Development of new anticancer therapy utilizing the innate immunity
| Project/Area Number |
23591611
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAWAMURA Daisuke 弘前大学, 大学院医学研究科, 教授 (60196334)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | メラノーマ / RIG-I / 1メラノーマ |
|---|
| Research Abstract |
I confirmed that cultured melanoma cells expressed RIG-I protein by IFN-beta stimulation. Moreover, proliferation activities of melanoma cells were suppressed by IFN-beta. Poly-(I:C), known as synthetic analog of double-stranded RNA, has no effect on the induction of RIG-I expression in the human melanoma cells.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Diffuse and focal palmoplantar keratoderma can be caused by a keratin 6c mutation2011
Author(s)
Akasaka E, Nakano H, Nakano A, Toyomaki Y, Takiyoshi N, Rokunohe D, Nishikawa Y, Korekawa A, Matsuzaki Y, Mitsuhashi Y, Sawamura D
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Journal Title
Br J Dermatol
Volume: 165(6)
Issue: 6
Pages: 1290-1292
DOI
Related Report
Peer Reviewed
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