Elucidation of the role of signal crosstalk by reactive oxygen species and cell adhesion in nephrogenesis and CAKUT
| Project/Area Number |
23591571
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | The University of Tokushima |
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Principal Investigator |
KONDO Shuji 徳島大学, ヘルスバイオサイエンス研究部, 講師 (00380080)
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| Co-Investigator(Kenkyū-buntansha) |
KAGAMI Shoji 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 (00224337)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | CAKUT / 活性酸素 / NADPHオキシダーゼ / 尿管芽分岐 / ネフロン形成 / メサンギウム細胞 |
|---|
| Research Abstract |
Two nephrogenic basic phenomena, ureteric bud branching and nephrogenesis, closely participate in the development of congenital anomalies of the kidney and urinary tract (CAKUT). In this study, NADPH oxidase and the product, reactive oxygen species (ROS), were detected in the area of ureteric bud branching and nephrogenesis. The inhibition of NADPH oxidase and ROS production resulted in the suppression of ureteric bud branching and nephrogenesis, which contributed to hypoplastic and dysplastic kidney. Cell behavior (cell proliferation, migration, apoptosis) and phosphorylation signal transduction by both of cell adhesion-related molecules and MAP kinase were closely associated with the mechanism. Thus, ROS produced by NADPH oxidase plays an important role in ureteric bud branching and nephrogenesis.
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Report
(4 results)
Research Products
(86 results)
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[Journal Article] A case of infantile systemic lupus erythematosus with severe lupus nephritis and EBV infection2013
Author(s)
Kishi N, Suga K, Matsuura S, Kinoshita Y, Urushihara M, Kondo S, Kitano E, Hatanaka M, Kitamura H, Sato T, Maeda A, Kagami S.
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Journal Title
CEN Case Rep
Volume: 2
Pages: 190-193
Related Report
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[Journal Article] Angiotensin II type I receptor blockade suppresses glomerular renin-angiotensin system activation, oxidative stress, and progressive glomerular injury in rat anti-glomerular basement membrane glomerulonephritis2012
Author(s)
Kinoshita Y, Kondo S, Urushihara M, Suga K, Matsuura S, Takamatsu M, Shimizu M, Nishiyama A, Kawachi H, Kagami S
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Journal Title
Transl Res
Volume: 158
Issue: 4
Pages: 235-48
DOI
Related Report
Peer Reviewed
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[Journal Article] A case of a 6-year-old girl with ANCA-negative pauci-immune crescentic glomerulonephritis2011
Author(s)
Shimizu M, Sekiguchi T, Kishi N, Goji A, Takahashi T, Kozan H, Sakaguchi Z, Kinoshita Y, Matsuura S, Suga K, Urushihara M, Kondo S, Kagami S, Ohara K
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Journal Title
Clin Exp Nephrol
Volume: 21
Issue: 4
Pages: 2380-2390
DOI
Related Report
Peer Reviewed
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[Presentation] Reacitve oxygen species generated by NADPH oxidase contribute to ureteric bud branching and nephrogenesis2012
Author(s)
Matsuura S, Kondo S, Kinoshita Y, Suga K, Urushihara M, Kishi N, Nagai T, Jamba A, Kagami S
Organizer
Pediatric Academic societies annual meeting 2012
Place of Presentation
Hynes Convention Center, Boston, MA, USA
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[Presentation] Urinary angiotensinogen as a biomarker of the intrarenal status of the renin-angiotensin system in patients with chronic glomerulonephritis2011
Author(s)
Urushihara M, Kinoshita Y, Matsuura S, Suga K, Takamatsu M, Shimizu M, Kondo S, Kobori H, Kagami S.
Organizer
11th Asian Congress of Pediatric Nephrology 2011
Place of Presentation
Fukuoka International Congress Center, Fukuoka, Japan
Related Report
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[Presentation] The role of NADPH oxidase (Nox) in ureteric bud branching and nephrogenesis2011
Author(s)
Matsuura S, Kondo S, Kinoshita Y, Suga K, Urushihara M, Takamatsu M, Shimizu M, Kishi N, Kagami S.
Organizer
11th Asian Congress of Pediatric Nephrology 2011
Place of Presentation
Fukuoka International Congress Center, Fukuoka, Japan
Related Report
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[Presentation] A case of membranous nephropathy and open angle glaucoma complicated with asymptomatic Siogren's syndrome2011
Author(s)
Matsuura S, Kondo S, Suga K, Kinoshita Y, Urushihara M, Takamatsu M, Shimizu M, Kishi N, Kagami S.
Organizer
11th Asian Congress of Pediatric Nephrology 2011
Place of Presentation
Fukuoka International Congress Center, Fukuoka, Japan
Related Report
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