-01-24  

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