• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Evaluation of oxidative stress in children with non-alcoholic steatohepatitis

Research Project

Project/Area Number 23591589
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionOsaka Medical College

Principal Investigator

TAMAI HIROSHI  大阪医科大学, 医学部, 教授 (30179874)

Co-Investigator(Kenkyū-buntansha) TAKITANI Kimitaka  大阪医科大学, 医学部, 講師 (80319540)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords非アルコール性脂肪性肝疾患 / 非アルコール性脂肪肝炎 / 抗酸化剤 / 脂肪性肝疾患
Research Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in developed countries, and its incidence is increasing in adults and children. As an antioxidant, vitamin E is effective in treatment of NAFLD, although the mechanism is still unclear. Methionine-choline deficient (MCD) rats used as an experimental model of NAFLD were fed a vitamin E-enriched diet. In the MCD rats, vitamin E treatment altered the hepatic alpha-tocopherol-related protein expression, which may affect the alpha-tocopherol status in the liver and reduce lipid peroxidation.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (30 results)

All 2014 2013 2012 2011 Other

All Journal Article (27 results) (of which Peer Reviewed: 27 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] Theα-tocopherol status and expression ofα-tocopherol-related proteins in methionine-choline deficient rats treated with vitamin E2014

    • Author(s)
      Miyazaki H, Takitani K, Koh M, Yoden A, Tamai H
    • Journal Title

      J Clin Biochem Nutr

      Volume: 54 Pages: 190-197

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Variant cardiovascular regulation in children with postural tachycardia syndrome2014

    • Author(s)
      Yoshida S, Tanaka H, Nakao R, Okamoto N, Kajiura M, Kanbara Y, Azuma S, Tamai H
    • Journal Title

      Pediatr Int

      Volume: 56 Pages: 328-335

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The α-tocopherol status and expression of α-tocopherol -related proteins in methionine-choline deficient rats treated with vitamin E.2014

    • Author(s)
      Miyazaki H, Takitani K, Koh M, Yoden A, Tamai H.
    • Journal Title

      J Clin Biochem Nutr.

      Volume: 54 Pages: 190-197

    • NAID

      130004466749

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retinol status and expression of retinol-related proteins in methionine-choline deficient rats.2014

    • Author(s)
      Miyazaki H, Takitani K, Koh M, Inoue A, Kishi K, Tamai H.
    • Journal Title

      J Nutr Sci Vitaminol.

      Volume: 60 Pages: 78-85

    • NAID

      130004491369

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinico-radiological spectrum of reversible splenial lesions in children.2014

    • Author(s)
      Kashiwagi M, Tanabe T, Shimakawa S, Nakamura M, Murata S, Shabana K, Shinohara J, Odanaka Y, Matsumura H, Koh M, Okumura K, Okasora K, Tamai H.
    • Journal Title

      Brain Dev.

      Volume: 36 Issue: 4 Pages: 330-6

    • DOI

      10.1016/j.braindev.2013.05.007

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] α-Tocopherol status and expression ofα-tocopherol transfer protein in type 2 diabetic Goto-Kakizaki rats2013

    • Author(s)
      Mi yazaki H, Takitani K, Koh M, Takaya R, Yoden A, Tamai H
    • Journal Title

      J Nutr Sci Vitaminol

      Volume: 59 Pages: 64-68

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of uric acid with obesity and endothelial dysfunction in children and early adolescents2013

    • Author(s)
      Ishiro M, Takaya R, Mori Y, Takitani K, Kono Y, Okasora K, Kasahara T, Tamai H
    • Journal Title

      Ann Nutr Metab

      Volume: 62 Pages: 169-176

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Liver X receptor up-regulates α-tocopherol transfer protein expression and α-tocopherol status.2013

    • Author(s)
      Koh M, Takitani K, Miyazaki H, Yamaoka S, Tamai H.
    • Journal Title

      J Nutr Biochem.

