Epigenetics in differentiation of acute promyelocytic leukemia cells by synthetic retinoids

• Project/Area Number: 23591558
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Osaka Medical College
• Principal Investigator: INOUE Akiko 大阪医科大学, 医学部, 講師 (90330076)
• Co-Investigator(Kenkyū-buntansha): TAKITANI Kimitaka 大阪医科大学, 医学部, 講師 (80319540)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 急性前骨髄球性白血病 / レチノイド / エピジェネティクス

Outline of Final Research Achievements

Recently, it is reported that the differentiation of acute promyelocytic leukemia (APL) cells by all-trans retinoic acid (ATRA) is related with epigenetics mechanism. In the current study, we examined the epigenetics in differentiation of APL cells by synthetic retinoids. Am80 as synthetic retinoid up-regulated transcriptional activity of RAR and RXR with MLL5 (mixed lineage leukemia 5, short form), which is the key molecule of epigenetics in differentiation of APL cells. Further investigations are required to clarify this issue.

Research Products

• [Journal Article] Altered retinol status and expression of retinol-related proteins in streptozotocin-induced type 1 diabetic model rats. (2015)
  • Author(s): Takitani K, Inoue K, Koh M, Miyazaki H, Kishi K, Inoue A, Tamai H.
  • Journal Title: J Clin Biochem Nutr. Volume: 56(3) Pages: 195-200
  • NAID: 130005068186
  • Peer Reviewed / Open Access
• [Journal Article] α-Tocopherol Status and Altered Expression of α-Tocopherol-Related Proteins in Streptozotocin-Induced Type 1 Diabetes in Rat Models (2014)
  • Author(s): Takitani K, Inoue K, Koh M, Miyazaki H, Kishi K, Inoue A, Tamai H.
  • Journal Title: Journal of Nutritional Science and Vitaminology Volume: 60 Issue: 6 Pages: 380-386
  • DOI: 10.3177/jnsv.60.380
  • NAID: 130005060910
  • ISSN: 0301-4800, 1881-7742
  • Peer Reviewed / Open Access
• [Journal Article] Retinol status and expression of retinol-related proteins in methionine-choline deficient rats. (2014)
  • Author(s): Miyazaki H, Takitani K, Koh M, Inoue A, Kishi K, Tamai H.
  • Journal Title: J Nutr Sci Vitaminol. Volume: 60(6) Pages: 78-85
  • NAID: 130004491369
  • Peer Reviewed / Open Access
• [Journal Article] Azacitidine in the treatment of pediatric therapy-related myelodysplastic syndrome after allogeneic hematopoietic stem cell transplantation. (2014)
  • Author(s): Inoue A, Kawakami C, Takitani K, Tamai H.
  • Journal Title: J Pediatr Hematol Oncol. Volume: 36(5) Issue: 5 Pages: 322-324
  • DOI: 10.1097/mph.0000000000000042
  • Peer Reviewed / Open Access
• [Journal Article] Azacitidine in the treatment of pediatric therapy-related myelodysplastic syndrome after allogeneic hematopoietic stem cell transplantation (2014)
  • Author(s): Akiko Inoue, Chihiro Kawakami, Kimitaka Takitani, Hiroshi Tamai
  • Journal Title: Journal of Pediatric Hematology / Oncology Volume: Mar.6
  • Peer Reviewed
• [Journal Article] Retinol status and expression of retinol-related proteins in methionine-choline deficient rats (2014)
  • Author(s): Hiroshi Miyazaki, Kimitaka Takitani, Maki Koh, Akiko Inoue, Kanta Kishi, Hiroshi Tamai
  • Journal Title: Journal of nutrition science and vitaminology Volume: 60 Pages: 78-85
  • NAID: 130004491369
