Analysis of the association between the abnormal skin and intestinal barrier function and food allergy.
Project/Area Number |
23591556
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Fujita Health University |
Principal Investigator |
URISU Atsuo 藤田保健衛生大学, 医学部, 教授 (20193972)
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Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 食物アレルギー / filaggrin / 皮膚バリア異常 / 皮膚バリア / フィラグリン / アトピー性皮膚炎 / 乳児 |
Research Abstract |
For the purpose of verifying the relationship between food allergy and the skin barrier function, we examined the association of filaggrin (FLG) gene variation with clinical findings of food allergy in infants. Subjects were 116 cases of infants (9 months to 14 months old) who were suspected food allergy and referred to Fujita Health University Ban Buntane Hotokukai hospital or its related facilities. FLG loss of function mutations, SNPs and copy number variations (CNVs) of FLG locus, were analyzed and their association with clinical findings, and laboratory findings were evaluated. As a result, association of a SNP present in the FLG gene promoter region with number of sensitized foods, and ImmnoCAP class of both egg and milk was observed. This SNP was considered to be in linkage disequilibrium with unknown loss-of-function mutations or promoter activity affecting its expression, and this finding is a new evidence suggesting the involvement of FLG on food sensitization.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] Effect of Japanese cedar specific immunotherapy on allergen-specific TH2 cells in peripheral blood2013
Author(s)
Nomura T, Tsuge I, Inuo C, Nakajima Y, Tanaka K, Naruse N, Suzuki S, Ando H, Kondo Y, Saitoh S, Urisu A
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Journal Title
Ann Allergy Asthma Immunol
Volume: 110
Pages: 380-385
Related Report
Peer Reviewed
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[Journal Article] Food sensitization in Japanese infants is associated with a common Filaggrin variant2013
Author(s)
Nomura T, Tsuge I, Inuo C, Nakajima Y, Kondo Y, Sugiura S, Murata H, Iguchi T, Terada A, Saitoh S, Hashimoto S, Urisu A
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Journal Title
Ann Allergy Asthma Immunol
Volume: 110
Pages: 388-390
Related Report
Peer Reviewed
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[Journal Article] Effect of Japanese cedar specific immunotherapy on allergen-specific T(H)2 cells in peripheral blood.2013
Author(s)
Nomura T, Tsuge I, Inuo C, Nakajima Y, Tanaka K, Naruse N, Suzuki S, Ando H, Kondo Y, Saitoh S, Urisu A.
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Journal Title
Ann Allergy Asthma Immunol.
Volume: 110
Issue: 5
Pages: 380-385
DOI
Related Report
Peer Reviewed
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[Journal Article] Food sensitization in Japanese infants is associated with a common Filaggrin variant.2013
Author(s)
Nomura T, Tsuge I, Inuo C, Nakajima Y, Kondo Y, Sugiura S, Murata H, Iguchi T, Terada A, Saitoh S, Hashimoto S, Urisu A.
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Journal Title
Ann Allergy Asthma Immunol.
Volume: 110
Issue: 5
Pages: 388-390
DOI
Related Report
Peer Reviewed
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[Journal Article] Food sensitization in Japanese infants is associated with a common Filaggrin variant2013
Author(s)
Takayasu Nmura, Ikuya Tsuge, Chisato Inuo, Yoichi Nakajima, Yasuto Kondo, Shiro Sugiura, Hiroaki Murata, Toshifumi Iguchi, Akihiko Terada, Shinji Saitoh, Shuji Hashimoto, Atsuo Urisu
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Journal Title
Annals of Allergy, Asthma and Immunology
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Effect of Japanese cedar specific immunotherapy on allegen-spedific TH2 cells in peripheral blood2013
Author(s)
Nomura T, Tsuge I, Inuo C, Nakajima Y, Tanaka K, Naruse N, Suzuki S, Ando H, Kondo Y, Saitoh S, Urisu A
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Journal Title
Annals of Allergy Asthma and Immunology
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] New approach for improving the safety of oral immunotherapy for food allergy2012
Author(s)
Urisu A, Tanaka K, Ogura K, Naruse N, Hirata N, Nakajima Y, Inuo C, Suzuki S, Ando H, Kondo Y, Tsuge I, Yamada K, Kimura, M.
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Journal Title
Clin Exp Allergy Rev
Volume: 12
Related Report
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[Journal Article] New approach for improving the safety of oral immunotherapy for food allergy.2012
Author(s)
Urisu A, Tanaka K, Ogura K, Naruse N, Hirata N, Nakajima Y, Inuo C, Suzuki S, Ando H, Kondo Y, Tsuge I, Yamada K, Kimura, M.
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Journal Title
Clin Exp Allergy Rev
Volume: 12
Issue: n2
Pages: 25-28
DOI
Related Report
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[Journal Article] Effects of oral administration of Lactobacillus acidophilus L-92 on the symptoms and serum markers of atopic dermatitis in children2011
Author(s)
Torii S, Torii A, Itoh K, Urisu A, Terada A, Fujisawa T, Yamada K, Suzuki H,Ishida Y, Nakamura F, Kanzato H, Sawada D, Nonaka A, Hatanaka M, Fujiwara S.
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Journal Title
Int Arch Allergy Immunol
Volume: 154
Pages: 236-236
Related Report
Peer Reviewed
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[Presentation] 卵白未摂取アトピー性皮膚炎児のオボムコイド減量ベビーフードに対するアレルギー反応誘発の検討2013
Author(s)
森 雄司, 大久保 悠里子, 山脇 一夫, 田中 健一, 犬尾 千聡, 中島 陽一, 平田 典子, 鈴木 聖子, 近藤 康人, 柘植 郁哉, 木村 守, 宇理須 厚雄
Organizer
第50回日本小児アレルギー学会
Place of Presentation
横浜
Related Report
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[Presentation] 食物アレルギー最前線 皮膚粘膜バリア機能と食物アレルギー2013
Author(s)
柘植 郁哉, 野村 孝泰, 近藤 康人, 中島 陽一, 森 雄司, 大久保 悠里子, 田中 健一, 山脇 一夫, 成瀬 徳彦, 犬尾 千聡, 平田 典子, 鈴木 聖子, 高松 伸枝, 宇理須 厚雄
Organizer
第63回日本アレルギー学会秋季学術大会
Place of Presentation
東京
Related Report
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[Presentation] Antigen-Specific TH Cell Monitoring by CD154 Expression in Japanese Cedar-Specific SCIT2012
Author(s)
T. Nomura, I. Tsuge, C. Inuo, Y. Nakajima, K. Tanaka, N. Naruse, S. Suzuki, H. Ando, Y. Kondo, S. Saitoh, A. Urisu
Organizer
2013 Annual Meeting, American Academy of Allergy, Asthma and Immunology (AAAAI)
Place of Presentation
San Antonio, USA
Related Report
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