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Integrated molecular analyses of T cell acute lymphoblastic leukemia using SNP and methyration arrays

Research Project

Project/Area Number 23591560
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionGunma Institute of Public Health and Environmental Sciences

Principal Investigator

PARK Myoung-ja  群馬県衛生環境研究所, 研究企画係, 研究員 (50450375)

Co-Investigator(Kenkyū-buntansha) HAYASHI Yasuhide  群馬県衛生環境研究所, 研究企画係, 研究員 (30238133)
SOTOMATSU Manabu  群馬県衛生環境研究所, 研究企画係, 研究員 (70251113)
OHKI Kentaro  群馬県衛生環境研究所, 研究企画係, 研究員 (50400966)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords遺伝子 / ゲノム / 癌 / マイクロアレイ / マイクロアレ
Research Abstract

Molecular analysis was performed on 55 newly diagnosed T-ALL and 14 T-NHL patients treated by JACLS protocol using SNP array. Alterations were identified in 4q,6q,11p,9p,and 17p13 locus. Among them LEF1 alteration was found in 5(7.5%) of 67 patients. LEF1 alteration was associated with a younger age, but not with sex, white blood cell count(WBC) or event-free survival..
IL7R mutations were found in 4 (7.2%) of 55 T-ALL and none (0%) of 14 T-NHL patients. IL7R gene mutation was not associated with event-free survival in T-ALL children. Notably, all 4 patients with IL7R mutations have been alive without relapse. IL7R mutation was not associated with sex or WBC.
Whole exome sequencing was performed in 16 T-ALL patients, including 6 relapsed patients. Mean alteration was found in 19 genes per one patient. Mutations of NOTCH1 and FBXW7genes were found in 56 % and 32% patients, respectively. Novel mutations identified will be further examined in future.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (169 results)

All 2014 2013 2012 2011 Other

All Journal Article (33 results) (of which Peer Reviewed: 33 results) Presentation (136 results)

  • [Journal Article] Liver disease is frequently observed in Down syndrome patients with transient abnormal myelopoiesis.2014

    • Author(s)
      Park MJ, Sotomatsu M, Ohki K, Arai K, Maruyama K, Kobayashi T, Nishi A, Sameshima K, Takagi T, Hayashi Y.
    • Journal Title

      Int J Hematol

      Volume: 99 Issue: 2 Pages: 154-161

    • DOI

      10.1007/s12185-013-1487-5

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Significance of CD66c expression in childhood acute lymphoblastic leukemia2014

    • Author(s)
      Kiyokawa N, Iijima K, Tomita O, Miharu M, Hasegawa D, Kobayashi K, Okita H, Kajiwara M, Shimada H, Inukai T, Makimoto A, Fukushima T, Nanmoku T, Koh K, Manabe A, Kikuchi A, Sugita K, Fujimoto J, Hayashi Y, Ohara A.
    • Journal Title

      Leuk Res

      Volume: 38 Pages: 42-48

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutations of the GATA2 and CEBPA genes in paediatric acute myeloid leukaemia.2014

    • Author(s)
      Shiba N, Funato M, Ohki K, Park MJ, Mizushima Y, Adachi S, Kobayashi M, Kinoshita A, Sotomatsu M, Arakawa H, Tawa A, Horibe K, Tsukimoto I, Hayashi Y.
    • Journal Title

      Brit J Haematol

      Volume: 印刷中 Issue: 1 Pages: 142-159

    • DOI

      10.1111/bjh.12559

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Significance of CD66c expression in childhood acute lymphoblastic leukemia.2014

    • Author(s)
      Kiyokawa N, Iijima K, Tomita O, Miharu M, Hasegawa D, Kobayashi K, Okita H, Kajiwara M, Shimada H, Inukai T, Makimoto A, Fukushima T, Nanmoku T, Koh K, Manabe A, Kikuchi A, Sugita K, Fujimoto J, Hayashi Y, Ohara A.
    • Journal Title

      Leuk Res.

      Volume: 38 Pages: 42-48

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SETBP1 mutations in juvenile myelomonocytic leukaemia and myelodysplastic syndrome but not in paediatric acute myeloid leukaemia2013

    • Author(s)
      Shiba N, Ohki K, Park MJ, Sotomatsu M, Kudo K, Ito E, Sako M, Arakawa H, Hayashi Y
    • Journal Title

      Br J Haematol

      Volume: Epub ahead of print Issue: 1 Pages: 156-159

    • DOI

      10.1111/bjh.12595

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The landscape of somatic mutations in Down syndrome-related myeloid disorders.2013

    • Author(s)
      Yoshida K
    • Journal Title

      Nature Genet.

      Volume: 45 Issue: 11 Pages: 1293-1200

    • DOI

      10.1038/ng.2759

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] WT1 mutation in pediatric patients with acute myeloid leukemia: A study of the Japanese Childhood AML Cooperative Study Group2013

    • Author(s)
      Sano H, Shimada A, Tabuchi K, Taki T, Murata C, Park M, Sotomatsu Tawa A, Kobayashi R, Horibe K, Tsuchida M, Hanada R, Tsukimoto I, Hayashi Y
    • Journal Title

      Int J Hematol

      Volume: 98 Issue: 4 Pages: 437-445

    • DOI

      10.1007/s12185-013-1409-6

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of genetic lesions in rhabdomyosarcoma using a high-density single nucleotide polymorphism array2013

    • Author(s)
      Nishimura R, Takita J, Sato-Otsubo A, Kato M, Koh K, Hanada R, Tanaka Y, Kato K, Maeda D, Fukuyama M, Sanada M, Hayashi Y, Ogawa S
    • Journal Title

      Cancer Sci

      Volume: 104 Issue: 7 Pages: 856-864

    • DOI

      10.1111/cas.12173

    • NAID

      120007089073

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] NUP98-NSD1 related gene expression signature is strongly associated with a poor prognosis in pediatric acute myeloid leukemia: a study of the Japanese Childhood AML Cooperative Study Group Cooperative Study Group2013

    • Author(s)
      Shiba N, Ichikawa H, Taki T, Park M, Jo A, Mitani S, Shimada A, Sotomatsu M, Arakawa H, Tabuchi K, Adachi S, Tawa A, Horibe K, Tsuchida M, Hanada R, Tsukimoto I, Hayashi Y
    • Journal Title

      Genes Chromosomes Cancer

      Volume: 52 Issue: 7 Pages: 683-693

    • DOI

      10.1002/gcc.22064

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] An empirical Bayesian framework for somatic mutation detection from cancer genome sequencing data2013

    • Author(s)
      Yuichi Shiraishi
    • Journal Title

      Nucleic Acid Research

      Volume: 41 Issue: 7 Pages: e89-e89

    • DOI

      10.1093/nar/gkt126

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Naturally occurring oncogenic GATA1 mutants with internal deletions in transient abnormal myelopoiesis in Down syndrome2013

    • Author(s)
      Toki T, Kanezaki R, Kobayashi E, Kaneko H, Suzuki M, Wang R, Terui K, Kanegane H, Maeda M, Endo M, Mizuochi T, Adachi S, Hayashi Y, Yamamoto M, Shimizu R, Ito E.
    • Journal Title

      Blood

      Volume: 121(16) Issue: 16 Pages: 3181-3184

    • DOI

      10.1182/blood-2012-01-405746

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cytomegalovirus Retinitis During Maintenance Therapy for T-Cell Acute Lymphoblastic Leukemia2013

