Alloreactive NK-cells activity to leukemia with HLA-LOH after HLA haplomismatch stem cell transplantation

• Project/Area Number: 23591536
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Nagoya University
• Principal Investigator: TAKAHASHI Yoshiyuki 名古屋大学, 医学(系)研究科(研究院), 准教授 (40432273)
• Co-Investigator(Kenkyū-buntansha): KOJIMA Seiji 名古屋大学, 大学院医学系研究科, 教授 (20313992)
• Co-Investigator(Renkei-kenkyūsha): OGAWA Seishi 京都大学, 大学院医学研究科, 教授 (60292900)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 白血病 / NK細胞 / GVL効果 / KIR / 造血幹細胞移植 / HLA

Research Abstract

We investigated HLA expression on leukemic blasts derived from patients at diagnosis and relapse after hematopoietic stem cell transplantation (HSCT) using flow cytometry with locus-specific antibodies. HLA expression analysis was useful for analysis of donor chimerism and minimal residual diseases. We found that leukemic blasts with HLA-LOH at relapse were efficiently killed by donor NK cells. This was partially explained because ULBP2 on the leukemic blasts with HLA-LOH was highly expressed. We could monitor single KIR positive NK cells that are not inhibited by patient's HLA. Increased single KIR positive NK cells were related to higher NK cell alloreactivity. Finally, GMP grade NK cell expansion method was established using FDA approved gene modified K562 cells. These findings could establish the rationale of allogeneic NK cell therapy using KIR mismatched donor NK cells.

Research Products

• [Journal Article] PBSCT is associated with poorer survival and increased chronic GvHD than BMT in Japanese paediatric patients with acute leukaemia and an HLA-matched sibling donor. (2013)
  • Author(s): Shinzato A, Adachi S, et al.
  • Journal Title: Pediatric Blood and Cancer Volume: in press Issue: 9 Pages: 1513-1519
  • DOI: 10.1002/pbc.24524
  • Peer Reviewed
• [Journal Article] Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia. (2013)
  • Author(s): Sakaguchi H, Yoshida K
  • Journal Title: Nature Genet. Volume: 46 Issue: 8 Pages: 937-941
  • DOI: 10.1038/ng.2698
  • Peer Reviewed
• [Journal Article] Rabbit antithymocyte globulin and cyclosporine as first-line therapy for children with acquired aplastic anemia (2012)
  • Author(s): Takahashi Y, Muramatsu H, Sakata N, Hyakuna N, Hamamoto K, Kobayashi R, Ito E, Yagasaki H, Ohara A, Kikuchi A, Morimoto A, Yabe H, Kudo K, Watanabe K, Ohga S, Kojima S
  • Journal Title: Blood Volume: 121(5) Issue: 5 Pages: 862-3
  • DOI: 10.1182/blood-2012-11-465633
  • Peer Reviewed
• [Journal Article] Zoledronate sensitizes neuroblastoma-derived tumor-initiating cells to cytolysis mediated by human gammadelta T cells (2012)
  • Author(s): Nishio N, Fujita M, Tanaka Y, Maki H, Zhang R, Hirosawa T, Demachi-Okamura A, Uemura Y, Taguchi O, Takahashi Y, Kojima S and Kuzushima K.
  • Journal Title: J Immunother Volume: 35(8) Issue: 8 Pages: 598-606
  • DOI: 10.1097/cji.0b013e31826a745a
  • Peer Reviewed
• [Journal Article] Somatic mosaicism for oncogenic NRAS mutations in juvenile myelomonocytic leukemia (2012)
  • Author(s): Doisaki S, Muramatsu H, Shimada A, Takahashi Y, Mori-Ezaki M, Sato M, Kawaguchi H, Kinoshita A, Sotomatsu M, Hayashi Y, Furukawa-Hibi Y, Yamada K, Hoshino H, Kiyoi H, Yoshida N, Sakaguchi H, Narita A, Wang X, Ismael O, Xu Y, Nishio N, Tanaka M, Hama A, Koike K, Kojima S
  • Journal Title: Blood Volume: 120 Issue: 7 Pages: 1485-1488
  • DOI: 10.1182/blood-2012-02-406090
  • Peer Reviewed
• [Journal Article] Excellent outcome of allogeneic bone marrow transplantation for Fanconi anemia using fludarabine-based reduced-intensity conditioning regimen (2012)
  • Author(s): Shimada A, Takahashi Y, Muramatsu H, Hama A, Ismael O, Narita A, Sakaguchi H, Doisaki S, Nishio N, Tanaka M, Yoshida N, Matsumoto K, Kato K, Watanabe N and Kojima S.
