| Project/Area Number |
23591637
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMASAKI Kenshi 東北大学, 医学系研究科, 准教授 (40294798)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 皮膚バリア機能 / 角層 / 自然免疫 / アトピー性皮膚炎 / 尋常性ざ瘡 / 脂漏性皮膚炎 / 酒さ / 角層バリア / ざ瘡 / バリア機能 / 角層機能 / アクネ桿菌 / 表皮ブドウ球菌 |
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| Research Abstract |
The barrier function of the skin on the face is deteriorated as compared to that of the skin of other part and rosacea, acne and seborrheic dermatitis are often observed on the face. The lipophilic skin flora such as p. acnes and malassezia have been implicated as causative agents of acne, rosacea and seborrheic dermatitis, respectively. In healthy control, the skin surface lipid level on the eyelid skin and earlobe skin, where rosacea and seborrheic dermatitis hardly observed, found to be significantly lower than on the cheek skin. In addition to the higher skin surface lipid level, the barrier function of the stratum corneum on the perioral skin assessed by TEWL was found to be more deteriorated than on the cheek. The impaired barrier function on the perioral skin might affect to the development of the perioral dermatitis, related disorder to rosacea.
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