Elucidation of abnormal epigenetic mechanisms through S-phse of the cell cycle in the psoriatic epidermal keratinocytes

• Project/Area Number: 23591617
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Nagoya University
• Principal Investigator: SUGIURA Kazumitsu 名古屋大学, 医学(系)研究科(研究院), 准教授 (70335032)
• Co-Investigator(Kenkyū-buntansha): MURO Yoshinao 名古屋大学, 大学院医学系研究科, 准教授 (80270990)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 乾癬 / 表皮角化細胞 / 細胞周期 / エピジェネティクス / LEDGF / RanBP2 / RanGaP1 / トランスジェニックマウス / 乾癬モデルマウス / MLL1 / トランスジェニック / 核膜孔 / RanGAP1 / MLL

Outline of Final Research Achievements

We indicated that RanBP2 and RanGAP1 are overexpressed and that the phosphorylation of S53 in MCM2 is significantly upregulated not only in the spinous layers but also in the basal layers of psoriatic epidermis. We also suggest that RanBP2 and RanGAP1 regulate the intracellular localization of LEDGF and phosphorylated Y705 STAT3 via the PI3K/Akt and MAPK /Erk1/2 pathways in our psoriatic model systems of HaCaT cells. These findings suggest that RanBP2 and RanGAP1 may play pivotal roles in the pathogenesis of psoriasis via translocation of LEDGF and phosphorylated Y705 STAT3 into the nucleus in psoriatic KCs Moreover, we created a KC speficif LEDGF transgenic mouse.

Research Products

• [Journal Article] Childhood-onset psoriatic arthritis in Down syndrome with psoriasis susceptibility variant CARD14 rs11652075 (2015)
  • Author(s): Sugiura K, Kitoh T, Watanabe D, Muto M, Akiyama M
  • Journal Title: Rheumatology (Oxford) Volume: 54 Issue: 1 Pages: 197-199
  • DOI: 10.1093/rheumatology/keu419
  • Peer Reviewed
• [Journal Article] Acute generalized exanthematous pustulosis caused by dihydrocodeine phosphate in a psoriasis vulgaris patient with a heterozygous IL36RN mutation (2015)
  • Author(s): Nakai N, Sugiura K, Akiyama M, Katoh N
  • Journal Title: JAMA Dermatol Volume: 151 Issue: 3 Pages: 311-315
  • DOI: 10.1001/jamadermatol.2014.3002
  • Peer Reviewed / Open Access
• [Journal Article] Founder mutation in dystonin-e underlying autosomal recessive epidermolysis bullosa simplex in Kuwait (2015)
  • Author(s): Takeichi T, Nanda A, Liu L, Aristodemou S, McMillan JR, Sugiura K, Akiyama M, Al-Ajmi H, Simpson MA, McGrath JA
  • Journal Title: Br J Dermatol Volume: 172 Issue: 2 Pages: 527-531
  • DOI: 10.1111/bjd.13294
  • Peer Reviewed
• [Journal Article] Darier's Disease: A novel ATP2A2 Missense Mutation at One of the Calcium-binding Residues (2015)
  • Author(s): Kaibuchi-Noda K, Sugiura K, Takeichi T, Miura S, Kagami S, Takama H, Hino H, Akiyama M
  • Journal Title: Acta Derm Venereol Volume: 95 Issue: 3 Pages: 362-363
  • DOI: 10.2340/00015555-1927
  • Peer Reviewed / Open Access
• [Journal Article] Anti-PM/Scl antibodies are found in Japanese patients with various systemic autoimmune conditions besides myositis and scleroderma (2014)
  • Author(s): Muro Y, Hosono Y, Sugiura K, Ogawa Y, Mimori T, Akiyama M.
  • Journal Title: Arthritis Res Ther Volume: 17 Issue: 1 Pages: 573-573
  • DOI: 10.1186/s13075-015-0573-x
  • NAID: 120005753819
  • Peer Reviewed / Open Access
• [Journal Article] A palindromic motif in the -2084 to -2078 upstream region is essential for ABCA12 promoter function in cultured human keratinocytes (2014)
  • Author(s): Shimizu Y, Ogawa Y, Sugiura K, Takeda J, Sakai-Sawada K, Yanagi T, Kon A, Sawamura D, Shimizu H, Akiyama M
  • Journal Title: Sci Rep Volume: 4 Issue: 1 Pages: 6737-6737
  • DOI: 10.1038/srep06737
  • Peer Reviewed / Open Access
• [Journal Article] Autoantibodies to DNA mismatch repair enzymes in polymyositis/dermatomyositis and other autoimmune diseases: a possible marker of favorable prognosis (2014)
  • Author(s): Muro Y, Nakashima R, Hosono Y, Sugiura K, Mimori T, Akiyama M
  • Journal Title: Arthritis Rheumatol Volume: 66 Issue: 12 Pages: 3457-3462
  • DOI: 10.1002/art.38866
  • Peer Reviewed
• [Journal Article] Pustular psoriasis occurring after total colectomy for ulcerative colitis and relieved by administration of infliximab (2014)
  • Author(s): Saito K, Ito A, Ishikawa K, Shimada H, Hatano Y, Sugiura K, Akiyama M, Inomata M, Kitano S, Fujiwara S
  • Journal Title: J Dermaol Volume: 41 Issue: 11 Pages: 1033-1034
  • DOI: 10.1111/1346-8138.12629
  • Peer Reviewed
• [Journal Article] Varicella zoster virus-induced generalized pustular psoriasis in a baby with heterozygous IL36RN mutation (2014)
  • Author(s): Sugiura K, Uchiyama R, Okuyama R, Akiyama M
  • Journal Title: J Am Acad Dermatol Volume: 71 Issue: 5 Pages: e216-e218
  • DOI: 10.1016/j.jaad.2014.07.015
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Is the measurement of anti-PM-1 α antibodies at least as important as that of other scleroderma-specific antibodies? (2014)
