| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Fetal exposure to high fat diet (HFD) has been implicated in metabolic syndrome in later life.In addition, accumulating evidence indicates the critical role of biological clock in the development of metabolic syndrome. Based on these, the effect of fetal exposure to HFD on the circadian rhythm of genes involved in glucose and lipid metabolism was analyzed. Fetal exposure to HFD caused a significant increase in the fat accumulation in the abdomen accompanied by the impaired glucose tolerance and insulin sensitivity. Expression profile of Pparg showd the circadian pattren in the epididymal adipose tissue with lower expression during the dark phase, whereas its expression was enhanced in mice exposed to HFD during fetal period. These findings suggest that the alteration of Pparg expression profile may have a significant impact on the development of metabolic syndrome in mice exposed to HFD during fetal life.
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