  • Journal Title: Int J Hematol Volume: 95(6) Issue: 6 Pages: 675-679
  • DOI: 10.1007/s12185-012-1079-9
  • NAID: 10030793696
  • Peer Reviewed
• [Journal Article] Incidence, clinical features, and risk factors of idiopathic pneumonia syndrome followins hematopoietic stem cell transplantation in children (2012)
  • Author(s): Sakaguchi H, et al
  • Journal Title: Pediatric blood & cancer Volume: 58 Issue: 5 Pages: 780-784
  • DOI: 10.1002/pbc.23298
  • Peer Reviewed
• [Journal Article] EBV-associated T/NK-cell lymphoproliferative diseases in nonimmunocompromised hosts: prospective analysis of 108 cases (2012)
  • Author(s): Kimura H
  • Journal Title: Blood Volume: 119 Issue: 3 Pages: 673-686
  • DOI: 10.1182/blood-2011-10-381921
  • Peer Reviewed
• [Journal Article] Molecular lesions in childhood and adult acute megakaryoblastic leukaemia (2012)
  • Author(s): Hama A
  • Journal Title: BRITISH JOURNAL OF HAEMATOLOGY Volume: 156 Pages: 316-325
  • Peer Reviewed
• [Journal Article] Childhood acute myeloid leukemia with bone marrow eosinophilia caused by t(16;21)(q24;q22) (2012)
  • Author(s): Kawashima N, Shimada A, Taketani T, Hayashi Y, Yoshida N, Matsumoto K, Takahashi Y, Kojima S, Kato K
  • Journal Title: Int J Hematol Volume: 95 Issue: 5 Pages: 577-580
  • DOI: 10.1007/s12185-012-1044-7
  • NAID: 10030633418
  • Peer Reviewed
• [Journal Article] De novo childhood myelodysplastic/myeloproliferative disease with unique molecular characteristics (2012)
  • Author(s): ISMAEL O
  • Journal Title: BRITISH JOURNAL OF HAEMATOLOGY Volume: 158 Pages: 129-137
  • Peer Reviewed
• [Journal Article] Mutation in the THPO gene is not associated with aplastic anaemia in Japanese children (2012)
  • Author(s): Wang X
  • Journal Title: BRITISH JOURNAL OF HAEMATOLOGY Volume: 158 Pages: 553-555
  • Peer Reviewed
• [Journal Article] Zoledronate Sensitizes Neuroblastoma-derived Tumor-initiating Cells to Cytolysis Mediated by Human gamma delta T Cells (2012)
  • Author(s): Nishio N
  • Journal Title: JOURNAL OF IMMUNOTHERAPY Volume: 35 Pages: 598-606
  • Peer Reviewed
• [Journal Article] EBV-associated T/NK-cell lymphoproliferative diseases in nonimmunocompromised hosts: prospective analysis of 108 cases. (2012)
  • Author(s): Kimura H et al.
  • Journal Title: Blood Volume: 119(3) Pages: 673-686
  • Peer Reviewed
• [Journal Article] Aberrant phosphorylation of STAT5 by granulocyte-macrophage colony-stimulating factor in infant cytomegalovirus infection mimicking juvenile myelomonocytic leukemia (2011)
  • Author(s): Nishio N, Takahashi Y, Tanaka M, Xu Y, Yoshida N, Sakaguchi H, Doisaki S, Hama A, Muramatsu H, Shimada A and Kojima S.
  • Journal Title: Leuk Res Volume: 35(9) Issue: 9 Pages: 1261-1264
  • DOI: 10.1016/j.leukres.2011.04.014
• [Journal Article] Total body irradiation and melphalan as a conditioning regimen for children with hematological malignancies undergoing transplantation with stem cells from HLA-identical related donors (2011)
  • Author(s): Watanabe N, Takahashi Y, Matsumoto K, Horikoshi Y, Hama A, Muramatsu H, Yoshida N, Yagasaki H, Kudo K, Horibe K, Kato K and Kojima S.