  • Author(s): Muro Y, Sugiura K, Akiyama M
  • Journal Title: Arthritis Rheumatol Volume: 66 Issue: 11 Pages: 3248-3248
  • DOI: 10.1002/art.38803
  • Peer Reviewed
• [Journal Article] Hydroxyurea-induced amyopathic dermatomyositis presenting heliotrope erythema (2014)
  • Author(s): Ito E, Muro Y, Sugiura K, Akiyama M
  • Journal Title: Dermatol Online J Volume: 20
  • Peer Reviewed / Open Access
• [Journal Article] Dorfman-Chanarin syndrome without mental retardation caused by a homozygous ABHD5 splice site mutation that skips exon 6 (2014)
  • Author(s): Sugiura K, Suga Y, Akiyama M
  • Journal Title: J Dermatol Sci Volume: 75 Issue: 3 Pages: 199-201
  • DOI: 10.1016/j.jdermsci.2014.05.009
  • Peer Reviewed
• [Journal Article] Highly prevalent SERPINB7 founder mutation causes pseudodominant inheritance pattern in Nagashima-type palmoplantar keratosis (2014)
  • Author(s): Mizuno O, Nomura T, Suzuki S, Takeda M, Ohguchi Y, Fujita Y, Nishie W, Sugiura K, Akiyama M, Shimizu H
  • Journal Title: Br J Dermatol Volume: 171 Issue: 4 Pages: 847-853
  • DOI: 10.1111/bjd.13076
  • Peer Reviewed / Open Access
• [Journal Article] IL36RN Mutations Underlie Impetigo Herpetiformis (2014)
  • Author(s): Sugiura K, Oiso N, Iinuma S, Matsuda H, Minami-Hori M, Ishida-Yamamoto A, Kawada A, Iizuka H, Akiyama M
  • Journal Title: J Invest Dermatol Volume: 134 Issue: 9 Pages: 2472-2474
  • DOI: 10.1038/jid.2014.177
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Author's reply to "detection of anti-periplakin autoantibodies during idiopathic pulmonary fibrosis" by Taillé et al. (2014)
  • Author(s): Muro Y, Tsuchisaka A, Ishii N, Hashimoto T, Sugiura K, Akiyama M
  • Journal Title: Clin Chim Acta Volume: 433 Pages: 194-194
  • DOI: 10.1016/j.cca.2014.03.026
  • Peer Reviewed
• [Journal Article] Solitary organizing pneumonia in systemic sclerosis mimicking lung adenocarcinoma (2014)
  • Author(s): Sugiura K, Muro Y, Akiyama M
  • Journal Title: Arthritis Rheumatol Volume: 66 Issue: 9 Pages: 2648-2648
  • DOI: 10.1002/art.38670
  • Peer Reviewed
• [Journal Article] The genetic background of generalized pustular psoriasis: IL36RN mutations and CARD14 gain-of-function variants (2014)
  • Author(s): Sugiura K
  • Journal Title: J Dermatol Sci Volume: 74 Issue: 3 Pages: 187-192
  • DOI: 10.1016/j.jdermsci.2014.02.006
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Revertant Mutation Releases Confined Lethal Mutation, Opening Pandora' s Box : A Novel Genetic Pathogenesis (2014)
  • Author(s): Ogawa Y, Takeichi T, Kono M, Hamajima N, Yamamoto T, Sugiura K, Akiyama M
  • Journal Title: PLoS Genet Volume: 10(5) Issue: 5 Pages: e1004276-e1004276
  • DOI: 10.1371/journal.pgen.1004276
  • Peer Reviewed / Open Access
• [Journal Article] Generalized pustular psoriasis caused by deficiency of interleukin-36 receptor antagonist successfully treated with granulocyte and monocyte adsorption apheresis (2014)
  • Author(s): Sugiura K, Haruna K, Suga Y, Akiyama M
  • Journal Title: J Eur Acad Dermatol Venereol Volume: 28 Issue: 12 Pages: 1835-1836
  • DOI: 10.1111/jdv.12383
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A case of Björnstad syndrome caused by novel compound heterozygous mutations in the BCS1L gene (2014)
  • Author(s): Yanagishita T, Sugiura K, Kawamoto Y, Ito K, Marubashi Y, Taguchi N, Akiyama M, Watanabe D
  • Journal Title: Br J Dermatol Volume: 170 Issue: 4 Pages: 970-973
  • DOI: 10.1111/bjd.12736
  • Peer Reviewed
• [Journal Article] Novel TGM1 missense mutation p.Arg727Gln in a case of self-healing collodion baby (2014)
  • Author(s): Tanahashi K, Sugiura K, Asagoe K, Aoyama Y, Iwatsuki K, Akiyama M
  • Journal Title: Acta Derm Venereol Volume: 94 Issue: 5 Pages: 589-590
  • DOI: 10.2340/00015555-1765
  • Peer Reviewed / Open Access
• [Journal Article] Annular erythema associated with Sjögren’s syndrome preceding overlap syndrome of rheumatoid arthritis and polymyositis with anti-PL-12 autoantibodies (2014)
  • Author(s): Sugiura K, Muro Y, Akiyama M
  • Journal Title: Acta Derm Venereol Volume: 94 Issue: 4 Pages: 470-471
  • DOI: 10.2340/00015555-1744
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Symmetrical giant facial plaque-type juvenile xanthogranuloma persisting beyond 10 years of age (2014)
  • Author(s): Sugiura K, Hasegawa Y, Shimoyama Y, Hashizume H, Akiyama M
  • Journal Title: Acta Derm Venereol Volume: 94 Issue: 4 Pages: 465-466
  • DOI: 10.2340/00015555-1712
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Establishment of an ELISA to detect anti-glycyl-tRNA synthetase antibody (anti-EJ), a serological marker of dermatomyositis/polymyositis and interstitial lung disease. (2014)
  • Author(s): Hane H, Muro Y, Watanabe K, Ogawa Y, Sugiura K, Akiyama M.
