The role of angiopoietin-like protein 4 (ANGPTL4) in the glomerular endothelial cell injury and progressive glomerular injury

• Project/Area Number: 23591570
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: The University of Tokushima
• Principal Investigator: KAGAMI Shoji 徳島大学, ヘルスバイオサイエンス研究部, 教授 (00224337)
• Co-Investigator(Kenkyū-buntansha): KONDO Shuji 徳島大学, 大学院ヘルスバイオサイエンス研究部, 講師 (00380080) ; ROKUTAN Kazuhito 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 (10230898)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: アンジオテンシンII / 糸球体内皮細胞 / アンジオテンシノーゲン / ANGPTL4 / p63 / アンジオテンシン変換酵素 / 国際情報交換 イギリス / 国際情報交流 イギリス

Research Abstract

This study is performed to find the molecular targets in treatment for preventing the progression of kidney diseases. We identified the angiopoietin-like protein 4 (ANGPTL4) involved in glomerular endothelial cell (GEC) injury among many induced genes during the course of progressive kidney injury. In the rat models of chronic glomerulonephritis, we found the good correlation among the expression of glomerular renin-angiotensin (ang) system (RAS) components, the expression of GEC- ANGPTL4 and the level of glomerular injury. Inhibition of RAS with inhibitors decrease the levels of those molecules as well as glomerular injury, suggesting that GEC- ANGPTL4 may be regulated under control of glomerular RAS expression. Additionally, we also found that p63 is involved in ang II-induced GEC- ANGPTL4 expression. Therefore, weconclude that ANGPTL4 as well as p63 protein in GEC may be novel molecular targets for regulating the progression of kidney diseases.

Research Products

• [Journal Article] .Glomerular angiotensin-converting enzyme 2 in pediatric IgA nephropathy. (2013)
  • Author(s): Urushihara M, Seki Y, Tayama T, Nagai T, Kinoshita Y, Jamba A, Kondo S, Kagami S.
  • Journal Title: Am J Nephrol. Volume: 38 Issue: 5 Pages: 355-367
  • DOI: 10.1159/000355618
• [Journal Article] Japan Renal Biopsy Registry and Japan Kidney Disease Registry: Committee Report for 2009 and 2010. (2013)
  • Author(s): Sugiyama H, Yokoyama H, Sato H, Saito T, Kohda Y, Nishi S, Tsuruya K, Kiyomoto H, Iida H, Sasaki T, Higuchi M, Hattori M, Oka K, Kagami S, Kawamura T, Takeda T, Hataya H, Fukasawa Y, Fukatsu A, Morozumi K, Yoshikawa N, Shimizu A, Kitamura H, Yuzawa Y, Matsuo S, Kiyohara Y, Joh K, Nagata M, Taguchi T, Makino H
  • Journal Title: Clin Exp Nephrol. Volume: 17(2) Issue: 2 Pages: 155-73
  • DOI: 10.1007/s10157-012-0746-8
  • NAID: 10031169463
  • Peer Reviewed
• [Journal Article] A case of infantile systemic lupus erythematosus with severe lupus nephritis and EBV infection (2013)
  • Author(s): Kishi N, Suga K, Matsuura S, Kinoshita Y, Urushihara M, Kondo S, Kitano E, Hatanaka M, Kitamura H, Sato T, Maeda A, Kagami S.
  • Journal Title: CEN Case Rep Volume: 2 Pages: 190-193
• [Journal Article] A case of infantile systemic lupus erythematosus with severe lupus nephritis and EBV infection. (2013)
  • Author(s): Kishi N, Suga K, Matsuura S, Kinoshita Y, Urushihara M, Kondo S, Kitano E, Hatanaka M, Kitamura H, Sato T, Maeda A, Kagami S
  • Journal Title: CEN Case Rep Volume: 2 Pages: 190-193
• [Journal Article] 急性腎不全-ワンランク上の小児の臨床検査－病態生理に基づく選び方・考え方－ (2013)
  • Author(s): 永井隆, 香美祥二
  • Journal Title: 小児科学レクチャー Volume: 3 Pages: 423-428
• [Journal Article] A proton magnetic resonance spectroscopic study in autism spectrum disorders: amygdala and orbito-frontal cortex (2013)
  • Author(s): Mori K, et al
  • Journal Title: Brain Dev Volume: 35 Issue: 2 Pages: 139-145
  • DOI: 10.1016/j.braindev.2012.09.016
  • Peer Reviewed
• [Journal Article] Left Atrial Volume Change Throughout the Cardiac Cycle in Children With Congenital Heart Disease Associated With Increased Pulmonary Blood Flow : Evaluation Using a Novel Left Atrium-Tracking Method (2013)
  • Author(s): Sakata M, Hayabuchi Y, Inoue M, Onishi T, Kagami S
  • Journal Title: Pediatric Cardiology Volume: 34 Issue: 1 Pages: 105-111
  • DOI: 10.1007/s00246-012-0395-4
  • Peer Reviewed
• [Journal Article] Effective treatment of a 13-year-old boy with steroid-dependent ocular myasthenia gravis using tacrolimus (2013)
  • Author(s): Mori T, et al
  • Journal Title: Brain Dev Volume: 35 Issue: 5 Pages: 445-448
  • DOI: 10.1016/j.braindev.2012.06.012
  • Peer Reviewed
• [Journal Article] Subclavian and pulmonary artery steal phenomenon in a patient with isolated left subclavian artery and right aortic arch (2013)
  • Author(s): Hayabuchi Y, Inoue M, Sakata M, Ohnishi T, Kagami S
  • Journal Title: J Clin Ultrasound Volume: 41 Issue: 4 Pages: 265-268
  • DOI: 10.1002/jcu.21874
  • Peer Reviewed
• [Journal Article] Involvement of glomerular renin-angiotensin system (RAS) activation in the development and progression of glomerular injury (2012)
  • Author(s): Kagami S
  • Journal Title: Clin Exp Nephrol Volume: 16 Issue: 2 Pages: 214-220
  • DOI: 10.1007/s10157-011-0568-0
  • NAID: 10030738704
  • Peer Reviewed
• [Journal Article] Involvement of the intrarenal renin-angiotensin system in experimental models of glomerulonephritis (2012)
  • Author(s): Urushihara M, Kinoshita Y, Kondo S, Kagami S
  • Journal Title: J Biomed Biotechnol Volume: 2012 Pages: 601786-601786
  • DOI: 10.1155/2012/601786
  • Peer Reviewed
• [Journal Article] Glomerular expression of hydrogen peroxide-inducible clone-5 in human and rat progressive mesangial proliferative glomerulonephritis (2012)
  • Author(s): Suga K, Kondo S, Matsuura S, Kinoshita Y, Urushihara M, Kagami S
  • Journal Title: Nephron Exp Nephrol Volume: 120 Issue: 2 Pages: e59-e68
  • DOI: 10.1159/000335780
  • Peer Reviewed
• [Journal Article] Angiotensin II type I receptor blockade suppresses glomerular renin-angiotensin system activation, oxidative stress, and progressive glomerular injury in rat anti-glomerular basement membrane glomerulonephritis (2012)
  • Author(s): Kinoshita Y, Kondo S, Urushihara M, Suga K, Matsuura S, Takamatsu M, Shimizu M, Nishiyama A, Kawachi H, Kagami S
  • Journal Title: Transl Res Volume: 158 Issue: 4 Pages: 235-48
  • DOI: 10.1016/j.trsl.2011.05.003
  • Peer Reviewed
• [Journal Article] D-Amino acid oxidase-induced oxidative stress, 3-bromopyruvate and citrate inhibit angiogenesis, exhibiting potent anticancer effects (2012)
  • Author(s): El Sayed SM, et al
  • Journal Title: J Bioenerg Biomembr Volume: 44 Issue: 5 Pages: 513-523
  • DOI: 10.1007/s10863-012-9455-y
  • Peer Reviewed
• [Journal Article] Multidetector-row computed tomography evaluation of bilateral bronchial narrowing associated with increased pulmonary blood flow in children with congenital heart disease (2012)
  • Author(s): Watanabe N, Hayabuchi Y, Nakagawa R, Saijo T, Kagami S
  • Journal Title: Congenital Heart Disease Volume: 7 Issue: 5 Pages: 410-416
  • DOI: 10.1111/j.1747-0803.2012.00653.x
  • Peer Reviewed
• [Journal Article] 3-Bromopyruvate antagonizes effects of lactate and pyruvate, synergizes with citrate and exerts novel anti-glioma effects (2012)
  • Author(s): Salah Mohamed El Sayed, et al
  • Journal Title: Journal of Bioenergetics and Biomembranes Volume: 44 Issue: 1 Pages: 61-79
  • DOI: 10.1007/s10863-012-9409-4
  • Peer Reviewed
• [Journal Article] Evaluation of the GABAergic nervous system in autistic brain: (123)I-iomazenil SPECT study (2012)
  • Author(s): Mori T, et al
  • Journal Title: Brain Dev Volume: 34 Issue: 8 Pages: 648-654
  • DOI: 10.1016/j.braindev.2011.10.007
  • Peer Reviewed
• [Journal Article] Decreased benzodiazepine receptor and increased GABA level in cortical tubers in tuberous sclerosis complex (2012)
  • Author(s): Mori K, et al
  • Journal Title: Brain Dev Volume: 34 Issue: 6 Pages: 478-486
  • DOI: 10.1016/j.braindev.2011.09.001
  • Peer Reviewed
• [Journal Article] Urinary Angiotensinogen as a Biomarker of Nephropathy in Childhood (2011)
  • Author(s): Urushihara M, Kagami S
  • Journal Title: Int J Nephrol Pages: 206835-206835
  • Peer Reviewed
• [Journal Article] Expression and localization of focal adhesion proteins in the developing rat kidney (2011)
  • Author(s): Matsuura S, Kondo S, Suga K, Kinoshita Y, Urushihara M, Kagami S
  • Journal Title: J Histochem Cytochem Volume: 59 Issue: 9 Pages: 864-874
  • DOI: 10.1369/0022155411413929
  • Peer Reviewed
• [Journal Article] A case of a 6-year-old girl with ANCA-negative pauci-immune crescentic glomerulonephritis (2011)
  • Author(s): Shimizu M, Sekiguchi T, Kishi N, Goji A, Takahashi T, Kozan H, Sakaguchi Z, Kinoshita Y, Matsuura S, Suga K, Urushihara M, Kondo S, Kagami S, Ohara K
  • Journal Title: Clin Exp Nephrol Volume: 21 Issue: 4 Pages: 2380-2390
  • DOI: 10.1007/s10157-011-0423-3
  • Peer Reviewed
• [Journal Article] 尿管芽分岐とネフロン形成におけるNADPHオキシダーゼの役割 (2011)
  • Author(s): 松浦里、近藤秀治、須賀健一、木下ゆき子、漆原真樹、香美祥二
  • Journal Title: 発達腎研究会誌 Volume: 19 Pages: 11-13
  • Peer Reviewed
• [Journal Article] Japan Renal Biopsy Registry: the first nationwide, web-based,and prospective registry system of renal biopsies in Japan (2011)
  • Author(s): Sugiyama H, Joh K
  • Journal Title: ClinExpNephrol Volume: 15 Issue: 4 Pages: 493-503
  • DOI: 10.1007/s10157-011-0430-4
  • Peer Reviewed
• [Journal Article] Urinary Angiotensinogen as a Biomarker of Nephropathy in Childhood (2011)
  • Author(s): Urushihara M
  • Journal Title: Int J Nephrol Volume: 206835 Pages: 1-7
  • DOI: 10.4061/2011/206835
  • Peer Reviewed
• [Presentation] レニンアンジオテンシン系阻害薬を投与しているアルポート症候群の3例 (2013)
  • Author(s): 松浦里、永井隆、木下ゆき子、須賀健一、漆原真樹、近藤秀治、香美祥二
  • Organizer: 第30回中国四国小児腎臓病学会
  • Place of Presentation: 徳島シビックセンター,徳島市
  • Year and Date: 2013-11-17
• [Presentation] 精神運動発達遅滞と右多趾症を合併した常染色体劣性多発性嚢胞腎(ARPKD)と考えられた1例 (2013)
  • Author(s): 今田久美子、永井隆、漆原真樹、近藤秀治、高橋正幸、庄野実希、藤野修司、山上貴司、松岡優、香美祥二
  • Organizer: 第30回中国四国小児腎臓病学会
  • Place of Presentation: 徳島シビックセンター,徳島市
  • Year and Date: 2013-11-17
• [Presentation] Urinary angiotensinogen as a biomarker of chronic glomerulonephritis in childhood (2013)
  • Author(s): Kagami S
  • Organizer: The 1st International Conference on Urinomics. 2013Caparica
  • Place of Presentation: Hotel Costa de Caparica, Portugal
  • Year and Date: 2013-09-10
• [Presentation] Contribution of hydrogen peroxide-inducible clone-5 to the regulation of mesangial cell proliferation in mesangioproliferative glomerulonephritis (2013)
  • Author(s): Jamba A, Kondo S, Urushihara M, Nagai T, Tamaki T, Kagami S
  • Organizer: The annual meeting of American society of nephrology Kidney Week 2013
  • Place of Presentation: Georgia World Congress Center,Atlanta, GA,USA
• [Presentation] Septo-optic dysplasiaの末期腎不全に対して維持血液透析を導入した一例 (2013)
  • Author(s): 永井隆,富本亜由美,木下ゆき子,漆原真樹,近藤秀治,宮崎雅仁,香美祥二
  • Organizer: 第35回日本小児腎不全学会学術集会
  • Place of Presentation: 磐梯熱海温泉ホテル華の湯,福島県
• [Presentation] 重症心身障害児(者)に透析を導入した二症例 (2013)
  • Author(s): 永井隆、尾崎夏子、木下ゆき子、松浦里、漆原真樹、近藤秀治、香美祥二
  • Organizer: 第43回日本腎臓学会学術集会西部大会
  • Place of Presentation: 松山全日空ホテル,愛媛県松山市
• [Presentation] Effect of direct renin inhibitor on renal inflammation and (pro)renin receptor in crescentic glomerulonephritis (2013)
  • Author(s): Tayama T, Urushihara M, Seki Y, Kinoshita Y, Nagai T, Jamba A, Kondo S, Kagami S
  • Organizer: The Sixteen Congress of the International Pediatric Nephrology Association
  • Place of Presentation: Shanghai International Convention Center, Shanghai, China
• [Presentation] Glomerular ACE2 expression is enhanced in pediatric IgA nephropathy (2013)
  • Author(s): Seki Y, Urushihara M, Tayama T, Nagai T, Kinoshita Y, Jamba A, Kondo S, Kagami S
  • Organizer: The Sixteen Congress of the International Pediatric Nephrology Association
  • Place of Presentation: Shanghai International Convention Center, Shanghai, China
• [Presentation] 小児IgA腎症の病態進展におけるACE2の役割検討 (2013)
  • Author(s): 漆原真樹、関勇輔、田山貴広、永井隆、木下ゆき子、Ariunbold Jamba、近藤秀治、香美祥二
  • Organizer: 第48回日本小児腎臓病学会学術集会
  • Place of Presentation: あわぎんホール,徳島市
• [Presentation] ネフローゼ症候群を呈したCockayne症候群の一例 (2013)
  • Author(s): 永井隆、万野朱美、漆原真樹、近藤秀治、森健治、香美祥二
  • Organizer: 第48回日本小児腎臓病学会学術集会
  • Place of Presentation: あわぎんホール,徳島市
• [Presentation] Hic-5 regulates mesangial cell proliferation in proliferative glomerulonephritis (2013)
  • Author(s): Jamba A, Kondo S, Urushihara M, Nagai T, Kaneyama J K, MiyazakiA, Kagami S
  • Organizer: 第48回日本小児腎臓病学会学術集会
  • Place of Presentation: あわぎんホール,徳島市
• [Presentation] ラット半月体形成性腎炎モデルにおけるアリスキレンの治療効果 (2013)
  • Author(s): 漆原真樹、木下ゆき子、永井隆、Ariunbold Jamba、近藤秀治、香美祥二
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム,東京都
• [Presentation] ネフローゼ症候群を呈したCockayne症候群の一例 (2013)
  • Author(s): 永井隆,万野朱美,漆原真樹,近藤秀治,森健治,香美祥二
  • Organizer: 第116回日本小児科学会学術集会
  • Place of Presentation: アステールプラザ,広島県
• [Presentation] Effect of direct renin inhibitor on renal inflammation and (pro)renin receptor in crescentic glomerulonephritis. (2013)
  • Author(s): Tayama T, Urushihara M, Seki Y, Kinoshita Y, Nagai T, Jamba A, Kondo S, Kagami S
  • Organizer: The Sixteenth Congress of the International Pediatric Nephrology Association
  • Place of Presentation: Shanghai International Convention Center、 Shanghai, China
• [Presentation] Glomerular ACE2 expression is enhanced in pediatric IgA nephropathy. (2013)
  • Author(s): Seki Y, Urushihara M, Tayama T, Nagai T, Kinoshita Y, Jamba A, Kondo S, Kagami S
  • Organizer: The Sixteenth Congress of the International Pediatric Nephrology Association
  • Place of Presentation: Shanghai International Convention Center、 Shanghai, China
• [Presentation] Contribution of hydrogen peroxide-inducible clone-5 to the regulation of mesangial cell proliferation in mesangioproliferative glomerulonephritis (2013)
