| Project/Area Number |
23591571
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
KONDO Shuji 徳島大学, ヘルスバイオサイエンス研究部, 講師 (00380080)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KAGAMI Shoji 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 (00224337)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | CAKUT / 活性酸素 / NADPHオキシダーゼ / 尿管芽分岐 / ネフロン形成 / メサンギウム細胞 |
|---|
| Research Abstract |
Two nephrogenic basic phenomena, ureteric bud branching and nephrogenesis, closely participate in the development of congenital anomalies of the kidney and urinary tract (CAKUT). In this study, NADPH oxidase and the product, reactive oxygen species (ROS), were detected in the area of ureteric bud branching and nephrogenesis. The inhibition of NADPH oxidase and ROS production resulted in the suppression of ureteric bud branching and nephrogenesis, which contributed to hypoplastic and dysplastic kidney. Cell behavior (cell proliferation, migration, apoptosis) and phosphorylation signal transduction by both of cell adhesion-related molecules and MAP kinase were closely associated with the mechanism. Thus, ROS produced by NADPH oxidase plays an important role in ureteric bud branching and nephrogenesis.
|