  • Journal Title: Clin Chim Acta Volume: 431C Pages: 9-14
  • DOI: 10.1016/j.cca.2014.01.005
  • Peer Reviewed / Open Access
• [Journal Article] Nuclear envelope localization of Ran-binding-protein 2 and Ran-GTPase-activating protein 1 in psoriatic epidermal keratinocytes. (2014)
  • Author(s): Yasuda K, Sugiura K, Takeichi T, Ogawa Y, Muro Y, Akiyama M.
  • Journal Title: Exp Dermatol Volume: 23 Issue: 2 Pages: 119-124
  • DOI: 10.1111/exd.12324
  • Peer Reviewed / Open Access
• [Journal Article] Highly prevalent LIPH founder mutations causing autosomal recessive woolly hair/hypotrichosis in Japan and the genotype/phenotype correlations (2014)
  • Author(s): Tanahashi K, Sugiura K, Kono M, Takama H, Hamajima N, Akiyama M
  • Journal Title: PLoS ONE Volume: 9(2) Issue: 2 Pages: e89261-e89261
  • DOI: 10.1371/journal.pone.0089261
  • Peer Reviewed
• [Journal Article] Detection of autoantibodies to periplakin and envoplakin in paraneoplastic pemphigus but not idiopathic pulmonary fibrosis using full-length recombinant proteins. (2014)
  • Author(s): Muro Y, Sugiura K, Shiraki A, Ishii N, Hashimoto T, Akiyama M.
  • Journal Title: Clin Chim Acta Volume: 429 Pages: 14-17
  • DOI: 10.1016/j.cca.2013.11.020
  • Peer Reviewed
• [Journal Article] High survival rate of harlequin ichthyosis in Japan (2014)
  • Author(s): Shibata A, Ogawa Y, Sugiura K, Muro Y, Abe R, Suzuki T, Akiyama M
  • Journal Title: High survival rate of harlequin ichthyosis in Japan Volume: 70(2) Issue: 2 Pages: 387-388
  • DOI: 10.1016/j.jaad.2013.10.055
  • Peer Reviewed
• [Journal Article] Six-year-old boy with palmoplantar keratoderma with ichthyosis. (2014)
  • Author(s): Sugiura K, Oiso N, Kawada A, Akiyama M.
  • Journal Title: J Am Acad Dermatol Volume: 70 Issue: 3 Pages: e51-e52
  • DOI: 10.1016/j.jaad.2013.08.054
  • Peer Reviewed
• [Journal Article] Generalized pusular psoriasis triggered by amoxicillin in monozygotic twins with compound heterozygous IL36RN mutations : Comment on the article by Navarini et al (2014)
  • Author(s): Sugiura K, Shoda Y, Akiyama M
  • Journal Title: J Invest Dermatol Volume: 134(2) Issue: 2 Pages: 578-579
  • DOI: 10.1038/jid.2013.354
  • Peer Reviewed
• [Journal Article] Alopecia totalis in monosomy 18p (2013)
  • Author(s): Sugiura K, Takeichi T, Akiyama M.
  • Journal Title: Eur J Dermatol Volume: 23 Issue: 6 Pages: 899-900
  • DOI: 10.1684/ejd.2013.2211
  • Peer Reviewed
• [Journal Article] Pulmonary mucosa-associated lymphoid tissue lymphoma in Sjögren’s syndrome without interstitial pneumonia. (2013)
  • Author(s): Kobayashi T, Muro Y, Sugiura K, Akiyama M.
  • Journal Title: Int J Rheum Dis Volume: 16 Issue: 6 Pages: 780-782
  • DOI: 10.1111/1756-185x.12210
  • Peer Reviewed
• [Journal Article] Extraordinarily long linear cutaneous lupus erythematosus along the lines of blaschko (2013)
  • Author(s): Aiyama A, Muro Y, Sugiura K, Onouchi H, Akiyama M.
  • Journal Title: Dermatol Online J Volume: 19 Pages: 18960-18960
  • Peer Reviewed
• [Journal Article] What autoantibody tests should become widely available to help scleroderma diagnosis and management? (2013)
  • Author(s): Muro Y, Sugiura K, Akiyama M.
