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Development of new anticancer therapy utilizing the innate immunity

Research Project

Project/Area Number 23591611
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dermatology
Research InstitutionHirosaki University

Principal Investigator

MATSUZAKI YASUSHI  弘前大学, 医学部附属病院, 講師 (50322946)

Co-Investigator(Kenkyū-buntansha) SAWAMURA Daisuke  弘前大学, 大学院医学研究科, 教授 (60196334)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsメラノーマ / RIG-I / 1メラノーマ
Research Abstract

I confirmed that cultured melanoma cells expressed RIG-I protein by IFN-beta stimulation. Moreover, proliferation activities of melanoma cells were suppressed by IFN-beta. Poly-(I:C), known as synthetic analog of double-stranded RNA, has no effect on the induction of RIG-I expression in the human melanoma cells.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (35 results)

All 2013 2012 2011

All Journal Article (20 results) (of which Peer Reviewed: 20 results) Presentation (15 results)

  • [Journal Article] Mutational analysis on 16 Japanese population cases with epidermolysis bullosasimplex2013

    • Author(s)
      Minakawa S, Nakano H, Nakajima K, Matsuzaki Y, Takiyoshi N, Akasaka E, Rokunohe D, Sawamura D
    • Journal Title

      J Dermatol Sci

      Volume: 72(3) Issue: 3 Pages: 330-332

    • DOI

      10.1016/j.jdermsci.2013.08.001

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Signet-ring cutaneous squamous cell carcinoma arising on the back of thefinger2013

    • Author(s)
      Nakajima K, Kaneko T, Aizu T, Nakano H, Matsuzaki Y, Sawamura D
    • Journal Title

      Case Rep Dermatol

      Volume: 5(2) Issue: 2 Pages: 215-218

    • DOI

      10.1159/000354536

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deep pseudocystic dermatophytosis caused by Trichophyton rubrum in a patient withmyastheniagravis2013

    • Author(s)
      Matsuzaki Y, Ota K, Sato K, Nara S, Yagushi T, Nakano H, Sawamura D
    • Journal Title

      Acta Derm Venereol

      Volume: 93(3) Issue: 3 Pages: 358-9

    • DOI

      10.2340/00015555-1452

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of stimulator of interferon genes (STING) expression in human epidermal keratinocytes2013

    • Author(s)
      Nishikawa Y, Matsuzaki Y, et al.
    • Journal Title

      Hirosaki Med J

      Volume: 64

    • NAID

      110009616075

    • URL

      http://hdl.handle.net/10129/4867

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of stimulator of interferon genes (STING) expression in human epidermal keratinocytes2013

    • Author(s)
      Nishikawa Y, Matsuzaki Y, Nakano H, Sawamura D
    • Journal Title

      Hirosaki Med J

      Volume: 64

    • NAID

      110009616075

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acantholysis caused repeated hemorrhagic bullae in a case of acantholytic acanthoma.2012

    • Author(s)
      Minakawa S, Matsuzaki Y, Nakano H, Sawamura D, Elenitsas R.
    • Journal Title

      J Dermatol.

      Volume: 39 Issue: 12 Pages: 1107-1108

    • DOI

      10.1111/j.1346-8138.2012.01564.x

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Spindle cell hemangioma and decorin expression.2012

    • Author(s)
      Daiki Rokunohe
    • Journal Title

      Journal of Cosmetics, Dermatological Sciences and Applications

      Volume: 2 Issue: 01 Pages: 8-10

    • DOI

      10.4236/jcdsa.2012.21002

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multiple aplasia cutis congenita lesions located along Blaschko's lines in a patient with tetralogy of Fallot-A.2012

    • Author(s)
      Rokunohe D
    • Journal Title

      J Dermatol Case Rep

      Volume: 6 Issue: 2 Pages: 40-42

    • DOI

      10.3315/jdcr.2012.1096

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sawamura D. : Characterization of retinoic acid-inducible gene-I (RIG-I) expression corresponding to viral infection and UVB in human keratinocytes2012

    • Author(s)
      Kimura K, Matsuzaki Y, Nishikawa Y, Kitamura H, Akasaka E, Rokunohe D, Nakano H, Imaizumi T, Satoh K
    • Journal Title

      J Dermatol Sci 2012

      Volume: 66(1) Issue: 1 Pages: 66-70

    • DOI

      10.1016/j.jdermsci.2012.02.006

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Late-onset, Eruptive Syringoma in an Elderly Man : Correlation with Carbamazepine2012

