• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The diversity of clinical course and the pathogensis in primary antibody deficiency

Research Project

Project/Area Number 23591535
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research Institution独立行政法人国立病院機構長良医療センター(臨床研究部) (2013)
Gifu University (2011-2012)

Principal Investigator

KANEKO Hideo  独立行政法人国立病院機構長良医療センター(臨床研究部), その他部局等, その他 (80293554)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords抗体産生不全症 / XLA / BTK / ガンマグロブリン補充 / 骨髄炎 / 胸膜炎 / 皮下注 / 抗体産生不全 / EDA-ID / IKBA / XLA / 免疫不全症 / 高IgM症候群 / Helicobacter equorum
Research Abstract

X-linked agammaglobulinemia (XLA) develops due to mutation of tyrosine kinase BTK gene essential for B-cell differentiation. We examined the long-term course of four cases in 2 XLA family. Family 1 had missense mutations (L111R) in the BTK gene. Proband was suffering from severe infection, such as pleurisy and osteomyelitis. He developed pleurisy as an opportunistic infection by Helicobacter bacteria. The abnormally high level of endotoxin persisted. In family 2 mutation of the splice donor site of the BTK gene (IVS11+3 G>T) caused the skipping of exon 11. Proband (38 years), have not developed serious infections. Cousin of the proband, are enforced at the home once a week gamma globulin subcutaneous injection. The susceptibility to infection is not observed in family 2. The clinical course was variable in any individual case even with enough trough IgG level.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (63 results)

All 2014 2013 2012 2011 Other

All Journal Article (47 results) (of which Peer Reviewed: 24 results) Presentation (8 results) Book (7 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Total IgE at 6 months predicts remittance or persistence of atopic dermatitis at 14 months2013

    • Author(s)
      Kawamoto N, Fukao T, Kaneko H.(他13名)
    • Journal Title

      Allergy Asthma Proc

      Volume: 34(4) Pages: 362-9

    • Related Report
      2013 Final Research Report
  • [Journal Article] ITIH4 and Gpx3 are potential biomarkers for amyotrophic lateral sclerosis2013

    • Author(s)
      Tanaka H, Shimazawa M, Takata M, Kaneko H. (他10名)
    • Journal Title

      J Neurol

      Volume: 260(7) Pages: 1782-97

    • Related Report
      2013 Final Research Report
  • [Journal Article] Peripheral blood stem cell transplantation in a significant body weight difference between a smaller donor and a larger recipient : A case report2013

    • Author(s)
      Funato M, Kaneko H, Sasai H, Kubota K, Ozeki M, Kanda K, Kato Z, Kondo N.
    • Journal Title

      Transfus Apher Sci

      Volume: 49(3) Pages: 504-6

    • Related Report
      2013 Final Research Report
  • [Journal Article] In vitro analysis of the functional effects of an NLRP3 G809S variant with the co-existence of MEFV haplotype variants in atypical autoinflammatory syndrome2013

    • Author(s)
      Kubota K, Ohnishi H, Teramoto T, Matsui E, Murase K, Kanoh H, Kato Z, Kaneko H, Seishima M, Kondo N.
    • Journal Title

      J Clin Immunol

      Volume: 33(2) Pages: 325-34

    • Related Report
      2013 Final Research Report
  • [Journal Article] Paclitaxel-based chemotherapy for aggressive kaposiform hemangioendothelioma of the temporomastoid region : Case report and review of the literature2013

    • Author(s)
      Funato M, Fukao T, Sasai H, Hori T, Terazawa D, Kanda K, Ozeki M, Mizuta K, Hirose Y, Kaneko H, Kondo N.
    • Journal Title

      Head Neck

      Volume: 35(8)

    • Related Report
      2013 Final Research Report
  • [Journal Article] 免疫不全を伴う特徴的な症候群―毛細血管拡張症、Bloom症候群―2013

    • Author(s)
      金子英雄
    • Journal Title

      小児科診療

      Volume: 76 Pages: 413-418

    • Related Report
      2013 Final Research Report
  • [Journal Article] Good症候群(免疫不全症を伴う胸腺腫)2013

    • Author(s)
      金子英雄
    • Journal Title

      別冊日本臨床血液症候群(第2版)

