The influence of the innate immune system on the barrier function of the stratum corneum of the skin

• Project/Area Number: 23591637
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Tohoku University
• Principal Investigator: KIKUCHI KATSUKO 東北大学, 大学病院, 講師 (50250759)
• Co-Investigator(Kenkyū-buntansha): YAMASAKI Kenshi 東北大学, 医学系研究科, 准教授 (40294798)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 皮膚バリア機能 / 角層 / 自然免疫 / アトピー性皮膚炎 / 尋常性ざ瘡 / 脂漏性皮膚炎 / 酒さ / 角層バリア / ざ瘡 / バリア機能 / 角層機能 / アクネ桿菌 / 表皮ブドウ球菌

Research Abstract

The barrier function of the skin on the face is deteriorated as compared to that of the skin of other part and rosacea, acne and seborrheic dermatitis are often observed on the face. The lipophilic skin flora such as p. acnes and malassezia have been implicated as causative agents of acne, rosacea and seborrheic dermatitis, respectively. In healthy control, the skin surface lipid level on the eyelid skin and earlobe skin, where rosacea and seborrheic dermatitis hardly observed, found to be significantly lower than on the cheek skin. In addition to the higher skin surface lipid level, the barrier function of the stratum corneum on the perioral skin assessed by TEWL was found to be more deteriorated than on the cheek. The impaired barrier function on the perioral skin might affect to the development of the perioral dermatitis, related disorder to rosacea.

