• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Understanding between the histone-chromatin modification and the possible augmentation of therapeutic sensitivity for malignant melanoma

Research Project

Project/Area Number 23591627
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dermatology
Research InstitutionTakasaki University of Health and Welfare

Principal Investigator

MURAKAMI Takashi  高崎健康福祉大学, 薬学部, 教授 (00326852)

Co-Investigator(Renkei-kenkyūsha) OHTSUKI Mamitaro  自治医科大学, 医学部, 教授 (90185330)
SATO Atsuko  自治医科大学, 医学部, 助教 (50382916)
SAITO Katsuyo  高崎健康福祉大学, 薬学部, 助手 (90455288)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsがん / シグナル伝達 / 発現制御 / 治療感受性 / 生体内イメージング / エピジェネティック修飾 / メラノーマ / 薬剤反応性
Research Abstract

BRAF (V600E) is the common oncogenic driver mutation in 60-70% of melanoma patients. Melanoma cells that have BRAF (V600E) mutation accumulated aberrant gene suppression through the histone-chromatin modification, and subsequently the aberrancy was well correlated with metastatic potentials of examined melanoma cells. The histone deacetylase inhibitor (HDACi) is a potent agent to improve the aberrantly deacetylated-histones. Some of HDACi were able to improve levels of deacetylated-histones and sensitized melanoma cells to the therapeutic cell death partially. Unfortunately the effects of HDACi did not always appear sufficient for BRAF (V600E)-positive melanoma cells. Thus, it is necessary to think the possibility that BRAF (V600E)-mediated constitutive activation may maintain the abnormal histone methylation, and that particular gene amplification accompanied with melanoma development may be involved in the therapeutic resistance.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (41 results)

All 2014 2013 2012 2011 Other

All Journal Article (20 results) (of which Peer Reviewed: 13 results) Presentation (17 results) Book (3 results) Remarks (1 results)

  • [Journal Article] Transplantation of engineered chimeric liver with autologous hepatocytes and xenobiotic scaffold2013

    • Author(s)
      Hata T, Uemoto S, Fujimito Y, Murakami T, Tateno C, Yoshizato K, Kobayashi E
    • Journal Title

      Ann Surg

      Volume: 257(3) Pages: 542-547

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic Modifier as a Potential Radiosensitizer for Heavy-ion Therapy on Malignancy2013

    • Author(s)
      Saito K, Funayama T, Kobayashi Y, Murakami T
    • Journal Title

      JAEA-Review 2013-059, JAEA Takasaki Annual Report 2012

      Volume: 80

    • Related Report
      2013 Final Research Report
  • [Journal Article] Transplantation of engineered chimeric liver with autologous hepatocytes and xenobiotic scaffold.2013

    • Author(s)
      Hata T, Uemoto S, Fujimoto Y, Murakami T, Tateno C, Yoshizato K, Kobayashi E.
    • Journal Title

      Ann Surg.

      Volume: 257 Issue: 3 Pages: 542-547

    • DOI

      10.1097/sla.0b013e31825c5349

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic Modifier as a Potential Radiosensitizer for Heavy-ion Therapy on Malignancy.2013

    • Author(s)
      Saito K, Funayama T, Kobayashi Y, Murakami T.
    • Journal Title

      JAEA-Review 2013-059

      Volume: Annual Report 2012 Pages: 80-80

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Potential antitumor effect of IFN-lambda2 (IL-28A) against human lung cancer cells2012

    • Author(s)
      Teszuka Y, Endo S, Matsui A, Sato A, Saito K, Semba K, Takahashi M, Murakami T
    • Journal Title

      Lung Cancer

      Volume: 78(3) Pages: 185-192

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] CXCL17 Expression by Tumor Cells Recruits CD11b<sup>+</sup>Gr1<sup>high</sup>F4/80<sup>-</sup> Cells and Promotes Tumor Progression2012

    • Author(s)
      Matsui A, Yokoo H, Negishi Y, Endo-Takahashi Y, Chun NA, Kadouchi I, Suzuki R,Maruyama K, Aramaki Y, Semba K, Kobayashi E, Takahashi M, Murakami T.
    • Journal Title

      PLoS One.

