Development of new anticancer therapy utilizing the innate immunity

• Project/Area Number: 23591611
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Hirosaki University
• Principal Investigator: MATSUZAKI YASUSHI 弘前大学, 医学部附属病院, 講師 (50322946)
• Co-Investigator(Kenkyū-buntansha): SAWAMURA Daisuke 弘前大学, 大学院医学研究科, 教授 (60196334)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: メラノーマ / RIG-I / 1メラノーマ

Research Abstract

I confirmed that cultured melanoma cells expressed RIG-I protein by IFN-beta stimulation. Moreover, proliferation activities of melanoma cells were suppressed by IFN-beta. Poly-(I:C), known as synthetic analog of double-stranded RNA, has no effect on the induction of RIG-I expression in the human melanoma cells.

Research Products

• [Journal Article] Mutational analysis on 16 Japanese population cases with epidermolysis bullosasimplex (2013)
  • Author(s): Minakawa S, Nakano H, Nakajima K, Matsuzaki Y, Takiyoshi N, Akasaka E, Rokunohe D, Sawamura D
  • Journal Title: J Dermatol Sci Volume: 72(3) Issue: 3 Pages: 330-332
  • DOI: 10.1016/j.jdermsci.2013.08.001
  • Peer Reviewed
• [Journal Article] Signet-ring cutaneous squamous cell carcinoma arising on the back of thefinger (2013)
  • Author(s): Nakajima K, Kaneko T, Aizu T, Nakano H, Matsuzaki Y, Sawamura D
  • Journal Title: Case Rep Dermatol Volume: 5(2) Issue: 2 Pages: 215-218
  • DOI: 10.1159/000354536
  • Peer Reviewed
• [Journal Article] Deep pseudocystic dermatophytosis caused by Trichophyton rubrum in a patient withmyastheniagravis (2013)
  • Author(s): Matsuzaki Y, Ota K, Sato K, Nara S, Yagushi T, Nakano H, Sawamura D
  • Journal Title: Acta Derm Venereol Volume: 93(3) Issue: 3 Pages: 358-9
  • DOI: 10.2340/00015555-1452
  • Peer Reviewed
• [Journal Article] Characterization of stimulator of interferon genes (STING) expression in human epidermal keratinocytes (2013)
  • Author(s): Nishikawa Y, Matsuzaki Y, et al.
  • Journal Title: Hirosaki Med J Volume: 64
  • NAID: 110009616075
  • URL: http://hdl.handle.net/10129/4867
  • Peer Reviewed
• [Journal Article] Characterization of stimulator of interferon genes (STING) expression in human epidermal keratinocytes (2013)
  • Author(s): Nishikawa Y, Matsuzaki Y, Nakano H, Sawamura D
  • Journal Title: Hirosaki Med J Volume: 64
  • NAID: 110009616075
  • Peer Reviewed
• [Journal Article] Acantholysis caused repeated hemorrhagic bullae in a case of acantholytic acanthoma. (2012)
  • Author(s): Minakawa S, Matsuzaki Y, Nakano H, Sawamura D, Elenitsas R.
  • Journal Title: J Dermatol. Volume: 39 Issue: 12 Pages: 1107-1108
  • DOI: 10.1111/j.1346-8138.2012.01564.x
  • Peer Reviewed
• [Journal Article] Spindle cell hemangioma and decorin expression． (2012)
  • Author(s): Daiki Rokunohe
  • Journal Title: Journal of Cosmetics, Dermatological Sciences and Applications Volume: 2 Issue: 01 Pages: 8-10
  • DOI: 10.4236/jcdsa.2012.21002
  • Peer Reviewed
• [Journal Article] Multiple aplasia cutis congenita lesions located along Blaschko's lines in a patient with tetralogy of Fallot-A. (2012)
  • Author(s): Rokunohe D