    • Author(s)
      Wakai K, Sano H, Shimada A, Shiozawa Y, Park MJ, Sotomatsu M, Yanagisawa R, Koike K, Kozawa K, Ryo A, Tsukagoshi H, Kimura H, Hayashi Y
    • Journal Title

      J Pediatr Hematol Oncol

      Volume: 35 Issue: 2 Pages: 162-163

    • DOI

      10.1097/mph.0b013e318279e920

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] An Inv(16)(p13.3q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein Defines an Aggressive Subtype of Pediatric Acute Megakaryoblastic Leukemia2012

    • Author(s)
      Gruber TA, Larson Gedman A, Zhang J, Koss CS, Marada S, Ta HQ, Chen SC, Su X, Ogden SK, Dang J, Wu G, Gupta V, Andersson AK, Pounds S, Shi L, Easton J, Barbato MI, Mulder HL, Manne J, Wang J, Rusch M, Ranade S, Ganti R, Parker M, Ma J, Radtke I, Ding L, Cazzaniga G, Biondi A, Kornblau SM, Ravandi F, Kantarjian H, Nimer SD, Dohner K, Dohner H, Ley TJ, Ballerini P, Shurtleff S, Tomizawa D, Adachi S, Hayashi Y, Tawa A, Shih LY, Liang DC, Rubnitz JE, Pui CH, Mardis ER, Wilson RK, Downing JR.
    • Journal Title

      Cancer Cell

      Volume: 22 Issue: 5 Pages: 683-697

    • DOI

      10.1016/j.ccr.2012.10.007

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Somatic mosaicism for oncogenic NRAS mutations in juvenile myelomonocytic leukemia2012

    • Author(s)
      Doisaki S, Muramatsu H, Shimada A, Takahashi Y, Mori-Ezaki M, Sato M, Kawaguchi H, Kinoshita A, Sotomatsu M, Hayashi Y, Furukawa-Hibi Y, Yamada K, Hoshino H, Kiyoi H, Yoshida N, Sakaguchi H, Narita A, Wang X, Ismael O, Xu Y, Nishio N, Tanaka M, Hama A, Koike K, Kojima S
    • Journal Title

      Blood

      Volume: 120 Issue: 7 Pages: 1485-1488

    • DOI

      10.1182/blood-2012-02-406090

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] RAS mutations are frequent in FAB type M4 and M5 of acute myeloid leukemia, and related to late relapse : a study of the Japanese Childhood AML Cooperative Study Group2012

    • Author(s)
      Sano H, Shimada A, Taki T, Murata C, Park MJ, Sotomatsu M, Tabuchi K, Tawa A, Kobayashi R, Horibe K, Tsuchida M, Hanada R, Tsukimoto I, Hayashi Y.
    • Journal Title

      Int J Hematol

      Volume: 95 Issue: 5 Pages: 509-515

    • DOI

      10.1007/s12185-012-1033-x

    • NAID

      10030633077

    • Related Report
      2013 Final Research Report 2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of TRIB1 R107L gain-of-function mutation in human acute megakaryocytic leukemia2012

    • Author(s)
      Yokoyama T, Toki T, Aoki Y, Kanezaki R, Park MJ, Kanno Y, Takahara T, Yamazaki Y, Ito E, Hayashi Y, Nakamura T.
    • Journal Title

      Blood

      Volume: 119 Issue: 11 Pages: 2608-2611

    • DOI

      10.1182/blood-2010-12-324806

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] CBL mutation in chronic myelomonocytic leukemia secondary to familial platelet disorder with propensity to develop acute myeloid leukemia2012

    • Author(s)
      Shiba N, Hasegawa D, Park MJ, Murata C, Matsubara A, Ogawa C, Manabe A, Arakawa H, Ogawa S, Hayashi Y.
    • Journal Title

      Blood

      Volume: 119 Issue: 11 Pages: 2612-2614

    • DOI

      10.1182/blood-2011-02-333435

    • Related Report
      2013 Final Research Report 2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of early T-cell precursor acute lymphoblastic leukaemia : Results of the Tokyo Children's Cancer Study Group Study L99-152012

    • Author(s)
      Inukai T, Kiyokawa N, Campana D, Coustan-Smith E, Kikuchi A, Kobayashi M, Takahashi H, Koh K, Manabe A, Kumagai M, Ikuta K, Hayashi Y, Tsuchida M, Sugita K, Ohara A.
    • Journal Title

      Brit J Haematol

      Volume: 156 Issue: 3 Pages: 358-365

    • DOI

      10.1111/j.1365-2141.2011.08955.x

    • Related Report
      2013 Final Research Report 2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] DNMT3A mutations are rare in childhood acute myeloid leukaemia, myelodysplastic syndromes and juvenile myelomonocytic leukaemia2012

    • Author(s)
      Shiba N, Taki T, Park MJ, Shimada A, Sotomatsu M, Adachi S, Tawa A, Horibe K, Tsuchida M, Hanada R, Tsukimoto I, Arakawa H, Hayashi Y.
    • Journal Title

      Br J Haematol

      Volume: 156 Issue: 3 Pages: 413-414

    • DOI

      10.1111/j.1365-2141.2011.08879.x

    • Related Report
      2013 Final Research Report 2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] CBL mutations in infant acute lymphoblastic leukaemia2012

    • Author(s)
      6. Shiba N, Park MJ, Taki T, Takita J, Hiwatari M, Kanazawa T, Sotomatsu M, Ishii E, Arakawa H, Ogawa S, Hayashi Y
    • Journal Title

      Br J Haematol

      Volume: 156 Issue: 5 Pages: 672

    • DOI

      10.1111/j.1365-2141.2011.08900.x

    • Related Report
      2013 Final Research Report 2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] High WT1 mRNA expression after induction chemotherapy and FLT3-ITD have prognostic impact in pediatric acute myeloid leukemia: a study of the Japanese Childhood AML Cooperative Study Group2012

    • Author(s)
      Shimada A, Taki T, Koga D, Tabuchi K, Tawa A, Hanada R, Tsuchida M, Horibe K, Tsukimoto I, Adachi S, Kojima S, Hayashi Y
    • Journal Title

      Int J Hematol

      Volume: 96 Issue: 4 Pages: 469-476

    • DOI

      10.1007/s12185-012-1163-1

    • NAID

      10031126738

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Eosinophil granular proteins damage bronchial epithelial cells infected with respiratory syncytial virus.2012

    • Author(s)
      Kato M, et al.
    • Journal Title

      Int Arch Allergy Immunol.

      Volume: 158 Suppl 1 Issue: Suppl. 1 Pages: 11-18

    • DOI

      10.1159/000337752

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Childhood acute myeloid leukemia with bone marrow eosinophilia caused by t(16;21)(q24;q22)2012

    • Author(s)
      Kawashima N, Shimada A, Taketani T, Hayashi Y, Yoshida N, Matsumoto K, Takahashi Y, Kojima S, Kato K
    • Journal Title

      Int J Hematol

      Volume: 95 Issue: 5 Pages: 577-580

    • DOI

      10.1007/s12185-012-1044-7

    • NAID

      10030633418

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Novel splicing-factor mutations in juvenile myelomonocytic leukemia2012

    • Author(s)
      滝田順子、吉田健一
    • Journal Title

      Leukemia

      Volume: 26 Issue: 8 Pages: 1879

    • DOI

      10.1038/leu.2012.45

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Aberrant activation of ALK kinase by a novel truncated form ALK protein in neuroblastoma2012

    • Author(s)
      Okubo J, Takita J, Chen Y, Oki K, Nishimura R, Kato M, Sanada M, Hiwatari M, Hayashi Y, Igarashi T, Ogawa S.
    • Journal Title

      Oncogene

      Volume: 31 Issue: 44 Pages: 4667

    • DOI

      10.1038/onc.2011.616

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] CBL mutation in childhood therapy-related leukemia2011

    • Author(s)
      Shiba N, Taki T, Park MJ, Nagasawa M, Kanazawa T, Takita J, Ohnishi H, Sotomatsu M, Arakawa H, Hayashi Y.
    • Journal Title

      Leukemia

      Volume: 25 Issue: 8 Pages: 1356-1358

    • DOI

      10.1038/leu.2011.75

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chromosome abnormalities in advanced stage T-cell lymphoblastic lymphoma of children and adolescents : a report from Japanese Paediatric Leukaemia/Lymphoma Study Group(JPLSG) and review of the literature2011

    • Author(s)
      Sekimizu M, Sunami S, Nakazawa A, Hayashi Y, Okimoto Y, Saito AM, Horibe K, Tsurusawa M, Mori T.
    • Journal Title

      Br J Haematol

      Volume: 154 Issue: 5 Pages: 612-617

    • DOI

      10.1111/j.1365-2141.2011.08788.x

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] IDH1 and IDH2 mutations are rare in pediatric myeloid malignancies2011

    • Author(s)
      Oki K, Takita J, Hiwatari M, Nishimura R, Sanada M, Okubo J, Adachi M, Sotomatsu M, Kikuchi A, Igarashi T, Hayashi Y, Ogawa S.
    • Journal Title

      Leukemia

      Volume: 25 Issue: 2 Pages: 382

    • DOI

      10.1038/leu.2010.307

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Different cytokine profile and eosinophil activation are involved in rhinovirus-and RS virus-induced acute exacerbation of childhood wheezing2011

    • Author(s)
      Kato M, et al
    • Journal Title

      Pediatr Allergy Immunol

      Volume: 22 Issue: 1pt2

    • DOI

      10.1111/j.1399-3038.2010.01026.x

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differential effects of corticosteroids on serum eosinophil cationic protein and cytokine production in rhinovirus- and respiratory syncytial virus-induced acute exacerbation of childhood asthma2011

    • Author(s)
      Kato M, et al
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 155Suppl1 Issue: Suppl. 1 Pages: 77-84

    • DOI

      10.1159/000327434

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Eosinophilic gastrointestinal disorders in infants : a Japanese case series2011

    • Author(s)
      Yamada Y, et al
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 155Suppl1 Issue: Suppl. 1 Pages: 40-45

    • DOI

      10.1159/000327264

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Aberrations of NEGR1 on 1p31 and MYEOV on 11q13 in neuroblastoma2011

    • Author(s)
      Takita J, Chen Y, Okubo J, et al
    • Journal Title

      Canser Science

      Volume: 102 Issue: 9 Pages: 1645-1650

    • DOI

      10.1111/j.1349-7006.2011.01995.x

    • NAID

      10030242926

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Oncogenic mutations of ALK in neuroblastoma2011

    • Author(s)
      Ogawa S, Takita J, Sanada M, Hayashi Y.
    • Journal Title

      Cancer Science

      Volume: 102 Issue: 2 Pages: 302-308

    • DOI

      10.1111/j.1349-7006.2010.01825.x

    • NAID

      10029289653

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 網羅的ゲノム解析による小児T-ALL再発例、非再発例の検討2013

    • Author(s)
      関正史,吉田健一,白石友一,佐藤悠佑,千葉健一,田中陽子,加藤元博,花田良二,岡明,宮野悟,林泰秀,小川誠司,滝田順子
    • Organizer
      第55回日本小児血液・がん学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2013-11-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Genome-wide analysis of relapsed T cell acute lymphoblastic leukemia2013

    • Author(s)
      Seki M, Hoshino N, Nishimura R, Okuno Y, Shiraishi Y, Yoshida K, Kato M, Kho K, Hanada R, Miyano S, Hayashi Y, Ogawa S, Takita J.
    • Organizer
      The 75th Annual Meeting of the Japanese Society of Hematolgy
    • Place of Presentation
      Sapporo
    • Year and Date
      2013-10-12
    • Related Report
      2013 Final Research Report
  • [Presentation] 13q欠失を伴ったダウン症合併TAMとAMKLの遺伝子解析2013

    • Author(s)
      朴明子,吉田健一,大木健太郎,新井心,外松学,伊藤悦朗,小川誠司,林泰秀
    • Organizer
      The 75th Annual Meeting of the Japanese Society of Hematolgy
    • Place of Presentation
      Sapporo
    • Year and Date
      2013-10-12
    • Related Report
      2013 Final Research Report
  • [Presentation] 小児T細胞性ALLにおける網羅的ゲノム解析2013

    • Author(s)
      関正史,西村力,星野諭子,吉田健一,佐藤悠佑,奥野雄介,白石悠一,加藤元博,康勝好,宮野悟,林泰秀,小川誠司,滝田順子
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2013-10-05
    • Related Report
      2013 Final Research Report
  • [Presentation] 染色体異常を伴ったダウン症合併TAMとAMKLの遺伝子解析2013

    • Author(s)
      朴明子,大木健太郎,新井心,外松学,林泰秀
    • Organizer
      第116回日本小児科学会学術集会
    • Place of Presentation
      広島
    • Year and Date
      2013-04-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 再発T細胞性ALLにおける網羅的ゲノム解析2013

    • Author(s)
      関正史,西村力,星野諭子,奥野友介,白石友一,吉田健一,宮野悟,林泰秀,小川誠司,滝田順子
    • Organizer
      第116回日本小児科学会学術集会
    • Place of Presentation
      広島
    • Year and Date
      2013-04-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Low Frequency and Poor Prognosis Of MLL-Partial Tandem Duplications In Pediatric Acute Myeloid Leukemia Using MLPA Method : The Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) AML-05 Trial2013

    • Author(s)
      Ohki K, Park MJ, Sano H, Hara Y, Shiba N, Tomizawa D, Taga T, Moriya Saito A, Fujimoto J, Tawa A, Horibe K, Adachi S, Hayashi Y.
    • Organizer
      55rd ASH
    • Place of Presentation
      New Orleans
    • Related Report
      2013 Final Research Report
  • [Presentation] Whole Exome Sequencing Reveals Clonal Evolution Pattern and Driver Mutations Of Relapsed Pediatric AML2013

    • Author(s)
      Yoshida K, Shiba N, Shiraishi Y, Shimada A, Terui K, Kato M, Okuno Y, Nagata Y, Kon A, Yoshizato T, Matsunawa, M, Chiba K, Tanaka H, Sanada M, Miyano S, Ito E, Hayashi Y, Ogawa S.
    • Organizer
      55rd ASH
    • Place of Presentation
      New Orleans
    • Related Report
      2013 Final Research Report
  • [Presentation] Genetic Landscapes Of Childhood T-Cell Acute Lymphoblastic Leukemia2013

