Genome instability caused by EVI1 oncogene activation

• Project/Area Number: 23591548
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Jichi Medical University
• Principal Investigator: KUME Akihiro 自治医科大学, 医学部, 准教授 (10264293)
• Co-Investigator(Renkei-kenkyūsha): ONODERA Masafumi (独)国立成育医療研究センター, 部長 (10334062)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 遺伝子 / ゲノム / エピジェネティクス / ヒストン修飾 / 癌

Research Abstract

H3K9 methylation is considered to be one of crucial factors in tumor progression.

Research Products

• [Journal Article] Novel anti-tumor mechanism of galanin receptor type 2 in head and neck squamous cell carcinoma cells (2014)
  • Author(s): Uehara T, Kanazawa T, Mizukami H, Uchibori R, Tsukahara T, Urabe M, Kume A, Misawa K, Carey T, Suzuki M, Ichimura K, Ozawa K.
  • Journal Title: Cancer Sci Volume: 105 Pages: 72-80
• [Journal Article] Novel anti-tumor mechanism of galanin receptor type 2 in head and neck squamous cell carcinoma cells (2014)
  • Author(s): Uehara T, Kanazawa T, Mizukami H, Uchibori R, Tsukahara T, Urabe M, Kume A, Misawa K, Carey T, Suzuki M, Ichimura K, Ozawa K
  • Journal Title: Cancer Science Volume: 105 Issue: 1 Pages: 72-80
  • DOI: 10.1111/cas.12315
  • Peer Reviewed / Open Access
• [Journal Article] NF-B activity regulates mesenchymal stem cell accumulation at tumor sites (2013)
  • Author(s): Uchibori R, Tsukahara T, Mizuguchi H, Saga Y, Urabe M, Mizukami H, Kume A, Ozawa K.
  • Journal Title: Cancer Res Volume: 73 Pages: 364-372
• [Journal Article] Suppression of lymph node and lung metastases of endometrial cancer by muscle-mediated expression of soluble VEGF receptor-3 (2013)
  • Author(s): Takahashi K, Mizukami H, Saga Y, Takei Y, Urabe M, Kume A, Machida S, Fujiwara H, Suzuki M, Ozawa K.
  • Journal Title: Cancer Sci Volume: 104 Pages: 1107-1111
• [Journal Article] CD19 target-engineered T-cells accumulate at tumor lesions in human B-cell lymphoma xenograft mouse models (2013)
  • Author(s): Tsukahara T, Ohmine K, Yamamoto C, Uchibori R, Ido H, Teruya T, Urabe M, Mizukami H, Kume A, Nakamura M, Mineno J, Takesako K, Riviere I, Sadelain M, Brentjens R, Ozawa K.
  • Journal Title: Biochem Biophys Res Commun Volume: 438 Pages: 84-89
• [Journal Article] An R132H mutation in isocitrate dehydrogenase 1 enhances p21 expression and inhibits phosphorylation of retinoblastoma protein in glioma cells (2013)
  • Author(s): Miyata S, Urabe M, Gomi A, Nagai M, Yamaguchi T, Tsukahara T, Mizukami A, Kume A, Ozawa K, Watanabe E.
  • Journal Title: Neurol Med Chir (Tokyo) Volume: 53 Pages: 645-654
  • NAID: 10031191634
• [Journal Article] Suppression of lymph node and lung metastases of endometrial cancer by muscle-mediated expression of soluble VEGF receptor-3 (2013)
  • Author(s): Takahashi K, Mizukami H, Saga Y, Takei Y, Urabe M, Kume A, Machida S, Fujiwara H, Suzuki M, Ozawa K
  • Journal Title: Cancer Science Volume: 104 Issue: 8 Pages: 1107-1111
  • DOI: 10.1111/cas.12184
  • Peer Reviewed
• [Journal Article] CD19 target-engineered T-cells accumulate at tumor lesions in human B-cell lymphoma xenograft mouse models (2013)
  • Author(s): Tsukahara T, Ohmine K, Yamamoto C, Uchibori R, Ido H, Teruya T, Urabe M, Mizukami H, Kume A, Nakamura M, Mineno J, Takesako K, Riviere I, Sadelain M, Brentjens R, Ozawa K
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 438 Issue: 1 Pages: 84-89
  • DOI: 10.1016/j.bbrc.2013.07.030
  • Peer Reviewed
• [Journal Article] An R132H mutation in isocitrate dehydrogenase 1 enhances p21 expression and inhibits phosphorylation of retinoblastoma protein in glioma cells (2013)
  • Author(s): Miyata S, Urabe M, Gomi A, Nagai M, Yamaguchi T, Tsukahara T, Mizukami A, Kume A, Ozawa K, Watanabe E
  • Journal Title: Neurologia medico-chirurgica (Tokyo) Volume: 53 Pages: 645-654
  • NAID: 10031191634
  • Peer Reviewed
• [Journal Article] NF-κB activity regulates mesenchymal stem cell accumulation at tumor sites. (2013)
  • Author(s): Uchibori R, Tsukahara T, Mizuguchi H, Saga Y, Urabe M, Mizukami H, Kume A, Ozawa K
  • Journal Title: Cancer Research Volume: 73 Issue: 1 Pages: 364-372
  • DOI: 10.1158/0008-5472.can-12-0088
  • Peer Reviewed
• [Journal Article] Recovery of neurogenic amines in phenylketonuria mice after liver-targeted gene therapy (2012)
  • Author(s): Yagi H, Sanechika S, Ichinose H, Sumi-Ichinose C, Mizukami H, Urabe M, Ozawa K, Kume A.
