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The role of M1, M2 macrophage and regenerative factors in renal injury and recovery process

Research Project

Project/Area Number 23591575
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionFukushima Medical University

Principal Investigator

KAWASAKI Yukihiko  福島県立医科大学, 医学部, 准教授 (00305369)

Co-Investigator(Kenkyū-buntansha) HOSOYA Mitsuaki  福島県立医科大学, 医学部, 教授 (80192318)
HASHIMOTO Kouichi  福島県立医科大学, 医学部, 准教授 (50322342)
SUYAMA Kazuhide  福島県立医科大学, 医学部, 講師 (90423798)
SUZUKI Junzo  福島県立医科大学, 看護学部, 教授 (20171217)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsM2マクロファージ / M1マクロファージ / HUS / IgA腎症 / 紫斑病性腎炎 / 腎糸球体障害 / 腎組織再生 / M2マクロファージ / VEGF / Angiopoietin 1 / HUS / ケモカイン / MRPマクロファージ / CD204 / スキッドマウス / Thy-1腎炎 / 硬化性腎炎 / 糸球体再生 / CD163 / CD86
Research Abstract

To efficacy the role of Macrophage subclasses in renal injury and glomerulonephritis(GN), we investigate the relationship between M1,M2 macrophage, myeloid-related protein(MRP) 8/14 complex and the laboratory and pathological findings in HUS mice model and IgA nephropathy(IgAN) and Henoch-Schoenlein purpura nephritis(HSPN).
The scores of renal M2 macrophage expression in the recovery phase of HUS mice model were higher than those in control mice. MRP 8/14 levels, and glomerular and interstitial MRP8+CD68+ scores at the second biopsy were all higher in unfavorable IgAN than in favorable IgAN. Pathological findings revealed that the proportions of patients with ISKDC more grades III in HSPN with high MRP8/14 values were higher than those in HSPN with low MRP8/14 values. Our findings suggest that M2 macrophage plays important role in the recovery phase of renal injury, and serum MRP8/14 complex levels may be associated with the severity of renal injury.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (25 results)

All 2014 2013 2012 2011 Other

All Journal Article (18 results) (of which Peer Reviewed: 18 results,  Open Access: 3 results) Presentation (7 results)

  • [Journal Article] Risk factors for non-responsiveness to treatment for IgA nephropathy with diffuse mesangial proliferation2014

    • Author(s)
      Kawasaki Y, Suyama K, Miyazaki K, Kannno S, Ono A, Suzuki Y, Sato M, Hashimoto K, Hosoya M
    • Journal Title

      Nephrologyl

      Volume: 19 Issue: 7 Pages: 384-391

    • DOI

      10.1111/nep.12232

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Incidence and index of severity of hemolytic uremic syndrome in a 26 year period in Fukushima Prefecture, Japan2014

    • Author(s)
      Kawasaki Y, Suyama K, Maeda R, Yugeta E, Takano K, Suzuki S, Sakuma H, Nemoto K, Sato T, Nagasawa K, Hosoya M
    • Journal Title

      Pediatr. Int

      Volume: Vol.56、No.1 Issue: 1 Pages: 77-82

    • DOI

      10.1111/ped.12193

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Two children with obesity-related glomerulopathy identified in a school urinary screening program2014

    • Author(s)
      Kawasaki Y, Isome M, Ono A, Suzuki Y, Takano K, Suyama K, Hosoya M
    • Journal Title

      Pediatr. Int

      Volume: Vol.56、No.1 Issue: 1 Pages: 115-118

    • DOI

      10.1111/ped.12213

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Two children with obesity-related glomerulopathy identified in a school urinary screening program2014

    • Author(s)
      Kawasaki Y, Isome M, Ono A, Suzuki Y, Takano K, Suyama K, Hosoya M.
    • Journal Title

      Pediatr Int

      Volume: 56 Pages: 115-118

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Incidence and index of severity of hemolytic uremic syndrome in a 26 year period in Fukushima Prefecture, Japan2014

    • Author(s)
      Kawasaki Y, Suyama K, Maeda R, Yugeta E, Takano K, Suzuki S, Sakuma H, Nemoto K, Sato T, Nagasawa K, Hosoya M.
    • Journal Title

      Pediatr Int

      Volume: 56 Pages: 77-82

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of recombinant human soluble thrombomodulin for childhood hemolytic uremic syndrome2013

    • Author(s)
      Kawasaki Y, Suyama K, Ono A, Oikawa T, Ohara S, Suzuki Y, Sakai N, Hosoya M
    • Journal Title

      Pediatr. Int

      Volume: Vol.55、No.5 Issue: 5

    • DOI

      10.1111/ped.12165

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Henoch-Schönlein purpura nephritis in childhood : pathogenesis, prognostic factors and treatment2013

    • Author(s)
      Kawasaki Y, Ono A, Ohara S, Suzuki Y, Suyama K, Suzuki J, Hosoya M
    • Journal Title

      Fukushima J. Med. Sci

      Volume: Vol.59、No.1 Pages: 15-26

    • NAID

      130003376082

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of recombinant human soluble thrombomodulin for childhood hemolytic uremic syndrome2013

    • Author(s)
      Kawasaki Y, Suyama K, Ono A, Oikawa T, Ohara S, Suzuki Y, Sakai N, Hosoya M.
    • Journal Title

      Fukushima J Med Sci

      Volume: 59 Pages: 102-107

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Henoch-Schoenlein purpura nephritis in childhood: pathogenesis, prognostic factors and treatment2013

    • Author(s)
      Kawasaki Y, Ono A, Ohara S, Suzuki Y, Suyama K, Suzuki J, Hosoya M.
    • Journal Title

      Fukushima J Med Sci

      Volume: 59 Pages: 15-26

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of vascular endothelial growth factor and angiopoietin 1 in renal injury in hemolytic uremic syndrome2012

    • Author(s)
      Ohara S, Kawasaki Y, Abe Y, Watanabe M, Ono A, Suyama K, Hashimoto K, Honda T, Suzuki J, Hosoya M
    • Journal Title

      Am. J. Nephrol

      Volume: Vol.36、No.6 Issue: 6 Pages: 516-523

    • DOI

      10.1159/000345142

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The role of serum meyloid-related protein 8/14 complex in Henoch-Schoenlein purpura nephritis2012

    • Author(s)
      1. Kawasaki Y, Ohara S, Abe Y, Watanabe M, Suyama K, Sato M, Hashimoto K, Hosoya M.
    • Journal Title

      Pediatr Nephrol

      Volume: 27 Issue: 1 Pages: 65-71

    • DOI

      10.1007/s00467-011-1937-3

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of common variable immunodeficiency in IgA- and IgG2-deficient patients with systemic lupus erythematosus2012

    • Author(s)
      Suyama K, Kawasaki Y, Abe Y, Watanabe M, Ohara S, Oikawa T, Sakai N, Hashimoto K, Hosoya M.
    • Journal Title

      Pediatr Nephrol

      Volume: 27 Issue: 3 Pages: 489-492

    • DOI

      10.1007/s00467-011-2063-y

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The role of serum meyloid-related protein 8/14 complex in Henoch-Schoenlein purpura nephritis2012

    • Author(s)
      川崎 幸彦
    • Journal Title

      Pediatr.Nephrol.

      Volume: 27 Pages: 65-71

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mechanism of onset and exacerbation of chronic glomerulonephritis and its treatment2011

    • Author(s)
      Kawasaki Y
    • Journal Title

      Pediatr. Int

      Volume: Vol.53、No.6 Issue: 6 Pages: 795-806

    • DOI

      10.1111/j.1442-200x.2011.03469.x

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The pathogenesis and treatment of pediatrics Henoch-Schönlein purpura nephritis2011

    • Author(s)
      Kawasaki Y
    • Journal Title

      Clin. Exp. Nephrol

      Volume: Vol.15、No.5 Pages: 648-657

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Methylprednisolone pulse plus mizoribine in children with Henoch- Schönlein purpura nephritis2011

    • Author(s)
      Kawasaki Y, Suyama K, Hashimoto K, Hosoya M
    • Journal Title

      Clin. Rheumatol

      Volume: Vol.30、No.4 Issue: 4 Pages: 529-535

    • DOI

      10.1007/s10067-010-1572-6

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The pathogenesis and treatment of pediatric Henoch- Schönlein purpura nephritis2011

    • Author(s)
      川崎 幸彦
    • Journal Title

      Clin.Exp.Nephrol.

      Volume: 15 Pages: 648-657

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The mechanism of onset and exacerbation of chronic glomerulonephritis and its treatment2011

    • Author(s)
      川崎 幸彦
    • Journal Title

      Pediatr.Int.

      Volume: 53 Pages: 795-806

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 溶血性尿毒症症候群(HUS)に対するトロンボモジュリン[recombinant human soluble thrombomodulin (rhTM)]の治療効果2013

    • Author(s)
      川崎幸彦
    • Organizer
      第45回日本小児感染症学会総会・学術集会
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Year and Date
      2013-10-26
    • Related Report
      2013 Final Research Report
  • [Presentation] 慢性糸球体腎炎の活動性指標としての血清Myeloid-related protein (MRP)8/14と腎組織浸潤MRP陽性マクロファージ2013

    • Author(s)
      川崎幸彦
    • Organizer
      第48回日本小児腎臓病学会学術集会
    • Place of Presentation
      あわぎんホール(徳島)
    • Year and Date
      2013-06-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 重症・軽症HUSモデルマウスにおける経時的なサイトカインプロファイリング-rhTMの抗サイトカイン作用2013

    • Author(s)
      川崎幸彦
    • Organizer
      第48回日本小児腎臓病学会学術集会
    • Place of Presentation
      あわぎんホール(徳島)
    • Year and Date
      2013-06-28
    • Related Report
      2013 Final Research Report
  • [Presentation] ステロイド剤加味ミゾリビン多剤併用療法を施行した重症型IgA腎症患児の予後と予後規定因子の解析2013

    • Author(s)
      川崎幸彦
    • Organizer
      第56回日本腎臓学会学術総会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2013-05-12
    • Related Report
      2013 Final Research Report
  • [Presentation] 紫斑病性腎炎発症病態における血清MRP8/14の役割2012

    • Author(s)
      川崎幸彦
    • Organizer
      第115回日本小児科学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2012-04-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 紫斑病性腎炎発症病態における血清MRP8/14の役割2012

    • Author(s)
      川崎 幸彦
    • Organizer
      日本小児科学会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 紫斑病性腎炎発症病態における血清MRP8/14の役割

    • Author(s)
      川崎 幸彦
    • Organizer
      日本小児科学会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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