    • Author(s)
      Seki M, Yoshida K, Sato Y, Shiraishi Y, Chiba K, TanakaH, Kato M, Hiwatari M, Koh K, Hanada R, Sanada M, Miyano S, Oka A, Hayashi Y, Ogawa S, Takita J.
    • Organizer
      55rd ASH
    • Place of Presentation
      New Orleans
    • Related Report
      2013 Final Research Report
  • [Presentation] Whole-Exome Resequencing Identifies Somatic Mutations Of BCOR and BCORL1 Transcriptional Corepressor Genes and Major Cohesin Complex Component Genes In Pediatric Acute Myeloid Leukemia.2013

    • Author(s)
      Shiba N, Ohki K, Nagata Y, Kon A, Okuno Y,Shiraishi Y, Kato M, Park MJ, Ohki K, Takita J, Kanazawa T, Kudo K, Ito E, Sanada M, Tomizawa D, Tawa A, Adachi S, Miyano S, Ogawa S, Hayashi Y.
    • Organizer
      55rd Annual Meeting of the American Society of Hematology
    • Place of Presentation
      New Orleans
    • Related Report
      2013 Annual Research Report
  • [Presentation] Low Frequency and Poor Prognosis Of MLL-Partial Tandem Duplications In Pediatric Acute Myeloid Leukemia Using MLPA Method: The Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) AML-05 Trial.2013

    • Author(s)
      Ohki K, Park MJ, Sano H, Hara Y, Shiba N, Tomizawa D, Taga T, Moriya Saito A, Fujimoto J, Tawa A, Horibe K, Adachi S, Hayashi Y.
    • Organizer
      55rd Annual Meeting of the American Society of Hematology
    • Place of Presentation
      New Orleans
    • Related Report
      2013 Annual Research Report
  • [Presentation] Whole Exome Sequencing Reveals Clonal Evolution Pattern and Driver Mutations Of Relapsed Pediatric AML.2013

    • Author(s)
      Yoshida K, Shiba N, Shiraishi Y, Shimada A, Terui K, Kato M, Okuno Y, Nagata Y, Kon A, Yoshizato T, Matsunawa, M, Chiba K, Tanaka H, Sanada M, Miyano S, Ito E, Hayashi Y, Ogawa S.
    • Organizer
      55rd Annual Meeting of the American Society of Hematology
    • Place of Presentation
      New Orleans
    • Related Report
      2013 Annual Research Report
  • [Presentation] Comprehensive Fusion Gene Analysis Of Pediatric Non-Down Syndrome Acute Megakaryoblasitc Leukemia.2013

    • Author(s)
      Hara Y, Shiba n, Ohki K, Park MJ, Tomizawa D, Taga T, Saito A, Fujimoto J, Arakawa H, Tawa A, Horibe K, Adachi S, Hayashi Y.
    • Organizer
      55rd Annual Meeting of the American Society of Hematology
    • Place of Presentation
      New Orleans
    • Related Report
      2013 Annual Research Report
  • [Presentation] An Analysis Of Ph-Like ALL In Japanese Patients.2013

    • Author(s)
      Kiyokawa N, Iijima K, Yoshihara H, Ohki K, Kato M, Fukushima T, Kikuchi A, Fujimoto J, Hayashi Y, Koh K, Manabe A, Ohara A.
    • Organizer
      55rd Annual Meeting of the American Society of Hematology
    • Place of Presentation
      New Orleans
    • Related Report
      2013 Annual Research Report
  • [Presentation] CSF3R Gene Mutations In Myeloid Malignancy Of Childhood.2013

    • Author(s)
      Sano H, Ohki K, Park MJ, Hara Y, Shiba N, Tomizawa D, Taga T, Moriya Saito A, Fujimoto J, Tawa A, Horibe K, Adachi S, Hayashi Y.
    • Organizer
      55rd Annual Meeting of the American Society of Hematology
    • Place of Presentation
      New Orleans
    • Related Report
      2013 Annual Research Report
  • [Presentation] Whole exome sequencing reveals spectrum of gene mutations in pediatric AML2012

    • Author(s)
      Shiba N, Yoshida K, Okuno Y, Shiraishi Y, Nagata Y, Ohki K, Kato M, MJ Park, Takita J, Kanazawa T, Kudo K, Ito E, Sanada M, Miyano S, Ogawa S, Hayashi Y.
    • Organizer
      54rd ASH
    • Place of Presentation
      Atlanta
    • Year and Date
      2012-12-09
    • Related Report
      2013 Final Research Report
  • [Presentation] 進行期T細胞性リンパ芽球性リンパ腫の染色体異常解析―JPLSGからの報告2012

    • Author(s)
      関水匡大,角南勝介,中澤温子,林泰秀,沖本由理,齋藤明子,堀部敬三,鶴澤正仁,森鉄也
    • Organizer
      第54回日本小児血液・がん学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2012-11-30
    • Related Report
      2013 Final Research Report
  • [Presentation] MLPA法を用いたT-ALL遺伝子異常についての解析2012

    • Author(s)
      朴明子,大木健太郎,新井心,外松学,清河信敬,小田慈,堀部敬三,林泰秀
    • Organizer
      第54回日本小児血液・がん学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2012-11-30
    • Related Report
      2013 Final Research Report
  • [Presentation] t(17;19)(q22;p13.3)を含む染色体異常を呈したT細胞性急性リンパ性白血病の1例2012

    • Author(s)
      西眞範,磯村直子,野村優子,柳井文男,犬飼岳史,渡辺新,林泰秀
    • Organizer
      第54回日本小児血液・がん学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2012-11-30
    • Related Report
      2013 Final Research Report
  • [Presentation] IL-7R gene mutations in childhood T-cell acute lymphoblastic leukemia2012

    • Author(s)
      Park MJ, Oda M, Kobayashi R, Suzuki N, Hara J, Horibe K, Hayashi Y.
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2012-10-19
    • Related Report
      2013 Final Research Report
  • [Presentation] TAMに合併する肝機能障害について2012

    • Author(s)
      朴明子,林泰秀
    • Organizer
      第48回日本周産期・新生児医学会学術集会
    • Place of Presentation
      さいたま
    • Year and Date
      2012-07-08
    • Related Report
      2013 Final Research Report
  • [Presentation] TCCSGの小児B前駆細胞型急性リンパ性白血病におけるCRLF2とIKZF1、JAK遺伝子解析2012

    • Author(s)
      大木健太郎,大喜多肇,清河信敬,朴明子,康勝好,花田良二,真部淳,菊地陽,小原明,林泰秀
    • Organizer
      第115回日本小児科学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2012-04-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 再発後にMLL-AF4陽性となったB前駆型急性リンパ性白血病の1例2012

    • Author(s)
      大木健太郎,他
    • Organizer
      日本血液学会第167回例会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] TCCSG小児B前駆細胞型急性リンパ性白血病におけるCRLF2とIKZF1の解析2011

    • Author(s)
      大木健太郎,大喜多肇,小林健一郎,清河信敬,朴明子,新井心,外松学,柴徳生,福島敬,康勝好,花田良二,真部淳,菊地陽,小原明,土田昌宏,林泰秀
    • Organizer
      第53回日本小児血液・がん学会学術集会
    • Place of Presentation
      前橋
    • Year and Date
      2011-11-27
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] Gene expression profiles of early T-cell precursor (ETP-) ALL and T-ALL treated in TCCSG trials2011

    • Author(s)
      清河信敬,林泰秀,小原明
    • Organizer
      第53回日本小児血液・がん学会学術集会
    • Place of Presentation
      前橋
    • Year and Date
      2011-11-27
    • Related Report
      2013 Final Research Report
  • [Presentation] T細胞型小児急性リンパ性白血病における遺伝子異常の解析2011

    • Author(s)
      朴明子,清河信敬,小田慈,真部淳,原純一,小原明,花田良二,土田昌宏,小川誠司,堀部敬三,林泰秀
    • Organizer
      第53回日本小児血液・がん学会学術集会
    • Place of Presentation
      前橋
    • Year and Date
      2011-11-25
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] Clinical significance of ETP-ALL in childhood T-ALL; the TCCSG L99-15 study2011

    • Author(s)
      Inukai T, Kiyokawa N, Ohara A, Takahashi H, Koh K, Manabe A, Kumagai M, Ikuta K, Hayashi Y, Tsuchida M, Campana D, Sugita K.
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Molecular characteristics of early T-cell precursor (ETP) ALL and T-ALL treated in TCCSG trials2011

    • Author(s)
      Kiyokawa N, Iijima K, Inukai T, Takahashi H, Fukushima T, Koh Y, Sugita K, Manabe A, Kikuchi A, Kumagai M, Ohara A, Fujimoto J, Hayashi Y.
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-15
    • Related Report
      2013 Final Research Report
  • [Presentation] The clinical significance of LEF1 mutation in childhood acute lymphblastic leukemia2011

    • Author(s)
      Park MJ, Kiyokawa N, Oda M, Manabe A, Hara J, Ohara A, Hanada R, Tsuchida M, Ogawa S, Horibe K, Hayashi Y.
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-15
    • Related Report
      2013 Final Research Report
  • [Presentation] 小児T細胞性急性リンパ性白血病におけるLEF1遺伝子の異常と臨床像について2011

    • Author(s)
      朴明子,清河信敬,小田慈,真部淳,小原明,花田良二,土田昌宏,小川誠司,堀部敬三,林泰秀
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-04
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] 乳児白血病におけるIDH 1/2遺伝子の変異解析2011

    • Author(s)
      樋渡光輝,滝田順子,真田昌,西村力,大久保淳,井田孔明,外松学,菊地陽,五十嵐隆,林泰秀,小川誠司
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] 肝機能障害を伴うTAMの臨床像について2011

    • Author(s)
      朴明子,外松学,林泰秀
    • Organizer
      第114回日本小児科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-08-12
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] 小児T-ALLにおけるLEF1遺伝子異常と臨床像2011

    • Author(s)
      朴明子,林泰秀
    • Organizer
      平成23年度第1回足立班・堀部班・牧本班・清河班合同班会議
    • Place of Presentation
      名古屋
    • Year and Date
      2011-06-18
    • Related Report
      2013 Final Research Report
  • [Presentation] NUP98-NSD1 fusion gene is strongly associated with a poor prognosis in pediatric acute myeloid leukemia : a study of the Japanese Childhood AML99 Cooperative Study Group2011

    • Author(s)
      Shiba N, Taki T, Park M, Murata C, Oki K, Ichikawa H, Shimada A, Kanazawa T, Sotomatsu M, Tabuchi K, Adachi S, Tawa A, Horibe K, Tsuchida M, Hanada R, Tsukimoto I, Arakawa H, Hayashi Y.
    • Organizer
      53rd ASH
    • Place of Presentation
      San Diego
    • Related Report
      2013 Final Research Report
  • [Presentation] ダウン症候群に合併した一過性骨髄異常増殖症153例の後方視的解析2011

    • Author(s)
      村松秀城,他
    • Organizer
      第114回日本小児科学会学術集会(招待講演)
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] ダウン症候群にみられる一過性骨髄異常増殖症(TAM)についての新生児施設への調査2011

    • Author(s)
      塚本桂子,他
    • Organizer
      第114回日本小児科学会学術集会(招待講演)
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] TAMにおける遺伝学的基盤探索2011

    • Author(s)
      小川誠司,他
    • Organizer
      第114回日本小児科学会学術集会(招待講演)
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 革新的ゲノム解析技術を用いた難治性小児固形腫瘍における発症分子機構の解明2011

    • Author(s)
      滝田順子,他
    • Organizer
      第114回日本小児科学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 治療関連白血病と乳児白血病におけるCBL遺伝子変異の解析2011

    • Author(s)
      柴 徳生,他
    • Organizer
      第114回日本小児科学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] TCCSG登録例における小児ALL関連キメラ遺伝子発現量の推移について2011

    • Author(s)
      福島 敬,他
    • Organizer
      第114回日本小児科学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 10カラーフローサイトメトリー解析による小児白血病のマーカー診断2011

    • Author(s)
      清河信敬,他
    • Organizer
      第114回日本小児科学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] MLL関連キメラが検出されないCD10陰性ALLのマーカーと発現遺伝子の特徴2011

    • Author(s)
      清河信敬,他
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] 次世代シーケンサーによる神経芽腫のエクソーム解析2011

    • Author(s)
      西村 力,他
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] Mutation analysis for IDH1 and IDH2 in infantile leukemia.2011

    • Author(s)
      Hiwatari M, et al.
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] CBL mutation in CMML secondary to familial platelet disorder with propensity to develop AML.2011

    • Author(s)
      Shiba N, et al.
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] Clinical significance of ETP-ALL in childhood T-ALL; the TCCSG L99-15 study.2011

    • Author(s)
      Inukai T, et al.
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] Molecular characteristics of early T-cell precursor (ETP) ALL and T-ALL treated in TCCSG trials.2011

    • Author(s)
      Kiyokawa N, et al.
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] Novel GATA1 mutants with internal deletions in transient abnormal myelopoiesis in down syndrome.2011

    • Author(s)
      Toki T, et al.
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] Whole exome analysis of transient abnormal myelopoiesis and acute megakaryocytic leukemia with Down syndrome.2011

    • Author(s)
      Yoshida K, et al.
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] Aberrations of DNMT3A in pediatric myeloid malignancies.2011

    • Author(s)
      Motomura A, et al.
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] The clinical significance of LEF1 mutation in childhood acute lymphblastic leukemia.2011

    • Author(s)
      Park MJ, et al.
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] ダウン症候群関連ALLの発症におけるJAK2、およびCRLF2遺伝子異常の解析2011

    • Author(s)
      花田 勇,他
    • Organizer
      第53回日本小児血液・がん学会学術集会
    • Place of Presentation
      前橋
    • Related Report
      2011 Research-status Report
  • [Presentation] 乳児AMLの後方視的解析2011

    • Author(s)
      嶋田 明,他
    • Organizer
      第53回日本小児血液・がん学会学術集会
    • Place of Presentation
      前橋
    • Related Report
      2011 Research-status Report
  • [Presentation] 小児急性白血病におけるDNMT3A遺伝子変異の解析2011

    • Author(s)
      柴 徳生,他
    • Organizer
      第53回日本小児血液・がん学会学術集会
    • Place of Presentation
      前橋
    • Related Report
      2011 Research-status Report
  • [Presentation] JPLSG AML-05臨床試験におけるWHO分類に基づいた小児急性骨髄性白血病の中央診断2011

    • Author(s)
      木下明俊,他
    • Organizer
      第53回日本小児血液・がん学会学術集会
    • Place of Presentation
      前橋
    • Related Report
      2011 Research-status Report
  • [Presentation] 小児急性骨髄性白血病におけるNUP98-NSD転座の解析2011

    • Author(s)
      柴 徳生,他
    • Organizer
      第53回日本小児血液・がん学会学術集会
    • Place of Presentation
      前橋
    • Related Report
      2011 Research-status Report
  • [Presentation] 染色体11p15異常を有する造血器腫瘍における遺伝子変異と臨床像の関連2011

    • Author(s)
      竹谷 健,他
    • Organizer
      第53回日本小児血液・がん学会学術集会
    • Place of Presentation
      前橋
    • Related Report
      2011 Research-status Report
  • [Presentation] 東京小児がんグループ(TCCSG)ALL治療研究登録症例の網羅的遺伝子発現解析2011

    • Author(s)
      飯島一智,他
    • Organizer
      第53回日本小児血液・がん学会学術集会
    • Place of Presentation
      前橋
    • Related Report
      2011 Research-status Report
  • [Presentation] TCCSG ALL登録症例の細胞抗原とキメラ遺伝子との関連性についての検討2011

    • Author(s)
      小林健一郎,他
    • Organizer
      第53回日本小児血液・がん学会学術集会
    • Place of Presentation
      前橋
    • Related Report
      2011 Research-status Report
  • [Presentation] MLL再構成陽性の小児急性リンパ性白血病のエクソーム解析2011

    • Author(s)
      堤 修一,他
    • Organizer
      第53回日本小児血液・がん学会学術集会
    • Place of Presentation
      前橋
    • Related Report
      2011 Research-status Report
  • [Presentation] 乳児白血病におけるIDH1およびIDH2遺伝子の解析2011

    • Author(s)
      樋渡光輝,他
    • Organizer
      第53回日本小児血液・がん学会学術集会
    • Place of Presentation
      前橋
    • Related Report
      2011 Research-status Report
  • [Presentation] ダウン症候群に合併した一過性骨髄増殖症(TAM)および急性巨核芽球性白血病(AMKL)の全エクソンシーケンス2011

    • Author(s)
      吉田健一,他
    • Organizer
      第53回日本小児血液・がん学会学術集会
    • Place of Presentation
      前橋
    • Related Report
      2011 Research-status Report
  • [Presentation] 脾破裂を契機に診断された家族性血小板血症2011

    • Author(s)
      黒澤秀光,他
    • Organizer
      第53回日本小児血液・がん学会学術集会
    • Place of Presentation
      前橋
    • Related Report
      2011 Research-status Report
  • [Presentation] 次世代シークエンサによる神経芽腫のエクソーム解析2011

    • Author(s)
      西村 力,他
    • Organizer
      第53回日本小児血液・がん学会学術集会
    • Place of Presentation
      前橋
    • Related Report
      2011 Research-status Report
  • [Presentation] Gene expression profiles of early T-cell precursor (ETP-) ALL and T-ALL treated in TCCSG trials.2011

    • Author(s)
      清河信敬,他
    • Organizer
      第53回日本小児血液・がん学会学術集会(招待講演)
    • Place of Presentation
      前橋
    • Related Report
      2011 Research-status Report
  • [Presentation] 10カラーフローサイトメトリーを用いたB前駆細胞急性リンパ芽球性白血病のMRD検出2011

    • Author(s)
      三春昌嗣,他
    • Organizer
      第53回日本小児血液・がん学会学術集会
    • Place of Presentation
      前橋
    • Related Report
      2011 Research-status Report
  • [Presentation] 小児急性リンパ性白血病高危険群に対するBFM95-HR強化療法:TCCSG ALL L99-1502研究2011

    • Author(s)
      康 勝好,他
    • Organizer
      第53回日本小児血液・がん学会学術集会
    • Place of Presentation
      前橋
    • Related Report
      2011 Research-status Report
  • [Presentation] 小児ALL関連キメラ遺伝子発現量の抹消血中推移と既知リスク因子との関連について2011

    • Author(s)
      福島 敬,他
    • Organizer
      第53回日本小児血液・がん学会学術集会
    • Place of Presentation
      前橋
    • Related Report
      2011 Research-status Report
  • [Presentation] t(9;17)(p24;q23)を伴うJAK2遺伝子関連急性リンパ性白血病の遺伝子解析2011

    • Author(s)
      川村眞智子,他
    • Organizer
      第53回日本小児血液・がん学会学術集会
    • Place of Presentation
      前橋
    • Related Report
      2011 Research-status Report
  • [Presentation] 再発後にMLL-AF4陽性となったBCP-ALLの一例2011

    • Author(s)
      奥野はるな,他
    • Organizer
      第53回日本小児血液・がん学会学術集会
    • Place of Presentation
      前橋
    • Related Report
      2011 Research-status Report
  • [Presentation] NUP98-NSD1 fusion gene is strongly associated with a poor prognosis in pediatric acute myeloid leukemia: a study of the Japanese Childhood AML99 Cooperative Study Group.2011

    • Author(s)
      Shiba N, et al.
    • Organizer
      53rd Annual Meeting of the American Society of Hematology
    • Place of Presentation
      San Diego
    • Related Report
      2011 Research-status Report
  • [Presentation] The Concurrent mutations in hematological malignancies with NUP98-fusion genes are associated with clinical prognosis.2011

    • Author(s)
      Taketani T, et al.
    • Organizer
      53rd Annual Meeting of the American Society of Hematology
    • Place of Presentation
      San Diego
    • Related Report
      2011 Research-status Report
  • [Presentation] JAK2 mutations and CRLF2 rearrangements in down syndrome associated acute lymphoblastic leukemia in Japan.2011

    • Author(s)
      Hanada I, et al.
    • Organizer
      53rd Annual Meeting of the American Society of Hematology
    • Place of Presentation
      San Diego
    • Related Report
      2011 Research-status Report
  • [Presentation] Heterogeneity in infants with acute myeloid leukemia : retrospective analysis of a Japanese nationwide survey.2011

    • Author(s)
      Shimada A, et al.
    • Organizer
      53rd Annual Meeting of the American Society of Hematology
    • Place of Presentation
      San Diego
    • Related Report
      2011 Research-status Report
  • [Presentation] GATA1 mutants lacking Rb-binding motif observed in transient abnormal myelopoiesis in down syndrome.2011

    • Author(s)
      Toki T, et al.
    • Organizer
      53rd Annual Meeting of the American Society of Hematology
    • Place of Presentation
      San Diego
    • Related Report
      2011 Research-status Report
  • [Presentation] 小児急性骨髄性白血病におけるGATA2遺伝子変異の解析.

    • Author(s)
      柴 徳生, 朴 明子, 舩戸道徳, 小林正夫, 木下明俊, 足立壮一, 荒川浩一, 多和昭雄, 月本一郎, 林 泰秀.
    • Organizer
      第116回日本小児科学会学術集会
    • Place of Presentation
      広島
    • Related Report
      2013 Annual Research Report
  • [Presentation] NUP98-NSD1融合遺伝子陽性例は小児急性骨髄性白血病において予後不良である.

    • Author(s)
      原 勇介, 柴 徳生, 嶋田 明, 工藤寿子, 富澤大輔, 多賀 崇, 多和昭雄, 荒川浩一, 足立壮一, 林 泰秀.
    • Organizer
      第116回日本小児科学会学術集会
    • Place of Presentation
      広島
    • Related Report
      2013 Annual Research Report
  • [Presentation] 小児B型前駆細胞型ALLにおけるCRLF2高発現例の特徴:TCCSG-ALL研究.

    • Author(s)
      大木健太郎, 朴 明子, 柴 徳生, 清河信敬, 康 勝好, 花田良二, 真部 淳, 菊地 陽, 小原 明, 林 泰秀.
    • Organizer
      第116回日本小児科学会学術集会
    • Place of Presentation
      広島
    • Related Report
      2013 Annual Research Report
  • [Presentation] 染色体異常を伴ったダウン症合併TAMとAMKLの遺伝子解析.

    • Author(s)
      朴 明子, 大木健太郎, 新井 心, 外松 学, 林 泰秀.
    • Organizer
      第116回日本小児科学会学術集会
    • Place of Presentation
      広島
    • Related Report
      2013 Annual Research Report
  • [Presentation] NUP98-MSD1 gene fusion is a strong poor prognostic factor in pediatric AML.

    • Author(s)
      Hara Y, Shiba N, Shimada A, Kudo K, Tomizawa D, Taga T, Horibe K, Adachi S, Arakawa H, Tawa A, Hayashi Y.
    • Organizer
      45th Congress of the International Society of Pediatric Oncology.
    • Place of Presentation
      Hong Kong
    • Related Report
      2013 Annual Research Report
  • [Presentation] RNAシークエンシングによる小児AMLの融合遺伝子探索.

    • Author(s)
      三谷幸代, 坂本裕美, 柴 徳生, 林 泰秀, 吉田輝彦, 市川 仁.
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 小児non-Down急性巨核芽球性白血病における遺伝子解析.

    • Author(s)
      原 勇介, 柴 徳生, 大木健太郎, 朴 明子, 富澤大輔, 多賀 崇, 足立壮一, 荒川浩一, 多和昭雄, 堀部敬三, 林 泰秀.
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] NUP98-NSD1 gene fusion is a strong poor prognostic factor in pediatric AML.

    • Author(s)
      Hara Y, Shiba N, Ichikawa H, Taki T, Shimada A, Kudo K, Tomizawa D, Taga T, Adachi S, Arakawa H, Tawa A, Hayashi Y.
    • Organizer
      The 75th Annual Meeting of the Japanese Society of Hematolgy.
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] Clonal architecture in a case of acute myeloid leukemia with trisomy 8 and MLL-AF9.

    • Author(s)
      Ohki K, Kama Y, Shiba N, Arai K, Park MJ, Sotomatsu M, Hayashi Y.
    • Organizer
      The 75th Annual Meeting of the Japanese Society of Hematolgy.
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] Genetic basisi of myeloid leukemogenesisi in Down syndrome.

    • Author(s)
      Yoshida K, Toki T, Okuno Y, Kanezaki R, Shiraishi Y, Sanada M, Park MJ, Terui K, Kon A, Nagata Y, Sato-Otsubo A, Sato Y, Wang R, Shiba N, Chiba K, Tanaka H, Hama A, Muramatsu H, Hasegawa D, Nakamura K, Kanegane H, Tsukamoto K, Adachi S, Kawakami K, Hayashi Y, Miyano S, Kojima S, Ito E, Ogawa S.
    • Organizer
      The 75th Annual Meeting of the Japanese Society of Hematolgy.
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] Gene expression profile in childhood BCP-ALL without common chimeric genes. The 75th Annual Meeting of the Japanese Society of Hematolgy.

    • Author(s)
      Iijima K, Kiyokawa N, Yoshihara H, Osumi T, Kato M, Kobayashi K, Okita H, Fujimoto J, Hanada R, Tsuchida M, Shimada H, Fukushima T, Koh K, Manabe A, Kikuchi A, Hayashi Y, Ohara A.
    • Organizer
      The 75th Annual Meeting of the Japanese Society of Hematolgy.
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] Genome-wide analysis of relapsed T cell acute lymphoblastic leukemia.

    • Author(s)
      Seki M, Hoshino N, Nishimura R, Okuno Y, Shiraishi Y, Yoshida K, Kato M, Kho K, Hanada R, Miyano S, Hayashi Y, Ogawa S, Takita J.
    • Organizer
      The 75th Annual Meeting of the Japanese Society of Hematolgy.
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] 13q欠失を伴ったダウン症合併TAMとAMKLの遺伝子解析.

    • Author(s)
      朴 明子, 吉田健一, 大木健太郎, 新井 心, 外松 学, 伊藤悦朗, 小川誠司, 林 泰秀.
    • Organizer
      The 75th Annual Meeting of the Japanese Society of Hematolgy.
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] Gata2 mutations are found in pediatric AML but not in other leukemias including JMML.

    • Author(s)
      Hara Y, Shiba N, Funato M, Oki K, Park MJ, Mizushima Y, Adachi S, Kobayashi M, Kinoshita A, Sotomatsu M, Arakawa H, Tawa A, Horibe K, Tsukimoto I, Hayashi Y.
    • Organizer
      The 75th Annual Meeting of the Japanese Society of Hematolgy.
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] Whole-exome resequencing reveals novel pathogenetic gene mutations in pediatric AML.

    • Author(s)
      Shiba N, Yoshida K, Okuno Y, Shiraishi Y, Nagata Y, Kon A, Chiba K, Tanaka H, Ohki K, Kato M, Terui K, Park MJ, Kanazawa T, Takita J, Kudo K, Arakawa H, Ito E, Sanada M, Miyano S, Ogawa S, Hayashi Y.
    • Organizer
      The 75th Annual Meeting of the Japanese Society of Hematolgy.
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] Recurrent SETBP1 mutation in juvenile myelomonocytic leukemia and myelodysplastic syndrome.

    • Author(s)
      Shiba N, Hara Y, Park MJ, Ohki K, Fukushima K, Sako M, Kudo K, Arakawa H, Ito E, Hayashi Y.
    • Organizer
      The 75th Annual Meeting of the Japanese Society of Hematolgy.
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] 全エクソーム解析による小児急性骨髄性白血病の新規原因遺伝子の同定.

    • Author(s)
      柴 徳生, 林 泰秀.
    • Organizer
      第55回日本小児血液・がん学会学術集会(シンポジウム)
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] 小児白血病におけるSETBP1遺伝子変異の解析.

    • Author(s)
      柴 徳生, 大木健太郎, 朴 明子, 工藤寿子, 福島啓太郎, 伊藤悦朗, 迫 正廣, 多和昭雄, 荒川浩一, 林 泰秀.
    • Organizer
      第55回日本小児血液・がん学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] 急性骨髄性白血病におけるWT1遺伝子変異の解析.

    • Author(s)
      佐野弘純, 嶋田 明, 田渕 健, 滝 智彦, 村田知里, 朴 明子, 大木健太郎, 外松 学, 足立壮一, 多和昭雄, 小林良二, 堀部敬三, 土田昌宏, 花田良二, 月本一郎, 林 泰秀.
    • Organizer
      第55回日本小児血液・がん学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] 小児骨髄造血器腫瘍におけるCSF3R遺伝子異常の解析.

    • Author(s)
      佐野仁志, 大木健太郎, 朴 明子, 柴 徳生, 原 勇介, 外松 学, 足立壮一, 堀部敬三, 多和昭雄, 花田良二, 月本一郎, 林 泰秀.
    • Organizer
      第55回日本小児血液・がん学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] 先端的ゲノムスキャニングを用いた難治性小児固形腫瘍における標的分子の探索.

    • Author(s)
      滝田順子, 他
    • Organizer
      第115回日本小児科学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] 次世代シークエンサーを用いた神経芽腫のエクソーム解析.

    • Author(s)
      西村力, 他.
    • Organizer
      第115回日本小児科学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] 次世代シークエンサーを用いたEwing肉腫のエクソーム解析.

    • Author(s)
      大久保純, 他
    • Organizer
      第115回日本小児科学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] 発現アレイを用いた小児急性骨髄性白血病における、NUP98-NSD1融合遺伝子の解析.

    • Author(s)
      柴 徳生, 他
    • Organizer
      第115回日本小児科学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] TCCSGの小児B前駆細胞型急性リンパ性白血病におけるCRLF2とIKZF1、JAK遺伝子解析.

    • Author(s)
      大木健太郎, 他
    • Organizer
      第115回日本小児科学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] 第2再発時に初めてMLL-AF4陽性となったB前駆型急性リンパ性白血病1例におけるクローン構造の検討.

    • Author(s)
      大木健太郎, 他
    • Organizer
      第8回北関東小児がんセミナー
    • Place of Presentation
      高崎
    • Related Report
      2012 Research-status Report
  • [Presentation] TAMに合併する肝機能障害について.

    • Author(s)
      朴 明子, 他
    • Organizer
      第48回日本周産期・新生児医学会学術集会
    • Place of Presentation
      さいたま
    • Related Report
      2012 Research-status Report
  • [Presentation] 2遺伝子の発現に基づく高リスク小児急性骨髄性白血病の同定.

    • Author(s)
      三谷幸代, 他
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] BLNK欠損preB-ALLとB細胞分化におけるC/Ebpbの働き.

    • Author(s)
      倉田盛人, 他
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] 神経芽腫におけるエピジェネティック関連遺伝子の網羅的ゲノム解析

    • Author(s)
      星野諭子, 他
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] 全エクソーム解析による小児急性骨髄性白血病の新規発症原因遺伝子変異の同定,

    • Author(s)
      柴 徳生, 他
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] 次世代シーケンサーによる再発肺芽腫のエクソーム解析.

    • Author(s)
      関 正史, 他
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] SNPアレイをエクソーム解析を用いた横紋筋肉腫の初発・再発/転移巣のクローン比較.

    • Author(s)
      西村 力, 他
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] 次世代シークエンサーを用いたユーイング肉腫発生の分子生物学的検討.

    • Author(s)
      樋渡光輝, 他
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] Fusion gene-specific signature of microRNR expression in childhood ALL.

    • Author(s)
      Kiyokawa N, et al.
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] Gene expression profile related to prognosis of childhood ALL without fusion genes.

    • Author(s)
      Iijima K, et al.
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] IL-7R gene mutations in childhood T-cell acute lymphoblastic leukemia.

    • Author(s)
      Park MJ, et al.
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] Analysisi of CRLF2 and IKZF1, JAK, IL7R genes in pediatric B-precursor ALL treated on TCCSG protocol.

    • Author(s)
      Oki K, et al.
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] JAK2 V617F mutation in pediatric myeloproliferative neoplasm.

    • Author(s)
      Shimada A, et al.
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] Clonal architecture and evolution of pediatric AML.

    • Author(s)
      Okuno Y, et al.
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] Whole exome resequencing reveals novel gene mutations in pediatric AML.

    • Author(s)
      Shiba N, et al.
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] Characteristics and prognostic impacts of structural chromosomal abnormalities in childhood ALL.

    • Author(s)
      Takahashi H, et al.
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] NUP98-NSD1 related gene expression signature is associated with a poor prognosis in pediatric AML.

    • Author(s)
      Shiba N, et al.
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] 小児B前駆細胞型急性リンパ性白血病におけるclonal evolutionの解析.

    • Author(s)
      大木健太郎,他
    • Organizer
      第54回日本小児血液・がん学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 進行期T細胞性リンパ芽球性リンパ腫の染色体異常解析―JPLSGからの報告.

    • Author(s)
      関水匡大,他
    • Organizer
      第54回日本小児血液・がん学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 先端的ゲノム解析技術を用いた胸膜肺芽腫における発症分子機構の解明.

    • Author(s)
      関 正史,他
    • Organizer
      第54回日本小児血液・がん学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] MLPA法を用いたT-ALL遺伝子異常についての解析.

    • Author(s)
      朴 明子,他
    • Organizer
      第54回日本小児血液・がん学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] t(17;19)(q22;p13.3)を含む染色体異常を呈したT細胞性急性リンパ性白血病の1例.

    • Author(s)
      西 眞範,他
    • Organizer
      第54回日本小児血液・がん学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 神経芽腫におけるエピジェネティック関連遺伝子の網羅的ゲノム解析

    • Author(s)
      星野諭子,他
    • Organizer
      第54回日本小児血液・がん学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 神経芽腫における網羅的メチル化解析

    • Author(s)
      関 正史,他
    • Organizer
      第54回日本小児血液・がん学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 全エクソーム解析による小児急性骨髄性白血病の新規発症原因遺伝子変異の同定

    • Author(s)
      柴 徳生,他
    • Organizer
      第54回日本小児血液・がん学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 小児急性骨髄性白血病におけるGATA2遺伝子変異同定.

    • Author(s)
      柴 徳生,他
    • Organizer
      第54回日本小児血液・がん学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] TAM芽球におけるCD117発現と末梢血中芽球割合の相関.

    • Author(s)
      出口隆生,他
    • Organizer
      第54回日本小児血液・がん学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] ダウン症候群に合併した一過性骨髄異常増殖症に対する少量シタラビン療法による腫瘍崩壊症候群.

    • Author(s)
      村松秀城,他
    • Organizer
      第54回日本小児血液・がん学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 小児骨髄増殖疾患におけるJAK2V617F遺伝子変異.

    • Author(s)
      嶋田 明,他
    • Organizer
      第54回日本小児血液・がん学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] CD66c陽性小児急性リンパ芽球性白血病の特徴.

    • Author(s)
      富田 理,他
    • Organizer
      第54回日本小児血液・がん学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 小児リンパ腫における遺伝子異常の解析.

    • Author(s)
      大木健太郎,他
    • Organizer
      第54回日本小児血液・がん学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 次世代シーケンサとSNPアレイを用いた横紋筋肉腫3例における初発/再発・転移巣の比較.

    • Author(s)
      西村 力,他
    • Organizer
      第54回日本小児血液・がん学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] NUP98-NSD1 related gene expression signature is strongly associated with a poor prognosis in pediatric acute myeloid leukemia.

    • Author(s)
      Shiba N, et al.
    • Organizer
      54rd Annual Meeting of the American Society of Hematology
    • Place of Presentation
      Atlanta
    • Related Report
      2012 Research-status Report
  • [Presentation] Whole exome sequencing reveals spectrum of gene mutations in pediatric AML.

    • Author(s)
      Shiba N, et al.
    • Organizer
      54rd Annual Meeting of the American Society of Hematology
    • Place of Presentation
      Atlanta
    • Related Report
      2012 Research-status Report
  • [Presentation] GATA2 mutations in pediatric acute myeloid leukemia: a study of the Japanese Childhood AML Cooperative Study Group.

    • Author(s)
      Shiba N, et al.
    • Organizer
      54rd Annual Meeting of the American Society of Hematology
    • Place of Presentation
      Atlanta
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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