• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analysis and therapeutic research for growth impairment accompanied with chronic inflammatory syndrome of children as dysregulation of proinflammatory cytokines

Research Project

Project/Area Number 23591546
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionYokohama City University

Principal Investigator

YOKOTA Shumpei  横浜市立大学, 医学(系)研究科(研究院), 教授 (10158363)

Co-Investigator(Renkei-kenkyūsha) IMAGAWA Tomoyuki  横浜市立大学, 附属病院, 准教授 (20336548)
MIYAMAE Takako  横浜市立大学, 附属病院, 非常勤診療医 (90322354)
KIKUCHI Masako  横浜市立大学, 附属病院, 助教 (90555129)
NOZAWA Tomo  横浜市立大学, 附属病院, 指導診療医 (10588106)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords小児免疫学 / 小児免疫・アレルギー・膠原病学
Research Abstract

Growth impairment accompanied with systemic juvenile idiopathic arthritis (sJIA) is thought to be associated with suppression of proliferation of chondrocyte by IL-6, the key cytokine causing systemic inflammation, and suppression of bone extension by corticosteroid. Tocilizumab, anti-IL-6 receptor antibody, was approved in 2008 in Japan, so now bloadly used as treatment for steroid-refractory or -dependent sJIA. We have investigated height and height velocity of 45 sJIA patient administered with TCZ and analyzed correlation between them and several factors such as age, gender, disease duration and corticosteroid exposure, then inverse correlation between standard deviation score for height (HTSDS) and disease duration and strong correlation between reduction of corticosteroid and improvement of height velocity.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (15 results)

All 2013 2012 2011

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (3 results) (of which Invited: 2 results)

  • [Journal Article] Effect of Tocilizumab on growth impairment in systemic juvenile idiopathic arthritis with long-term corticosteroid therapy2013

    • Author(s)
      Miyamae T, Yokoya S, Yamanaka H, Yokota S.
    • Journal Title

      Mod Rheumatol

      Volume: (Epub ahead of print)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Radiologic analysis of the effect of tocilizumab on hands and large joints in children with systemic juvenile idiopathic arthritis2013

    • Author(s)
      Inaba Y, Ozawa R, Aoki C, Imagawa T, Mori M, Hara R, Miyamae T, Saito T, Yokota S.
    • Journal Title

      Mod Rheumatol

      Volume: 23(4) Issue: 4 Pages: 667-73

    • DOI

      10.1007/s10165-012-0711-0

    • NAID

      10031189160

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Tocilizumab on growth impairment in systemic juvenile idiopathic arthritis with long-term corticosteroid therapy2013

    • Author(s)
      Takako Miyamae, Susumu Yokoya, Hisashi Yamanaka, Shumpei Yokota
    • Journal Title

      Modern Rheumatology

      Volume: Early Online Issue: 4 Pages: 1-5

    • DOI

      10.3109/14397595.2013.844404

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy, pharmacokinetics, and safety of adalimumab in pediatric patients with juvenile idiopathic arthritis in Japan.2012

    • Author(s)
      Imagawa T, Takei S, ---, Kawai S, Yokota S
    • Journal Title

      Clin Rheumatol.

      Volume: 31 Issue: 12 Pages: 1713-1721

    • DOI

      10.1007/s10067-012-2082-5

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Safety and efficacy of long-term etanercept in the treatment of methotrexate-refractory polyarticular-course juvenile idiopathic arthritis in Japan.2012

    • Author(s)
      .Mori M, Takei S, Imagawa T, Imanaka H, Nerome Y, Higuchi R, Kawano Y, Yokota S, et al
    • Journal Title

      Mod Rheumatol

      Volume: 22 Issue: 5 Pages: 720-6

    • DOI

      10.1007/s10165-011-0578-5

    • NAID

      10031027821

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Guidance on the use of adalimumab for juvenile idiopathic arthritis in Japan2012

    • Author(s)
      Yokota S, Imagawa T, Murata T, Tomiita M, Itoh Y, Fujikawa S, Takei S, Mori M.
    • Journal Title

      Mod Rheumatol

      Volume: 22(4) Issue: 4 Pages: 491-7

    • DOI

      10.1007/s10165-011-0561-1

    • NAID

      10031026845

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Definitive differences in laboratory and radiological characteristics between two subtypes of juvenile idiopathic arthritis : systemic arthritis and polyarthritis2012

    • Author(s)
      Ozawa R, Inaba Y, Mori M, Hara R, Kikuchi M, Higuchi R, Miyamae T, Imagawa T, Fujiwara T, Saito T, Yokota S.
    • Journal Title

      Mod Rheumatol

      Volume: 22(4) Issue: 4 Pages: 558-64

    • DOI

      10.1007/s10165-011-0540-6

    • NAID

      10031027084

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy, pharmacokinetics, and safety of adalimumab in pediatric patients with juvenile idiopathic arthritis in Japan2012

    • Author(s)
      .Imagawa T, Takei S, Umebayashi H, Yamaguchi K, Itoh Y, Kawai T, Iwata N, Murata T, Okafuji I, Miyoshi M, Onoe Y, Kawano Y, Kinjo N, Mori M, Mozaffarian N, Yokota S, et al
    • Journal Title

      Clin Rheumatol.

      Volume: -

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Radiologic analysis of the effect of tocilizumab on hands and large joints in children with systemic juvenile idiopathic arthritis2012

    • Author(s)
      Inaba Y, Ozawa R, Aoki C, Imagawa T, Mori M, Hara R, Miyamae T, Saito T, Yokota S
    • Journal Title

      Mod Rheumatol

      Volume: -

    • NAID

      10031189160

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Guidance on the use of adalimumab for juvenile idiopathic arthritis in Japan2012

    • Author(s)
      Yokota S, Imagawa T, Murata T, Tomiita M, Itoh Y, Fujikawa S, Takei S, Mori M
    • Journal Title

      Mod Rheumatol.

      Volume: 22 Pages: 491-7

    • NAID

      10031026845

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Definitive differences in laboratory and radiological characteristics between two subtypes of juvenile idiopathic arthritis: systemic arthritis and polyarthritis2012

    • Author(s)
      Ozawa R, Inaba Y, Mori M, Hara R, Kikuchi M, Higuchi R, Miyamae T, Imagawa T, Fujiwara T, Saito T, Yokota S
    • Journal Title

      Mod Rheumatol

      Volume: 22 Pages: 558-64

    • NAID

      10031027084

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Definitive differences inn laboratory and radiological characteristics between two subtypes of juvenile idiopathic arthritis:systemic arthiritis and polyarthritis2011

    • Author(s)
      Ozawa R,Inaba Y,Mori M,Hara R,Kikuchi M,Miyamae T,Imagawa T,Yokota s
    • Journal Title

      Mod Rheumatol

      Volume: -

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Recent Advances in Pediatric Rheumatic Diseases from the Viewpoint of Dysregulation of Proinflammatory Cytokines2013

    • Author(s)
      Yokota S.
    • Organizer
      APLAR Congress 2012
    • Place of Presentation
      Amman Jordan
    • Year and Date
      2013-09-01
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Recent Advanxes in Pediatric Rheumatic Deseases from the Viewpoint of Dysregulation of Proinflammatory Cytokines2012

    • Author(s)
      Yokota s
    • Organizer
      APLAR
    • Place of Presentation
      アンマン(ヨルダン)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 2nd Tocilizumab JIA Advisory Board2011

    • Author(s)
      Yokota s
    • Organizer
      EULAR(招待講演)
    • Place of Presentation
      ロンドン・イギリス
    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi