| Project/Area Number |
23591598
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Osamu 大分大学, 医学部, 講師 (40284799)
ISHIKAWA Kazushi 大分大学, 医学部, 助教 (80600452)
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| Co-Investigator(Renkei-kenkyūsha) |
CHIBA Seiichi 大分大学, 医学部, 助教 (20457633)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | 新生児皮下脂肪壊死症 / 褐色脂肪組織 / ミトコンドリア / UCP-1 / アポトーシス / FDG-PET |
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| Research Abstract |
Subcutaneous fat necrosis (SCFN) of the newborn is a rare condition that is manifest within days of birth. The interscapular region, axillae and shoulders are the most commonly affected sites, corresponding to anatomic sites of brown fat tissue (BAT) in newborns. We postulated the specific involvement of BAT in SCFN and searched for brown adipocytes at affected sites. Biopsy specimens were immunostained with antibodies against uncoupling protein 1 (UCP-1) and examined by electron microscopy. We also examined BAT by 18F-fluorodeoxyglucose (18F-FDG) positron-emission tomographic and computed tomographic (PET-CT) scanning. A few cells in biopsy specimens from two patients bound antibodies against UCP-1, and brown adipocytes were detected at several stages of degeneration. PET-CT scans revealed lower uptake of 18F-FDG at major sites of SCFN. SCFN and BAT can be found in the same sites, suggesting a pathophysiological connection.
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