  • Author(s): Jamba A, Kondo S, Urushihara M, Nagai T, Tamaki T, Kagami S
  • Organizer: The annual meeting of American society of nephrology Kidney Week 2013
  • Place of Presentation: Georgia World Congress Center、Atlanta, GA, USA
• [Presentation] ネフローゼ症候群を呈したCockayne症候群の一例 (2013)
  • Author(s): 永井隆, 万野朱美, 漆原真樹, 近藤秀治, 森健治, 香美祥二
  • Organizer: 第116回日本小児科学会学術集会
  • Place of Presentation: アステールプラザ, 広島県
• [Presentation] ラット半月体形成性腎炎モデルにおけるアリスキレンの治療効果 (2013)
  • Author(s): 漆原真樹、木下ゆき子、永井隆、Ariunbold Jamba、近藤秀治、香美祥二
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム, 東京都
• [Presentation] 小児IgA腎症の病態進展におけるACE2の役割検討 (2013)
  • Author(s): 漆原真樹、関勇輔、田山貴広、永井隆、木下ゆき子、Ariunbold Jamba、近藤秀治、香美祥二
  • Organizer: 第48回日本小児腎臓病学会学術集会
  • Place of Presentation: あわぎんホール、徳島県
• [Presentation] ネフローゼ症候群を呈したCockayne症候群の一例 (2013)
  • Author(s): 永井隆、万野朱美、漆原真樹、近藤秀治、森健治、香美祥二
  • Organizer: 第48回日本小児腎臓病学会学術集会
  • Place of Presentation: あわぎんホール、徳島県
• [Presentation] Hic-5 regulates mesangial cell proliferation in proliferative glomerulonephritis (2013)
  • Author(s): Jamba A, Kondo S, Urushihara M, Nagai T, Kaneyama J K, Miyazaki A, Kagami S
  • Organizer: 第48回日本小児腎臓病学会学術集会
  • Place of Presentation: あわぎんホール、徳島県
• [Presentation] 重症心身障害児（者）に透析を導入した二症例 (2013)
  • Author(s): 永井隆、尾崎夏子、木下ゆき子、松浦里、漆原真樹、近藤秀治、香美祥二
  • Organizer: 第43回日本腎臓学会学術集会西部大会
  • Place of Presentation: 松山全日空ホテル、愛媛県
• [Presentation] Septo-optic dysplasiaの末期腎不全に対して維持血液透析を導入した一例 (2013)
  • Author(s): 永井隆, 富本亜由美, 木下ゆき子, 漆原真樹, 近藤秀治, 宮崎雅仁, 香美祥二
  • Organizer: 第35回日本小児腎不全学会学術集会
  • Place of Presentation: 磐梯熱海温泉 ホテル華の湯, 福島県
• [Presentation] Effect of aliskiren on renal inflammation and (pro)renin receptor in crescentic glomerulonephritis (2012)
  • Author(s): Urushihara M, Kinoshita Y, Nagai T, Kondo S, Jamba A, Tamaki T, Kagami S
  • Organizer: The American Society of Nephrology Renal Week 2012
  • Place of Presentation: San Diego Convention Center, San Diego, USA
• [Presentation] ブドウ膜炎に伴う尿細管間質性腎炎の再発に対してシクロスポリンが奏効した一女児例 (2012)
  • Author(s): 永井隆、木下ゆき子、岸夏子、松浦里、須賀健一、漆原真樹、近藤秀治、香美祥二
  • Organizer: 第42回日本腎臓学会学術集会西部大会
  • Place of Presentation: 沖縄コンベンションセンター,沖縄県
• [Presentation] 進行性糸球体腎炎と培養糸球体内皮細胞におけるp63の発現検討 (2012)
  • Author(s): 近藤秀治、松浦里、Ariunbold Jamba、漆原真樹、木下ゆき子、永井隆、須賀健一、岸夏子、香美祥二
  • Organizer: 第47回日本小児腎臓病学会学術集会
  • Place of Presentation: 都市センターホテル,東京都
• [Presentation] Enhanced expression of glomerular angiotensinogen in the progressive mesangioproliferative glomerulonephritis in the rat (2012)
  • Author(s): Ariunbold Jamba、近藤秀治、漆原真樹、木下ゆき子、永井隆、松浦里、須賀健一、岸夏子、香美祥二
  • Organizer: 第47回日本小児腎臓病学会学術集会
  • Place of Presentation: 都市センターホテル,東京都
• [Presentation] 進行性糸球体腎炎でのアンジオテンシンII関連糸球体内皮細胞障害におけるp63の発現 (2012)
  • Author(s): 近藤秀治、Ariunbold Jamba、松浦里、漆原真樹、木下ゆき子、須賀健一、永井隆、香美祥二
  • Organizer: 第55回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜,神奈川県横浜市
• [Presentation] ラット進行性メサンギウム増殖性糸球体腎炎におけるアンジオテンシノーゲンの発現亢進(glomerular angiotensinogen expression is enhanced in the progressive mesangioproliferative glomerulonephritis in the rat) (2012)
  • Author(s): Ariunbold Jamba、近藤秀治、漆原真樹、木下ゆき子、松浦里、須賀健一、永井隆、香美祥二
  • Organizer: 第55回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜,神奈川県横浜市
• [Presentation] Reacitve oxygen species generated by NADPH oxidase contribute to ureteric bud branching and nephrogenesis (2012)
