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The effect of diffuse chorioamniotic hemosiderosis on fetal lung development

Research Project

Project/Area Number 23591593
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Embryonic/Neonatal medicine
Research InstitutionTohoku University

Principal Investigator

WATANABE Tatsuya  東北大学, 医学(系)研究科(研究院), 非常勤講師 (70400380)

Co-Investigator(Kenkyū-buntansha) MATSUDA Tadashi  東北大学, 大学病院, 准教授 (50361100)
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsびまん性絨毛膜羊膜ヘモジデローシス / 新生児慢性肺疾患 / 胎児肺発育 / 鉄
Outline of Final Research Achievements

We studied the effect of diffuse chorioamniotic hemosiderosis (DCH) on fetal lung development using an experimental DCH model in the second trimester of pregnant rats. At first, we established the animal experimental model of DCH, infused iron dextran into the amniotic cavity of pregnant rats. Next, we confirmed that intra-amniotic iron exposure could induce emphysematous injuries in fetal lung, i.e., arrest of alveolarization, which changes had remain until the adult period.Based on the above results, DCH would be important as a risk factor for serious chronic lung disease and expected further researches for clarifying its pathophysiology and preventive measures.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (11 results)

All 2014 2013 2012 2011 Other

All Journal Article (6 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (4 results) Book (1 results)

  • [Journal Article] Cerebral Ischemia or Intrauterine Inflammation Promotes Differentiation of Oligodendroglial Precursors in Preterm Ovine Fetuses: Possible Cellular Basis for White Matter Injury2014

    • Author(s)
      Kitanishi R, Matsuda T, Watanabe S, Saito M, Hanita T, Watanabe T, Kobayashi Y.
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 234 Issue: 4 Pages: 299-307

    • DOI

      10.1620/tjem.234.299

    • NAID

      130004704767

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Renal Vasodilatory Action of Arginine Vasopressin in Extremely Low Birth Weight Infants2013

    • Author(s)
      Kaga M, Matsuda T, Watanabe T, Onodera S, Watanabe S, Usuda H, Ito S.
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 231 Issue: 3 Pages: 159-164

    • DOI

      10.1620/tjem.231.159

    • NAID

      130004460091

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 内分泌機能に大きく依存する新生児の循環調節 バゾプレッシンの循環器系に及ぼす影響2013

    • Author(s)
      松田直、加賀麻衣子、臼田治夫、伊藤智子、渡邊真平、小野寺幸子、新関昌枝、秋山志津子、北西隆太、渡邉達也
    • Journal Title

      日本周産期・新生児医学会雑誌

      Volume: 49 Pages: 165-167

    • Related Report
      2013 Research-status Report
  • [Journal Article] 臍動・静脈カテーテル留置2012

    • Author(s)
      渡辺達也
    • Journal Title

      周産期医学

      Volume: 42 Pages: 1549-1552

    • Related Report
      2012 Research-status Report
  • [Journal Article] 臍帯炎2011

    • Author(s)
      加賀麻衣子、松田直、渡邉達也、小野寺幸子、渡邊真平、臼田治夫、八重樫伸生.
    • Journal Title

      産科と婦人科

      Volume: 78 Pages: 720-726

    • Related Report
      2011 Research-status Report
  • [Journal Article] 胎児期に心房粗動と診断され早期娩出した低出生体重児の1例2011

    • Author(s)
      新田恩、松田直、井上若葉、荒井那津子、渡邊真平、秋山志津子、北西龍太、渡邉達也、田澤星一、柿崎周平.
    • Journal Title

      周産期医学

      Volume: 41 Pages: 1222-1225

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 生育限界児の就学前における発達予後の特徴2014

    • Author(s)
      渡邉達也、松田直、高橋立子、山田雅明、齊藤潤子、奈良千恵子、上埜高志
    • Organizer
      第59回日本未熟児新生児学会
    • Place of Presentation
      ひめぎんホール(愛媛)
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] ラット羊水内に鉄を投与することにより胎仔肺発育が遅延する2013

    • Author(s)
      渡辺達也、松田直、名和達郎、小野寿和、臼田治夫、新関昌枝、秋山志津子、北西龍太、埴田卓志
    • Organizer
      第58回日本未熟児新生児学会
    • Place of Presentation
      石川
    • Related Report
      2013 Research-status Report
  • [Presentation] Induction of an arrest of alveolarization by intra-amniotic iron exposure in fetal rat.2012

    • Author(s)
      Watanabe T, Matsuda T, Hanita T, Miura Y, Kitanishi R, Kure S.
    • Organizer
      FAOPS and PSANZ Sydney 2012
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2011 Research-status Report
  • [Presentation] モバイルアンサーシンポジウム2 「超低出生体重児の治療選択」 新生児慢性肺疾患

    • Author(s)
      渡邉達也
    • Organizer
      第47回日本周産期・新生児医学会
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Book] 今日の治療指針2011版 新生児の慢性肺疾患2011

    • Author(s)
      渡邉達也 他
    • Publisher
      医学書院
    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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