| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
The pathogenic mechanisms has been still unknown in cancer-associated dermatomyositis (CADM). We investigated whether malignant tissues in CADM have the aberrant expression of TIF1-γ, which is a serological marker of CADM, and also investigated the possibility of interaction between TIF1-γ, and TGFβand other associated molecules. We showed the high expression of TIF1-γ
in malignant tissues in patients with anti-TIF1-γ and suggested the possibility of tumor growth by the phosphorylation of STAT3 through IL-6.
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