  • Peer Reviewed
• [Journal Article] 小児急性前骨髄球性白血病に対する三酸化ヒ素による治療 (2013)
  • Author(s): 高橋 浩之, 盛武 浩, 照井 君典, 井上 彰子, 落合 秀匡, 金井 理恵, 豊田 秀実, 松野 良介, 塩原 正明, 中尾 朋平, 富澤 大輔, 多賀 崇, 多和 昭雄, 足立 壮一
  • Journal Title: 日本小児血液・がん学会雑誌 Volume: 50 Pages: 32-37
  • Peer Reviewed
• [Journal Article] Severe bone marrow failure associated with human parvovirus B19 infection in a case with no underlying disorder. (2012)
  • Author(s): Kawakami C, Kono Y, Inoue A, Takitani K, Ikemoto T, Tamai H.
  • Journal Title: Int J Hematol. Volume: 96 Issue: 6 Pages: 820-821
  • DOI: 10.1007/s12185-012-1214-7
  • NAID: 10031144627
  • Peer Reviewed
• [Journal Article] Sustained molecular remission after arsenic trioxide and gemutuzumab ozogamicin in a pediatric patient with relapsed acute promyelocytic leukemia. (2012)
  • Author(s): Inoue A, Kawakami C, Takitani K, Tamai H.
  • Journal Title: Pediatr Hematol Oncol. Volume: 29 Issue: 2 Pages: 170-172
  • DOI: 10.3109/08880018.2011.622834
  • Peer Reviewed
• [Journal Article] Acute monoblastic leukemia that switched lineage at relapse to acute lymphoblastic leukemia: a case report. (2012)
  • Author(s): Inoue A, Kawakami C, Takitani K, Ikemoto T, Tamai H.
  • Journal Title: J Pediatr Hematol Oncol. Volume: 34 Issue: 6 Pages: 258-260
  • DOI: 10.1097/mph.0b013e318233219d
  • Peer Reviewed
• [Journal Article] Sustained molecular remission after arsenic trioxide and gemutuzumab ozogamicin in a pediatric patient with relapsed acute promyelocytic leukemia. (2012)
  • Author(s): Akiko Inoue, Chihiro Kawakami, Kimitaka Takitani, and Hiroshi Tamai
  • Journal Title: Pediatric Hematology and Oncology Volume: 29 Pages: 170-172
  • Peer Reviewed
• [Journal Article] GVHDを合併したC型慢性肝炎に対するインターフェロン治療経験 (2011)
  • Author(s): 井上彰子，河上千尋，青松友槻，宮崎敬士，瀧谷公隆，余田 篤，玉井 浩
  • Journal Title: 日本小児血液学会雑誌 Volume: 25 Pages: 26-30
  • Peer Reviewed
• [Journal Article] 小児急性前骨髄球性白血病に対するATO/GOの使用経験 (2011)
  • Author(s): 井上彰子，河上千尋，瀧谷公隆，玉井 浩
  • Journal Title: 日本小児臨床薬理学会雑誌 Volume: 24 Pages: 78-81
  • Peer Reviewed
• [Journal Article] Induction of apoptosis by γ-tocotrienol in human cancer cell lines and leukemic blasts from patients: dependency on Bid, cytochrome c and caspase pathway. (2011)
  • Author(s): Akiko Inoue, Kimitaka Takitani, Maki Koh, Chihiro Kawakami, Tomoko Kuno, and
  • Journal Title: Nutrition and Cancer Volume: 63 Pages: 763-770
  • Peer Reviewed
• [Journal Article] Acute monoblastic leukemia that switched lineage at relapse to acute lymphoblastic leukemia: A case report (2011)
  • Author(s): Akiko Inoue, Chihiro Kawakami, Kimitaka Takitani, and Hiroshi Tamai
  • Journal Title: Journal of Pediatric Hematology / Oncology Volume: Dec31 Pages: 1-3
  • Peer Reviewed
• [Presentation] 造血幹細胞移植時のリコンビナントトロンボモジュリン使用経験-小児3症例- (2012)
  • Author(s): 井上彰子、河上千尋、玉井 浩
  • Organizer: 第34回日本造血細胞移植学会
  • Place of Presentation: 大阪
• [Presentation] 造血幹細胞移植前後にAzacitidineを投与した治療関連骨髄異形成症候群 (2011)
  • Author(s): 井上彰子、河上千尋、玉井 浩
  • Organizer: 第53回日本小児血液学会・第27回日本小児がん学会
  • Place of Presentation: 群馬
• [Presentation] 小児急性前骨髄球性白血病に対する三酸化ヒ素による治療の実態調査 (2011)
  • Author(s): 高橋 浩之、富澤大輔、盛武 浩、照井君典、井上彰子、日野もえ子、金井理恵、
  • Organizer: 第53回日本小児血液学会・第27回日本小児がん学会
  • Place of Presentation: 群馬