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Comparison of the relationship between cerebral and systemic perfusion in newborn infants - investigation of cerebral auto-regulation -

Research Project

Project/Area Number 23591604
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Embryonic/Neonatal medicine
Research InstitutionTokyo Medical University

Principal Investigator

TAKAMI Takeshi  東京医科大学, 医学部, 兼任講師 (20287147)

Co-Investigator(Kenkyū-buntansha) FUJIOKA Tao  東京医科大学, 医学部, 臨床研究医 (30421043)
ISHII Hiroki  東京医科大学, 医学部, 助教 (60449171)
NARA Shonosuke  東京医科大学, 医学部, 助教 (70459569)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords新生児 / 近赤外線時間分解分光法(TRS法) / 脳血液量(CBV) / 脳組織Hb酸素飽和度(cSO2) / 心エコー / 脳自動調節能 / 超低出生体重児(ELBW) / 新生児仮死 / NIRS / 脳循環 / 脳血液量
Research Abstract

NIR-TRS system may contributed to the pathophysiological background knowledge of cerebral oxygenation, perfusion, and metabolism, including the time course changes in both term and preterm infants, chronological changes in preterm infants, differences between AGA and SGA infants, the effects in cases of significant PDA, and the evaluation in extremely low birth weight infants.
The evaluation of NIRS parameters may help clinicians in identifying newborn infants at risk, and prevent brain injury.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (58 results)

All 2014 2013 2012 2011 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (46 results) (of which Invited: 2 results) Book (2 results)

  • [Journal Article] Comparison of changes in cerebral and systemic perfusion between appropriate- and small-for-gestational-age infants during the first three days after birth2014

    • Author(s)
      Ishii H, Takami T, Fujioka T, et al
    • Journal Title

      Brain & Development

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Difference in Cerebral and Peripheral Hemodynamics among Term and Preterm Infants during the First 3 Days of Life2014

    • Author(s)
      Fujioka T, Takami T, Ishii H, et al
    • Journal Title

      Neonatology

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chronological changes in cerebral perfusion and oxygenation parameters in preterm neonates measured using a portable near-infrared time-resolved spectroscopy system2014

    • Author(s)
      Nara S, Takami T, Ishii H, et al
    • Journal Title

      The Journal of Tokyo Medical University

      Volume: 72 (in press)

    • NAID

      120005494780

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of changes in cerebral and systemic perfusion between appropriate- and small-for-gestational-age infants during the first three days after birth2014

    • Author(s)
      Hiroki Ishii
    • Journal Title

      Brain & Development

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Difference in cerebral and peripheral hemodynamics among term and preterm infants during the first 3 days of life2014

    • Author(s)
      Tao Fujioka
    • Journal Title

      Neonatology

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronological changes in cerebral perfusion and oxygenation parameters in preterm neonates measured using a portable near-infrared time-resolved spectroscopy system2014

    • Author(s)
      Shonosuke Nara
    • Journal Title

      The Journal of Tokyo Medical University

      Volume: in press

    • NAID

      120005494780

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Umbilical cord milking stabilizes cerebral oxygenation and perfusion in infants born 29 weeks of gestation2012

    • Author(s)
      Takami T, Suganami Y, Sunohara D, Kondo A, Mizukaki N, Fujioka T, et al
    • Journal Title

      The Journal of Pediatrics

      Volume: 161 Pages: 742-7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of time-course changes in cerebral blood volume in preterm infants during the first 3 days of lefe using a portable near-infrared time-resolved spectroscopy system2012

    • Author(s)
      Fujioka T, Takami T, Ishii H, et al
    • Journal Title

      The Journal of Tokyo Medical University

      Volume: 70(1) Pages: 26-33

    • URL

      http://mol.medicalonline.jp/archive/search?jo=cr4tokyo&ye=2012&vo=70&issue=1

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Umbilical cord milking stabilizes cerebral oxygenation and perfusion in infants born 29 weeks of gestation2012

    • Author(s)
      Takami T, Suganami Y, Sunohara D, Kondo A, Mizukaki N, Fujioka T, Hoshika A, Akutagawa O, Isaka K
    • Journal Title

      The Journal of Pediatrics

      Volume: 161 Pages: 742-747

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Assessment of time-course changes in cerebral blood volume in preterm infants during the first 3 days of lefe using a portable near-infrared time-resolved spectroscopy system2012

    • Author(s)
      Fujioka T, Takami T, Ishii H, Suganami Y, Mizukaki N, Kondo A, Sunohara D, Hoshika A
    • Journal Title

      The Journal of Tokyo Medical University

      Volume: 70 Pages: 26-33

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 低体温療法を施行した新生児仮死における近赤外線時間分解分光法による脳循環評価2014

