Effects of probiotics on expression of short chain fatty acid receptors in low birth weight infants.
| Project/Area Number |
23591601
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHTSUKA Yoshikazu 順天堂大学, 医学部, 准教授 (90338335)
SHOJI Hiromichi 順天堂大学, 医学部, 准教授 (30365621)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 低出生体重児 / プロバイオティクス / 短鎖脂肪酸 / バリヤー機能 / マイクロアレイ / Bifidobacterium / IgA |
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| Research Abstract |
To study the efficacy and safety of Bifidobacterium breve (B.breve) on low birth weight infant in NICU we examined the optimum way of B.breve administration. 10 extended 9 CFU of B.breve dissolved 4ml of distilled water should be ingested at once during stable period. Early administration of B. breve indicated that the microbiota could colonize in the later life of infants.
After B.breve administration, significant increases in the numbers of Bifidobacterium in both the cecum and colon were confirmed during the newborn period. The expression of inflammation-related genes, including glutathione peroxidase 2 was significantly reduced in the colon during the newborn period. On the other hand expression of CXCL13 and IgA production in the colonic mucosa was significantly increased.
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Report
(4 results)
Research Products
(56 results)
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[Journal Article] Albumin concentration determined by the modified bromocresol purple method is superior to that by the bromocresol green method for assessing nutritional status in malnourished patients with inflammation.2013
Author(s)
Ueno T, Hirayama S, Ito M, Nishioka E, Fukushima Y, Satoh T, Idei M, Horiuchi Y, Shoji H, Ohmura H, Shimizu T, Miida T.
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Journal Title
Ann Clin Biochem
Volume: 50
Pages: 576-584
Related Report
Peer Reviewed
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