Research Products

• [Journal Article] Sweat constitutes several natural moisturizing factors, lactate, urea, sodium, and potassium (2013)
  • Author(s): Watabe, A., Sugawara, T., Kikuchi, K., Yamasaki, K., Sakai, S., and Aiba, S.
  • Journal Title: J Dermatol Sci Volume: 72 Issue: 2 Pages: 177-182
  • DOI: 10.1016/j.jdermsci.2013.06.005
  • Peer Reviewed
• [Journal Article] スキルアップのためのQ&Aバリア機能の測り方を教えてください (2013)
  • Author(s): 菊地克子
  • Journal Title: 皮膚アレルギーフロンティア Volume: 11巻3号 Pages: 174-174
• [Journal Article] 【スキンケア-乳幼児から高齢者まで-】皮膚バリア機能とスキンケア (2013)
  • Author(s): 菊地克子
  • Journal Title: Derma Volume: 210号 Pages: 31-36
• [Journal Article] 適切な顔面のスキンケアがアトピー性皮膚炎患者の皮膚生理機能とQOLに及ぼす影響 (2013)
  • Author(s): 菊地克子、小澤麻紀,相場節也,森田栄伸
  • Journal Title: 西日本皮膚科 Volume: 75巻1号 Pages: 65-71
  • NAID: 130004475504
  • Peer Reviewed
• [Journal Article] 【アトピー性皮膚炎の発症とバリア機能】バリア機能と易刺激性 (2013)
  • Author(s): 菊地克子
  • Journal Title: アレルギーの臨床 Volume: 33巻2号 Pages: 138-141
• [Journal Article] 【かゆみ大全】よくある痒みの対処法頭皮の痒みとフケ (2013)
  • Author(s): 菊地克子
  • Journal Title: JIM : Journal of Integrated Medicine Volume: 23巻2号 Pages: 126-128
• [Journal Article] 【Common disease鑑別マニュアル「初診に帰って考えよう」】感染症ざ瘡「たかがニキビと思うなかれ」 (2013)
  • Author(s): 山崎研志
  • Journal Title: Derma Pages: 41-44
• [Journal Article] Functional melanocytes are readily reprogrammable from multilineage-differentiating stress-enduring (muse) cells, distinct stem cells in human fibroblasts (2013)
  • Author(s): Tsuchiyama K, Wakao S, Kuroda Y, Ogura F, Nojima M, Sawaya N, Yamasaki K, Aiba S, Dezawa M
  • Journal Title: J Invest Dermatol Volume: 133(10) Issue: 10 Pages: 2425-35
  • DOI: 10.1038/jid.2013.172
  • Peer Reviewed
• [Journal Article] In vivo imaging demonstrates ATP release from murine keratinocytes and its involvement in cutaneous inflammation after tape-stripping (2013)
  • Author(s): Takahashi, T., Kimura, Y., Niwa, K., Ohmiya, Y., Fujimura, T., Yamasaki, K., and Aiba, S.
  • Journal Title: J Invest Dermatol Volume: 133 Issue: 10 Pages: 2407-15
  • DOI: 10.1038/jid.2013.163
  • Peer Reviewed
• [Journal Article] Antimicrobial peptide LL-37 produced by HSV-2-infected keratinocytes enhances HIV infection of Langerhans cells (2013)
  • Author(s): Ogawa Y, Kawamura T, Matsuzawa T, Aoki R, Gee P, Yamashita A, Moriishi K, Yamasaki K, Koyanagi Y. Blauvelt A, Shimada S.
  • Journal Title: Cell Host and Microbe Volume: 13 Issue: 1 Pages: 77-86
  • DOI: 10.1016/j.chom.2012.12.002
  • Peer Reviewed
• [Journal Article] HSV-1 exploits the innate immune scavenger receptor MARCO to enhance epithelial adsorption and infection (2013)
  • Author(s): Macleod, D. T., Nakatsuji, T., Yamasaki, K., Kobzik, L., and Gallo, R. L.
  • Journal Title: Nature communications Volume: 4 Issue: 1 Pages: 1963-1963
  • DOI: 10.1038/ncomms2963
  • Peer Reviewed
• [Journal Article] Activation of epidermal toll-like receptor 2 enhances tight junction function : implications for atopic dermatitis and skin barrier repair (2013)
  • Author(s): Kuo, I. H., Carpenter-Mendini, A., Yoshida, T., McGirt, L. Y., Ivanov, A. I., Barnes, K. C., Gallo, R. L., Borkowski, A. W., Yamasaki, K., Leung, D. Y., Georas, S. N., De Benedetto, A., and Beck, L. A.
  • Journal Title: J Invest Dermatol Volume: 133 Issue: 4 Pages: 988-998
  • DOI: 10.1038/jid.2012.437
  • Peer Reviewed
• [Journal Article] Cathelicidin, kallikrein 5, and serine protease activity is inhibited during treatment of rosacea with azelaic acid 15% gel (2013)
  • Author(s): Coda, A. B., Hata, T., Miller, J., Audish, D., Kotol, P., Two, A., Shafiq, F., Yamasaki, K., Harper, J. C., Del Rosso, J. Q., and Gallo, R. L.
  • Journal Title: J Am Acad Dermatol Volume: 69 Issue: 4 Pages: 570-577
  • DOI: 10.1016/j.jaad.2013.05.019
  • Peer Reviewed
• [Journal Article] 【乾燥肌】環境とドライスキン低湿度環境が皮膚に与える影響 (2012)
  • Author(s): 菊地克子
  • Journal Title: Derma Volume: 196号 Pages: 63-67
• [Journal Article] 【乾燥肌】顔面の「乾燥肌」 (2012)
  • Author(s): 菊地克子
  • Journal Title: Derma Volume: 196号 Pages: 56-61
• [Journal Article] 【脂漏性皮膚炎を極める】脂漏性皮膚炎とスキンケア (2012)
  • Author(s): 菊地克子
  • Journal Title: Derma Volume: 195号 Pages: 55-59