  • Journal Title: J Dermatol Case Rep Volume: 6 Issue: 2 Pages: 40-42
  • DOI: 10.3315/jdcr.2012.1096
  • Peer Reviewed
• [Journal Article] Sawamura D. : Characterization of retinoic acid-inducible gene-I (RIG-I) expression corresponding to viral infection and UVB in human keratinocytes (2012)
  • Author(s): Kimura K, Matsuzaki Y, Nishikawa Y, Kitamura H, Akasaka E, Rokunohe D, Nakano H, Imaizumi T, Satoh K
  • Journal Title: J Dermatol Sci 2012 Volume: 66(1) Issue: 1 Pages: 66-70
  • DOI: 10.1016/j.jdermsci.2012.02.006
  • Peer Reviewed
• [Journal Article] Late-onset, Eruptive Syringoma in an Elderly Man : Correlation with Carbamazepine (2012)
  • Author(s): Korekawa, Matsuzaki Y, et al.
  • Journal Title: Acta Derm Venereol Volume: 92 Issue: 1 Pages: 87-88
  • DOI: 10.2340/00015555-1156
  • Peer Reviewed
• [Journal Article] 各種皮膚感染症に対するナジフロキサシン軟膏1%の治療効果 (2012)
  • Author(s): 澤村大輔、松崎康司、他
  • Journal Title: 臨床医薬 Volume: 第28巻第5号 Pages: 419-425
  • Peer Reviewed
• [Journal Article] 各種皮膚感染症に対するナジフロキサシン軟膏１%の治療効果 (2012)
  • Author(s): 澤村大輔、松﨑康司、六戸亜希子、金子高英、皆川智子、中野 創、野口雅久、中南秀将、内田博子
  • Journal Title: 臨床医薬 Volume: 28 Pages: 419-425
  • Peer Reviewed
• [Journal Article] Characterization of retinoic acid-inducible gene-I (RIG-I) expression corresponding to viral infection and UVB in human (2012)
  • Author(s): Kimura K, Matsuzaki Y, Nishikawa Y, Kitamura H, Akasaka E, Rokunohe D, Nakano
  • Journal Title: J Dermatol Sci Volume: 66 Pages: 64-70
  • Peer Reviewed
• [Journal Article] Normolipidaemic xanthomatosis with systemic involvement of the skin, bone and pharynx (2011)
  • Author(s): Akasaka E
  • Journal Title: Clin Exp Dermatol Volume: 37 Issue: 3 Pages: 305-307
  • DOI: 10.1111/j.1365-2230.2011.04187.x
  • Peer Reviewed
• [Journal Article] Diffuse and focal palmoplantar keratoderma can be caused by a keratin 6c mutation (2011)
  • Author(s): Akasaka E, Nakano H, Nakano A, Toyomaki Y, Takiyoshi N, Rokunohe D, Nishikawa Y, Korekawa A, Matsuzaki Y, Mitsuhashi Y, Sawamura D
  • Journal Title: Br J Dermatol Volume: 165(6) Issue: 6 Pages: 1290-1292
  • DOI: 10.1111/j.1365-2133.2011.10552.x
  • Peer Reviewed
• [Journal Article] Follicular mucinosis associated with radiation therapy (2011)
  • Author(s): Takeda H
  • Journal Title: J Dermatol Volume: 38 Issue: 11 Pages: 1116-1118
  • DOI: 10.1111/j.1346-8138.2010.01187.x
  • Peer Reviewed
• [Journal Article] Actinic granuloma associated with erythema nodosum (2011)
  • Author(s): Matsuzaki Y, et al.
  • Journal Title: Eur J Dermatol Volume: 21 Issue: 5 Pages: 806-807
  • DOI: 10.1684/ejd.2011.1480
  • Peer Reviewed
• [Journal Article] Immunohistochemical analysis of in vivo UVB-induced secretion of IL-1αand IL-6 in keratinocytes (2011)
  • Author(s): Hiromi N, Matsuzaki Y, et al.
  • Journal Title: Mol Med Report Volume: 4 Pages: 611-614
  • DOI: 10.3892/mmr.2011.478
  • Peer Reviewed
• [Journal Article] Garlic-induced irritant contact dermatitis mimicking nail psoriasis (2011)
  • Author(s): Takeuchi S, Matsuzaki Y, et al.
  • Journal Title: J Dermatol Volume: 38 Issue: 3 Pages: 280-282
  • DOI: 10.1111/j.1346-8138.2010.00940.x
  • NAID: 10029330800
  • Peer Reviewed
• [Journal Article] Late-onset, Eruptive Syringoma in an Elderly Man: Correlation with Carbamazepine (2011)
  • Author(s): Korekawa A, Nakajima K, Nishikawa Y, Matsuzaki Y, Nakano H, Sawamura D
  • Journal Title: Acta Derm Venereol Volume: 92 Pages: 87-88
  • Peer Reviewed
• [Presentation] 円形脱毛症に対するステロイド中用量間欠内服療法 (2013)
  • Author(s): 神可代、会津隆幸、松﨑康司、中野創、澤村大輔
  • Organizer: 日本皮膚科学会青森地方会第362回例会
  • Place of Presentation: 弘前市
• [Presentation] Facial porokeratosisの１例 (2013)
  • Author(s): 滝吉典子、竹内園子、金子高英、松﨑康司、中野創、澤村大輔
  • Organizer: 第112回日本皮膚科学会総会
  • Place of Presentation: 横浜市
• [Presentation] 家族性良性慢性天疱瘡の1例 (2013)
  • Author(s): 皆川智子、松﨑康司、金子高英、中野創、澤村大輔、三橋善比古
  • Organizer: 第40回皮膚かたち研究会
  • Place of Presentation: 東京
• [Presentation] Stevens - Johnson syndrome associated with TS-1 (2013)
  • Author(s): Satoko MINAKAWA, Yasushi MATSUZAKI, Koji NAKAJIMA, Hajime Nakano, Daisuke SAWAMURA
  • Organizer: 71st Annual Meeting of the American Academy of Dermatology
  • Place of Presentation: Miami (アメリカ）
• [Presentation] Trichophyton rubrumによる嚢腫様深在性白癬の1例 (2012)
  • Author(s): 松﨑康司、矢口貴志、中野創、澤村大輔
  • Organizer: 第111回日本皮膚科学会総会
  • Place of Presentation: 京都
• [Presentation] ヒトメラノーマ細胞におけるRETINOIC ACID-INDUCIBLE GENE-I発現との関連と細胞増殖 (2012)
  • Author(s): 松﨑康司、西川陽平、木村一之、北村英夫、中野創、今泉忠淳、佐藤敬、澤村大輔
  • Organizer: 第19回分子皮膚科学フォーラム
  • Place of Presentation: 青森
• [Presentation] ヒトメラノーマ細胞におけるRETINOIC ACID-INDUCIBLE GENE-I発現との関連と細胞増殖 (2012)
  • Author(s): 松﨑康司、西川陽平、木村一之、北村英夫、中野 創、今泉忠淳、佐藤 敬、澤村大輔
  • Organizer: 第19回分子皮膚科学フォーラム
  • Place of Presentation: 青森市
• [Presentation] Trichophyton rubrumによる嚢腫様深在性白癬の1例 (2012)
  • Author(s): 松﨑康司、矢口貴志、中野 創、澤村大輔
  • Organizer: 第111回日本皮膚科学会総会
  • Place of Presentation: 京都市
• [Presentation] 臨床的に隆起性皮膚線維肉腫などの間葉系腫瘍との鑑別を要した石灰化上皮腫の1例 (2012)
  • Author(s): 是川あゆ美、金子高英、松﨑康司、赤坂英二郎、中野 創、澤村大輔、中野あおい
  • Organizer: 日本皮膚科学会青森地方会第358回例会
  • Place of Presentation: 弘前市
• [Presentation] 高Ca血症を合併したアポクリン腺癌の多発骨転移の1例 (2012)
  • Author(s): 中島康爾、福井智久、西川陽平、金子高英、松﨑康司、中野 創、澤村大輔、小原 理
  • Organizer: 日本皮膚科学会青森地方会第358回例会
  • Place of Presentation: 弘前市
• [Presentation] 前胸部皮下に生じた皮膚腺病の1例 (2012)
  • Author(s): 萩原千尋、皆川智子、金子高英、松﨑康司、中野 創、澤村大輔、林 彰仁、久保田 滋
  • Organizer: 日本皮膚科学会青森地方会第358回例会
  • Place of Presentation: 弘前市
• [Presentation] 棘細胞癌、Bowen、日光角化症を伴った眼皮膚白皮症の１例 (2012)
  • Author(s): 皆川智子、金子高英、松﨑康司、中野 創、澤村大輔、三上 誠、鈴木民夫、三橋善比古
  • Organizer: 第39回皮膚かたち研究学会学術大会
  • Place of Presentation: 東京
• [Presentation] Richner-Hanhart症候群；臨床症状と血中チロシン濃度との関係 (2012)
  • Author(s): 滝吉典子、福井智久、赤坂英二郎、松﨑康司、中野 創、澤村大輔
  • Organizer: 第27回角化症研究会
  • Place of Presentation: 東京
• [Presentation] ウステキヌマブで改善した乾癬の2例 (2012)
  • Author(s): 皆川智子、金子高英、松崎康司、中野 創、澤村大輔、木村淳也
  • Organizer: 日本皮膚科学会青森地方会第359回例会
  • Place of Presentation: 青森市
• [Presentation] Characterization of stimulator of interferon genes (STING) expression in human epidermal keratinocytes (2011)
  • Author(s): Nishikawa Y, Matsuzaki Y, Nakano H, Sawamura D
  • Organizer: 41th Annual European Society for Dermatological Research meeting
  • Place of Presentation: Barcelona, Spain