Role of Rab family small G proteins in the development of neuroblastoma cancer stem cells
| Project/Area Number |
23591540
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HAYAKAWA Akira 神戸大学, 大学院医学研究科, 准教授 (40379376)
西尾 久英 神戸大学, 医学(系)研究科(研究院), 教授 (80189258)
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIO Hisahide 神戸大学, 大学院医学研究科, 教授 (80189258)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 神経芽腫 / がん幹細胞 / MRD / Rab / 微小残存病変 / Rab15 / 選択的スプライシング |
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| Research Abstract |
More than 50% of high-risk neuroblastoma patients have experienced tumor relapses caused by chemoresistant cancer stem cells (CSCs). Consequently, their overall survival rates remain less than 40%. To improve their prognosis, it is essential to understand the molecular mechanism of how CSCs are generated and maintained in neuroblastoma. In the present study, we have focused on the key regulators of membrane traffic, Rab family small G proteins (Rabs), and identified a member of Rabs controlling the development of neuroblastoma CSCs.
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Report
(4 results)
Research Products
(15 results)
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[Presentation] Induction of ALDH1A2 expression is critical for cancer stem cell properties in neuroblastoma2014
Author(s)
Nishimura N, Hartomo TB, Pham TVH, Yamamoto N, Hirase S, Hayakawa A, Hasegawa D, Kawasaki K, Kosaka Y, Matsuo M, Takeshima Y, Iijima K, and Nishio H.
Organizer
AACR Annual Meeting 2014
Place of Presentation
San Diego, CA, USA
Related Report
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[Presentation] Identification of ALDH1A2 as a critical ALDH isoform in neuroblastoma cells with cancer stem cell phenotype2013
Author(s)
Hartomo TB, Pham TVH, Yamamoto N, Hirase S, Hayakawa A, Hasegawa D, Kawasaki K, Kosaka Y, Matsuo M, Takeshima Y, Iijima K, Nishio H, and Nishimura N.
Organizer
AACR Special Conference : Pediatric Cancer at the Crossroads
Place of Presentation
San Diego, CA, USA
Related Report
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[Presentation] 神経芽腫症例におけるmultiple real-time RT-PCR markerを用いた微小残存病変(MRD)解析2012
Author(s)
田中愛子,長谷川大一郎, Tri Budi Hartomo,山本暢之,宮田憲二,越智聡史,斎藤敦郎,山下達也,石田敏章,川崎圭一郎,松尾雅文, Thi Van Huyen Pham,大橋浩基,森健,矢内友子,早川晶,竹島泰弘,小阪嘉之,飯島一誠,西尾久英,西村範行
Organizer
第54回日本小児血液・がん学会学術集会
Place of Presentation
横浜(口演)
Related Report
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[Presentation] Rab15 alternative splicing correlates with differentiation of neuroblastoma cells.2012
Author(s)
Hartomo TB, Pham TVH, Hasegawa D, Kosaka Y, Hayakawa A, Takeshima Y, Iijima K, Matsuo M, Nishio H, and Nishimura N.
Organizer
Advances in Neuroblastoma Research Conference 2012
Place of Presentation
Tronto, Canada
Related Report
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[Presentation] Minimal residual disease monitoring in neuroblastoma patients by a set of real-time RT-PCR markers.2012
Author(s)
Tanaka A, Hasegawa D, Hartomo TB, Ishida T, Kawasaki K, Kosaka Y, Iijima K, Matsuo M, Nishio H, and Nishimura N.
Organizer
Advances in Neuroblastoma Research Conference 2012
Place of Presentation
Tronto, Canada
Related Report
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