      Volume: No.22 Pages: 300-303

    • Related Report
      2013 Final Research Report
  • [Journal Article] ブルーム(Bloom)症候群2013

    • Author(s)
      金子英雄
    • Journal Title

      別冊日本臨床血液症候群(第2版)

      Volume: No.22 Pages: 297-299

    • Related Report
      2013 Final Research Report
  • [Journal Article] 小児食物アレルギーの自然経過と治療2013

    • Author(s)
      金子英雄
    • Journal Title

      Monthly Book Derma

      Volume: 205 Pages: 69-76

    • Related Report
      2013 Final Research Report
  • [Journal Article] 食物アレルギーにおける経口免疫療法2013

    • Author(s)
      金子英雄
    • Journal Title

      小児科診療

      Volume: 5 Pages: 857-861

    • Related Report
      2013 Final Research Report
  • [Journal Article] Total IgE at 6 months predicts remittance or persistence of atopic dermatitis at 14 months.2013

    • Author(s)
      Kawamoto N, Fukao T, Kaneko H, Hirayama K, Sakurai S, Arai T, Kondo M, Kawamoto M, Matsui E, Orii K, Kasahara K, Takemura M, Seishima M, Shiraki M, Iwasa S, Kondo N.
    • Journal Title

      Allergy Asthma Proc.

      Volume: 34 Pages: 362-9

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ITIH4 and Gpx3 are potential biomarkers for amyotrophic lateral sclerosis.2013

    • Author(s)
      Tanaka H.. Shimazawa M., Takata M., Kaneko H., Tsuruma K., Ikeda T., Warita H., Aoki M., Yamada M., Takahashi H., Hozumi I., Minatsu H., Inuzuka T. and Hara H.
    • Journal Title

      Journal of Neurology

      Volume: (Epub ahead of print) Issue: 7 Pages: 1782-1797

    • DOI

      10.1007/s00415-013-6877-3

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peripheral blood stem cell transplantation in a significant body weight difference between a smaller donor and a larger recipient: a case report.2013

    • Author(s)
      Funato M, Kaneko H, Sasai H, Kubota K, Ozeki M, Kanda K, Kato Z, Kondo N.
    • Journal Title

      Transfus Apher Sci.

      Volume: 49 Issue: 3 Pages: 504-6

    • DOI

      10.1016/j.transci.2013.01.015

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In Vitro Analysis of the Functional Effects of an NLRP3 G809S Variant with the co-Existence of MEFV Haplotype Variants in Atypical Autoinflammatory Syndrome2013

    • Author(s)
      Kubota K, Ohnishi H, Teramoto T, Matsui E, Murase K, Kanoh H, Kato Z, Kaneko H, Seishima M, Kondo N
    • Journal Title

      J Clin Immunol

      Volume: 33 Issue: 2 Pages: 325-34

    • DOI

      10.1007/s10875-012-9805-x

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Paclitaxel-based chemotherapy for aggressive kaposiform hemangioendothelioma of the temporomastoid region: Case report and review of the literature.2013

    • Author(s)
      Funato M, Fukao T, Sasai H, Hori T, Terazawa D, Kanda K, Ozeki M, Mizuta K, Hirose Y, Kaneko H, Kondo N.
    • Journal Title

      Head Neck.

      Volume: 35 Issue: 8 Pages: 258-61

    • DOI

      10.1002/hed.23107

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 免疫不全を伴う特徴的な症候群 ―毛細血管拡張症、Bloom症候群―2013

    • Author(s)
      金子英雄
    • Journal Title

      小児科診療

      Volume: 76 Pages: 413-418

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Good症候群(免疫不全症を伴う胸腺腫)2013

    • Author(s)
      金子英雄
    • Journal Title

      別冊日本臨床 血液症候群(第2版)

      Volume: 22 Pages: 300-303

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ブルーム(Bloom)症候群2013

    • Author(s)
      金子英雄
    • Journal Title

      別冊日本臨床 血液症候群(第2版)

      Volume: 22 Pages: 297-299

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In Vitro Analysis of the Functional Effects of an NLRP3 G809S Variant with the co-Existence of MEFV Haplotype Variants in Atypical Autoinflammatory Syndrome.2013

    • Author(s)
      Kubota K, Ohnishi H, Teramoto T, Matsui E, Murase K, Kanoh H, Kato Z, Kaneko H, Seishima M, Kondo N.
    • Journal Title

      J Clin Immunol.

