The role of biological clock in fetal programming by maternal overnutrition
| Project/Area Number |
23591526
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Research Institute, Osaka Medical Center for Maternal and Child Health |
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Principal Investigator |
KAWAI Masanobu 地方独立行政法人大阪府立病院機構大阪府立母子保健総合医療センター(研究所), その他部局等, 研究員 (50598117)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 概日リズム / 胎児期プログラミング / PPARガンマ / 胎仔プログラミング / 胎児プログラミング |
|---|
| Research Abstract |
Fetal exposure to high fat diet (HFD) has been implicated in metabolic syndrome in later life.In addition, accumulating evidence indicates the critical role of biological clock in the development of metabolic syndrome. Based on these, the effect of fetal exposure to HFD on the circadian rhythm of genes involved in glucose and lipid metabolism was analyzed. Fetal exposure to HFD caused a significant increase in the fat accumulation in the abdomen accompanied by the impaired glucose tolerance and insulin sensitivity. Expression profile of Pparg showd the circadian pattren in the epididymal adipose tissue with lower expression during the dark phase, whereas its expression was enhanced in mice exposed to HFD during fetal period. These findings suggest that the alteration of Pparg expression profile may have a significant impact on the development of metabolic syndrome in mice exposed to HFD during fetal life.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Dysregulated gene expression in the primary osteoblasts and osteocytes isolated from hypophosphatemic Hyp mice.2014
Author(s)
Miyagawa K, Yamazaki M, Kawai M, Nishino J, Koshimizu T, Ohata Y, Tachikawa K, Mikuni-Takagaki Y, Kogo M, Ozono K, Michigami T
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Journal Title
PLoS One
Volume: 9
Issue: 4
Pages: 0-0
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Sodium-coupled Neutral Amino Acid Transporter 4 Functions as a Regulator of Protein Synthesis during Liver Development2013
Author(s)
Kondou H, Kawai M, Tachikawa K, Kimoto A, Yamagata M, Koinuma T, Yamazaki M, Nakayama M, Mushiake S, Ozono K, Michigami T
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Journal Title
Hepatol Res
Volume: 43(11)
Pages: 1211-23
Related Report
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[Journal Article] Altered thermogenesis and impaired bone remodeling in Misty mice2013
Author(s)
Motyl KJ, Bishop KA, DeMambro VE, Bornstein SA, Le P, Kawai M, Lotinun S, Horowitz MC, Baron R, Bouxsein ML, Rosen CJ
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Journal Title
J Bone Miner Res
Volume: 28(9)
Pages: 1885-97
Related Report
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[Journal Article] Sodium-coupled Neutral Amino Acid Transporter 4 Functions as a Regulator of Protein Synthesis during Liver Development.2013
Author(s)
Kondou H, Kawai M, Tachikawa K, Kimoto A, Yamagata M, Koinuma T, Yamazaki M, Nakayama M, Mushiake S, Ozono K, Michigami T
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Journal Title
Hepatol Res
Volume: 43
Issue: 11
Pages: 1211-1223
DOI
Related Report
Peer Reviewed
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[Journal Article] Altered thermogenesis and impaired bone remodeling in Misty mice.2013
Author(s)
Motyl KJ, Bishop KA, Demambro VE, Bornstein SA, Le P, Kawai M, Lotinun S, Horowitz MC, Baron R, Bouxsein ML, Rosen CJ.
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Journal Title
J Bone Miner Res.
Volume: Apr2
Issue: 9
Pages: 1885-1897
DOI
Related Report
Peer Reviewed
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