  • Journal Title: Pediatr Transplant Volume: 15(6) Issue: 6 Pages: 642-649
  • DOI: 10.1111/j.1399-3046.2011.01544.x
• [Journal Article] CD20-negative Epstein-Barr virus-associated post-transplant lymphoproliferative disease refractory to rituximab in a patient with severe aplastic anemia (2011)
  • Author(s): Mur amatsu H, Takahashi Y, Shimoyama Y, Doisaki S, Nishio N, Ito Y, Hama A, Shimada A, Yagasaki H, Ito M and Kojima S.
  • Journal Title: Int J Hematol Volume: 93(6) Issue: 6 Pages: 779-781
  • DOI: 10.1007/s12185-011-0870-3
  • NAID: 10029535631
• [Journal Article] 骨髄移植後再発白血病における６番染色体Uniparental disomy (UPD)によるHLA欠失とその意義 (2011)
  • Author(s): 高橋 義行
  • Journal Title: Annual review 2011血液 Volume: 2011 Pages: 109-115
• [Journal Article] 免疫・細胞療法 (2011)
  • Author(s): 高橋 義行
  • Journal Title: 小児がん診療ハンドブック Volume: 2011 Pages: 243-251
• [Journal Article] 神経芽腫に対する移植療法 (2011)
  • Author(s): 高橋 義行
  • Journal Title: Pharma Medica Volume: Vol 29 Pages: 33-37
• [Journal Article] 先天性角化不全症 (2011)
  • Author(s): 高橋義行、西尾信博、小島勢二
  • Journal Title: 新しい診断と治療のABC７２／血液８ 再生不良性貧血 Volume: 72 Pages: 198-206
• [Journal Article] 疾患別に見た造血細胞移植の最新動向：小児進行期神経芽腫 (2011)
  • Author(s): 高橋 義行
  • Journal Title: 医学のあゆみ Volume: Vol240 Pages: 418-422
• [Journal Article] Inactivation of the von Hippel-Lindau tumor suppressor leads to selective expression of a human endogenous retrovirus in kidney cancer. (2011)
  • Author(s): Cherkasova E, et al.
  • Journal Title: Oncogene Volume: 30(47) Pages: 4697-706
  • Peer Reviewed
• [Journal Article] Prognostic factors for outcomes of pediatric patients with refractory or relapsed acute leukemia undergoing allogeneic progenitor cell transplantation. (2011)
  • Author(s): Watanabe N et al.
  • Journal Title: Biol Blood Marrow Transplant Volume: 17(4) Pages: 516-523
  • Peer Reviewed
• [Presentation] 小児重症再生不良性貧血に対する代替ドナーからの造血幹細胞移植:HLA不一致非血縁ドナーvs HLAハプロ一致血縁ドナー (2014)
  • Author(s): 高橋義行、川島希、成田敦、坂口大俊、村松秀城、濱麻人、小島勢二
  • Organizer: 第36回日本造血細胞移植学会総会
  • Place of Presentation: 沖縄コンベンションセンター.沖縄
  • Year and Date: 2014-03-08
• [Presentation] Unmanipulated HLA Haploidentical Bone Marrow Transplantation Combined With PBSC With The Options Of Donor Virus Specific CTLs and Mesenchymal Stem Cells Infusion (2013)
  • Author(s): Takahashi Y, Kawashima N, Narita A, Sakaguchi H, Muramatsu H, Hama A, Kojima S.
  • Organizer: The 55th ASH Annual Meeting and Exposition
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2013-12-07
• [Presentation] 小児ハイリスク神経芽腫に対する同種臍帯血移植の解析(Allogeneic cord blood transplantation for children with high risk neuroblastoma) (2013)
  • Author(s): 高橋義行、松本公一、藤崎弘之、岩崎史記、橋井佳子、中村和弘、杉田完爾、矢部普正、加藤剛二、高梨美乃子、熱田由子、井上雅美
  • Organizer: 第55回日本小児血液・がん学会学術集会
  • Place of Presentation: ヒルトン福岡シーホーク.福岡
  • Year and Date: 2013-11-29
• [Presentation] HLA haploidentical SCT with the options of donor's virus specific CTLs and mesenchymal stem cells (2013)
  • Author(s): 高橋義行、川島希、成田敦、坂口大俊、土居崎小夜子、村松秀城、中西康詞、濱麻人、小島勢二
  • Organizer: 第75回日本血液学会学術集会
  • Place of Presentation: ロイトン札幌.札幌
  • Year and Date: 2013-10-13
• [Presentation] Sequential autologous SCT/KIR mismatched cord blood transplantation for high-risk or recurrent neuroblastoma (2013)
  • Author(s): Takahashi Y.
  • Organizer: The 4th Mini-symposium of Samsung Children's Cancer Center
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2013-05-18
• [Presentation] HLA haploidentical stem cell transplantation for children with aplastic anaemia in urgent need of stem cell transplantation (2013)
  • Author(s): Takahashi Y, Kawashima N, Narita A, Sakaguchi H, Doisaki S, Muramatsu H, Nakanishi K, Hama A, Kojima S.
  • Organizer: 39th Annual Meeting of the EBMT
  • Place of Presentation: London, UK
  • Year and Date: 2013-04-09
• [Presentation] 再発または治療抵抗性4期神経芽腫に対するKIRリガンド不一致同種臍帯血移植を用いたアロNK細胞免疫療法の試み (2012)
  • Author(s): 高橋義行
  • Organizer: 第54回日本小児血液・がん学会学術集会
  • Place of Presentation: パシフィコ横浜会議センター.横浜
  • Year and Date: 2012-12-01
• [Presentation] KIR ligand incompatible cord blood transplantation for high risk neuroblastoma as allogeneic NK cell based immunotherapy (2012)
  • Author(s): Yoshiyuki Takahashi, Kanji Sugita, Kazuhiro Nakamura, Chihaya Imai, Etsuro Ito, Young-Dong Park, Masami Inoue, Seiji Kojima
  • Organizer: Advances in Neuroblastoma Research
  • Place of Presentation: Toronto. Canada
  • Year and Date: 2012-06-06
• [Presentation] 進行期または再発小児神経芽腫に対する同種臍帯血移植の検討 (2012)
  • Author(s): 高橋義行、松本公一、他
  • Organizer: 第34回造血細胞移植学会総会
  • Place of Presentation: 大阪国際会議場.大阪
  • Year and Date: 2012-02-24
• [Presentation] KIR ligand incompatible cord blood transplantation for high risk neuroblastoma as allogeneic NK cell based immunotherapy (2012)
  • Author(s): Yoshiyuki Takahashi
  • Organizer: Advances in Neuroblastoma Research 2012
  • Place of Presentation: Toronto, Canada
• [Presentation] HLA-B61 is associated with idiopathic AA, hepatitis associated AA and fulminant hepatic failure in children (2012)
  • Author(s): Yoshiyuki Takahashi
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
• [Presentation] 再発または治療抵抗性4期神経芽腫に対するKIRリガンド不一致同種臍帯血移植を用いたアロNK細胞免疫療法の試み (2012)
  • Author(s): 高橋義行
  • Organizer: 第54回日本小児血液・がん学会学術集会
  • Place of Presentation: 横浜、神奈川
• [Presentation] Expression of human leukocyte antigen B61 is associated with idiopathic aplastic anemia, hepatitis-associated Aplastic Anemia and Fulminant Hepatic Failure in Children. (2012)
  • Author(s): Yoshiyuki Takahashi
  • Organizer: 54th Annual Meeting of the American Society of Hematology
  • Place of Presentation: Atlanta, USA
• [Presentation] アロ反応性ＮＫ細胞を利用した造血幹細胞移植の進歩 (2012)
  • Author(s): 高橋義行
  • Organizer: 第５回 弘前大学造血幹細胞移植研究会
  • Place of Presentation: 弘前大学、青森
  • Invited
• [Presentation] Increase in NK-cell lysis of leukemic blasts due to loss of mismatched HLA haplotype after haploidentical stem cell transplantation (2012)
  • Author(s): Yoshiyuki Takahashi
  • Organizer: 名古屋BMTシンポジウム
  • Place of Presentation: 名古屋、愛知
  • Invited
• [Presentation] 難治性ウイルス感染症、がんに対する免疫療法の進歩 (2012)
  • Author(s): 高橋義行
  • Organizer: 三重大学がんワクチンセミナー
  • Place of Presentation: 三重大学、三重
  • Invited
• [Presentation] Virus specific cytotoxic T-cell therapy for drug resistant virus infection after hematopoietic stem cell transplantation (2012)
  • Author(s): Yoshiyuki Takahashi
  • Organizer: 第１７回東海HSCT懇話会(招待講演)
  • Place of Presentation: 名古屋マリオットホテルアソシア
• [Presentation] 免疫細胞療法としての同種造血細胞移植療法の進歩 (2012)
  • Author(s): 高橋 義行
  • Organizer: 第５回弘前大学造血幹細胞移植研究会(招待講演)
  • Place of Presentation: 弘前大学コミュニケーションセンター
• [Presentation] 造血幹細胞移植後難治性ウイルス感染症に対するウイルス特異的抗原特異的細胞障害性T細胞（CTL）の対外増幅法の開発と臨床第一相試験 (2012)
  • Author(s): 高橋 義行
  • Organizer: 第３４回日本造血細胞移植学会総会
  • Place of Presentation: 大阪国際会議場、大阪
• [Presentation] 年長児発症4期神経芽腫に対する自家末梢血幹細胞移植+KIRリガンド不一致臍帯血移植を用いた新規治療法 (2011)
  • Author(s): 高橋義行、坂口大俊、村松秀城、嶋田明、濱麻人、小島勢二、他
  • Organizer: 第53回小児血液・がん学会学術集会
  • Place of Presentation: ベイシア文化ホール.前橋
  • Year and Date: 2011-11-26
• [Presentation] Alloreactive NK-cell based immnotherapy in children with leukemia and neurobalstoma (2011)
  • Author(s): Yoshiyuki Takahashi
  • Organizer: 第２回小児がん学術セミナー(招待講演)
  • Place of Presentation: ウェスティンホテル東京
• [Presentation] アロ反応性ＮＫ細胞を利用した同種造血幹細胞移植の進歩 (2011)
  • Author(s): 高橋 義行
  • Organizer: 第20回新潟同種造血細胞移植研究会(招待講演)
  • Place of Presentation: ホテル日航新潟
• [Presentation] Natural Killer Cell Therapy; Strategy of NK cell based immunotherapy (2011)
  • Author(s): Yoshiyuki Takahashi
  • Organizer: The 2nd Samusung medical center mini symposium(招待講演)
  • Place of Presentation: サムソンメディカルセンター、ソウル
• [Presentation] Immunosuppressive therapy with rabbit antithymocyte globulin for acquired aplastic anemia (2011)
  • Author(s): Yoshiyuki Takahashi
  • Organizer: 第７３回日本血液学会学術集会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] KIR ligand mismatched umbilical cord blood transplantation as NK cell based immunotherapy for children with ultrahigh-risk neuroblastoma (2011)
  • Author(s): Yoshiyuki Takahashi
  • Organizer: 第７０回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] Pediatric Aplastic Anemia - Immunosupressive Therapy (2011)
  • Author(s): Yoshiyuki Takahashi
  • Organizer: Asia-Pacific transplant and hematology forum(招待講演)
  • Place of Presentation: The Westin Bund Center, Shanghai, China
• [Presentation] Sequential autologous SCT/KIR mismatched cord blood transplantation for high-risk or recurrent neuroblastoma.
  • Author(s): Takahashi Y.
  • Organizer: The 4th Mini-symposium of Samsung Children's Cancer Center.
  • Place of Presentation: Seoul, Korea
• [Presentation] Unmanipulated HLA Haploidentical Bone Marrow Transplantation Combined With PBSC With The Options Of Donor Virus Specific CTLs and Mesenchymal Stem Cells Infusion.
  • Author(s): Takahashi Y, Kawashima N, Narita A, Sakaguchi H, Muramatsu H, Hama A, Kojima S.
  • Organizer: The 55th ASH Annual Meeting and Exposition.
  • Place of Presentation: New Orleans, USA
• [Presentation] HLA haploidentical SCT with the options of donor's virus specific CTLs and mesenchymal stem cells.
  • Author(s): 高橋 義行、川島 希、成田 敦、坂口 大俊、土居崎 小夜子、村松 秀城、中西 康詞、濱 麻人、小島 勢二.
  • Organizer: 第75回日本血液学会学術集会.
  • Place of Presentation: ロイトン札幌、札幌
• [Presentation] 小児ハイリスク神経芽腫に対する同種臍帯血移植の解析. Allogeneic cord blood transplantation for children with high risk neuroblastoma.
  • Author(s): 高橋 義行、松本 公一、藤崎 弘之、岩崎 史記、橋井 佳子、中村 和弘、杉田 完爾、矢部 普正、加藤 剛二、高梨 美乃子、熱田 由子、井上 雅美.
  • Organizer: 第55回日本小児血液・がん学会学術集会.
  • Place of Presentation: ヒルトン福岡シーホーク、福岡
• [Book] 造血幹細胞移植における抑制性NK細胞受容体の意義,Annual review血液 (2014)
  • Author(s): 高橋義行
  • Total Pages: 236
  • Publisher: 中外医学社
• [Book] 小児ハイリスク神経芽腫に対する抗ヒトGD2抗体(ch14.18)療法.日本臨床72巻増刊号2.最新がん薬物療法学―がん薬物療法の最新知見― (2014)
  • Author(s): 高橋義行
  • Total Pages: 704
• [Book] 小児進行期神経芽腫、別冊・医学のあゆみ造血幹細胞移植の最新動向 (2013)
  • Author(s): 高橋義行
  • Total Pages: 146
  • Publisher: 医歯薬出版株式会社
• [Book] 再生不良性貧血に対する免疫抑制療法：Annual Review血液2013 (2013)
  • Author(s): 高橋義行
  • Total Pages: 7
  • Publisher: 中外医学社
• [Book] 小児進行期神経芽腫,医学のあゆみ(Vol240 No5) (2012)
  • Author(s): 高橋義行
  • Total Pages: 484
  • Publisher: 医歯薬出版株式会社
• [Book] 移植後EBウイルス関連リンパ増殖性疾患,みんなに役立つ造血幹細胞移植の基礎と臨床改訂版 (2012)
  • Author(s): 高橋義行
  • Total Pages: 700
  • Publisher: (株)医薬ジャーナル社
• [Book] 神経芽腫の骨転移,がん骨転移のバイオロジーとマネジメント (2012)
  • Author(s): 高橋義行
  • Total Pages: 400
  • Publisher: (株)医薬ジャーナル社
• [Book] 疾患別に見た造血細胞移植の最新動向：小児進行期神経芽腫、医学のあゆみ、vol 240, No5 (2012)
  • Author(s): 高橋義行
  • Total Pages: 5
  • Publisher: 医歯薬出版株式会社
• [Book] 移植後EBウイルス関連リンパ増殖性疾患、みんなに役立つ造血幹細胞移植の基礎と臨床改訂版 (2012)
  • Author(s): 高橋義行
  • Total Pages: 9
  • Publisher: 医薬ジャーナル社
• [Book] 神経芽腫の骨転移、がん骨転移のバイオロジーとマネージメント (2012)
  • Author(s): 高橋義行
  • Total Pages: 10
  • Publisher: 医薬ジャーナル社
• [Book] 骨髄移植後再発白血病における6番染色体Uniparental disomy (UPD)によるHLA欠失とその意義, Annual Review血液 (2011)
  • Author(s): 高橋義行
  • Total Pages: 230
  • Publisher: 中外医学社
• [Book] サイトメガロウイルスに対する細胞療法,症例とエビデンスに学ぶ造血細胞移植と感染症 (2011)
  • Author(s): 高橋義行
  • Total Pages: 292
  • Publisher: (株)医薬ジャーナル社
• [Book] 第5章免疫・細胞療法、小児がん診療ハンドブック (2011)
  • Author(s): 高橋義行
  • Total Pages: 520
  • Publisher: (株)医薬ジャーナル社
• [Book] 神経芽腫に対する移植療法, Pharma Medica(Vol 29 No5) (2011)
  • Author(s): 高橋義行
  • Total Pages: 252
  • Publisher: (株)メディカルレビュー社