      Volume: 24 Issue: 12 Pages: 2158-67

    • DOI

      10.1016/j.jnutbio.2013.08.008

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Case treated with triple therapy of lamivudine, interferon-β and prednisolone for acute exacerbation of chronic hepatitis B during pregnancy.2013

    • Author(s)
      Koh M, Shinohara J, Hongo Y, Okazaki T, Takitani K, Tamai H.
    • Journal Title

      Hepatol Res.

      Volume: 43 Issue: 4 Pages: 425-9

    • DOI

      10.1111/j.1872-034x.2012.01077.x

    • NAID

      10031194555

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] α-Tocopherol status and expression of α-tocopherol transfer protein in type 2 diabetic Goto-Kakizaki rats.2013

    • Author(s)
      Miyazaki H, Takitani K, Koh M, Takaya R, Yoden A, Tamai H.
    • Journal Title

      J Nutr Sci Vitaminol.

      Volume: 59 Pages: 64-8

    • NAID

      130003368150

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association of uric acid with obesity and endothelial dysfunction in children and early adolescents.2013

    • Author(s)
      Ishiro M, Takaya R, Mori Y, Takitani K, Kono Y, Okasora K, Kasahara T, Tamai H.
    • Journal Title

      Ann Nutr Metab.

      Volume: 62 Issue: 2 Pages: 169-76

    • DOI

      10.1159/000346227

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neutralization of complement component C5 ameliorates the development of dextran sulfate sodium (DSS)-colitis in mice2013

    • Author(s)
      Aomatsu T, Imaeda H, Takahashi K, Fujimoto T, Kasumi E, Ban H, Bamba S, Yoden A, Tamai H, Fujiyama Y, Andoh A.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 52 Issue: 1 Pages: 72-75

    • DOI

      10.3164/jcbn.12-63

    • NAID

      130004879316

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] GNB3 C825T polymorphism is associated with postural tachycardia syndrome in children2012

    • Author(s)
      Nakao R, Tanaka H, Takitani K, Kajiura M, Okamoto N, Kanbara Y, Tamai H
    • Journal Title

      Pediatr Int

      Volume: 54 Pages: 829-837

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antenatal exposure to Ureaplasma species exacerbates bronchopulmonary dysplasia synergistically with subsequent prolonged mechanical ventilation in preterm infants2012

    • Author(s)
      Inatomi T, Oue S, Ogihara T, Hira S, Hasegawa M, Yamaoka S, Yasui M, Tamai H
    • Journal Title

      Pediatr Res

      Volume: 71 Pages: 267-273

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tacrolimus (FK506) suppresses TNF-α-induced CCL2 (MCP-1) and CXCL10 (IP-10) expression via the inhibition of p38 MAP kinase activation in human colonic myofibroblasts.2012

    • Author(s)
      Aomatsu T, Imaeda H, Takahashi K, Fujimoto T, Kasumi E, Yoden A, Tamai H, Fujiyama Y, Andoh A.
    • Journal Title

      Int J Mol Med.

      Volume: 30 Issue: 5 Pages: 1152-8

    • DOI

      10.3892/ijmm.2012.1094

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] GNB3 C825T polymorphism is associated with postural tachycardia syndrome in children.2012

    • Author(s)
      Nakao R, Tanaka H, Takitani K, Kajiura M, Okamoto N, Kanbara Y, Tamai H.
    • Journal Title

      Pediatr Int.

      Volume: 54 Issue: 6 Pages: 829-37

    • DOI

      10.1111/j.1442-200x.2012.03707.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Terminal restriction fragment length polymorphism analysis of the gut microbiota profiles of pediatric patients with inflammatory bowel disease.2012

    • Author(s)
      Aomatsu T, Imaeda H, Fujimoto T, Takahashi K, Yoden A, Tamai H, Fujiyama Y, Andoh A.
    • Journal Title

      Digestion.

