The pathophysiology of EB virus infection, and screening investigational drugs using a new human tissue model
Project/Area Number |
23591564
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Nagoya University |
Principal Investigator |
ITO Yoshinori 名古屋大学, 医学部附属病院, 講師 (20373491)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | Epstein-Barr ウイルス / ヒト組織モデル / ラパマイシン / mTOR / 感染細胞 / 治療効果 / EBウイルス / 感染モデル / 扁桃組織 / スクリーニング |
Research Abstract |
Epstein-Barr virus (EBV) causes intractable diseases, including EBV-associated malignancies. Using a new human tissue model, EBV-infected cells were analyzed during the early stage of infection. Naive and memory B cells were found to be infected with EBV. The potential effects of the investigational drugs bortezomib, rapamycin, and mogamulizumab were analyzed using the human tissue model and a murine xenograft model. They showed therapeutic effects in the models.
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Report
(4 results)
Research Products
(68 results)
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[Journal Article] Risk factors for poor outcome in congenital cytomegalovirus infection and neonatal herpes on the basis of a nationwide survey in Japan2013
Author(s)
Ito Y, Kimura H, Torii Y, Hayakawa M, Tanaka T, Tajiri H, Yoto Y, Tanaka-Taya K, Kanegane H, Nariai A, Sakata H, Tsutsumi H, Oda M, Yokota S, Morishima T, Moriuchi H
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Journal Title
Pediatr Int
Volume: 55
Issue: 5
Pages: 566-571
DOI
Related Report
Peer Reviewed
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[Journal Article] Identification of a novel HLA-A^*24:02-restricted adenovirus serotype 11-specific CD8+ T-cell epitope for adoptive immunotherapy2013
Author(s)
Imahashi N, Nishida T, Ito Y, Kawada J, Nakazawa Y, Toji S, Suzuki S, Terakura S, Kato T, Murata M, Naoe T.
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Journal Title
Molecular Immunolgy
Volume: 56
Issue: 4
Pages: 399-405
DOI
Related Report
Peer Reviewed
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[Journal Article] Epstein-Barr virus-positive cytotoxic T-cell lymphoma followed by chronic active Epstein-Barr virus infection-associated T/NK-cell lymphoproliferative disorder: a case report2013
Author(s)
Kato S, Miyata T, Takata K, Shimada S, Ito Y, Tomita A, Elsayed A, Takahashi E, Asano N, Kinoshita T, Kimura H, Nakamura S.
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Journal Title
Human Pathology
Volume: 44
Issue: 12
Pages: 2849-2852
DOI
Related Report
Peer Reviewed
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[Journal Article] Application of flow cytometric in situ hybridization assay to Epstein-Barr virus-associated T/natural killer cell lymphoproliferative2012
Author(s)
Kawabe S, Ito Y, Gotoh K, Kojima S, Matsumoto K, Kinoshita T, Iwata S, Nishiyama Y, Kimura, H,
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Journal Title
Cancer Sci
Volume: 103
Issue: 8
Pages: 1481-1488
DOI
Related Report
Peer Reviewed
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