  • Author(s): Matsuura S, Kondo S, Kinoshita Y, Suga K, Urushihara M, Kishi N, Nagai T, Jamba A, Kagami S
  • Organizer: Pediatric Academic societies annual meeting 2012
  • Place of Presentation: The Hynes Convention Center,Boston, USA
• [Presentation] 尿中アンジオテンシノーゲン測定による小児慢性腎炎患者の新たな病態指標 (2012)
  • Author(s): 漆原真樹、木下ゆき子、近藤秀治、須賀健一、松浦里、高松昌徳、香美祥二
  • Organizer: 第115回日本小児科学会学術集会
  • Place of Presentation: 福岡国際会議場,福岡県
• [Presentation] 尿中アンジオテンシノーゲン測定による小児慢性腎炎患者の新たな病態指標 (2012)
  • Author(s): 漆原真樹、他
  • Organizer: 第115回日本小児科学会学術集会
  • Place of Presentation: 福岡国際会議場 (福岡県)
• [Presentation] 進行性糸球体腎炎でのアンジオテンシンII関連糸球体内皮細胞障害におけるp63の発現 (2012)
  • Author(s): 近藤秀治、他
  • Organizer: 第55回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜 (神奈川県)
• [Presentation] glomerular angiotensinogen expression is enhanced in the progressive mesangioproliferative glomerulonephritis in the rat (2012)
  • Author(s): Ariunbold Jamba、他
  • Organizer: 第55回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜 (神奈川県)
• [Presentation] 進行性糸球体腎炎と培養糸球体内皮細胞におけるp63の発現検討 (2012)
  • Author(s): 近藤秀治、他
  • Organizer: 第47回日本小児腎臓病学会学術集会
  • Place of Presentation: 都市センターホテル (東京都)
• [Presentation] Enhanced expression of glomerular angiotensinogen in the progressive mesangioproliferative glomerulonephritis in the rat (2012)
  • Author(s): Ariunbold Jamba、他
  • Organizer: 第47回日本小児腎臓病学会学術集会
  • Place of Presentation: 都市センターホテル (東京都)
• [Presentation] ブドウ膜炎に伴う尿細管間質性腎炎の再発に対してシクロスポリンが奏効した一女児例 (2012)
  • Author(s): 永井隆、他
  • Organizer: 第42回日本腎臓学会学術集会西部大会
  • Place of Presentation: 沖縄コンベンションセンター (沖縄県)
• [Presentation] Reacitve oxygen species generated by NADPH oxidase contribute to ureteric bud branching and nephrogenesis (2012)
  • Author(s): Matsuura S, et al
  • Organizer: Pediatric Academic societies annual meeting 2012
  • Place of Presentation: The Hynes Convention Center (USA)
• [Presentation] Effect of aliskiren on renal inflammation and (pro)renin receptor in crescentic glomerulonephritis (2012)
  • Author(s): Urushihara M, et al
  • Organizer: The American Society of Nephrology Renal Week 2012
  • Place of Presentation: San Diego Convention Center (USA)
• [Presentation] 半月体形成性糸球体腎炎の進展におけるRAS、活性酸素の役割 (2011)
  • Author(s): 木下ゆき子、近藤秀治、須賀健一、松浦里、清水真樹、高松昌徳、漆原真樹、香美祥二
  • Organizer: 第23回腎とフリーラジカル研究会
  • Place of Presentation: ホテルグランドパレス徳島,徳島市
  • Year and Date: 2011-10-02
• [Presentation] 伊藤白斑、滑脳症、難治性てんかんに膀胱尿管逆流(VUR)を合併した一男児例 (2011)
  • Author(s): 木下ゆき子、森達夫、須賀健一、松浦里、近藤秀治、漆原真樹、永井隆、中川竜二、西條隆彦、森健治、香美祥二
  • Organizer: 第41回日本腎臓学会西部学術大会
  • Place of Presentation: あわぎんホール,徳島市
  • Year and Date: 2011-09-30
• [Presentation] ラット腎発生でのFAKの発現とそのリン酸化 (2011)
  • Author(s): 近藤秀治、Jamba Ariunbold、松浦里、漆原真樹、木下ゆき子、須賀健一、香美祥二
  • Organizer: 第20回発達腎研究会
  • Place of Presentation: 駿河台日本大学病院,東京都
  • Year and Date: 2011-08-27
• [Presentation] 1型糖尿病では尿中アンジオテンシノーゲン排泄の増加はアルブミン尿より先行する (2011)
  • Author(s): 漆原真樹、小谷裕美子、小堀浩幸、香美祥二
  • Organizer: 第114回日本小児科学会学術集会
  • Place of Presentation: グランドプリンスホテル新高輪,東京都
• [Presentation] 腎発生におけるNADPHオキシダーゼ(Nox)の役割 (2011)
  • Author(s): 松浦里、近藤秀治、須賀健一、木下ゆき子、漆原真樹、香美祥二
  • Organizer: 第54回日本腎臓学会学術集会
  • Place of Presentation: パシフィコ横浜,神奈川県横浜市
• [Presentation] Urinary angiotensinogen as a biomarker of the intrarenal status of the renin-angiotensin system in patients with chronic glomerulonephritis (2011)
  • Author(s): Urushihara M, Kinoshita Y, Matsuura S, Suga K, Takamatsu M, Shimizu M, Kondo S, Kobori H, Kagami S.