      Volume: 86 Issue: 2 Pages: 129-35

    • DOI

      10.1159/000339777

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Utstein Osaka Project. Age-specific differences in outcomes after out-of-hospital cardiac arrests2011

    • Author(s)
      Nitta M, Iwami T, Kitamura T, Nadkarni VM, Berg RA, Shimizu N, Ohta K, Nishiuchi T, Hayashi Y, Hiraide A, Tamai H, Kobayashi M, Morita H
    • Journal Title

      Pediatrics

      Volume: 128 Issue: 4 Pages: e812-e820

    • DOI

      10.1542/peds.2010-3886

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of apoptosis byγ-tocotrienol in human cancer cell lines and leukemic blasts from patients : dependency on Bid, cytochrome c, and caspase pathway2011

    • Author(s)
      Inoue A, Takitani K, Koh M, Kawakami C, Kuno T, Tamai H
    • Journal Title

      Nutr Cancer

      Volume: 63 Pages: 763-70

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered expression of bothβ-carotene 15,15' monooxygenase and lecithin : retinol acyltransferase in obese Zucker rats2011

    • Author(s)
      Takitani K, Miyazaki H, Fukunishi S, Takaya R, Yoden A, Higuchi K, Tamai H
    • Journal Title

      J Nutr Sci Vitaminol

      Volume: 57 Pages: 108-13

    • NAID

      10028106443

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] α-Tocopherol suppresses lipid peroxidation and behavioral and cognitive impairments in the Ts65Dn mouse model of Down syndrome2011

    • Author(s)
      Shichiri M, Yoshida Y, Ishida N, Hagihara Y, Iwahashi H, Tamai H, Niki E
    • Journal Title

      Free Radic Biol Med

      Volume: 50 Pages: 1801-1811

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fecal calprotectin is a useful marker for disease activity in pediatric patients with inflammatory bowel disease2011

    • Author(s)
      Aomatsu T, Yoden A, Matsumoto K, Kimura E, Inoue K, Andoh A, Tamai H
    • Journal Title

      Dig Dis Sci

      Volume: 56 Pages: 2372-2327

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Meconium aspiration delays normal decline of pulmonary vascular resistance shortly after birth through lung parenchymal injury2011

    • Author(s)
      Ban R, Ogihara T, Mori Y, Oue S, Ogawa S, Tamai H
    • Journal Title

      Neonatology

      Volume: 99 Pages: 272-9

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Faecal chitinase 3-like-1 : a novel biomarker of disease activity in paediatric inflammatory bowel disease2011

    • Author(s)
      Aomatsu T
    • Journal Title

      Aliment Pharmacol Ther.

      Volume: 34 Issue: 8 Pages: 941-948

    • DOI

      10.1111/j.1365-2036.2011.04805.x

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Induction of apoptosis by γ-tocotrienol in human cancer cell lines and leukemic blasts from patients: dependency on Bid, cytochrome c, and caspase pathway.2011

    • Author(s)
      Inoue A, Takitani K, Koh M, Kawakami C, Kuno T, Tamai H.
    • Journal Title

      Nutr Cancer.

      Volume: 63 Pages: 763-770

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Altered expression of both β-carotene 15,15' monooxygenase and lecithin:retinol acyltransferase in obese Zucker rats.2011

    • Author(s)
      Takitani K, Miyazaki H, Fukunishi S, Takaya R, Yoden A, Higuchi K, Tamai H.
    • Journal Title

      J Nutr Sci Vitaminol.

      Volume: 57 Pages: 108-113

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] α-Tocopherol suppresses lipid peroxidation and behavioral and cognitive impairments in the Ts65Dn mouse model of Down syndrome.2011

    • Author(s)
      Shichiri M, Yoshida Y, Ishida N, Hagihara Y, Iwahashi H, Tamai H, Niki E.
    • Journal Title

      Free Radic Biol Med.

      Volume: 50

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] ビタミンEの臨床的意義2013

    • Author(s)
      玉井浩
    • Organizer
      第65回日本ビタミン学会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] ビタミンE研究の進歩2013

    • Author(s)
      玉井浩
    • Organizer
      第40回日本小児栄養消化器肝臓学会
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.osaka-med.ac.jp/deps/ped/index.html

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi