| Project/Area Number |
23591575
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HOSOYA Mitsuaki 福島県立医科大学, 医学部, 教授 (80192318)
HASHIMOTO Kouichi 福島県立医科大学, 医学部, 准教授 (50322342)
SUYAMA Kazuhide 福島県立医科大学, 医学部, 講師 (90423798)
SUZUKI Junzo 福島県立医科大学, 看護学部, 教授 (20171217)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | Ｍ２マクロファージ / Ｍ１マクロファージ / ＨＵＳ / ＩｇＡ腎症 / 紫斑病性腎炎 / 腎糸球体障害 / 腎組織再生 / M2マクロファージ / VEGF / Angiopoietin 1 / HUS / ケモカイン / MRPマクロファージ / CD204 / スキッドマウス / Thy-1腎炎 / 硬化性腎炎 / 糸球体再生 / CD163 / CD86 |
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| Research Abstract |
To efficacy the role of Macrophage subclasses in renal injury and glomerulonephritis(GN), we investigate the relationship between M1,M2 macrophage, myeloid-related protein(MRP) 8/14 complex and the laboratory and pathological findings in HUS mice model and IgA nephropathy(IgAN) and Henoch-Schoenlein purpura nephritis(HSPN).
The scores of renal M2 macrophage expression in the recovery phase of HUS mice model were higher than those in control mice. MRP 8/14 levels, and glomerular and interstitial MRP8+CD68+ scores at the second biopsy were all higher in unfavorable IgAN than in favorable IgAN. Pathological findings revealed that the proportions of patients with ISKDC more grades III in HSPN with high MRP8/14 values were higher than those in HSPN with low MRP8/14 values. Our findings suggest that M2 macrophage plays important role in the recovery phase of renal injury, and serum MRP8/14 complex levels may be associated with the severity of renal injury.
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