  • Organizer: 11th Asian Congress of Pediatric Nephrology 2011
  • Place of Presentation: Fukuoka International Congress Center,Fukuoka,Japan
• [Presentation] The role of NADPH oxidase (Nox) in ureteric bud branching and nephrogenesis (2011)
  • Author(s): Matsuura S, Kondo S, Kinoshita Y, Suga K, Urushihara M, Takamatsu M, Shimizu M, Kishi N, Kagami S.
  • Organizer: 11th Asian Congress of Pediatric Nephrology 2011
  • Place of Presentation: Fukuoka International Congress Center,Fukuoka,Japan
• [Presentation] A case of membranous nephropathy and open angle glaucoma complicated with asymptomatic Siogren's syndrome (2011)
  • Author(s): Matsuura S, Kondo S, Suga K, Kinoshita Y, Urushihara M, Takamatsu M, Shimizu M, Kishi N, Kagami S.
  • Organizer: 11th Asian Congress of Pediatric Nephrology 2011
  • Place of Presentation: Fukuoka International Congress Center,Fukuoka,Japan
• [Presentation] A case of membranous nephropathy with cavernous hemangioma (2011)
  • Author(s): Nagai T, Kinoshita Y, Matsuura S, Suga K, Urushihara M, Kondo S, Kagami S
  • Organizer: 11th Asian Congress of Pediatric Nephrology 2011
  • Place of Presentation: Fukuoka International Congress Center, Fukuoka,Japan
• [Presentation] The expression of NADPH oxidase and reactive oxygen species (ROS) production contribute to ureteric bud branching and nephrogenesis (2011)
  • Author(s): Kondo S, Matuura S, Kinoshita Y, Suga K, Urushihara M, Nagai T, Tamaki T, Kagami S
  • Organizer: World Congress of Nephrology 2011
  • Place of Presentation: Vancouver Convention Center, Vancouver, Canada
• [Presentation] Involvement of glomerular renin-angiotensin system (RAS) activation in development and progression of glomerular injury (2011)
  • Author(s): Shoji Kagami
  • Organizer: The 11th Asian Congress of Pediatric Nephrology 2011(招待講演)
  • Place of Presentation: 福岡国際会議場 (福岡県)
• [Presentation] Renal Protection with Renin-Angiotensin System Inhibitors in Pediatric CKD (2011)
  • Author(s): Shoji Kagami
  • Organizer: The 11th Asian Congress of Pediatric Nephrology 2011(招待講演)
  • Place of Presentation: 福岡国際会議場 (福岡県)
• [Presentation] 小児CKDの発症・進展における組織レニン・アンジオテンシン系(RAS)の関与 とRAS阻害療法 (2011)
  • Author(s): 香美祥二
  • Organizer: 第２回小児腎臓フォーラム(招待講演)
  • Place of Presentation: 国際ホテル松山（愛媛県）
• [Presentation] 小児慢性腎臓病(CKD)における腎内レニン・アンジオテンシン系 (RAS)の関与とRAS阻害療法 (2011)
  • Author(s): 香美祥二
  • Organizer: 第41回日本腎臓学会西部学術大会(招待講演)
  • Place of Presentation: 阿波銀ホール（徳島県）
• [Presentation] 小児疾患に関する市民公開講座 (2011)
  • Author(s): 香美祥二
  • Organizer: 小児疾患に関する市民公開講座(招待講演)
  • Place of Presentation: 回生病院（香川県）
• [Presentation] Urinary angiotensinogen as a biomarker of the intrarenal status of the renin-angiotensin system in patients with chronic glomerulonephritis (2011)
  • Author(s): Urushihara M
  • Organizer: 11th Asian Congress of Pediatric Nephrology 2011
  • Place of Presentation: 福岡国際会議場 (福岡県)
• [Presentation] The role of NADPH oxidase (Nox) in ureteric bud branching and nephrogenesis (2011)
  • Author(s): Matsuura S
  • Organizer: 11th Asian Congress of Pediatric Nephrology 2011
  • Place of Presentation: 福岡国際会議場 (福岡県)
• [Presentation] A case of membranous nephropathy with cavernous hemangioma (2011)
  • Author(s): Nagai T
  • Organizer: 11th Asian Congress of Pediatric Nephrology 2011
