| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
Among the Japanese children with Chediak-Higashi syndrome who have or dont have hemophagocytic lymphohistiocytosis (HLH) registered at our laboratory. We analyzed the cytotoxicity and degranulation activity of CTLs. In Chediak-Higashi syndrome who have hemophagocytic lymphohistiocytosis In HLH positive patient with CTL-mediated cytotoxicity was low or deficient, and degranulation activity was also low .
Chediak-Higashi syndrome who have hemophagocytic lymphohistiocytosis can be diagnosed and classified on the basis of CTL-mediated cytotoxicity, degranulation activity, and genetic analysis. Based on the data obtained from functional analysis of CTLs.
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