  • Journal Title: NeuroReport Volume: 23 Pages: 30-34
• [Journal Article] Interleukin-10 expression induced by adeno-associated virus vector suppresses proteinuria in Zucker obese rats (2012)
  • Author(s): Ogura M, Urabe M, AkimotoT, Onishi A, Ito T, Tsukahara T, Mizukami H, Kume A, Muto S, Kusano E, Ozawa K.
  • Journal Title: Gene Ther Volume: 19 Pages: 476-482
• [Journal Article] Interleukin-10 expression induced by adeno-associated virus vector suppresses proteinuria in Zucker obese rats (2012)
  • Author(s): Ogura M, Urabe M, Akimoto T, Onishi A, Ito C, Ito T, Tsukahara T, Mizukami H, Kume A, Muto S, Kusano E, and Ozawa K.
  • Journal Title: Gene Ther Volume: 19巻 Issue: 5 Pages: 476-82
  • DOI: 10.1038/gt.2011.183
  • Peer Reviewed
• [Journal Article] Reciprocal upregulation of Notch signaling molecules in hematopoietic progenitor and mesenchymal stromal cells (2011)
  • Author(s): Kikuchi Y, Kume A, Urabe M, Mizukami H, Suzuki T, Ozaki K, Nagai T, Ozawa K.
  • Journal Title: J Stem Cells Regen Med Volume: 7 Pages: 61-68
• [Journal Article] Reciprocal upregulation of Notch signaling molecules in hematopoietic progenitor and mesenchymal stromal cells (2011)
  • Author(s): Kikuchi Y, Kume A, Urabe M, Mizukami H, Suzuki T, Ozaki K, Nagai T, Ozawa K
  • Journal Title: Journal of Stem Cells and Regenerative Medicine Volume: 7 Pages: 61-68
  • Peer Reviewed
• [Presentation] Accurate measurement of Nab status against AAV vector capsids and an approach toward managing its inhibitory effect (2013)
  • Author(s): Mizukami H, Mimuro J, Hishikawa S, Ikemoto T, Uchibori R, Tsukahara T, Urabe M, Kume A, Sakata A, Ohmori T, Madoiwa S, Sakata Y, Ozawa K.
  • Organizer: European Society of Gene and Cell Therapy and French Society for Cell and Gene Therapy Collaborative Congress 2013
  • Place of Presentation: Madrid, Spain
  • Year and Date: 2013-10-25
• [Presentation] Tumor targeting using CD19-specific CAR (chimeric antigen receptor) for B-cell lymphoma (2013)
  • Author(s): Tsukahara T, Ohmine K, Uchibori R, Ido H, Urabe M, Mizukami H, Kume A, Nakamura M, Mineno J, Takesako K, Riviere I, Sadelain M, Brentjens R, Ozawa K.
  • Organizer: American Society of Gene and Cell Therapy 16th Annual Meeting
  • Place of Presentation: Salt Lake City, UT, USA
  • Year and Date: 2013-05-18
• [Presentation] Precise evaluation of Nab status against adeno-associated viral vectors and an approach toward managing its inhibitory effect (2013)
  • Author(s): Mizukami H, Mimuro J, Hishikawa S, Ikemoto T, Uchibori R, Tsukahara T, Urabe M, Kume A, Sakata A, Ohmori T, Madoiwa S, Sakata Y, Ozawa K.
  • Organizer: American Society of Gene and Cell Therapy 16th Annual Meeting
  • Place of Presentation: Salt Lake City, UT, USA
  • Year and Date: 2013-05-16
• [Presentation] Evaluation of anti-tumor effevts mediated by engineered T lymphocytes expressing a CD19 specific CAR for B cell lymphoma (2012)
  • Author(s): Tsukahara T, Ohmine K, Uchibori R, Ido H, Urabe M, Mizukami H, Kume A, Nakamura M, Riviere I, Sadelain M, Brentjens R, Ozawa K.
  • Organizer: American Society of Gene and Cell Therapy
  • Place of Presentation: Philadelphia, PA, USA
  • Year and Date: 2012-05-19
• [Presentation] Evaluation of anti-tumor effevts mediated by engineered T lymphocytes expressing a CD19 specific CAR for B cell lymphoma. (2012)
  • Author(s): Tsukahara T, Ohmine K, Uchibori R, Ido H, Urabe M, Mizukami H, Kume A, Nakamura M, Riviere I, Sadelain M, Brentjens R, Ozawa K
  • Organizer: American Society of Gene and Cell Therapy
  • Place of Presentation: Philadelphia, PA, USA
• [Presentation] Muscle-directed gene therapy for phenylketonuria with self-complementary AAV vectors (2011)
  • Author(s): Kume A, Yagi H, Mizukami H, Urabe M, Tsukahara T, Uchibori R, Ozawa K.
  • Organizer: XIXth Annual Congress of European Society of Gene and Cell Therapy
  • Place of Presentation: Brighton, UK
  • Year and Date: 2011-10-28
• [Presentation] Gene threrapy for phenylketonuria. Japan Society of Gene Therapy (2011)
  • Author(s): Kume A.
  • Organizer: 17th Annual Meeting
  • Place of Presentation: Fukuoka(Invited)
  • Year and Date: 2011-07-17
• [Presentation] Gene threrapy for phenylketonuria (2011)
  • Author(s): Kume A
  • Organizer: Japan Society of Gene Therapy 17th Annual Meeting(招待講演)
  • Place of Presentation: 福岡
• [Remarks]
  • URL: http://www.jichi.ac.jp/laboratory/molecula/gene/index.html