  • Journal Title: Arthritis Res Ther Volume: 15 Pages: 116-116
  • Peer Reviewed
• [Journal Article] Unilaterally dominant eosinophilic fasciitis after influenza vaccination (2013)
  • Author(s): Sugiura K, Matsumoto T, Muro Y, Akiyama M.
  • Journal Title: J Am Acad Dermatol Volume: 69 Issue: 5 Pages: e269-e270
  • DOI: 10.1016/j.jaad.2013.06.044
  • Peer Reviewed
• [Journal Article] Very mild lamellar ichthyosis with compound heterozygous TGM1 mutations including the novel missense mutation p.Leu693Phe. (2013)
  • Author(s): Sugiura K, Suga Y, Akiyama M.
  • Journal Title: J Dermatol Sci Volume: 72 Issue: 2 Pages: 197-199
  • DOI: 10.1016/j.jdermsci.2013.06.013
  • Peer Reviewed
• [Journal Article] Lamellar ichthyosis in a collodion baby caused by CYP4F22 mutations in a non-consanguineous family outside the Mediterranean. (2013)
  • Author(s): Sugiura K, Takeichi T, Tanahashi K, Ito Y, Kosho T, Saida K, Uhara H, Okuyama R, Akiyama M.
  • Journal Title: J Dermatol Sci Volume: 72 Issue: 2 Pages: 193-195
  • DOI: 10.1016/j.jdermsci.2013.06.008
  • Peer Reviewed
• [Journal Article] The novel CTSC homozygous nonsense mutation p.Lys106X in a patient with Papillon-Lefevre syndrome with all permanent teeth remaining at over 40 years of age. (2013)
  • Author(s): Kobayashi T, Sugiura K, Takeichi T, Akiyama M.
  • Journal Title: Br J Dermatol Volume: 169 Issue: 4 Pages: 948-950
  • DOI: 10.1111/bjd.12429
  • Peer Reviewed
• [Journal Article] Whole-exome sequencing identifies ADAM10 mutations as a cause of reticulate acropigmentation of Kitamura, a clinical entity distinct from Dowling-Degos disease. (2013)
  • Author(s): Kono M, Sugiura K, Suganuma M, Hayashi M, Takama H, Suzuki T, Matsunaga K, Tomita Y, Akiyama M.
  • Journal Title: Hum Mol Genet Volume: 22 Issue: 17 Pages: 3524-3533
  • DOI: 10.1093/hmg/ddt207
  • Peer Reviewed
• [Journal Article] The majority of generalized pusular psoriasis without psoriasis vulgaris is caused by deficiency of interleukin-36 receptor antagonist. (2013)
  • Author(s): Sugiura K, Takemoto A, Yamaguchi M, Takahashi H, Shoda Y, Mitsuma T, Tsuda K, Nishida E, Togawa Y, Nakajima K, Sakakibara A, Kawachi S, Shimizu M, Ito Y, Takeichi T, Kono M, Ogawa Y, Muro Y, Ishida-Yamamoto A, Sano S, Matsue H, Morita A, Mizutani H, Iizuka H, Muto M, Akiyama M.
  • Journal Title: J Invest Dermatol Volume: 133 Issue: 11 Pages: 2514-2521
  • DOI: 10.1038/jid.2013.230
  • Peer Reviewed
• [Journal Article] Cutaneous lupus mucinosis successfully treated with systemic corticosteroid and tacrolimus combination therapy (2013)
  • Author(s): Sugiura K, Tanahashi K, Muro Y, Akiyama M.
  • Journal Title: J Am Acad Dermatol Volume: 69 Issue: 4 Pages: e200-e202
  • DOI: 10.1016/j.jaad.2013.04.057
  • Peer Reviewed
• [Journal Article] Possible roles of barrier-to-autointegration factor 1 in regulation of keratinocyte differentiation and proliferation. (2013)
  • Author(s): Takama H, Sugiura K, Ogawa Y, Muro Y, Akiyama M.
  • Journal Title: J Dermatol Sci Volume: 71 Issue: 2 Pages: 100-106
  • DOI: 10.1016/j.jdermsci.2013.04.007
  • Peer Reviewed / Open Access
• [Journal Article] Clouston syndrome with heterozygous GJB6 mutation p.Ala88Val and GJB2 variant p.Val27Ile revealing mild sensorineural hearing loss and photophobia. (2013)
  • Author(s): Sugiura K, Teranishi M, Matsumoto Y, Akiyama M.
  • Journal Title: JAMA Dermatol Volume: 149 Issue: 11 Pages: 1350-1351
  • DOI: 10.1001/jamadermatol.2013.4766
  • Peer Reviewed
• [Journal Article] Prevalent founder mutation c.736T>A of LIPH in autosomal recessive woolly hair of Japanese leads to variable severity of hypotrichosis in adulthood. (2013)
  • Author(s): Tanahashi K, Sugiura K, Takeichi T, Takama H, Shinkuma S, Shimizu H, Akiyama M.
  • Journal Title: J Eur Acad Dermatol Venereol Volume: 27 Issue: 9 Pages: 1182-1184
  • DOI: 10.1111/j.1468-3083.2012.04526.x
  • Peer Reviewed
• [Journal Article] Novel ABCA12 missense mutation p.Phe2144Ser underlies congenital ichthyosiform erythroderma. (2013)
  • Author(s): Shimizu Y, Sugiura K, Aoyama Y, Ogawa Y, Hitomi K, Iwatsuki K, Akiyama M.
  • Journal Title: J Dermatol Volume: 40 Issue: 7 Pages: 581-582
  • DOI: 10.1111/1346-8138.12169
  • Peer Reviewed
• [Journal Article] Low prevalence of anti-small ubiquitin-like modifier activating enzyme antibodies in dermatomyositis patients (2013)
  • Author(s): Muro Y, Sugiura K, Akiyama M.
  • Journal Title: Autoimmunity Volume: 46 Issue: 4 Pages: 279-284
  • DOI: 10.3109/08916934.2012.755958
  • Peer Reviewed
• [Journal Article] A novel ATP2C1 early truncation mutation suggests haploinsufficiency as a pathogenic mechanism in a patient with Hailey-Hailey disease. (2013)
  • Author(s): Shibata A, Sugiura K, Kimura U, Takamori K, Akiyama M.
  • Journal Title: Acta Dermato-Venereol Volume: 93 Issue: 6 Pages: 719-720
  • DOI: 10.2340/00015555-1551
  • Peer Reviewed
• [Journal Article] Cryptococcal cellulitis in patient with bullous pemphigoid. (2013)
  • Author(s): Sugiura K, Sugiura N, Yagi T, Iguchi M, Ohno H, Miyazaki Y, Akiyama M.
  • Journal Title: Acta Derm Venereol Volume: 93 Issue: 2 Pages: 187-188
  • DOI: 10.2340/00015555-1385
  • Peer Reviewed
• [Journal Article] Paraneoplastic pemphigus with anti-laminin-332 autoantibodies in a patient with follicular dendritic cell sarcoma (2013)
  • Author(s): Sugiura K
  • Journal Title: JAMA Dermatol Volume: 149 Issue: 1 Pages: 111-113
  • DOI: 10.1001/2013.jamadermatol.512
  • Peer Reviewed
• [Journal Article] Low prevalence of autoantibodies to CENP-H, -I, -K, -L, -M, -N, -T and -U in a Japanese cohort of anti-centromere positive samples (2013)
  • Author(s): Saito A, Muro Y, Sugiura K, et al.
  • Journal Title: Immunopharmacol Immunotoxicol Volume: 35 Issue: 1 Pages: 57-63
  • DOI: 10.3109/08923973.2012.733707
  • Peer Reviewed
• [Journal Article] Low prevalence of anti-DFS70/LEDGF antibodies in patients with dermatomyositis and with other systemic autoimmune rheumatic diseases (2013)
  • Author(s): Muro Y, Sugiura K, et al.
  • Journal Title: J Rheumatol Volume: 40 Issue: 1 Pages: 92-93
  • DOI: 10.3899/jrheum.121168
  • Peer Reviewed
• [Journal Article] Novel ABCA12 splice site deletion mutation and ABCA12 mRNA analysis of pulled hair samples in harlequin ichthyosis (2013)
  • Author(s): Takeichi T, Sugiura K, et al.
  • Journal Title: J Dermatol Sci Volume: 69 Issue: 3 Pages: 259-261
  • DOI: 10.1016/j.jdermsci.2012.11.004
  • Peer Reviewed
• [Journal Article] Limitations of a single-point evaluation of anti-MDA5 antibody, ferritin, and IL-18 in predicting the prognosis of interstitial lung disease with anti-MDA5 antibody-positive dermatomyositis (2013)
  • Author(s): Muro Y
  • Journal Title: Clin Rheumatol Volume: 32 Issue: 3 Pages: 395-398
  • DOI: 10.1007/s10067-012-2142-x
  • Peer Reviewed
• [Journal Article] Unfolded protein response in keratinocytes: Impact on normal and abnormal keratinization (2013)
  • Author(s): Sugiura K.
  • Journal Title: J Dermatol Sci Volume: 69 Issue: 3 Pages: 181-186
  • DOI: 10.1016/j.jdermsci.2012.12.002
  • Peer Reviewed
• [Journal Article] Clinical features of anti-TIF1-α antibody-positive dermatomyositis patients are closely associated with coexistent dermatomyositis-specific autoantibodies and anti-TIF1-γ or anti-Mi-2 autoantibodies (2012)
  • Author(s): Muro Y
  • Journal Title: Rheumatology (Oxford) Volume: 51 Issue: 8 Pages: 1508-1513
  • DOI: 10.1093/rheumatology/kes073
  • Peer Reviewed
• [Journal Article] Perinatal cytomegalovirus-associated bullae in an immunocompetent infant (2012)
  • Author(s): Yasuda K, Sugiura K, et al.
  • Journal Title: Arch Dermatol Volume: 148 Issue: 6 Pages: 770-772
  • DOI: 10.1001/archdermatol.2011.3258
  • Peer Reviewed
• [Journal Article] Effects of single therapeutic doses of promethazine, fexofenadine and olopatadine on psychomotor function and histamine-induced wheal- and flare-responses: a randomized double-blind, placebo-controlled study in healthy volunteers (2012)
  • Author(s): Kamei H, Isaji A, Noda Y, Ishikawa K, Senzaki K, Yamada K, Sugiura K, et al.
  • Journal Title: Arch Dermatol Res. Volume: 304 Issue: 4 Pages: 263-272
  • DOI: 10.1007/s00403-011-1192-2
  • Peer Reviewed
• [Journal Article] Development of an ELISA for detection of autoantibodies to nuclear matrix protein 2 (2012)
  • Author(s): Ishikawa A
  • Journal Title: Rheumatology (Oxford) Volume: 51 Issue: 7 Pages: 1181-1187
  • DOI: 10.1093/rheumatology/kes033
  • Peer Reviewed
• [Journal Article] Drug eruption due to sodium picosulfate (2012)
  • Author(s): Ishikawa A
  • Journal Title: Eur J Dermatol Volume: 22 Issue: 3 Pages: 410-411
  • DOI: 10.1684/ejd.2012.1679
  • Peer Reviewed
• [Journal Article] Autoantibodies to nuclear matrix protein 2 /MJ in adult-onset dermatomyositis with severe calcinosis (2012)
  • Author(s): Sugiura K
  • Journal Title: J Am Acad Dermatol Volume: 67 Issue: 4 Pages: e167-e168
  • DOI: 10.1016/j.jaad.2012.01.015
  • Peer Reviewed
• [Journal Article] A novel IL36RN/IL1F5 homozygous nonsense mutation, p.Arg10X, in a Japanese patient with adult-onset generalized pustular psoriasis (2012)
  • Author(s): Sugiura K
  • Journal Title: Br J Dermatol Volume: 167 Issue: 3 Pages: 699-701
  • DOI: 10.1111/j.1365-2133.2012.10953.x
  • Peer Reviewed
• [Journal Article] Severe chilblain lupus is associated with heterozygous missense mutations of catalytic amino acids or their adjacent in the exonuclease domains of 3'-repair exonuclease 1 (2012)
  • Author(s): Sugiura K
  • Journal Title: J Invest Dermatol Volume: 132 Issue: 12 Pages: 2855-2857
  • DOI: 10.1038/jid.2012.210
  • Peer Reviewed
• [Journal Article] Angiokeratoma of the scrotum and sublingual varices in a patient with jejunal phlebectasia (2012)
  • Author(s): Takama H
  • Journal Title: Eur J Dermatol Volume: 22 Issue: 6 Pages: 818-819
  • DOI: 10.1684/ejd.2012.1868
  • Peer Reviewed
• [Journal Article] LEDGF/DFS70 activates the MK2/IL6/STAT3 pathway in HaCaT (2011)
  • Author(s): Takeichi T, Sugiura K, et al
  • Journal Title: J Dermatol Sci Volume: 63 Pages: 203-205
  • NAID: 10030892614
  • Peer Reviewed
• [Journal Article] IgE and IgG(4) autoantibodies against DFS70/LEDGF in atopic dermatitis (2011)
  • Author(s): Watanabe K, Muro Y, Sugiura K et al
  • Journal Title: Autoimmunity Volume: 44 Pages: 511-519
  • Peer Reviewed
• [Journal Article] Cyclosporin A induces the unfolded protein response in keratinocytes (2011)
  • Author(s): Hibino M, Sugiura K, et al
  • Journal Title: Arch Dermatol Res Volume: 303 Pages: 481-489
  • Peer Reviewed
• [Presentation] 汎発性膿疱性乾癬のバイオマーカー (2015)
  • Author(s): 杉浦一充
  • Organizer: 第88回日本薬理学会年会
  • Place of Presentation: 愛知県名古屋市 名古屋国際会議場
  • Year and Date: 2015-03-20
  • Invited
• [Presentation] Long-term survival of a patient with paraneoplastic pemphigus due to follicular dendritic cell sarcoma (2015)
  • Author(s): Mariko Ogawa, Kazumitsu Sugiura, Yoshinao Muro, Takaaki Matsumoto, Hiroshi Kog, Takashi Hashimoto, Masashi Akiyama
  • Organizer: 73ｔｈ annual meeting of American association of Dermatology
  • Place of Presentation: USA San Francisco
  • Year and Date: 2015-03-20
• [Presentation] 汎発性膿疱性乾癬 最新の知見 (2015)
  • Author(s): 杉浦一充
  • Organizer: 第4回皮膚科セミナー
  • Place of Presentation: 愛知県名古屋市 名古屋大学
  • Year and Date: 2015-02-18
  • Invited
• [Presentation] IL36RN mutations underlie impetigo herpetiformis and CARD14 c.526G>C (2014)
  • Author(s): Sugiura K, Oiso N, Iinuma S, Matsuda H, Minami-Hori M, Ishida- Yamamoto A, Akira Kawada A, Iizuka H, Muto M, Akiyama M
  • Organizer: 日本研究皮膚科学会第39回年次学術大会・総会
  • Place of Presentation: 大阪府吹田市 ホテル阪急エキスポパーク
  • Year and Date: 2014-12-13
• [Presentation] 膿疱性乾癬の免疫遺伝学 (2014)
  • Author(s): 杉浦一充
  • Organizer: 第44回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
  • Place of Presentation: 宮城県仙台市 仙台国際センター
  • Year and Date: 2014-11-23
  • Invited
• [Presentation] 膿疱性乾癬の病態と治療 (2014)
  • Author(s): 杉浦一充
  • Organizer: 平成26年度（第34回）難病講習会
  • Place of Presentation: 愛知県名古屋市 愛知県医師会館
  • Year and Date: 2014-11-05
  • Invited
• [Presentation] 遺伝性の炎症性角化症：IL36RN 遺伝子とCARD14 遺伝子 (2014)
  • Author(s): 杉浦一充
  • Organizer: 第6回高知乾癬フォーラム
  • Place of Presentation: 高知県高知市 第6回高知乾癬フォーラム
  • Year and Date: 2014-10-25
  • Invited
• [Presentation] 乾癬の免疫遺伝学的病態について (2014)
  • Author(s): 杉浦一充
  • Organizer: 第42回日本臨床免疫学会総会
  • Place of Presentation: 東京都新宿区 京王プラザホテル
  • Year and Date: 2014-09-26
  • Invited
• [Presentation] AUTOSOMAL RECESSIVE WOOLLY HAIR/HYPOTRICHOSIS CAUSED BY HIGHLY PREVALENT LIPH FOUNDER MUTATIONS IN JAPAN (2014)
  • Author(s): "Chiaki MURASE, Kazumitsu SUGIURA, Kana TANAHASHI, Kentarou MATSUMOTO, Daisuke WATANABE, Masashi AKIYAMA
  • Organizer: 3rd East Asian Dermatology Congress
  • Place of Presentation: 韓国 Jeju
  • Year and Date: 2014-09-25
• [Presentation] 汎発性膿疱性乾癬の病因遺伝子 (2014)
  • Author(s): 杉浦一充
  • Organizer: 第29回日本乾癬学会学術大会
  • Place of Presentation: 高知県高知市 高知市文化プラザかるぽーと
  • Year and Date: 2014-09-19
  • Invited
• [Presentation] 膿疱性乾癬の新知見 (2014)
  • Author(s): 杉浦一充
  • Organizer: 第12回遠州皮膚科医会
  • Place of Presentation: 静岡県浜松市 オークラアクトシティホテル浜松
  • Year and Date: 2014-09-17
  • Invited
• [Presentation] 意外な遺伝性皮膚疾患 (2014)
  • Author(s): 杉浦一充
  • Organizer: 第113回日本皮膚科学会総会
  • Place of Presentation: 京都府京都市 京都国際会館
  • Year and Date: 2014-05-30
• [Presentation] 膿疱性乾癬の責任遺伝子 (2014)
  • Author(s): 杉浦一充
  • Organizer: 第113回日本皮膚科学会総会
  • Place of Presentation: 京都府京都市 京都国際会館
  • Year and Date: 2014-05-30
• [Presentation] Novel ABCA12 splice site deletion mutation and ABCA12 mRNA analysis in harlequin ichthyosis (2013)
  • Author(s): Takuya Takeichi, Kazumitsu Sugiura, Michihiro Kono, Masashi Akiyama
  • Organizer: International Investigative Dermatology 2013
  • Place of Presentation: Edinburgh, Scotland
• [Presentation] 尋常性乾癬を伴わない汎発性膿疱性乾癬の大半はIL-36RN欠損症(DITRA)である (2013)
  • Author(s): 杉浦 一充, 武市 拓也, 河野 通浩, 小川 靖, 室 慶直, 武藤 正彦, 秋山 真志
  • Organizer: 第77回日本皮膚科学会東部支部学術大会
  • Place of Presentation: 大宮ソニックシティ,さいたま市
• [Presentation] TREX1新規変異p.Pro132Alaによる家族性凍瘡状狼瘡の1例 (2012)
  • Author(s): 杉浦一充、武市拓也、河野通浩、小川 靖、室 慶直、秋山真志
  • Organizer: 第63回日本皮膚科学会中部支部学術大会
  • Place of Presentation: 大阪国際会議場 （大阪市）
• [Presentation] Severe chilblain lupus is associated with heterozygous missense mutations of catalytic sites of 3’-repair exonuclease 1 (2012)
  • Author(s): Kazumitsu Sugiura, Takuya Takeichi, Michihiro Konoi, Yasushi Ogawa, Yoshinao Muro, Masashi Akiyama
  • Organizer: 第37回日本研究皮膚科学会学術大会・総会
  • Place of Presentation: ロワジールホテル那覇 （那覇市）
• [Presentation] LEDGF plays a crucial role in pathogenesis of psoriasis vulgaris via activation of P38MAPK/MK2/IL-6/STAT3 pathway (2011)
  • Author(s): Takeichi T, Sugiura K, et al
  • Organizer: Society of Investigative Dermatology Annual Meeting 2011
  • Place of Presentation: Phoenix, USA
• [Presentation] 尋常性乾癬を伴わない汎発性膿疱性乾癬の大半はIL-36RN欠損症(DITRA)である
  • Author(s): 杉浦一充, 武市拓也, 河野通浩, 小川 靖, 室 慶直, 秋山真志, 竹本朱美, 山口道也, 武藤正彦, 高橋英俊, 山本明美, 飯塚 一, 庄田祐紀子, 満間照之, 津田憲志郎, 水谷 仁, 西田絵美, 森田明理, 外川八英, 松江弘之, 中島喜美子, 佐野栄紀, 榊原章浩, 河内繁雄, 清水 真, 伊藤康友
  • Organizer: 第28回角化症研究会
  • Place of Presentation: 東京商工会議所,東京都千代田区
• [Presentation] 尋常性乾癬を伴わない汎発性膿疱性乾癬の大半はIL-36RN欠損症(DITRA)である
  • Author(s): 杉浦 一充, 武市 拓也, 河野 通浩, 小川 靖, 室 慶直, 武藤 正彦, 秋山 真志
  • Organizer: 第28回日本乾癬学会学術大会
  • Place of Presentation: 東京ドームホテル,東京都文京区
• [Presentation] 強皮症の診断と合併症の検索
  • Author(s): 杉浦一充
  • Organizer: 第64回日本皮膚科学会中部支部学術大会
  • Place of Presentation: 名古屋国際会議場,名古屋市
  • Invited
• [Presentation] 尋常性乾癬を伴わない汎発性膿疱性乾癬の大半はIL-36RN欠損症(DITRA)である
  • Author(s): 杉浦 一充, 武市 拓也, 河野 通浩, 小川 靖, 室 慶直, 武藤 正彦, 秋山 真志
  • Organizer: 第64回日本皮膚科学会中部支部学術大会
  • Place of Presentation: 名古屋国際会議場,名古屋市
• [Presentation] 尋常性乾癬を伴わない汎発性膿疱性乾癬の大半はIL-36RN欠損症(DITRA)である
  • Author(s): 杉浦 一充, 武市 拓也, 河野 通浩, 小川 靖, 室 慶直, 武藤 正彦, 秋山 真志
  • Organizer: 第43回日本皮膚アレルギー・接触皮膚炎学会学術大会
  • Place of Presentation: ホテル日航金沢,金沢市
• [Presentation] 地中海沿岸地域以外で認められた、CYP4F22遺伝子変異による葉状魚鱗癬
  • Author(s): 杉浦一充、武市拓也、棚橋華奈、古庄知己、宇原 久、奥山隆平、秋山真志
  • Organizer: 稀少難治性皮膚疾患に関する調査研究班 平成25年度第１回総会
  • Place of Presentation: KKRホテル東京,東京都千代田区
• [Presentation] TGM1遺伝子変異による非常に軽症の葉状魚鱗癬症例、および、self-healing collodion baby
  • Author(s): 杉浦一充、棚橋華奈、浅越健治、青山裕美、須賀 康、岩月啓氏、秋山真志
  • Organizer: 稀少難治性皮膚疾患に関する調査研究班 平成25年度第2回総会
  • Place of Presentation: KKRホテル東京,東京都千代田区
• [Presentation] Familial generalized pustular psoriasis
  • Author(s): 杉浦一充
  • Organizer: 第6回自己炎症性疾患研究会
  • Place of Presentation: ベルサール八重洲 （東京都）
  • Invited
• [Presentation] 小胞体ストレスと角化
  • Author(s): 杉浦一充
  • Organizer: 第21回日本Cell Death 学会
  • Place of Presentation: 名古屋大学医学部附属病院 （名古屋市）
  • Invited
• [Presentation] TREX1新規変異p.Pro132Alaによる家族性凍瘡状狼瘡の1例
  • Author(s): 杉浦一充、武市拓也、河野通浩、小川 靖、室 慶直、秋山真志
  • Organizer: 第61回東海膠原病研究会
  • Place of Presentation: ホテルサンルートプラザ名古屋 （名古屋市）
• [Presentation] 濾胞樹状細胞肉腫による腫瘍随伴性天疱瘡に対するIVIG療法
  • Author(s): 杉浦一充
  • Organizer: 第4回東海皮膚免疫疾患研究会
  • Place of Presentation: マリオットアソシアホテル （名古屋市）
• [Presentation] 脱毛を伴った18p monosomy syndrome
  • Author(s): 杉浦一充、武市拓哉、秋山真志
  • Organizer: 第27回角化症研究会
  • Place of Presentation: 東京商工会議所 （東京都）
• [Presentation] IL36RN新規変異p.Arg10Xによる家族性汎発性膿疱性乾癬の成人発症例
  • Author(s): 杉浦一充、武市拓也、河野通浩、小川 靖、室 慶直、秋山真志
  • Organizer: 第75回日本皮膚科学会東部支部学術大会
  • Place of Presentation: ロイトン札幌 （札幌市）
• [Presentation] 汎発性膿疱性乾癬12 例におけるIL36RN変異解析
  • Author(s): 杉浦一充、竹本朱美、武藤正彦、秋山真志
  • Organizer: 稀少難治性皮膚疾患に関する調査研究班 平成24年度 第2回総会
  • Place of Presentation: KKRホテル東京 （東京都）
• [Book] 今日の治療指針 2013 (2013)
  • Author(s): 山口徹 北原光夫 福井次矢
  • Publisher: 医学書院
• [Remarks] 無菌性の膿疱性疾患の病態解明と新規治療戦略の開拓
  • URL: http://www.aip.nagoya-u.ac.jp/unite/jp/detail/0000081.html
• [Remarks] 汎発性膿疱性乾癬の病因を特定: 遺伝子検査で的確な診断が可能に
  • URL: http://www.aip.nagoya-u.ac.jp/public/nu_research_ja/highlights/detail/0000802.html
• [Remarks] 汎発性膿疱性乾癬の病因を特定: 遺伝子検査で的確な診断が可能に
  • URL: http://www.nu-research.com/index.php/ja/research-highlights/85-generation-of-medicine.html
• [Remarks] 汎発性膿疱性乾癬の病因の解明
  • URL: http://www.nagoya-u.ac.jp/about-nu/public-relations/researchinfo/upload_images/20130523_med.pdf