      Volume: 33 Pages: 325-34

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Paclitaxel-based chemotherapy for aggressive kaposiform hemangioendothelioma of the temporomastoid region: Case report and review of the literature.2013

    • Author(s)
      Funato M, Fukao T, Sasai H, Hori T, Terazawa D, Kanda K, Ozeki M, Mizuta K, Hirose Y, Kaneko H, Kondo N
    • Journal Title

      Head Neck

      Volume: 35

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Peripheral blood stem cell transplantation in a significant body weight difference between a smaller donor and a larger recipient: A case report.2013

    • Author(s)
      Funato M, Kaneko H, Sasai H, Kubota K, Ozeki M, Kanda K, Kato Z, Kondo N.
    • Journal Title

      Transfus Apher Sci.

      Volume: in press

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Repeated-dose pharmacokinetics of inhaled ciclesonide (CIC-HFA) in Japanese children with bronchial asthma : a phase I study2012

    • Author(s)
      Teramoto T, Kaneko H, (他9名)
    • Journal Title

      Allergol Int

      Volume: 61(4) Pages: 619-24

    • NAID

      130004873052

    • Related Report
      2013 Final Research Report
  • [Journal Article] Autosomal-dominant chronic mucocutaneous candidiasis with STAT1-mutation can be complicated with chronic active hepatitis and hypothyroidism2012

    • Author(s)
      Hori T, Ohnishi H, Teramoto T, Tsubouchi K, Naiki T, Hirose Y, Ohara O, Seishima M, Kaneko H, Fukao T, Kondo
    • Journal Title

      J Clin Immunol

      Volume: 32(6) Pages: 1213-20

    • Related Report
      2013 Final Research Report
  • [Journal Article] Risk factors for infantile atopic dermatitis and recurrent wheezing2012

    • Author(s)
      Kawamoto N, Fukao T, Kaneko H, Hirayama K, Sakurai S, Arai T, Kondo M, Kawamoto M, Matsui E, Teramoto T, Kasahara K, Bai C, Zhang G, Omoya K, Matsukuma E, Morimoto M, Suzuki H, Aoki Y, Kimura T, Nada M, Morita H, Tokumi T, Takemura M, Seishima M, Shiraki M, Iwasa S, Kondo
    • Journal Title

      J Investig Allergol Clin Immunol

      Volume: 22(2) Pages: 116-25

    • Related Report
      2013 Final Research Report
  • [Journal Article] Characterization of NLRP3 variants in Japanese cryopyrin-associated periodic syndrome patients2012

    • Author(s)
      Ohnishi H, Kaneko H,(他8名)
    • Journal Title

      J Clin Immunol

      Volume: 32(2) Pages: 221-9

    • Related Report
      2013 Final Research Report
  • [Journal Article] A rapid screening method to detect autosomal-dominant ectodermal dysplasia with immune deficiency syndrome2012

    • Author(s)
      Ohnishi H, Miyata R, Suzuki T, Nose T, Kubota K, Kato Z, Kaneko H, Kondo N.
    • Journal Title

      J Allergy Clin Immunol

      Volume: 129(2) Pages: 578-80

    • Related Report
      2013 Final Research Report
  • [Journal Article] Structural property of soybean protein P34 and specific IgE response to recombinant P34 in patients with soybean allergy2012

    • Author(s)
      Morita H, Kaneko H.(他9名)
    • Journal Title

      Int J Mol Med

      Volume: 29(2) Pages: 153-8

    • Related Report
      2013 Final Research Report
  • [Journal Article] Characterization of NLRP3 Variants in Japanese Cryopyrin-Associated Periodic Syndrome Patients.2012

    • Author(s)
      Ohnishi H, Teramoto T, Iwata H, Kato Z, Kimura T, Kubota K, Nishikomori R, Kaneko H, Seishima M, Kondo N
    • Journal Title

      J Clin Immunol

      Volume: 32 Pages: 221-229

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A rapid screening method to detect autosomal-dominant ectodermal dysplasia with immune deficiency syndrome.2012

    • Author(s)
      Ohnishi H, Miyata R, Suzuki T, Nose T, Kubota K, Kato Z, Kaneko H, Kondo N
    • Journal Title

      J Allergy Clin Immunol.