• [Journal Article] 【冬場の乾燥対策とスキンケア】冬場の環境が皮膚にもたらす影響とは (2012)
  • Author(s): 菊地克子
  • Journal Title: おはよう Volume: 2123巻2号 Pages: 12-15
• [Journal Article] 【皮膚免疫学-免疫臓器としての意義と病態】皮膚疾患と自然免疫 (2012)
  • Author(s): 山崎研志
  • Journal Title: 医学のあゆみ Volume: 242 Pages: 785-790
• [Journal Article] 【皮膚科最新治療のすべて】酒さ自然免疫病態論に基づく治療 (2012)
  • Author(s): 山崎研志
  • Journal Title: Derma Pages: 26-33
• [Journal Article] 自然免疫に基づく酒さ病態論 (2012)
  • Author(s): 山崎研志
  • Journal Title: 皮膚病診療 Volume: 34 Pages: 235-240
• [Journal Article] 各科臨床のトピックス酒さの病因 自然免疫機構からみた最近の進歩 (2012)
  • Author(s): 山崎研志
  • Journal Title: 日本医師会雑誌 Volume: 140 Pages: 2144-2146
• [Journal Article] Cathelicidin antimicrobial peptide LL-37 in psoriasis enables keratinocyte reactivity against TLR9 ligands (2012)
  • Author(s): Morizane, S., Yamasaki, K., Muhleisen, B., Kotol, P. F., Murakami, M., Aoyama, Y., Iwatsuki, K., Hata, T., and Gallo, R. L.
  • Journal Title: J Invest Dermatol Volume: 132 Issue: 1 Pages: 135-143
  • DOI: 10.1038/jid.2011.259
  • Peer Reviewed
• [Journal Article] TH2 cytokines increase kallikrein 7 expression and function in patients with atopic dermatitis (2012)
  • Author(s): Morizane, S., Yamasaki, K., Kajita, A., Ikeda, K., Zhan, M., Aoyama, Y., Gallo, R. L., and Iwatsuki, K.
  • Journal Title: J Allergy Clin Immunol Volume: 130 Issue: 1 Pages: 259-261
  • DOI: 10.1016/j.jaci.2012.03.006
  • NAID: 130004505789
  • Peer Reviewed
• [Journal Article] ざ瘡と酒さの最新の知見(基礎から臨床まで)酒さの治療の今後の展開 (2011)
  • Author(s): 菊地克子
  • Journal Title: 日本皮膚科学会雑誌 Volume: 121巻13号 Pages: 2855-2857
• [Journal Article] ざ瘡と酒さの最新の知見(基礎から臨床まで)酒さの発症メカニズムとその最新知見自然免疫機構の皮膚疾患に与える影響 (2011)
  • Author(s): 山崎研志
  • Journal Title: 日本皮膚科学会雑誌 Volume: 121 Pages: 2852-2854
• [Journal Article] 抗菌ペプチド免疫反応を目覚めさせる"alarmin"としての作用 (2011)
  • Author(s): 山崎研志
  • Journal Title: 西日本皮膚科 Volume: 73 Pages: 3-7
  • NAID: 130004831753
• [Journal Article] 【最近のトピックス2011 Clinical Dermatology 2011】皮膚疾患の病態酒さをめぐる新しい病態論 (2011)
  • Author(s): 山崎研志
  • Journal Title: 臨床皮膚科 Volume: 65 Pages: 56-59
• [Journal Article] TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes (2011)
  • Author(s): Yamasaki, K., Kanada, K., Macleod, D. T., Borkowski, A. W., Morizane, S., Nakatsuji, T., Cogen, A. L., and Gallo, R. L.
  • Journal Title: J Invest Dermatol Volume: 131 Issue: 3 Pages: 688-697
  • DOI: 10.1038/jid.2010.351
  • Peer Reviewed
• [Journal Article] Rosacea as a disease of cathelicidins and skin innate immunity (2011)
  • Author(s): Yamasaki, K., and Gallo, R. L.
  • Journal Title: J Investig Dermatol Symp Proc Volume: 15 Issue: 1 Pages: 12-15
  • DOI: 10.1038/jidsymp.2011.4
  • Peer Reviewed
• [Journal Article] An in vitro test to screen skin sensitizers using a stable THP-1-derived IL-8 reporter cell line, THP-G8 (2011)
  • Author(s): Takahashi, T., Kimura, Y., Saito, R., Nakajima, Y., Ohmiya, Y., Yamasaki, K., and Aiba, S.
  • Journal Title: Toxicol Sci Volume: 124 Issue: 2 Pages: 359-369
  • DOI: 10.1093/toxsci/kfr237
  • Peer Reviewed
• [Journal Article] Exogenous addition of a C-xylopyranoside derivative stimulates keratinocyte dermatan sulfate synthesis and promotes migration (2011)
  • Author(s): Muto, J., Naidu, N. N., Yamasaki, K., Pineau, N., Breton, L., and Gallo, R. L.
  • Journal Title: PLoS One Volume: 6 Issue: 10 Pages: e25480-e25480
  • DOI: 10.1371/journal.pone.0025480
  • Peer Reviewed
• [Presentation] 皮膚のバリア機能障害と疾患乾燥肌とバリア機能 (2013)
  • Author(s): 菊地克子
  • Organizer: 第112回日本皮膚科学会総会
  • Place of Presentation: 横浜市
  • Year and Date: 2013-06-16
• [Presentation] 皮膚生理学的検査とその読み方 (2012)
  • Author(s): 菊地克子
  • Organizer: 第111回日本皮膚科学会総会
  • Place of Presentation: 京都市
  • Year and Date: 2012-06-03
• [Presentation] 酒皶治療の現状と今後の展望 (2012)
  • Author(s): 菊地克子
  • Organizer: 第111回日本皮膚科学会総会
  • Place of Presentation: 京都市
  • Year and Date: 2012-06-02
• [Book] 美肌科学の最前線「老化と皮膚生理指標の変化」 (2014)
  • Author(s): 菊地克子
  • Publisher: シーエムシー出版
• [Book] 女性の皮膚トラブルQ&A「女性の皮膚は男性とどう違う?」 (2012)
  • Author(s): 菊地克子
  • Publisher: 診断と治療社
• [Book] 思春期の皮膚トラブルQ&A「思春期皮膚トラブルとスキンケアのポイントは?」 (2012)
  • Author(s): 菊地克子
  • Publisher: 診断と治療社