| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
Polycystic kidney disease is an inherited disease, which is the most frequent in our country, and is one of main causes of chronic renal failure. There are two types of polycystic kidney disease, autosomal dominant (ADPKD) and autosomal recessive (ARPKD).
In this study, we elucidated ubiquitin-proteasome proteolysis mechanism in multiple pathophysiology of polycystic kidney disease, and aimed to confirm the effect with modification of ubiquitin-proteasome proteolysis using the model animal for disease specific therapy development based on the pathophysiology of polycystic kidney disease to adapt it to human. We focused on ubiquitin E3 ligase family, Smurf1 and Smurf2.
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