      Volume: 129 Pages: 578-580

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Structural property of soybean protein P34 and specific IgE response to recombinant P34 in patients with soybean allergy.2012

    • Author(s)
      Morita H, Kaneko H, Ohnishi H, Kato Z, Kubota K, Yamamoto T, Matsui E, Teramoto T, Fukao T, Kasahara K, Kondo N
    • Journal Title

      Int J Mol Med

      Volume: 29 Pages: 153-158

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Risk factors for infantile atopic dermatitis and recurrent wheezing.2012

    • Author(s)
      Kawamoto N, Fukao T, Kaneko H, Hirayama K, Sakurai S, et al.,
    • Journal Title

      J Investig Allergol Clin Immunol

      Volume: 22 Pages: 116-25

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Repeated-dose pharmacokinetics of inhaled ciclesonide (CIC-HFA) in Japanese children with bronchial asthma: a phase I study.2012

    • Author(s)
      Teramoto T, Matsui E, Fukao T, Sakai K, Yonezawa H, Kato Z, Ohnishi H, Kaneko H, Kondo N, Azuma J, Nishima S.
    • Journal Title

      Allergol Int

      Volume: 61 Pages: 619-24

    • NAID

      130004873052

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Autosomal-dominant chronic mucocutaneous candidiasis with STAT1-mutation can be complicated with chronic active hepatitis and hypothyroidism.2012

    • Author(s)
      Hori T, Ohnishi H, Teramoto T, Tsubouchi K, Naiki T, Hirose Y, Ohara O, Seishima M, Kaneko H, Fukao T, Kondo N
    • Journal Title

      J Clin Immunol.

      Volume: 32 Pages: 1213-20

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A rapid screening method to detect autosomal-dominant ectodermal dysplasia with immune deficiency syndrome.2012

    • Author(s)
      Ohnishi H, Miyata R, Suzuki T, Nose T, Kubota K, Kato Z, Kaneko H, Kondo N
    • Journal Title

      J Allergy Clin Immunol

      Volume: 129 Pages: 578-580

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Successful treatment of pediatric immune thrombocytopenic purpura associated with ulcerative colitis2011

    • Author(s)
      Funato M, Fukao T, Sasai H, Hori T, Terazawa D, Kubota K, Ozeki M, Orii K, Kaneko H, Kondo N.
    • Journal Title

      Pediatr Int

      Volume: 53(5) Pages: 771-3

    • Related Report
      2013 Final Research Report
  • [Journal Article] Pediatric acute lymphoblastic leukemia mimicking Henoch-Schönlein purpura2011

    • Author(s)
      Funato M, Kaneko H, Kubota K, Ozeki M, Kanda K, Orii K, Kato Z, Fukao T, Kondo .
    • Journal Title

      Pediatr Int

      Volume: 53(5) Pages: 766-8

    • Related Report
      2013 Final Research Report
  • [Journal Article] Refractory chronic pleurisy caused by Helicobacter equorum-like bacterium in a patient with X-linked agammaglobulinemia2011

    • Author(s)
      Funato M, Kaneko H, Ohkusu K, Sasai H, Kubota K, Ohnishi H, Kato Z, Fukao T, Kondo N.
    • Journal Title

      J Clin Microbiol

      Volume: 49(9) Pages: 3432-5

    • Related Report
      2013 Final Research Report
  • [Journal Article] Augmented cell death with Bloom syndrome helicase deficiency2011

    • Author(s)
      Kaneko H, Fukao T, Kasahara K, Yamada T, Kondo N.
    • Journal Title

      Mol Med Rep

      Volume: 4(4) Pages: 607-9

    • Related Report
      2013 Final Research Report
  • [Journal Article] Genetic variations in MyD88 adaptor-like are associated with atopic dermatitis2011

    • Author(s)
      An Y, Ohnishi H, Matsui E, Funato M, Kato Z, Teramoto T, Kaneko H, Kimura T, Kubota K, Kasahara K, Kondo N.
    • Journal Title

      Int J Mol Med

      Volume: 27(6) Pages: 795-801

    • NAID

      120006341946

    • Related Report
      2013 Final Research Report
  • [Journal Article] Antigen-specific immune response to endotoxin-free recombinant P342011

    • Author(s)
      Morita H, Kaneko H, Ohnishi H, Kato Z, Kondo N.
    • Journal Title

      Allergy

      Volume: 66(7) Pages: 985-6

    • Related Report
      2013 Final Research Report
  • [Journal Article] Antigen-specific immune response to endotoxin-free recombinant P34.2011

    • Author(s)
      Morita H, Kaneko H, Ohnishi H, Kato Z, Kondo N
    • Journal Title

      Allergy

      Volume: 66 Pages: 985-986

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genetic variations in MyD88 adaptor-like are associated with atopic dermatitis.2011

    • Author(s)
      An Y, Ohnishi H, Matsui E, Funato M, Kato Z, Teramoto T, Kaneko H, Kimura T, Kubota K, Kasahara K, Kondo N
    • Journal Title

      Int J Mol Med

      Volume: 27 Pages: 795-801

    • NAID

      120006341946

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Augmented cell death with Bloom syndrome helicase deficiency.2011

    • Author(s)
      Kaneko H, Fukao T, Kasahara K, Yamada T, Kondo N
    • Journal Title

      Mol Med Report

      Volume: 4 Pages: 607-609

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Refractory chronic pleurisy caused by Helicobacter equorum-like bacterium in a patient with X-linked agammaglobulinemia.2011

    • Author(s)
      Funato M, Kaneko H, Ohkusu K, Sasai H, Kubota K, Ohnishi H, Kato Z, Fukao T, Kondo N
    • Journal Title

      J Clin Microbiol

      Volume: 49 Pages: 3432-3435

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pediatric acute lymphoblastic leukemia mimicking Henoch-Schönlein purpura.2011

    • Author(s)
      Funato M, Kaneko H, Kubota K, Ozeki M, Kanda K, Orii K, Kato Z, Fukao T, Kondo N
    • Journal Title

      Pediatr Int

      Volume: 53 Pages: 766-768

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Successful treatment of pediatric immune thrombocytopenic purpura associated with ulcerative colitis.2011

    • Author(s)
      Funato M, Fukao T, Sasai H, Hori T, Terazawa D, Kubota K, Ozeki M, Orii K, Kaneko H, Kondo N
    • Journal Title

      Pediatr Int

      Volume: 53 Pages: 771-773

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Complement Factor B Mutation in a Large Kindred with Atypical Hemolytic Uremic Syndrome

    • Author(s)
      Funato M, Uemura O, Ushijima K, Ohnishi H, Orii K, Kato Z, Yamakawa S, Nagai T, Ohara O,Kaneko H, Kondo N.
    • Journal Title

      J Clin Immunol

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Presentation] X-linked agammaglobulinemia 2家系の長期経過の検討2014

    • Author(s)
      金子英雄、舩戸道徳 、森田秀行 、舘林宏治 、下川祐子、丸田香奈子 、内田靖、神田康司、大西秀典 、近藤直実
    • Organizer
      日本小児科学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 異なる免疫グロブリンの発現を示したXLAの一家系2013

    • Author(s)
      金子英雄、森田秀行、川本典生、大西秀典、寺本貴英、近藤直実
    • Organizer
      第50回日本小児アレルギー学会
    • Place of Presentation
      横浜
    • Year and Date
      2013-10-19
    • Related Report
      2013 Final Research Report
  • [Presentation] 常染色体優性遺伝形式が推測される分類不能型免疫不全症の1家系2013

    • Author(s)
      大西秀典、寺本貴英、川本典生、金子英雄、臼井新治、新井隆広、川尻美和、山岸篤至、加藤善一郎、深尾敏幸、近藤直実
    • Organizer
      第50回日本小児アレルギー学会
    • Place of Presentation
      横浜
    • Year and Date
      2013-10-19
    • Related Report
      2013 Final Research Report
  • [Presentation] 牛乳アレルギーにおける抗原改変β―ラクトグロブリン作製と臨床応用の試み2013

