The role of regulatory B cell in systemic sclerosis and cytokine-induced fibrosis models
| Project/Area Number |
23591640
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HASEGAWA Minoru 福井大学, 医学部, 教授 (50283130)
MATSUSHITA Takashi 金沢大学, 大学病院, 講師 (60432126)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | IL-10 / B細胞 / 全身性強皮症 / 制御性B細胞 |
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| Research Abstract |
Regulatory B cells that produce IL-10 are an important role for negative immune response. The frequency of regulatory B cell in PBMC from 28 systemic sclerosis patients and 24 healthy controls were examined. The frequency of regulatory B cell in PBMC was decreased in systemic sclerosis patients compared to healthy controls. Next, the role of regulatory B cell in the cytokine induced fibrosis models was examined using lack of regulatory B cell mice (CD19 deficient mice). There was no significant difference between wild type mice and CD19 deficient mice.These results suggest that decreased regulatory B cell may contribute to pathogenesis of systemic sclerosis, although regulatory B cell does not affect the development of fibrosis.
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] Autoantibodies to RuvBL1 and RuvBL2: a novel systemic sclerosis-related antibody associated with diffuse cutaneous and skeletal muscle involvement.2014
Author(s)
Kaji K, Fertig N, Medsger TA Jr, Satoh T, Hoshino K, Hamaguchi Y, Hasegawa M, Lucas M, Schnure A, Ogawa F, Sato S, Takehara K, Fujimoto M, Kuwana M.
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Journal Title
Arthritis Care Res
Volume: 66
Issue: 4
Pages: 575-84
DOI
Related Report
Peer Reviewed
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[Journal Article] A crucial role of L-selectin in C protein-induced experimental polymyositis of mice.2014
Author(s)
Oishi K, Hamaguchi Y, Matsushita T, Hasegawa M, Okiyama N, Dernedde J, Weinhart M, Haag R, Tedder TF, Takehara K, Kohsaka H, Fujimoto M.
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Journal Title
Arthritis Rheumatol.
Volume: mar 18
Issue: 7
Pages: 1864-71
DOI
Related Report
Peer Reviewed
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[Journal Article] Serum adhesion molecule levels as prognostic markers in patients with early systemic sclerosis: a multicentre, prospective, observational study.2014
Author(s)
Hasegawa M, Asano Y, Endo H, Fujimoto M, Goto D, Ihn H, Inoue K, Ishikawa O, Kawaguchi Y, Kuwana M, Ogawa F, Takahashi H, Tanaka S, Sato S, Takehara K.
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Journal Title
PLoS One.
Volume: 9
Issue: 2
Pages: e88150-e88150
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Autoantibodies to small ubiquitin-like modifier activating enzymes in Japanese patients with dermatomyositis: comparison with a UK Caucasian cohort.2013
Author(s)
Fujimoto M, Matsushita T, Hamaguchi Y, Kaji K, Asano Y, Ogawa F, Yamaoka T, Fujikawa K, Tsukada T, Sato K, Echigo T, Hasegawa M, Takehara K.
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Journal Title
Ann Rheum Dis.
Volume: 72
Pages: 151-3
Related Report
Peer Reviewed
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[Journal Article] Anti-NXP2 autoantibodies in adult patients with idiopathic inflammatory myopathies : possible association with malignancy2012
Author(s)
Ichimura Y, Matsushita T, Hamaguchi Y, Kaji K, Hasegawa M, Tanino Y, Inokoshi Y, Kawai K, Kanekura T, Habuchi M, Igarashi A, Sogame R, Hashimoto T, Koga T, Nishino A, Ishiguro N, Sugimoto N, Aoki R, Ando N, Abe T, Kanda T, Kuwana M, Takehara K, Fujimoto M
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Journal Title
Ann Rheum Dis
Volume: 71(5)
Issue: 5
Pages: 710-3
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Myositis-specific anti-155/140 autoantibodies target transcription intermediary factor 1 family proteins2012
Author(s)
Fujimoto M, Hamaguchi Y, Kaji K, Matsushita T, Ichimura Y, Kodera M, Ishiguro N, Ueda-Hayakawa I, Asano Y, Ogawa F, Fujikawa K, Miyagi T, Mabuchi E, Hirose K, Akimoto N, Hatta N, Tsutsui K, Higashi A, Igarashi A, Seishima M, Hasegawa M, Takehara K
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Journal Title
Arthritis Rheum
Volume: 64(2)
Issue: 2
Pages: 513-22
DOI
Related Report
Peer Reviewed
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[Journal Article] Investigation of prognostic factors for skin sclerosis and lung function in Japanese patients with early systemic sclerosis: a multicentre prospective observational study.2012
Author(s)
Hasegawa M, Asano Y, Endo H, Fujimoto M, Goto D, Ihn H, Inoue K, Ishikawa O, Kawaguchi Y, Kuwana M, Muro Y, Ogawa F, Sasaki T, Takahashi H, Tanaka S, Takehara K, Sato S.
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Journal Title
Rheumatology (Oxford)
Volume: 51
Issue: 1
Pages: 129-133
DOI
Related Report
Peer Reviewed
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[Journal Article] Association of UBE2L3 polymorphisms with diffuse cutaneous systemic sclerosis in a Japanese population.2012
Author(s)
Hasebe N, Kawasaki A, Ito I, Kawamoto M, Hasegawa M, Fujimoto M, Furukawa H, Tohma S, Sumida T, Takehara K, Sato S, Kawaguchi Y, Tsuchiya N.
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Journal Title
Ann Rheum Dis.
Volume: 71
Pages: 1259-60
Related Report
Peer Reviewed
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[Journal Article] Clinical correlations with dermatomyositis-specific autoantibodies in adult Japanese patients with dermatomyositis: a multicenter cross-sectional study.2011
Author(s)
Hamaguchi Y, Kuwana M, Hoshino K, Hasegawa M, Kaji K, Matsushita T, Komura K, Nakamura M, Kodera M, Suga N, Higashi A, Ogusu K, Muro Y, et al. （全37名中17番目）
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Journal Title
Arch. Dermatol.
Volume: 147
Issue: 4
Pages: 391-398
DOI
Related Report
Peer Reviewed
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