    • Author(s)
      廣瀬あかね,近藤敦,高見剛,奈良昇乃助,石井宏樹,他
    • Organizer
      第12回日本周産期循環管理研究会
    • Place of Presentation
      高知
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 近赤外線時間分解分光法による脳循環代謝評価-興味深い経過を示した新生児仮死1例と重症貧血の1例-2014

    • Author(s)
      近藤敦,廣瀬あかね,高見剛,奈良昇乃助,石井宏樹,他
    • Organizer
      第12回日本周産期循環管理研究会
    • Place of Presentation
      高知
    • Related Report
      2013 Final Research Report
  • [Presentation] 近赤外線時間分解分光法による脳循環代謝評価 -興味深い経過を示した新生児仮死1例と重度貧血の1例-2014

    • Author(s)
      近藤 敦
    • Organizer
      第12回日本周産期循環管理研究会
    • Place of Presentation
      高知
    • Related Report
      2013 Annual Research Report
  • [Presentation] 修正37週以降の新生児におけるHb値による脳循環と体循環への影響2014

    • Author(s)
      藤岡泰生
    • Organizer
      第50回日本周産期新生児医学会
    • Place of Presentation
      浦安
    • Related Report
      2013 Annual Research Report
  • [Presentation] 急性期脳循環評価を行った低酸素虚血性脳症を認めた新生児仮死2例2013

    • Author(s)
      廣瀬あかね,高見剛,奈良昇乃助,石井宏樹,他
    • Organizer
      第172回東京医科大学医学会
    • Place of Presentation
      東京
    • Year and Date
      2013-11-02
    • Related Report
      2013 Final Research Report
  • [Presentation] 近赤外線時間分解分光法(NIRS‐TRS法)のNICUにおけるベッドサイドモニターとしての有用性2013

    • Author(s)
      奈良昇乃助,高見剛,石井宏樹,藤岡泰生,他
    • Organizer
      第171回東京医科大学医学会総会
    • Place of Presentation
      東京
    • Year and Date
      2013-06-01
    • Related Report
      2013 Final Research Report
  • [Presentation] Chronological changes in the parameters of cerebral perfusion and oxygenation in preterm infants2013

    • Author(s)
      Nara S, Takami T, Fujioka T, et al
    • Organizer
      International Congress of Pediatrics 2013
    • Place of Presentation
      Melbourne, Australia
    • Related Report
      2013 Final Research Report
  • [Presentation] AGA児とSGA児における近赤外線時間分解分光法を用いた光散乱係数の比較2013

    • Author(s)
      奈良昇乃助,高見剛,石井宏樹,藤岡泰生,他
    • Organizer
      第49回日本周産期・新生児学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 超低出生体重児における脳循環代謝指標と短期予後の検討2013

    • Author(s)
      奈良昇乃助,高見剛,石井宏樹,藤岡泰生,他
    • Organizer
      第116回日本小児科学会
    • Place of Presentation
      広島
    • Related Report
      2013 Final Research Report
  • [Presentation] 急速輸液を行ったHb2g/dlの母子間輸血症候群の脳循環代謝評価2013

    • Author(s)
      近藤敦,高見剛,廣瀬あかね,奈良昇乃助,石井宏樹,他.
    • Organizer
      第49回日本周産期・新生児医学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 新生児仮死における近赤外線時間分解分光法による脳循環評価の有用性2013

    • Author(s)
      廣瀬あかね,高見剛,奈良昇乃助,石井宏樹,他
    • Organizer
      第58回日本未熟児新生児学会
    • Place of Presentation
      金沢
    • Related Report
      2013 Final Research Report
  • [Presentation] 新生児仮死における急性期脳循環指標2013

    • Author(s)
      廣瀬あかね,高見剛,奈良昇乃助,石井宏樹,他
    • Organizer
      第11回日本周産期循環管理研究会
    • Place of Presentation
      高槻
    • Related Report
      2013 Final Research Report
  • [Presentation] 超低出生体重児における脳循環代謝指標と短期予後の検討2013

    • Author(s)
      奈良昇乃助
    • Organizer
      第166回日本小児科学会
    • Place of Presentation
      広島
    • Related Report
      2013 Annual Research Report
  • [Presentation] AGA児とSGA児における近赤外線時間分解分光法を用いた光散乱係数の比較2013

    • Author(s)
      奈良昇乃助
    • Organizer
      第49回日本周産期新生児医学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 近赤外線時間分解分光法(NIRS-TRS法)のNICUにおけるベッドサイドモニターとしての有用性2013

    • Author(s)
      奈良昇乃助
    • Organizer
      東京医科大学医学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Chronological changes in the parameters of cerebral perfusion and oxygenation in preterm infants2013

    • Author(s)
      Shonosuke Nara
    • Organizer
      International congress of Pediatrics 2013
    • Place of Presentation
      Melbourne, Australia
    • Related Report
      2013 Annual Research Report
  • [Presentation] 新生児仮死における近赤外線時間分解分光法による脳循環評価の有用性2013

    • Author(s)
      廣瀬あかね
    • Organizer
      第49回日本周産期新生児医学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 急速輸液を行ったHb 2g/dlの母児間輸血症候群の脳循環代謝評価2013

    • Author(s)
      近藤 敦
    • Organizer
      第49回日本周産期新生児医学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] シンポジウム「NIRS臨床応用のup-to-date」新生児領域での臨床応用2012

    • Author(s)
      高見剛
    • Organizer
      第19回医用近赤外線分光法研究会
    • Place of Presentation
      東京
    • Year and Date
      2012-10-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of patent ductus arteriosus on cerebral and systemic perfusion in very low-birth-weight infants : Evaluation of changes pre/post indomethacin therapy2012

    • Author(s)
      Takami T, Fujioka T, Ishii H, et al
    • Organizer
      17th Congress of the FAOPS and the 16th Annual Congress of the PSANZ
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of patent ductus arteriosus on cerebral oxygenation and blood volume in very low birth weight infants2012

    • Author(s)
      Takami T, Ishii H, Fujioka T
    • Organizer
      26th Annual Meeting of FNWANZ
    • Place of Presentation
      NSW, Australia
    • Related Report
      2013 Final Research Report
  • [Presentation] Changes in cerebral and peripheral perfusion and cardiac function among appropriate and small for gestational age infants during the first 3 days after birth2012

    • Author(s)
      Ishii H, Takami T, Fujioka T, et al
    • Organizer
      17th Congress of the FAOPS and the 16th Annual Congress of the PSANZ
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2013 Final Research Report
  • [Presentation] 動脈管開存が脳循環と体循環に及ぼす影響-インドメサシン治療前後での検討-2012

    • Author(s)
      高見剛,藤岡泰生,石井宏樹,他
    • Organizer
      第115回日本小児科学会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] OB's Lecture「新生児の脳循環-NIRSによる評価」2012

    • Author(s)
      高見剛
    • Organizer
      第22回心研小児科夏季セミナー
    • Place of Presentation
      東京女子医大
    • Related Report
      2013 Final Research Report
  • [Presentation] 脳循環と体循環の急性期経時的評価-低血圧回復後に脳室内出血を認めた超早産児2例の検討-2012

    • Author(s)
      春原大介,高見剛,藤岡泰生,石井宏樹,他
    • Organizer
      第10回日本周産期循環管理研究会
    • Place of Presentation
      静岡
    • Related Report
      2013 Final Research Report
  • [Presentation] ワークショップ「個々の臓器循環に着目した循環管理」脳循環と体循環の急性期経時的評価-低血圧と脳循環および臨床所見との関連2012

    • Author(s)
      春原大介,高見剛,石井宏樹,藤岡泰生,他
    • Organizer
      第48回日本周産期・新生児学会
    • Place of Presentation
      大宮
    • Related Report
      2013 Final Research Report
  • [Presentation] 呼吸循環動態の安定した新生児における脳循環指標比較検討2012

    • Author(s)
      藤岡泰生,高見剛,石井宏樹,奈良昇乃助,他
    • Organizer
      第57回日本未熟児新生児学会
    • Place of Presentation
      熊本
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 早産児における脳循環代謝指標の出生後変化の検討2012

    • Author(s)
      奈良昇乃助,高見剛,石井宏樹,藤岡泰生,他
    • Organizer
      第57回日本未熟児新生児学会
    • Place of Presentation
      熊本
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 脳循環と体循環の急性期経時的評価-極低出生体重児の比較検討-2012

    • Author(s)
      志村優,高見剛,石井宏樹,藤岡泰生,奈良昇乃助,他
    • Organizer
      第57回日本未熟児新生児学会
    • Place of Presentation
      熊本
    • Related Report
      2013 Final Research Report
  • [Presentation] 動脈管開存が脳循環と体循環に及ぼす影響-インドメサシン治療前後での検討-2012

    • Author(s)
      高見 剛、他
    • Organizer
      第115回日本小児科学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] OB's Lecture 「新生児の脳循環-NIRSによる評価」2012

    • Author(s)
      高見 剛
    • Organizer
      第22回心研小児科夏季セミナー
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 脳循環と体循環の急性期経時的評価-極低出生体重児の比較検討-2012

    • Author(s)
      志村 優、高見 剛、他
    • Organizer
      第57回日本未熟児新生児学会
    • Place of Presentation
      熊本
    • Related Report
      2012 Research-status Report
  • [Presentation] 脳循環と体循環の急性期経時的評価-低血圧回復後に脳室内出血を認めた超早産児2例の検討-2012

    • Author(s)
      春原大介、高見 剛、他
    • Organizer
      第10回日本周産期循環管理研究会
    • Place of Presentation
      静岡
    • Related Report
      2012 Research-status Report
  • [Presentation] ワークショップ「個々の臓器循環に着目した循環管理」脳循環と体循環の急性期経時的評価-低血圧と脳循環および臨床所見との関連2012

    • Author(s)
      春原大介、高見 剛、他
    • Organizer
      第48回日本周産期・新生児学会
    • Place of Presentation
      大宮
    • Related Report
      2012 Research-status Report
  • [Presentation] Comparison of the time course changes in cerebral blood volume among different birth weight groups of neonates during the first 3 days of life2011

    • Author(s)
      Fujioka T, Takami T, Ishii H, et al
    • Organizer
      52nd Annual Meeting of the ESPR
    • Place of Presentation
      Newcastle, UK
    • Related Report
      2013 Final Research Report
  • [Presentation] 急性期の動脈管開存が脳循環と体循環に及ぼす影響-インドメサシン治療前後での検討-2011

    • Author(s)
      高見剛,藤岡泰生,石井宏樹,奈良昇乃助,他
    • Organizer
      第9回日本周産期循環管理研究会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] 脳循環と体循環の急性期経時的評価-出生体重別の心機能評価とCBVとの検討-2011

    • Author(s)
      藤岡泰生,高見剛,石井宏樹,他
    • Organizer
      第56回日本未熟児新生児学会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 脳循環と体循環の急性期経時的評価-AGA児とSGA児での組織血液量の比較-2011

    • Author(s)
      石井宏樹,高見剛,藤岡泰生,菅波佑介,奈良昇乃助,他
    • Organizer
      第47回日本周産期・新生児学会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] 脳循環と体循環の急性期経時的評価-AGA児とSGA児での心機能評価とCBVの検討2011

    • Author(s)
      石井宏樹,高見剛,藤岡泰生,菅波佑介,奈良昇乃助,他
    • Organizer
      第56回日本未熟児新生児学会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 生後3日以内の異なった在胎週数による脳血液量の変化2011

    • Author(s)
      藤岡泰生
    • Organizer
      第52回欧州小児科学会(ESPR)
    • Place of Presentation
      Newcastle, UK
    • Related Report
      2011 Research-status Report
  • [Presentation] 脳循環と末梢循環の急性期経時的評価-正期産児と早産児での組織血液量の比較-2011

    • Author(s)
      藤岡泰生
    • Organizer
      第47回日本周産期新生児医学会
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Presentation] 脳循環と体循環の急性期経時的評価-出生体重別の心機能評価とCBVとの検討-2011

    • Author(s)
      藤岡泰生
    • Organizer
      第56回日本未熟児新生児学会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 脳循環と体循環の急性期経時的評価-AGA児とSGA児での組織血液量の比較-2011

    • Author(s)
      石井宏樹
    • Organizer
      第47回日本周産期新生児医学会
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Presentation] 脳循環と体循環の急性期経時的評価-AGA児とSGA児での心機能評価とCBVの検討2011

    • Author(s)
      石井宏樹
    • Organizer
      第56回日本未熟児新生児学会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 急性期の動脈管開存が脳循環と体循環に及ぼす影響-インドメサシン治療前後での検討-2011

    • Author(s)
      高見 剛
    • Organizer
      第9回日本周産期循環管理研究会
    • Place of Presentation
      仙台
    • Related Report
      2011 Research-status Report
  • [Presentation] シンポジウム「NIRS臨床応用のup-to-date」新生児領域での臨床応用

    • Author(s)
      高見 剛
    • Organizer
      第19回医用近赤外線分光法研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] Applicability of near-infrared spectroscopy (NIRS) in clinical neonatology. In : Infrared spectroscopy : Theory, developments and applications2014

    • Author(s)
      Takami T
    • Publisher
      NOVA SCIENCE PUBLISHERS, INC
    • Related Report
      2013 Final Research Report
  • [Book] Infrared Spectroscopy; Theory, Developments and Applications2013

    • Author(s)
      Takeshi Takami
    • Total Pages
      557
    • Publisher
      NOVA publishers, New York
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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