    • Author(s)
      Korekawa, Matsuzaki Y, et al.
    • Journal Title

      Acta Derm Venereol

      Volume: 92 Issue: 1 Pages: 87-88

    • DOI

      10.2340/00015555-1156

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 各種皮膚感染症に対するナジフロキサシン軟膏1%の治療効果2012

    • Author(s)
      澤村大輔、松崎康司、他
    • Journal Title

      臨床医薬

      Volume: 第28巻第5号 Pages: 419-425

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 各種皮膚感染症に対するナジフロキサシン軟膏1%の治療効果2012

    • Author(s)
      澤村大輔、松﨑康司、六戸亜希子、金子高英、皆川智子、中野 創、野口雅久、中南秀将、内田博子
    • Journal Title

      臨床医薬

      Volume: 28 Pages: 419-425

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characterization of retinoic acid-inducible  gene-I (RIG-I) expression corresponding to viral infection and UVB in human2012

    • Author(s)
      Kimura K, Matsuzaki Y, Nishikawa Y, Kitamura H, Akasaka E, Rokunohe D, Nakano
    • Journal Title

      J Dermatol Sci

      Volume: 66 Pages: 64-70

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Normolipidaemic xanthomatosis with systemic involvement of the skin, bone and pharynx2011

    • Author(s)
      Akasaka E
    • Journal Title

      Clin Exp Dermatol

      Volume: 37 Issue: 3 Pages: 305-307

    • DOI

      10.1111/j.1365-2230.2011.04187.x

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Diffuse and focal palmoplantar keratoderma can be caused by a keratin 6c mutation2011

    • Author(s)
      Akasaka E, Nakano H, Nakano A, Toyomaki Y, Takiyoshi N, Rokunohe D, Nishikawa Y, Korekawa A, Matsuzaki Y, Mitsuhashi Y, Sawamura D
    • Journal Title

      Br J Dermatol

      Volume: 165(6) Issue: 6 Pages: 1290-1292

    • DOI

      10.1111/j.1365-2133.2011.10552.x

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Follicular mucinosis associated with radiation therapy2011

    • Author(s)
      Takeda H
    • Journal Title

      J Dermatol

      Volume: 38 Issue: 11 Pages: 1116-1118

    • DOI

      10.1111/j.1346-8138.2010.01187.x

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Actinic granuloma associated with erythema nodosum2011

    • Author(s)
      Matsuzaki Y, et al.
    • Journal Title

      Eur J Dermatol

      Volume: 21 Issue: 5 Pages: 806-807

    • DOI

      10.1684/ejd.2011.1480

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical analysis of in vivo UVB-induced secretion of IL-1αand IL-6 in keratinocytes2011

    • Author(s)
      Hiromi N, Matsuzaki Y, et al.
    • Journal Title

      Mol Med Report

      Volume: 4 Pages: 611-614

    • DOI

      10.3892/mmr.2011.478

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Garlic-induced irritant contact dermatitis mimicking nail psoriasis2011

    • Author(s)
      Takeuchi S, Matsuzaki Y, et al.
    • Journal Title

      J Dermatol

      Volume: 38 Issue: 3 Pages: 280-282

    • DOI

      10.1111/j.1346-8138.2010.00940.x

    • NAID

      10029330800

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Late-onset, Eruptive Syringoma in an Elderly Man: Correlation with Carbamazepine2011

    • Author(s)
      Korekawa A, Nakajima K, Nishikawa Y, Matsuzaki Y, Nakano H, Sawamura D
    • Journal Title

      Acta Derm Venereol

      Volume: 92 Pages: 87-88

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 円形脱毛症に対するステロイド中用量間欠内服療法2013

    • Author(s)
      神可代、会津隆幸、松﨑康司、中野創、澤村大輔
    • Organizer
      日本皮膚科学会青森地方会第362回例会
    • Place of Presentation
      弘前市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Facial porokeratosisの1例2013

    • Author(s)
      滝吉典子、竹内園子、金子高英、松﨑康司、中野創、澤村大輔
    • Organizer
      第112回日本皮膚科学会総会
    • Place of Presentation
      横浜市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 家族性良性慢性天疱瘡の1例2013

