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The elucidation of the mechanism of growth suppression of melanoma by kinase inhibitor

Research Project

Project/Area Number 23591614
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dermatology
Research InstitutionUniversity of Yamanashi

Principal Investigator

HARADA Kazutoshi  山梨大学, 医学部附属病院, 講師 (20324197)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsキナーゼ阻害薬 / シグナル伝達系 / 悪性黒色腫 / 有棘細胞癌 / 分子標的薬
Research Abstract

Wnt sinaling pathway has a crucial role in tumorgenesis. Some report have demonstrated that this signaling pathway was activated in melanoma. In this study, we evaluated whether celecoxib, a NSAIDs inhibited Wnt signaling pathway or not. If celecoxib suppressed Wnt signaling, this drug can be used as a molecular targeting drug. The expression of beta-catenin in melanoma samples was assessed by immunohistochemistry. Some melanoma samples expressed beta-catenin. Next, celecoxib was administrated in cell culture medium of melanoma cells. This experiment revealed that celecoxib inhibited the growth of melanoma cells. The relationship between the amount of beta-catenin in melanoma cells and the extent of growth suppression of melanoma cells was investigated, suggesting correlation of Wnt signal activation and the effect of growth inhibition of melanoma cells.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (15 results)

All 2014 2013 2012 2011 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Remarks (4 results)

  • [Journal Article] Case of primary cutaneous peripheral T-cell lymphoma, not otherwise specified, with characteristics of follicular helper T cells2014

    • Author(s)
      Takaki M, Inozume T, Matsuzawa T, Ando N, Y amaguchi M, Harada K, Kawamura T, Shibagaki N, Shimada S
    • Journal Title

      J Dermatol

      Volume: (In press) Issue: 6 Pages: 529-532

    • DOI

      10.1111/1346-8138.12493

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nodular melanoma on the hyponychium : clinical and dermoscopic features2014

    • Author(s)
      Yamamoto S, Harada K, Ando N, Kawamura T, Shibagaki N, Tanaka M, Shimada S
    • Journal Title

      J Dermatol

      Volume: 41(3)(PubMed PMID:24765666) Pages: 277-8

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] CD271 on Melanoma Cell Is an IFN-γ-Inducible Immunosuppressive Factor that Mediates Downregulation of Melanoma Antigens.2014

    • Author(s)
      Furuta J, Inozume T, Harada K, Shimada S.
    • Journal Title

      J Invest Dermatol.

      Volume: 134 Issue: 5 Pages: 1369-1377

    • DOI

      10.1038/jid.2013.490

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two cases of autosomal recessive woolly hair with LIPH gene mutations2013

    • Author(s)
      Harada K, Inozume T, Kawamura T, Shibagaki N, Kinoshita T, Deguchi N, Shimada S
    • Journal Title

      Int J Dermatol

      Volume: 52(5)(PubMed PMID:23590372) Issue: 5 Pages: 572-4

    • DOI

      10.1111/j.1365-4632.2012.05775.x

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Growth retardation and hair loss in transgenic mice overexpressing human H-ferritin gene2013

    • Author(s)
      Hasegawa S, Harada K, Morokoshi Y, Tsukamoto S, Furukawa T, Saga T
    • Journal Title

      Transgenic Res

      Volume: 22(3)(Epub 2012 Oct 31. PubMed PMID:23111618) Issue: 3 Pages: 651-8

    • DOI

      10.1007/s11248-012-9669-0

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Onychogryphosis by an elastic wire.2013

    • Author(s)
      Harada K, Yamaguchi M, Watanabe S, Shimada S.
    • Journal Title

      J Dermatol.

      Volume: 40 Issue: 12 Pages: 1055-1056

    • DOI

      10.1111/1346-8138.12295

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two cases of autosomal recessive woolly hair with LIPH gene mutations.2013

    • Author(s)
      Harada K, Inozume T, Kawamura T, Shibagaki N, Kinoshita T, Deguchi N, Shimada S.
    • Journal Title

      Int J Dermatol.

      Volume: 52 Pages: 572-574

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of dermatomyositis accompanied by spontaneous intramuscular hemorrhage despite normal coagulability2013

    • Author(s)
      Hanawa F, Inozume T, Harada K, Andou N, Kawamura T, Shibagaki N, Shimada S
    • Journal Title

      Rheumatol Int

      Volume: 33(11) Issue: 11 Pages: 2949-50

    • DOI

      10.1007/s00296-012-2492-3

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutation analysis of BRAF and KIT in circulating melanoma cells at the single cell level2012

    • Author(s)
      Sakaizawa K, Goto Y, Kiniwa Y, et al
    • Journal Title

      Br J Cancer

      Volume: 106 Issue: 5 Pages: 939-946

    • DOI

      10.1038/bjc.2012.12

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A patient with pseudochromhidrosis presenting with pink nails2012

    • Author(s)
      K. Harada, T. Morohoshi, T. Ikeda, and S. Shimada
    • Journal Title

      J. Am. Acad. Dermatol

      Volume: 67 Issue: 2 Pages: e74-e75

    • DOI

      10.1016/j.jaad.2011.08.026

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Marked response to imatinib mesylate in metastatic acral lentiginous melanoma on the thumb2011

    • Author(s)
      Yamaguchi M, Harada K, Ando N, Kawamura T, Shibagaki N, Shimada S
    • Journal Title

      Clin Exp Dermatol

      Volume: 36(2)(PubMed PMID:20545949) Issue: 2 Pages: 174-7

    • DOI

      10.1111/j.1365-2230.2010.03885.x

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Remarks]

    • URL

      http://www.med.yamanashi.ac.jp/clinical/dermatol/index.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 山梨大学医学部皮膚科

    • URL

      http://www.med.yamanashi.ac.jp/clinical/dermatol/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 山梨大学医学部皮膚科

    • URL

      http://www.med.yamanashi.ac.jp/clinical/dermatol/Index.html

    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.med.yamanashi.ac.jp/clinical/dermatol/Index.html

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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