Evaluation of vascular smooth muscle cell function and response mechanism according to transformation from constitution type to secretion type in acute phase of vasculitis
| Project/Area Number |
23591588
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KATSUBE Yasuhiro 日本医科大学, 医学部, 准教授 (20246523)
FUKAZAWA Ryuji 日本医科大学, 医学部, 准教授 (80277566)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 川崎病 / 血管平滑筋細胞 / 形質転換 |
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| Research Abstract |
I made a vasculitis animal model of the Kawasaki disease resemblance,and elucidated migration of a vascular smooth muscle cell from a media by the destruction of the inner elasticity band with a vasculitis histologically in the subendothelial site.
Furthermore, the possibility that the vascular smooth muscle cell which migrated in the subendothelial site was transformed in a secretion type from a constitution type by the expression of transcriptional factors such as KLF5 and Egr-1 was suggested. But enough estimation was not accomplished about the function and response mechanism of a transformed vascular smooth muscle cell.
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Report
(4 results)
Research Products
(82 results)
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[Journal Article] Efficacy of immunoglobulin plus predonisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial2012
Author(s)
Kobayashi T, Saji T, Otani T, Takeuchi K, Nakamura T, Arakawa H, Kato T, Hara T, Hamaoka K, Ogawa S,et al.
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Journal Title
Lancet
Volume: 379
Issue: 9826
Pages: 1613-1620
DOI
Related Report
Peer Reviewed
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