    • Author(s)
      金子英雄、大西秀典、川本典生、寺本貴英、松井永子、加藤善一郎、森田秀行、加藤晴彦、中埜拓、近藤直実
    • Organizer
      第25回日本アレルギー学会春期臨床大会
    • Place of Presentation
      横浜
    • Year and Date
      2013-05-12
    • Related Report
      2013 Final Research Report
  • [Presentation] 異なる免疫グロブリンの発現を示したXLAの一家系2013

    • Author(s)
      金子英雄 、森田秀行、川本典生 、大西秀典 、寺本貴英 、近藤直実
    • Organizer
      日本小児アレルギー学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 本邦におけるBloom症候群の実態調査2012

    • Author(s)
      金子英雄、内田靖、大西秀典、深尾敏幸、谷内江昭宏、清河信敬、滝田順子、山崎直也、田内久道、近藤直実
    • Organizer
      第49回日本小児アレルギー学会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
  • [Presentation] Pathogenesis and clinical feature of primary antibody deficiencies2011

    • Author(s)
      Kaneko H, Ohnishi H, Funato M, Kondo N
    • Organizer
      The 7th Congress of Asian Society for Pediatric Research(招待講演)
    • Place of Presentation
      Denver, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] Development of enzymatically digested peptides for immunomodulation therapy in patients with cow's milk allergy2011

    • Author(s)
      Kaneko H, Ohnishi H, Morita H, Yamamoto T, Kubota K, Teramoto T, Kato Z, Matsui E, Kato H, Nakano T, Kondo N
    • Organizer
      16th Asia Pacific Association of Pediatric Allergy, Respiratory and Immunology
    • Place of Presentation
      Fukuoka, Japan
    • Related Report
      2011 Research-status Report
  • [Book] DNA修復障害(近藤直実、平家俊男編集)自己炎症性疾患・自然免疫不全症とその近縁疾患2012

    • Author(s)
      金子英雄, 他
    • Publisher
      診断と治療社
    • Related Report
      2013 Final Research Report
  • [Book] 色素脱失を伴う免疫不全症  自己炎症性疾患・自然免疫不全症とその近縁疾患 編集 近藤直実、平家俊男2012

    • Author(s)
      金子英雄
    • Publisher
      診断と治療社
    • Related Report
      2012 Research-status Report
  • [Book] DNA修復障害  自己炎症性疾患・自然免疫不全症とその近縁疾患 編集 近藤直実、平家俊男2012

    • Author(s)
      金子英雄
    • Total Pages
      248
    • Publisher
      診断と治療社
    • Related Report
      2012 Research-status Report
  • [Book] 毛細血管拡張性小脳失調症(ataxia-telangiectasia)  自己炎症性疾患・自然免疫不全症とその近縁疾患 編集 近藤直実、平家俊男2012

    • Author(s)
      金子英雄
    • Publisher
      診断と治療社
    • Related Report
      2012 Research-status Report
  • [Book] Bloom症候群  自己炎症性疾患・自然免疫不全症とその近縁疾患 編集 近藤直実、平家俊男2012

    • Author(s)
      金子英雄
    • Publisher
      診断と治療社
    • Related Report
      2012 Research-status Report
  • [Book] 食物アレルギーに対する抗原改変牛乳による経口免疫療法 アレルギー疾患の免疫療法と分子標的療法―理論と実践2012

    • Author(s)
      金子英雄、大西秀典、近藤直実
    • Publisher
      診断と治療社
    • Related Report
      2012 Research-status Report
  • [Book] 症候群ハンドブック2011

    • Author(s)
      金子英雄: 井村裕夫総編集
    • Total Pages
      2
    • Publisher
      東京 中山書店
    • Related Report
      2011 Research-status Report
  • [Patent(Industrial Property Rights)] Th2サイトカイン阻害剤への感受性の検査方法2012

    • Inventor(s)
      近藤直実、松井永子、金子英雄、青木美奈子、近藤應
    • Industrial Property Rights Holder
      近藤直実、松井永子、金子英雄、青木美奈子、近藤應
    • Acquisition Date
      2012-04-20
    • Related Report
      2013 Final Research Report
    • Overseas

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi