Epigenetics in differentiation of acute promyelocytic leukemia cells by synthetic retinoids
| Project/Area Number |
23591558
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Osaka Medical College |
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Principal Investigator |
INOUE Akiko 大阪医科大学, 医学部, 講師 (90330076)
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| Co-Investigator(Kenkyū-buntansha) |
TAKITANI Kimitaka 大阪医科大学, 医学部, 講師 (80319540)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 急性前骨髄球性白血病 / レチノイド / エピジェネティクス |
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| Outline of Final Research Achievements |
Recently, it is reported that the differentiation of acute promyelocytic leukemia (APL) cells by all-trans retinoic acid (ATRA) is related with epigenetics mechanism. In the current study, we examined the epigenetics in differentiation of APL cells by synthetic retinoids. Am80 as synthetic retinoid up-regulated transcriptional activity of RAR and RXR with MLL5 (mixed lineage leukemia 5, short form), which is the key molecule of epigenetics in differentiation of APL cells. Further investigations are required to clarify this issue.
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Report
(5 results)
Research Products
(18 results)
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[Journal Article] 小児急性前骨髄球性白血病に対する三酸化ヒ素による治療2013
Author(s)
高橋 浩之, 盛武 浩, 照井 君典, 井上 彰子, 落合 秀匡, 金井 理恵, 豊田 秀実, 松野 良介, 塩原 正明, 中尾 朋平, 富澤 大輔, 多賀 崇, 多和 昭雄, 足立 壮一
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Journal Title
日本小児血液・がん学会雑誌
Volume: 50
Pages: 32-37
Related Report
Peer Reviewed
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