| Project/Area Number |
23591531
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YACHIE Akihiro 金沢大学, 医学系, 教授 (40210281)
WADA Taizou 金沢大学, 医学系, 講師 (30313646)
NISHIMURA Ryousei 金沢大学, 医学系, 講師 (50324116)
SUGIMOTO Naotoshi 金沢大学, 医学系, 准教授 (80272954)
OHTA Kunio 金沢大学, 医学系, 准教授 (00303280)
NIIDA Yo 金沢大学, 金沢医科大学, 准教授 (40293344)
SHIMIZU Masaki 金沢大学, 医学系, 講師 (10401902)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ヘムオキシゲナーゼ / ヘムオキシゲナーゼ１欠損症 / 炎症 / 血管炎 / 腎尿細管 / 溶血性貧血 / 血管内皮細胞 / ビリルビン代謝 / ヘムオキシゲナーゼ１欠損症、インド |
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| Research Abstract |
Heme oxygenase-1(HO-1) is the rate-limiting enzyme to metabolyze heme, showing antioxidant effects. In 1999, we reported the first case of human HO-1 deficiency. After the 2nd case was discovered in 2011, the 3 subsequent cases have been reported so far. All 5 patients with HO-1 deficiency were characterized by recalcitrant systemic inflammation, asplenia, microangiopathy and hypertention. Clinical data show hemolytic anemia with low serum bilirubin, thrombocytosis and evidences of renal tissue injury. From these data we would like to introduce HO-1 deficiency as a novel autoinflammatory disease.
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