| Project/Area Number |
23591579
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HAMAOKA Kenji 京都府立医科大学, 大学院医学研究科, 教授 (60189602)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 川崎病 / 真菌 / 動物モデル / 自然免疫 / 自己抗体 / IgM / 血管炎 / 自然抗体 / mannose binding lectin / 自然自己抗体 / 古典経路 / C1エステラーゼインヒビター / 血管炎動物モデル |
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| Research Abstract |
Kawasaki disease (KD) is an idiopathic vasculitis in children. As its coronary sequela could be a risk factor of ischemic heart diseases in young adulthood, elucidation of its pathogenesis is one of the most important issues in cardiovasular medicine. Using Candida albicans water soluble extract (CAWS)-induced mouse model for KD, we got the following results: 1 ) IgM, MBLs and C3-derived peptides deposited in the inflamed vasculature. 2) IgM type autoantibody was increased in response to CAWS-stimulation. 3) the autoantibody recognized some specific endogenous proteins including a mitochondrial enzyme. These findings suggest that some specific infectious stimuli provoke innate humoral immunity to cause sterile vasculitis such as Kawasaki disease.
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