      Volume: 7 Issue: 8 Pages: e44080-e44080

    • DOI

      10.1371/journal.pone.0044080

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Heart angiotensin II-induced cardiomyocyte hypertrophy suppresses coronary angiogenesis and progresses diabetic cardiomyopathy2012

    • Author(s)
      Masuda T, Muto S, Fujisawa G, Iwazu Y, Kimura M, Kobayashi T, Nonaka-Sarukawa M, Sasaki N, Watanabe Y, Shinohara M, Murakami T, Shimada K, Kobayashi E, Kusano E
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 302(9)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potential antitumor effect of IFN-lambda2 (IL-28A) against human lung cancer cells.2012

    • Author(s)
      Teszuka Y, Endo S, Matsui A, Sato A, Saito K, Semba K, Takahashi M, Murakami T.
    • Journal Title

      Lung Cancer

      Volume: 78(3) Issue: 3 Pages: 185-192

    • DOI

      10.1016/j.lungcan.2012.09.005

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of Host Immunity on Metastatic Potential in Renal Cell Carcinoma; the Assessment of Optimal in Vivo Models to Study Metastatic Behavior of Renal Cancer Cells.2012

    • Author(s)
      Kobayashi M, Morita T, Chun ALN, Matsui A, Takahashi M, Murakami T.
    • Journal Title

      Tumor Biology

      Volume: 33(2) Issue: 2 Pages: 551-559

    • DOI

      10.1007/s13277-011-0300-4

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of features of glomerulopathy in tumor-bearing rats: a potential model for paraneoplastic glomerulopathy.2012

    • Author(s)
      Takeda S, Chinda J, Murakami T, Numata A, Iwazu Y, Akimoto T, Hamano Y, Muto S, Takahashi M, Kusano E.
    • Journal Title

      Nephrol Dial Transplant.

      Volume: 27(5) Issue: 5 Pages: 1786-1792

    • DOI

      10.1093/ndt/gfr565

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Heart angiotensin II-induced cardiomyocyte hypertrophy suppresses coronary angiogenesis and progress es diabetic cardiomyopathy2012

    • Author(s)
      Takahiro Masuda
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 302 Issue: 9 Pages: H1871-H1883

    • DOI

      10.1152/ajpheart.00663.2011

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] GFP-Transgenic Animals for In Vivo Imaging: Rats, Rabbits, and Pigs.2012

    • Author(s)
      Murakami T, Kobayashi E
    • Journal Title

      Methods in Molecular Biology

      Volume: 872 Pages: 177-189

    • DOI

      10.1007/978-1-61779-797-2_12

    • ISBN
      9781617797965, 9781617797972
    • Related Report
      2012 Research-status Report
  • [Journal Article] Development of features of glomerulopathy in tumor-bearing rats: a potential model for paraneoplastic glomerulopathy2012

    • Author(s)
      Takeda S, Chinda J, Murakami T, Numata A, Iwazu Y, Akimoto T, Hamano Y, Muto S, Takahashi M, Kusano E.
    • Journal Title

      Nephrol Dial Transplant.

      Volume: 27 (5) Pages: 1786-1792

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of novel nucleic acid loaded-Bubble Liposomes using cholesterol-conjugated siRNA2011

    • Author(s)
      Negishi Y, Endo-Takahashi Y, Ishii K, Suzuki R, Oguri Y, Murakami T, Maruyama K, Aramaki Y
    • Journal Title

      J Drug Targeting

      Volume: 19(9) Pages: 830-836

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] CCL11-CCR3 interaction promotes survival of anaplastic large cell lymphoma cells via ERK1/2 activation2011

    • Author(s)
      Miyagaki T, Sugaya M, Murakami T, Kadono T, Okochi H, Tamaki K, Sato S
    • Journal Title

      Cancer Res

      Volume: 71(6) Pages: 2056-2065

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 動物モデルの最新技術—イメージング技術と分子標的治療—2011

    • Author(s)
      村上孝、高橋将文
    • Journal Title

      がん分子標的治療(メディカルレビュー社)

      Volume: Vol.9; No.4

    • Related Report
      2013 Final Research Report
  • [Journal Article] 悪性黒色腫の転写修飾による免疫学的感受性の増幅2011

    • Author(s)
      村上孝、松居彩、斎藤克代
    • Journal Title

      Biotherpay(癌と化学療法社)

      Volume: Vol.25; No.4 Pages: 756-761

    • Related Report
      2013 Final Research Report
  • [Journal Article] 動物モデルの最新技術―イメージング技術と分子標的治療―2011

    • Author(s)
      村上 孝、高橋将文
    • Journal Title

      がん分子標的治療(メディカルレビュー社)

      Volume: 9 (4) Pages: 234-243

    • Related Report
      2011 Research-status Report
  • [Journal Article] 悪性黒色腫の転写修飾による免疫学的感受性の増幅2011

    • Author(s)
      村上 孝、松居 彩、斎藤克代
    • Journal Title

      Biotherpay(癌と化学療法社)

      Volume: 25 (4) Pages: 756-761

    • Related Report
      2011 Research-status Report
  • [Journal Article] Development of features of glomerulopathy in tumor-bearing rats : a potential model for paraneoplastic glomerulopathy

    • Author(s)
      Takeda S, Chinda J, Murakami T, Numata A, Iwazu Y, Akimoto T, Hamano Y, Muto S, Takahashi M, Kusano E
    • Journal Title

      Nephrol Dial Transplant

      Volume: 27(5) Pages: 1786-1792

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 難治性がんに対するエピジェネティック制御と重粒子線感受性の増強2014

    • Author(s)
      斎藤克代、舟山和夫、小林泰彦、村上孝
    • Organizer
      第134回日本薬学会年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Final Research Report
  • [Presentation] 難治性がんに対するエピジェネティック制御と重粒子線感受性の増強.2014

    • Author(s)
      斎藤克代、舟山和夫、小林泰彦、村上 孝.
    • Organizer
      第134回日本薬学会年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] In vivo metastatic behaviors of H-RAS (G12V)- and v-SRC-transformed NIH3T3 cells in athymic nude mice2013

    • Author(s)
      Murakami T, Matsui A, Hayashi M, Kajita M
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] CXCL17-respoding neutrophil-like CD11b^+Gr-1^<hi> cells promote tumor progression2013

    • Author(s)
      Matsui A, Murakami T
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] New methylated DNA biomarkers in circulating tumor genomes for the aggressive type of breast cancer cells2013

    • Author(s)
      Kajita M, Murakami T, Hayashi M
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] がん創薬を促進する発光ヒトがん細胞資源の開発とその利用方法2013

    • Author(s)
      斎藤克代、村上孝
    • Organizer
      第8回日本分子イメージング学会総会•学術集会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 株化ヒトがん細胞を用いたNOD/SCIDマウス体内における転移動態の発光イメージング2013

    • Author(s)
      斎藤克代、村上孝
    • Organizer
      第133回日本薬学会年会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] In vivo metastatic behaviors of H-RAS (G12V)- and v-SRC-transformed NIH3T3 cells in athymic nude mice.2013

    • Author(s)
      Murakami T, Matsui A, Hayashi M, Kajita M.
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] CXCL17-respoding neutrophil-like CD11b+Gr-1hi cells promote tumor progression.2013

    • Author(s)
      Matsui A, Murakami T.
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] New methylated DNA biomarkers in circulating tumor genomes for the aggressive type of breast cancer cells.2013

    • Author(s)
      Kajita M, Murakami T, Hayashi M.
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] がん創薬を促進する発光ヒトがん細胞資源の開発とその利用方法.2013

    • Author(s)
      斎藤克代、村上 孝
    • Organizer
      第8回日本分子イメージング学会総会&#8226;学術集会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 株化ヒトがん細胞を用いたNOD/SCIDマウス体内における転移動態の発光イメージング.2013

    • Author(s)
      斎藤克代、村上 孝.
    • Organizer
      第133回日本薬学会年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] Effect of host immunity on metastatic potential in renal cell carcinoma : optimal in vivo models to study RCC metastasis2012

    • Author(s)
      Kobayashi M, Morita T, Matsui A, Murakami T
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect of host immunity on metastatic potential in renal cell carcinoma: optimal in vivo models to study RCC metastasis.2012

    • Author(s)
      Kobayashi M, Morita T, Matsui A, Murakami T.
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] CXCL17-expressing tumor cells recruit immature myeloid cells at tumor sites of mice2011

    • Author(s)
      Matsui A, Chun ALN, Semba K, Murakami T
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] 担癌ラットは糸球体腎症所見を呈する;腫瘍随伴性腎症モデル動物の作製2011

    • Author(s)
      武田真一、珍田純子、沼田暁彦、村上孝、高橋将文、草野英二
    • Organizer
      第54回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 担癌ラットは糸球体腎症所見を呈する: 腫瘍随伴性腎症モデル動物の作製2011

    • Author(s)
      武田真一、珍田純子、沼田暁彦、村上 孝、高橋将文、草野英二
    • Organizer
      第54回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Book] GFP-Transgenic Animals for In Vivo Imaging : Rats, Rabbits, and Pigs. In"In Vivo Cellular Imaging using Fluorescent Proteins": Methods in Molecular Biology. Vol. 872. Chapter 122012

    • Author(s)
      Murakami T, Kobayashi E(Edited by Hoffman RM)
    • Publisher
      Humana Press (Springer). New York
    • Related Report
      2013 Final Research Report
  • [Book] ケモカインシグナル.「キーワードで理解するシグナル伝達イラストマップ(改訂版)」2012

    • Author(s)
      村上孝(山本雅、仙波憲太郎、山梨裕司編集)
    • Publisher
      羊土社.東京
    • Related Report
      2013 Final Research Report
  • [Book] 第1部27.ケモカインシグナル「キーワードで徹底理解する-シグナル伝達イラストマップ(改訂版)」2012

    • Author(s)
      村上 孝 (山本 雅、仙波憲太郎、山梨裕司 編集)
    • Total Pages
      349
    • Publisher
      羊土社
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.takasaki-u.ac.jp/p_yaku/1577/

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi