| Project/Area Number |
23591619
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
|
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| Research Institution | Okayama University |
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Principal Investigator |
MINORU Takata 岡山大学, 医歯(薬)学総合研究科, 非常勤研究員 (20154784)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YAMASAKI Osamu 岡山大学, 大学病院, 講師 (90294462)
OTSUKA Masaki 岡山大学, 大学病院, 助教 (80452572)
SUZUKI Norihiro 岡山大学, 大学病院, 医員 (10600281)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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|---|
| Keywords | 皮膚腫瘍学 / 悪性黒色腫 / がん幹細胞 / 血液循環がん細胞 / melanoma / circulating tumor DNA / circulating tumor cells / gene mutation / oncogene / melanoma stem cells / メラノーマ / 癌幹細胞 / 血液循環癌細胞 |
|---|
| Research Abstract |
We have isolated circulating melanoma cells from peripheral blood of patients, and identified mutations in BRAF and KIT genes, which are molecular targets for oral kinase inhibitors. Quantitative expression analysis of several molecules implicated as melanoma-initiating cell markers in sentinel lymph nodes revealed ABCB5 as the most promising marker. However, expression analysis of ABCB5 in peripheral blood was difficult due to the low yields of melanoma-initiating cells.
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