    • Author(s)
      皆川智子、松﨑康司、金子高英、中野創、澤村大輔、三橋善比古
    • Organizer
      第40回皮膚かたち研究会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Stevens - Johnson syndrome associated with TS-12013

    • Author(s)
      Satoko MINAKAWA, Yasushi MATSUZAKI, Koji NAKAJIMA, Hajime Nakano, Daisuke SAWAMURA
    • Organizer
      71st Annual Meeting of the American Academy of Dermatology
    • Place of Presentation
      Miami (アメリカ)
    • Related Report
      2012 Research-status Report
  • [Presentation] Trichophyton rubrumによる嚢腫様深在性白癬の1例2012

    • Author(s)
      松﨑康司、矢口貴志、中野創、澤村大輔
    • Organizer
      第111回日本皮膚科学会総会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒトメラノーマ細胞におけるRETINOIC ACID-INDUCIBLE GENE-I発現との関連と細胞増殖2012

    • Author(s)
      松﨑康司、西川陽平、木村一之、北村英夫、中野創、今泉忠淳、佐藤敬、澤村大輔
    • Organizer
      第19回分子皮膚科学フォーラム
    • Place of Presentation
      青森
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒトメラノーマ細胞におけるRETINOIC ACID-INDUCIBLE GENE-I発現との関連と細胞増殖2012

    • Author(s)
      松﨑康司、西川陽平、木村一之、北村英夫、中野 創、今泉忠淳、佐藤 敬、澤村大輔
    • Organizer
      第19回分子皮膚科学フォーラム
    • Place of Presentation
      青森市
    • Related Report
      2012 Research-status Report
  • [Presentation] Trichophyton rubrumによる嚢腫様深在性白癬の1例2012

    • Author(s)
      松﨑康司、矢口貴志、中野 創、澤村大輔
    • Organizer
      第111回日本皮膚科学会総会
    • Place of Presentation
      京都市
    • Related Report
      2012 Research-status Report
  • [Presentation] 臨床的に隆起性皮膚線維肉腫などの間葉系腫瘍との鑑別を要した石灰化上皮腫の1例2012

    • Author(s)
      是川あゆ美、金子高英、松﨑康司、赤坂英二郎、中野 創、澤村大輔、中野あおい
    • Organizer
      日本皮膚科学会青森地方会第358回例会
    • Place of Presentation
      弘前市
    • Related Report
      2012 Research-status Report
  • [Presentation] 高Ca血症を合併したアポクリン腺癌の多発骨転移の1例2012

    • Author(s)
      中島康爾、福井智久、西川陽平、金子高英、松﨑康司、中野 創、澤村大輔、小原 理
    • Organizer
      日本皮膚科学会青森地方会第358回例会
    • Place of Presentation
      弘前市
    • Related Report
      2012 Research-status Report
  • [Presentation] 前胸部皮下に生じた皮膚腺病の1例2012

    • Author(s)
      萩原千尋、皆川智子、金子高英、松﨑康司、中野 創、澤村大輔、林 彰仁、久保田 滋
    • Organizer
      日本皮膚科学会青森地方会第358回例会
    • Place of Presentation
      弘前市
    • Related Report
      2012 Research-status Report
  • [Presentation] 棘細胞癌、Bowen、日光角化症を伴った眼皮膚白皮症の1例2012

    • Author(s)
      皆川智子、金子高英、松﨑康司、中野 創、澤村大輔、三上 誠、鈴木民夫、三橋善比古
    • Organizer
      第39回皮膚かたち研究学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Richner-Hanhart症候群;臨床症状と血中チロシン濃度との関係2012

    • Author(s)
      滝吉典子、福井智久、赤坂英二郎、松﨑康司、中野 創、澤村大輔
    • Organizer
      第27回角化症研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] ウステキヌマブで改善した乾癬の2例2012

    • Author(s)
      皆川智子、金子高英、松崎康司、中野 創、澤村大輔、木村淳也
    • Organizer
      日本皮膚科学会青森地方会第359回例会
    • Place of Presentation
      青森市
    • Related Report
      2012 Research-status Report
  • [Presentation] Characterization of stimulator of interferon genes (STING) expression in human epidermal keratinocytes2011

    • Author(s)
      Nishikawa Y, Matsuzaki Y, Nakano H, Sawamura D
    • Organizer
      41th Annual European Society for Dermatological Research meeting
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2013 Final Research Report 2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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