  • Place of Presentation: 福岡国際会議場 (福岡県)
• [Presentation] The expression of NADPH oxidase and reactive oxygen species (ROS) production contribute to ureteric bud branching and nephrogenesis (2011)
  • Author(s): Kondo S
  • Organizer: World Congress of Nephrology 2011
  • Place of Presentation: バンクーバーコンベンションセンター（カナダ）
• [Presentation] A case of membranous nephropathy and open angle glaucoma complicated with asymptomatic Sjogren’s syndrome (2011)
  • Author(s): Matsuura S
  • Organizer: 11th Asian Congress of Pediatric Nephrology 2011
  • Place of Presentation: 福岡国際会議場 (福岡県)
• [Presentation] 腎発生におけるNADPHオキシダーゼ(Nox)の役割 (2011)
  • Author(s): 松浦里
  • Organizer: 第54回日本腎臓学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県）
• [Presentation] １型糖尿病では尿中アンジオテンシノーゲン排泄の増加はアルブミン尿より先行する (2011)
  • Author(s): 漆原真樹
  • Organizer: 第114回日本小児科学会学術集会
  • Place of Presentation: グランドプリンスホテル新高輪（東京都）
• [Presentation] ラット腎発生でのFAKの発現とそのリン酸化 (2011)
  • Author(s): 近藤秀治
  • Organizer: 第20回発達腎研究会
  • Place of Presentation: 駿河台日本大学病院（東京都）
• [Presentation] 伊藤白斑、滑脳症、難治性てんかんに膀胱尿管逆流(VUR)を合併した一男児例 (2011)
  • Author(s): 木下 ゆき子
  • Organizer: 第41回日本腎臓学会西部学術大会
  • Place of Presentation: 阿波銀ホール（徳島県）
• [Presentation] 半月体形成性糸球体腎炎の進展におけるRAS、活性酸素の役割 (2011)
  • Author(s): 木下ゆき子
  • Organizer: 第23回腎とフリーラジカル研究会
  • Place of Presentation: ホテルグランドパレス徳島（徳島県）
• [Presentation] Urinary angiotensinogen as a biomarker of chronic glomerulonephritis in childhood. The 1st International Conference on Urinomics.
  • Author(s): Kagami S
  • Organizer: 2013 Caparica
  • Place of Presentation: Hotel Costa de Caparica, Portugal
• [Presentation] レニンアンジオテンシン系阻害薬を投与しているアルポート症候群の3例
  • Author(s): 松浦 里、永井 隆、木下ゆき子、須賀健一、漆原真樹、近藤秀治、香美祥二
  • Organizer: 第30回中国四国小児腎臓病学会
  • Place of Presentation: 徳島シビックセンター4階ホール、徳島県
• [Presentation] 精神運動発達遅滞と右多趾症を合併した常染色体劣性多発性嚢胞腎(ARPKD)と考えられた1例
  • Author(s): 今田久美子、永井 隆、漆原真樹、近藤秀治、高橋正幸、庄野実希、藤野修司、山上貴司、松岡 優、香美祥二
  • Organizer: 第30回中国四国小児腎臓病学会
  • Place of Presentation: 徳島シビックセンター4階ホール、徳島県
• [Book] Glomerular renin-angiotensin system activation-Implications in pathological glomerular remodeling(Chapter 6).In"Renin-angiotensin system"edited by Himura A and Sato T. (2013)
  • Author(s): Kagami S
  • Total Pages: 239
  • Publisher: Nova science publishers(USA)
• [Book] エビデンスに基づくCKD診療ガイドライン2013 (2013)
  • Author(s): 香美祥二,近藤秀治
  • Total Pages: 259
  • Publisher: 東京医学社
• [Book] “Renin-angiotensin system” (2013)
  • Author(s): Kagami S
  • Total Pages: 239
  • Publisher: Nova science publishers
• [Book] エビデンスに基づくCKD診療ガイドライン2013 (2013)
  • Author(s): 香美祥二、近藤秀治
  • Total Pages: 259
  • Publisher: 東京医学社
• [Book] 小児腎臓病学 日本小児腎臓病学会編 (2012)
  • Author(s): 香美祥二
  • Total Pages: 4
  • Publisher: 診断と治療社
• [Book] 小児腎臓病学日本小児腎臓病学会編 (2011)
  • Author(s): 香美祥二
  • Total Pages: 460
  • Publisher: 診断と治療社
• [Book] 小児の急性腎炎症候群,今日の治療指針2011 (2011)
  • Author(s): 香美祥二(東京)
  • Total Pages: 2096
  • Publisher: 医学書院
• [Book] 慢性腎炎症候群(IgA腎症を中心に),小児診療ガイドライン-最新の診療指針-(第2版) (2011)
  • Author(s): 香美祥二(東京)
  • Total Pages: 471
  • Publisher: 総合医学社
• [Book] 今日の治療指針2011 (2011)
  • Author(s): 香美祥二
  • Total Pages: 2
  • Publisher: 小児の急性腎炎症候群
• [Book] 小児診療ガイドライン-最新の診療指針― （第２版） (2011)
  • Author(s): 香美祥二
  • Total Pages: 4
  • Publisher: 慢性腎炎症候群（IgA腎症を中心に）
• [Remarks] 徳島大学医学部小児科
  • URL: http://www.tokudai-pediatrics.net/index.html