Prediction of the relapse frequency and/or the steroid resistance in minimal change nephrotic syndrome
Project/Area Number |
23591591
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Department of Clinical Research, National Hospital Organization Kanazawa Medical Center |
Principal Investigator |
OHTA Kazuhide 独立行政法人国立病院機構(金沢医療センター臨床研究部), その他部局等, 医師 (20283129)
|
Co-Investigator(Kenkyū-buntansha) |
SHIMIZU Masaki 金沢大学, 医薬保健領域 医学部, 小児科助教 (10401902)
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Project Period (FY) |
2011-04-28 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | ネフローゼ症候群 / T細胞抗原受容体 / 構造の多様性 / 予後の予測因子 / 免疫抑制剤 / T細胞抗原受容体 |
Outline of Final Research Achievements |
I examined the prediction factor for the relapse frequency and steroid reactivity in pediatric patients with nephrotic syndrome from the T-cell receptor (TCR) diversity. In evaluation by Complexity Score (CS) obtained from the both analysis of the Vβ repertoire and the CDR3 size spectra typing in CD8+ T-cell, I have predicted that a case whose CS was less than 5.0 points was intractable more. Based on this result, we produced a new protocol the clinical trial using the immunosuppressive agents from the early phase of this illness. We are going to start the new clinical trial in future. In addition, although clonal analysis in which the diversity of TCR structure is lost was also enforced, we ware not able to discover a same clone that suggests a cause of the nephrotic syndrome.
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Report
(5 results)
Research Products
(119 results)
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[Journal Article] Clinical, biochemical and molecular analysis of 13 Japanese patients with β-ureidopropionase deficiency demonstrates high prevalence of the c.977G > A (p.R326Q) mutation2014
Author(s)
Nakajima Y, Meijer J, Dobritzsch D, Ito T, Meinsma R, Abeling NGGM, Roelofsen J, Zoetekouw L, Watanabe Y, Lee T, Mitsubuchi H, Yoneyama A, Ohta K, Kuhara T, Eto K, Saito K, van Kuilenburg ABP
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Journal Title
J Inherit Metab Dis
Volume: 37
Issue: 5
Pages: 801-812
DOI
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Peer Reviewed / Open Access
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[Journal Article] Sustained elevation of serum interleukin-18 and its association with hemophagocytic lymphohistiocytosis in XIAP deficiency2014
Author(s)
Wada T, Kanegane H, Ohta K, Katoh F, Imamura T, Nakazawa Y, Miyashita R, Hara J, Hamamoto K, Yang X, Filipovich AH, Marsh RA, Yachie A.
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Journal Title
Cytokine
Volume: 65
Issue: 1
Pages: 74-78
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Thomsen-Friedenreich antigen exposure as a cause of Streptococcus pyogenes- associated hemolytic-uremic syndrome2012
Author(s)
Shimizu M, Yokoyama T, Sakashita N, Sato A, Ueno K, Akita C, Ohta K, Kitano Hatanaka E, Kitamura H, Saikawa Y, Yachie A
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Journal Title
Clin Nephrol
Volume: 78
Issue: 10
Pages: 328-331
DOI
Related Report
Peer Reviewed
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[Journal Article] Cytokine profiles of patients with enterohemorrhagic Escherichia coli O111-induced hemolytic-uremic syndrome2012
Author(s)
Shimizu M, Kuroda M, Sakashita N, Konishi M, Kaneda H, Igarashi N, Yamahana J, Taneichi H, Kanegane H, Ito M, Saito S, Ohta K, et al.
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Journal Title
Cytokine
Volume: 60
Issue: 3
Pages: 694-700
DOI
Related Report
Peer Reviewed
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[Journal Article] Yachie Molecular and immunohistochemica l detection of rotavirus in urinary sediment cells of children with ro tavirus gastroenteritis2011
Author(s)
Yokoyama T, Sugimoto N, Taniguchi K, Komoto S, Yuno T, Ohta K, Hashimot o H, Seno A, Ashida A, Fujieda M, N ishio S, Ueno K, Shimizu M
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Journal Title
Clin Micro biol Infect
Volume: 17
Issue: 8
Pages: 1190-1193
DOI
Related Report
Peer Reviewed
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[Presentation] Normal Values for Pediatric Urinary Biochemistry2013
Author(s)
Ohta K, Fujiki T, Ymamiya M, Inoue N, Senda Y, Sakazume S, Ueno K, Yokoyama T, Shimizu M, Yachie A
Organizer
The 16th Congress of the International Pediatric Nephrology Association
Place of Presentation
Shanghai, China
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