| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Epstein-Barr virus (EBV) causes intractable diseases, including EBV-associated malignancies. Using a new human tissue model, EBV-infected cells were analyzed during the early stage of infection. Naive and memory B cells were found to be infected with EBV. The potential effects of the investigational drugs bortezomib, rapamycin, and mogamulizumab were analyzed using the human tissue model and a murine xenograft model. They showed therapeutic effects in the models.
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