Investigation of two-step theory involved with TIF1-gamma in cancer-associated with dermatomyositis
Project/Area Number |
23591618
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Dermatology
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Research Institution | Nagoya University |
Principal Investigator |
MURO YOSHINAO 名古屋大学, 医学(系)研究科(研究院), 准教授 (80270990)
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Co-Investigator(Kenkyū-buntansha) |
SUGIURA Kazumitsu 名古屋大学, 医学系研究科, 准教授 (70335032)
OGAWA Yasushi 名古屋大学, 医学部附属病院, 助教 (10567754)
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Project Period (FY) |
2011-04-28 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 皮膚筋炎 / 悪性腫瘍 / 抗TIF1-γ抗体 / TIF1-α / TIF1-γ / 自己抗原 / 自己抗体 |
Outline of Final Research Achievements |
The pathogenic mechanisms has been still unknown in cancer-associated dermatomyositis (CADM). We investigated whether malignant tissues in CADM have the aberrant expression of TIF1-γ, which is a serological marker of CADM, and also investigated the possibility of interaction between TIF1-γ, and TGFβand other associated molecules. We showed the high expression of TIF1-γ in malignant tissues in patients with anti-TIF1-γ and suggested the possibility of tumor growth by the phosphorylation of STAT3 through IL-6.
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Report
(5 results)
Research Products
(70 results)
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[Journal Article] Investigation of prognostic factors for skin sclerosis and lung function in Japanese patients with early systemic sclerosis: a multicentre prospective observational study.2012
Author(s)
Hasegawa M, Asano Y, Endo H, Fujimoto M, Goto D, Ihn H, Inoue K, Ishikawa O, Kawaguchi Y, Kuwana M, Muro Y, Ogawa F, Sasaki T, Takahashi H, Tanaka S, Takehara K, Sato S.
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Journal Title
Rheumatology (Oxford)
Volume: 51
Issue: 1
Pages: 129-133
DOI
Related Report
Peer Reviewed
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[Journal Article] Clinical correlations with dermatomyositis-specific autoantibodies in adult Japanese patients with dermatomyositis: a multicenter cross-sectional study.2011
Author(s)
Hamaguchi Y, Kuwana M, Hoshino K, Hasegawa M, Kaji K, Matsushita T, Komura K, Nakamura M, Kodera M, Suga N, Higashi A, Ogusu K, Muro Y, et al. (全37名中17番目)
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Journal Title
Arch. Dermatol.
Volume: 147
Issue: 4
Pages: 391-398
DOI
Related Report
Peer Reviewed
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[Presentation] 皮膚筋炎を見出す
Author(s)
室慶直
Organizer
第77回日本皮膚科学会東京支部学術大会
Place of Presentation
東京国際フォーラム(東京)
Related Report
Invited
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[Presentation] 全身疾患と皮膚
Author(s)
室慶直
Organizer
AGA EXPERT MEETING in 東海
Place of Presentation
名古屋
Related Report
Invited
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